{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T21:18:19Z","timestamp":1791321499667,"version":"4.3.1"},"reference-count":93,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T00:00:00Z","timestamp":1502236800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T00:00:00Z","timestamp":1502236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["DE019629"],"award-info":[{"award-number":["DE019629"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1007\/s00223-017-0311-2","type":"journal-article","created":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T07:48:03Z","timestamp":1502264883000},"page":"457-464","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Bicarbonate Transport During Enamel Maturation"],"prefix":"10.1007","volume":"101","author":[{"given":"Kaifeng","family":"Yin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Paine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,8,9]]},"reference":[{"key":"311_CR1","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1113\/expphysiol.2005.031765","volume":"91","author":"SL Alper","year":"2006","unstructured":"Alper SL (2006) Molecular physiology of SLC4 anion exchangers. Exp Physiol 91:153\u2013161","journal-title":"Exp Physiol"},{"key":"311_CR2","doi-asserted-by":"publisher","first-page":"494","DOI":"10.1016\/j.mam.2012.07.009","volume":"34","author":"SL Alper","year":"2013","unstructured":"Alper SL, Sharma AK (2013) The SLC26 gene family of anion transporters and channels. Mol Aspects Med 34:494\u2013515","journal-title":"Mol Aspects Med"},{"key":"311_CR3","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/0030-4220(64)90509-2","volume":"17","author":"E Applebaum","year":"1964","unstructured":"Applebaum E, Zegarelli EV, Kutscher AH, Denning CR, Fahn B (1964) Discoloration of the teeth in patients with cystic fibrosis of the pancreas. Histologic studies. Oral Surg Oral Med Oral Pathol 17:366\u2013367","journal-title":"Oral Surg Oral Med Oral Pathol"},{"key":"311_CR4","doi-asserted-by":"publisher","first-page":"492","DOI":"10.1177\/154405910208100712","volume":"81","author":"CK Arquitt","year":"2002","unstructured":"Arquitt CK, Boyd C, Wright JT (2002) Cystic fibrosis transmembrane regulator gene (CFTR) is associated with abnormal enamel formation. J Dent Res 81:492\u2013496","journal-title":"J Dent Res"},{"key":"311_CR5","first-page":"159","volume":"73","author":"TD Azevedo","year":"2006","unstructured":"Azevedo TD, Feijo GC, Bezerra AC (2006) Presence of developmental defects of enamel in cystic fibrosis patients. J Dent Child 73:159\u2013163","journal-title":"J Dent Child"},{"key":"311_CR6","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1002\/hep.25691","volume":"56","author":"JM Banales","year":"2012","unstructured":"Banales JM, Saez E, Uriz M, Sarvide S, Urribarri AD, Splinter P, Tietz Bogert PS, Bujanda L, Prieto J, Medina JF, LaRusso NF (2012) Up-regulation of microRNA 506 leads to decreased Cl\u2212\/HCO3\n                           \u2212 anion exchanger 2 expression in biliary epithelium of patients with primary biliary cirrhosis. Hepatology 56:687\u2013697","journal-title":"Hepatology"},{"key":"311_CR7","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1177\/0022034515625939","volume":"95","author":"E Bori","year":"2016","unstructured":"Bori E, Guo J, Racz R, Burghardt B, Foldes A, Keremi B, Harada H, Steward MC, Den Besten P, Bronckers AL, Varga G (2016) Evidence for bicarbonate secretion by ameloblasts in a novel cellular model. J Dent Res 95:588\u2013596","journal-title":"J Dent Res"},{"key":"311_CR8","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1016\/j.bone.2009.12.002","volume":"46","author":"A Bronckers","year":"2010","unstructured":"Bronckers A, Kalogeraki L, Jorna HJ, Wilke M, Bervoets TJ, Lyaruu DM, Zandieh-Doulabi B, Denbesten P, de Jonge H (2010) The cystic fibrosis transmembrane conductance regulator (CFTR) is expressed in maturation stage ameloblasts, odontoblasts and bone cells. Bone 46:1188\u20131196","journal-title":"Bone"},{"key":"311_CR9","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1177\/0022034516681768","volume":"96","author":"AL Bronckers","year":"2017","unstructured":"Bronckers AL (2017) Ion transport by ameloblasts during amelogenesis. J Dent Res 96:243\u2013253","journal-title":"J Dent Res"},{"issue":"Suppl 1","key":"311_CR10","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1111\/j.1600-0722.2011.00901.x","volume":"119","author":"AL Bronckers","year":"2011","unstructured":"Bronckers AL, Guo J, Zandieh-Doulabi B, Bervoets TJ, Lyaruu DM, Li X, Wangemann P, DenBesten P (2011) Developmental expression of solute carrier family 26A member 4 (SLC26A4\/pendrin) during amelogenesis in developing rodent teeth. Eur J Oral Sci 119(Suppl 1):185\u2013192","journal-title":"Eur J Oral Sci"},{"key":"311_CR11","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1111\/eos.12163","volume":"123","author":"AL Bronckers","year":"2015","unstructured":"Bronckers AL, Lyaruu DM, Guo J, Bijvelds MJ, Bervoets TJ, Zandieh-Doulabi B, Medina JF, Li Z, Zhang Y, DenBesten PK (2015) Composition of mineralizing incisor enamel in cystic fibrosis transmembrane conductance regulator-deficient mice. Eur J Oral Sci 123:9\u201316","journal-title":"Eur J Oral Sci"},{"key":"311_CR12","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1002\/jez.b.21267","volume":"312B","author":"AL Bronckers","year":"2009","unstructured":"Bronckers AL, Lyaruu DM, Jansen ID, Medina JF, Kellokumpu S, Hoeben KA, Gawenis LR, Oude-Elferink RP, Everts V (2009) Localization and function of the anion exchanger Ae2 in developing teeth and orofacial bone in rodents. J Exp Zool B Mol Dev Evol 312B:375\u2013387","journal-title":"J Exp Zool B Mol Dev Evol"},{"key":"311_CR13","doi-asserted-by":"publisher","first-page":"1693","DOI":"10.1172\/JCI119694","volume":"100","author":"LJ Bruce","year":"1997","unstructured":"Bruce LJ, Cope DL, Jones GK, Schofield AE, Burley M, Povey S, Unwin RJ, Wrong O, Tanner MJ (1997) Familial distal renal tubular acidosis is associated with mutations in the red cell anion exchanger (Band 3, AE1) gene. J Clin Invest 100:1693\u20131707","journal-title":"J Clin Invest"},{"key":"311_CR14","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1177\/0022034510369304","volume":"89","author":"H Cao","year":"2010","unstructured":"Cao H, Wang J, Li X, Florez S, Huang Z, Venugopalan SR, Elangovan S, Skobe Z, Margolis HC, Martin JF, Amendt BA (2010) MicroRNAs play a critical role in tooth development. J Dent Res 89:779\u2013784","journal-title":"J Dent Res"},{"key":"311_CR15","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1159\/000324248","volume":"194","author":"EH Chang","year":"2011","unstructured":"Chang EH, Lacruz RS, Bromage TG, Bringas P Jr, Welsh MJ, Zabner J, Paine ML (2011) Enamel pathology resulting from loss of function in the cystic fibrosis transmembrane conductance regulator in a porcine animal model. Cells Tissues Organs 194:249\u2013254","journal-title":"Cells Tissues Organs"},{"key":"311_CR16","first-page":"343","volume":"90","author":"WR Chegwidden","year":"2000","unstructured":"Chegwidden WR, Dodgson SJ, Spencer IM (2000) The roles of carbonic anhydrase in metabolism, cell growth and cancer in animals. EXS 90:343\u2013363","journal-title":"EXS"},{"key":"311_CR17","doi-asserted-by":"publisher","first-page":"774","DOI":"10.1126\/science.1375392","volume":"256","author":"FS Collins","year":"1992","unstructured":"Collins FS (1992) Cystic fibrosis: molecular biology and therapeutic implications. Science 256:774\u2013779","journal-title":"Science"},{"key":"311_CR18","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1007\/BF02991422","volume":"30","author":"FT Cua","year":"1991","unstructured":"Cua FT (1991) Calcium and phosphorous in teeth from children with and without cystic fibrosis. Biol Trace Elem Res 30:277\u2013289","journal-title":"Biol Trace Elem Res"},{"key":"311_CR19","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1172\/JCI31474","volume":"120","author":"PA Dawson","year":"2010","unstructured":"Dawson PA, Russell CS, Lee S, McLeay SC, van Dongen JM, Cowley DM, Clarke LA, Markovich D (2010) Urolithiasis and hepatotoxicity are linked to the anion transporter Sat1 in mice. J Clin Invest 120:706\u2013712","journal-title":"J Clin Invest"},{"key":"311_CR20","doi-asserted-by":"publisher","first-page":"52238","DOI":"10.1074\/jbc.M406591200","volume":"279","author":"D Dinour","year":"2004","unstructured":"Dinour D, Chang MH, Satoh J, Smith BL, Angle N, Knecht A, Serban I, Holtzman EJ, Romero MF (2004) A novel missense mutation in the sodium bicarbonate cotransporter (NBCe1\/SLC4A4) causes proximal tubular acidosis and glaucoma through ion transport defects. J Biol Chem 279:52238\u201352246","journal-title":"J Biol Chem"},{"key":"311_CR21","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1177\/00220345830620070201","volume":"62","author":"AA Dogterom","year":"1983","unstructured":"Dogterom AA, Bronckers AL (1983) Carbonic anhydrase in developing hamster molars. J Dent Res 62:789\u2013791","journal-title":"J Dent Res"},{"key":"311_CR22","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1177\/0022034513507066","volume":"93","author":"X Duan","year":"2014","unstructured":"Duan X (2014) Ion channels, channelopathies, and tooth formation. J Dent Res 93:117\u2013125","journal-title":"J Dent Res"},{"key":"311_CR23","doi-asserted-by":"publisher","first-page":"175","DOI":"10.1177\/0022034510385687","volume":"90","author":"X Duan","year":"2011","unstructured":"Duan X, Mao Y, Wen X, Yang T, Xue Y (2011) Excess fluoride interferes with chloride-channel-dependent endocytosis in ameloblasts. J Dent Res 90:175\u2013180","journal-title":"J Dent Res"},{"key":"311_CR24","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1007\/s100480050043","volume":"1","author":"DD Einum","year":"1998","unstructured":"Einum DD, Zhang J, Arneson PJ, Menon AG, Ptacek LJ (1998) Genomic structure of human anion exchanger 3 and its potential role in hereditary neurological disease. Neurogenetics 1:289\u2013292","journal-title":"Neurogenetics"},{"key":"311_CR25","doi-asserted-by":"publisher","first-page":"2875","DOI":"10.1128\/MCB.01266-14","volume":"35","author":"Y Fan","year":"2015","unstructured":"Fan Y, Zhou Y, Zhou X, Sun F, Gao B, Wan M, Zhou X, Sun J, Xu X, Cheng L, Crane J, Zheng L (2015) MicroRNA 224 regulates ion transporter expression in ameloblasts to coordinate enamel mineralization. Mol Cell Biol 35:2875\u20132890","journal-title":"Mol Cell Biol"},{"key":"311_CR26","doi-asserted-by":"publisher","first-page":"G719","DOI":"10.1152\/ajpgi.00481.2005","volume":"290","author":"RW Freel","year":"2006","unstructured":"Freel RW, Hatch M, Green M, Soleimani M (2006) Ileal oxalate absorption and urinary oxalate excretion are enhanced in Slc26a6 null mice. Am J Physiol Gastrointest Liver Physiol 290:G719\u2013G728","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"311_CR27","doi-asserted-by":"publisher","first-page":"622","DOI":"10.1177\/00220345840630050301","volume":"63","author":"PR Garant","year":"1984","unstructured":"Garant PR, Nagy A, Cho MI (1984) A freeze-fracture study of ruffle-ended post-secretory ameloblasts. J Dent Res 63:622\u2013628","journal-title":"J Dent Res"},{"key":"311_CR28","doi-asserted-by":"publisher","first-page":"9042","DOI":"10.1074\/jbc.M607041200","volume":"282","author":"LR Gawenis","year":"2007","unstructured":"Gawenis LR, Bradford EM, Prasad V, Lorenz JN, Simpson JE, Clarke LL, Woo AL, Grisham C, Sanford LP, Doetschman T, Miller ML, Shull GE (2007) Colonic anion secretory defects and metabolic acidosis in mice lacking the NBC1 Na+\/HCO3\n                           \u2212 cotransporter. J Biol Chem 282:9042\u20139052","journal-title":"J Biol Chem"},{"key":"311_CR29","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1016\/0092-8674(94)90281-X","volume":"78","author":"J Hastbacka","year":"1994","unstructured":"Hastbacka J, de la Chapelle A, Mahtani MM, Clines G, Reeve-Daly MP, Daly M, Hamilton BA, Kusumi K, Trivedi B, Weaver A et al (1994) The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping. Cell 78:1073\u20131087","journal-title":"Cell"},{"key":"311_CR30","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1038\/ng1196-316","volume":"14","author":"P Hoglund","year":"1996","unstructured":"Hoglund P, Haila S, Socha J, Tomaszewski L, Saarialho-Kere U, Karjalainen-Lindsberg ML, Airola K, Holmberg C, de la Chapelle A, Kere J (1996) Mutations of the down-regulated in adenoma (DRA) gene cause congenital chloride diarrhoea. Nat Genet 14:316\u2013319","journal-title":"Nat Genet"},{"key":"311_CR31","doi-asserted-by":"publisher","first-page":"437","DOI":"10.1177\/10454411000110040401","volume":"11","author":"MJ Hubbard","year":"2000","unstructured":"Hubbard MJ (2000) Calcium transport across the dental enamel epithelium. Crit Rev Oral Biol Med 11:437\u2013466","journal-title":"Crit Rev Oral Biol Med"},{"key":"311_CR32","doi-asserted-by":"publisher","first-page":"438","DOI":"10.1007\/s00424-004-1278-1","volume":"448","author":"J Inatomi","year":"2004","unstructured":"Inatomi J, Horita S, Braverman N, Sekine T, Yamada H, Suzuki Y, Kawahara K, Moriyama N, Kudo A, Kawakami H, Shimadzu M, Endou H, Fujita T, Seki G, Igarashi T (2004) Mutational and functional analysis of SLC4A4 in a patient with proximal renal tubular acidosis. Pflugers Arch 448:438\u2013444","journal-title":"Pflugers Arch"},{"key":"311_CR33","doi-asserted-by":"publisher","first-page":"991","DOI":"10.1177\/00220345760550065101","volume":"55","author":"AE Jagels","year":"1976","unstructured":"Jagels AE, Sweeney EA (1976) Oral health of patients with cystic fibrosis and their siblings. J Dent Res 55:991\u2013996","journal-title":"J Dent Res"},{"key":"311_CR34","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1007\/s00441-014-1935-4","volume":"358","author":"R Jalali","year":"2014","unstructured":"Jalali R, Guo J, Zandieh-Doulabi B, Bervoets TJ, Paine ML, Boron WF, Parker MD, Bijvelds MJ, Medina JF, DenBesten PK, Bronckers AL (2014) NBCe1 (SLC4A4) a potential pH regulator in enamel organ cells during enamel development in the mouse. Cell Tissue Res 358:433\u2013442","journal-title":"Cell Tissue Res"},{"key":"311_CR35","doi-asserted-by":"publisher","first-page":"1732","DOI":"10.1177\/0022034515606873","volume":"94","author":"R Jalali","year":"2015","unstructured":"Jalali R, Zandieh-Doulabi B, DenBesten PK, Seidler U, Riederer B, Wedenoja S, Micha D, Bronckers AL (2015) Slc26a3\/Dra and Slc26a6 in murine ameloblasts. J Dent Res 94:1732\u20131739","journal-title":"J Dent Res"},{"key":"311_CR36","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1172\/JCI116935","volume":"93","author":"P Jarolim","year":"1994","unstructured":"Jarolim P, Rubin HL, Liu SC, Cho MR, Brabec V, Derick LH, Yi SJ, Saad ST, Alper S, Brugnara C et al (1994) Duplication of 10 nucleotides in the erythroid band 3 (AE1) gene in a kindred with hereditary spherocytosis and band 3 protein deficiency (band 3PRAGUE). J Clin Invest 93:121\u2013130","journal-title":"J Clin Invest"},{"key":"311_CR37","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1038\/ng1762","volume":"38","author":"Z Jiang","year":"2006","unstructured":"Jiang Z, Asplin JR, Evan AP, Rajendran VM, Velazquez H, Nottoli TP, Binder HJ, Aronson PS (2006) Calcium oxalate urolithiasis in mice lacking anion transporter Slc26a6. Nat Genet 38:474\u2013478","journal-title":"Nat Genet"},{"key":"311_CR38","first-page":"45","volume":"124","author":"K Josephsen","year":"1977","unstructured":"Josephsen K, Fejerskov O (1977) Ameloblast modulation in the maturation zone of the rat incisor enamel organ. A light and electron microscopic study. J Anat 124:45\u201370","journal-title":"J Anat"},{"key":"311_CR39","doi-asserted-by":"publisher","first-page":"C1299","DOI":"10.1152\/ajpcell.00218.2010","volume":"299","author":"K Josephsen","year":"2010","unstructured":"Josephsen K, Takano Y, Frische S, Praetorius J, Nielsen S, Aoba T, Fejerskov O (2010) Ion transporters in secretory and cyclically modulating ameloblasts: a new hypothesis for cellular control of preeruptive enamel maturation. Am J Physiol Cell Physiol 299:C1299\u2013C1307","journal-title":"Am J Physiol Cell Physiol"},{"key":"311_CR40","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1016\/0304-4165(95)00145-X","volume":"1289","author":"M Kakei","year":"1996","unstructured":"Kakei M, Nakahara H (1996) Aspects of carbonic anhydrase and carbonate content during mineralization of the rat enamel. Biochim Biophys Acta 1289:226\u2013230","journal-title":"Biochim Biophys Acta"},{"key":"311_CR41","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ceca.2017.03.006","volume":"65","author":"RS Lacruz","year":"2017","unstructured":"Lacruz RS (2017) Enamel: molecular identity of its transepithelial ion transport system. Cell Calcium 65:1\u20137","journal-title":"Cell Calcium"},{"key":"311_CR42","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1002\/jbmr.1779","volume":"28","author":"RS Lacruz","year":"2013","unstructured":"Lacruz RS, Brookes SJ, Wen X, Jimenez JM, Vikman S, Hu P, White SN, Lyngstadaas SP, Okamoto CT, Smith CE, Paine ML (2013) Adaptor protein complex 2-mediated, clathrin-dependent endocytosis, and related gene activities, are a prominent feature during maturation stage amelogenesis. J Bone Miner Res 28:672\u2013687","journal-title":"J Bone Miner Res"},{"key":"311_CR43","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1152\/physrev.00030.2016","volume":"97","author":"RS Lacruz","year":"2017","unstructured":"Lacruz RS, Habelitz S, Wright JT, Paine ML (2017) Dental enamel formation and implications for oral health and disease. Physiol Rev 97:939\u2013993","journal-title":"Physiol Rev"},{"key":"311_CR44","doi-asserted-by":"publisher","first-page":"883","DOI":"10.1016\/j.bbrc.2010.02.116","volume":"393","author":"RS Lacruz","year":"2010","unstructured":"Lacruz RS, Hilvo M, Kurtz I, Paine ML (2010) A survey of carbonic anhydrase mRNA expression in enamel cells. Biochem Biophys Res Commun 393:883\u2013887","journal-title":"Biochem Biophys Res Commun"},{"key":"311_CR45","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1007\/s00223-009-9326-7","volume":"86","author":"RS Lacruz","year":"2010","unstructured":"Lacruz RS, Nanci A, Kurtz I, Wright JT, Paine ML (2010) Regulation of pH during amelogenesis. Calcif Tissue Int 86:91\u2013103","journal-title":"Calcif Tissue Int"},{"key":"311_CR46","doi-asserted-by":"publisher","first-page":"24432","DOI":"10.1074\/jbc.M110.115188","volume":"285","author":"RS Lacruz","year":"2010","unstructured":"Lacruz RS, Nanci A, White SN, Wen X, Wang H, Zalzal SF, Luong VQ, Schuetter VL, Conti PS, Kurtz I, Paine ML (2010) The sodium bicarbonate cotransporter (NBCe1) is essential for normal development of mouse dentition. J Biol Chem 285:24432\u201324438","journal-title":"J Biol Chem"},{"key":"311_CR47","doi-asserted-by":"publisher","first-page":"2264","DOI":"10.1002\/jcp.22965","volume":"227","author":"RS Lacruz","year":"2012","unstructured":"Lacruz RS, Smith CE, Bringas P Jr, Chen YB, Smith SM, Snead ML, Kurtz I, Hacia JG, Hubbard MJ, Paine ML (2012) Identification of novel candidate genes involved in mineralization of dental enamel by genome-wide transcript profiling. J Cell Physiol 227:2264\u20132275","journal-title":"J Cell Physiol"},{"issue":"Suppl 1","key":"311_CR48","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1111\/j.1600-0722.2011.00881.x","volume":"119","author":"RS Lacruz","year":"2011","unstructured":"Lacruz RS, Smith CE, Chen YB, Hubbard MJ, Hacia JG, Paine ML (2011) Gene-expression analysis of early- and late-maturation-stage rat enamel organ. Eur J Oral Sci 119(Suppl 1):149\u2013157","journal-title":"Eur J Oral Sci"},{"key":"311_CR49","doi-asserted-by":"publisher","first-page":"122","DOI":"10.1177\/0022034512470954","volume":"92","author":"RS Lacruz","year":"2013","unstructured":"Lacruz RS, Smith CE, Kurtz I, Hubbard MJ, Paine ML (2013) New paradigms on the transport functions of maturation-stage ameloblasts. J Dent Res 92:122\u2013129","journal-title":"J Dent Res"},{"key":"311_CR50","doi-asserted-by":"publisher","first-page":"1776","DOI":"10.1002\/jcp.22911","volume":"227","author":"RS Lacruz","year":"2012","unstructured":"Lacruz RS, Smith CE, Moffatt P, Chang EH, Bromage TG, Bringas P Jr, Nanci A, Baniwal SK, Zabner J, Welsh MJ, Kurtz I, Paine ML (2012) Requirements for ion and solute transport, and pH regulation during enamel maturation. J Cell Physiol 227:1776\u20131785","journal-title":"J Cell Physiol"},{"key":"311_CR51","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/0888-7543(95)80097-6","volume":"26","author":"M Lagerstrom-Fermer","year":"1995","unstructured":"Lagerstrom-Fermer M, Nilsson M, Backman B, Salido E, Shapiro L, Pettersson U, Landegren U (1995) Amelogenin signal peptide mutation: correlation between mutations in the amelogenin gene (AMGX) and manifestations of X-linked amelogenesis imperfecta. Genomics 26:159\u2013162","journal-title":"Genomics"},{"key":"311_CR52","doi-asserted-by":"publisher","first-page":"e52256","DOI":"10.1371\/journal.pone.0052256","volume":"7","author":"A Li","year":"2012","unstructured":"Li A, Song T, Wang F, Liu D, Fan Z, Zhang C, He J, Wang S (2012) MicroRNAome and expression profile of developing tooth germ in miniature pigs. PLoS ONE 7:e52256","journal-title":"PLoS ONE"},{"key":"311_CR53","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1007\/BF00310167","volume":"55","author":"HM Lin","year":"1994","unstructured":"Lin HM, Nakamura H, Noda T, Ozawa H (1994) Localization of H(+)-ATPase and carbonic anhydrase II in ameloblasts at maturation. Calcif Tissue Int 55:38\u201345","journal-title":"Calcif Tissue Int"},{"key":"311_CR54","doi-asserted-by":"publisher","first-page":"9261","DOI":"10.1074\/jbc.M112.433730","volume":"288","author":"H Liu","year":"2013","unstructured":"Liu H, Lin H, Zhang L, Sun Q, Yuan G, Zhang L, Chen S, Chen Z (2013) miR-145 and miR-143 regulate odontoblast differentiation through targeting Klf4 and Osx genes in a feedback loop. J Biol Chem 288:9261\u20139271","journal-title":"J Biol Chem"},{"key":"311_CR55","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.matbio.2007.09.006","volume":"27","author":"DM Lyaruu","year":"2008","unstructured":"Lyaruu DM, Bronckers AL, Mulder L, Mardones P, Medina JF, Kellokumpu S, Oude Elferink RP, Everts V (2008) The anion exchanger Ae2 is required for enamel maturation in mouse teeth. Matrix Biol 27:119\u2013127","journal-title":"Matrix Biol"},{"key":"311_CR56","first-page":"F364","volume":"232","author":"GE Lyman","year":"1977","unstructured":"Lyman GE, Waddell WJ (1977) pH gradients in the developing teeth of young mice from autoradiography of [14C]DMO. Am J Physiol 232:F364\u2013F367","journal-title":"Am J Physiol"},{"key":"311_CR57","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1002\/hep.510250104","volume":"25","author":"JF Medina","year":"1997","unstructured":"Medina JF, Martinez A, Vazquez JJ, Prieto J (1997) Decreased anion exchanger 2 immunoreactivity in the liver of patients with primary biliary cirrhosis. Hepatology 25:12\u201317","journal-title":"Hepatology"},{"key":"311_CR58","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1002\/bdra.20787","volume":"91","author":"F Michon","year":"2011","unstructured":"Michon F (2011) Tooth evolution and dental defects: from genetic regulation network to micro-RNA fine-tuning. Birth Defects Res A 91:763\u2013769","journal-title":"Birth Defects Res A"},{"key":"311_CR59","volume-title":"Ten Cate\u2019s oral histology development, structure and function","author":"A Nanci","year":"2008","unstructured":"Nanci A (2008) Ten Cate\u2019s oral histology development, structure and function. Mosby Elsevier, St Louis"},{"key":"311_CR60","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1177\/154405910808700415","volume":"87","author":"ML Paine","year":"2008","unstructured":"Paine ML, Snead ML, Wang HJ, Abuladze N, Pushkin A, Liu W, Kao LY, Wall SM, Kim YH, Kurtz I (2008) Role of NBCe1 and AE2 in secretory ameloblasts. J Dent Res 87:391\u2013395","journal-title":"J Dent Res"},{"key":"311_CR61","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1113\/jphysiol.2005.102590","volume":"571","author":"P Pan","year":"2006","unstructured":"Pan P, Leppilampi M, Pastorekova S, Pastorek J, Waheed A, Sly WS, Parkkila S (2006) Carbonic anhydrase gene expression in CA II-deficient (Car2\u2212\/\u2212) and CA IX-deficient (Car9\u2212\/\u2212) mice. J Physiol 571:319\u2013327","journal-title":"J Physiol"},{"key":"311_CR62","doi-asserted-by":"publisher","first-page":"620","DOI":"10.1053\/j.gastro.2010.04.004","volume":"139","author":"HW Park","year":"2010","unstructured":"Park HW, Nam JH, Kim JY, Namkung W, Yoon JS, Lee JS, Kim KS, Venglovecz V, Gray MA, Kim KH, Lee MG (2010) Dynamic regulation of CFTR bicarbonate permeability by [Cl\u2212]i and its role in pancreatic bicarbonate secretion. Gastroenterology 139:620\u2013631","journal-title":"Gastroenterology"},{"key":"311_CR63","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1080\/14756360410001689540","volume":"19","author":"S Pastorekova","year":"2004","unstructured":"Pastorekova S, Parkkila S, Pastorek J, Supuran CT (2004) Carbonic anhydrases: current state of the art, therapeutic applications and future prospects. J Enzyme Inhib Med Chem 19:199\u2013229","journal-title":"J Enzyme Inhib Med Chem"},{"key":"311_CR64","doi-asserted-by":"publisher","first-page":"F161","DOI":"10.1152\/ajprenal.00219.2003","volume":"286","author":"S Petrovic","year":"2004","unstructured":"Petrovic S, Barone S, Xu J, Conforti L, Ma L, Kujala M, Kere J, Soleimani M (2004) SLC26A7: a basolateral Cl\u2212\/HCO3\n                           \u2212 exchanger specific to intercalated cells of the outer medullary collecting duct. Am J Physiol Renal Physiol 286:F161\u2013F169","journal-title":"Am J Physiol Renal Physiol"},{"key":"311_CR65","doi-asserted-by":"publisher","first-page":"G1093","DOI":"10.1152\/ajpgi.00454.2002","volume":"284","author":"S Petrovic","year":"2003","unstructured":"Petrovic S, Ju X, Barone S, Seidler U, Alper SL, Lohi H, Kere J, Soleimani M (2003) Identification of a basolateral Cl\u2212\/HCO3\n                           \u2212 exchanger specific to gastric parietal cells. Am J Physiol Gastrointest Liver Physiol 284:G1093\u2013G1103","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"311_CR66","doi-asserted-by":"publisher","first-page":"C608","DOI":"10.1152\/ajpcell.00084.2003","volume":"285","author":"S Petrovic","year":"2003","unstructured":"Petrovic S, Ma L, Wang Z, Soleimani M (2003) Identification of an apical Cl\u2212\/HCO3\n                           \u2212 exchanger in rat kidney proximal tubule. Am J Physiol Cell Physiol 285:C608\u2013C617","journal-title":"Am J Physiol Cell Physiol"},{"key":"311_CR67","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1016\/j.mam.2012.10.008","volume":"34","author":"MF Romero","year":"2013","unstructured":"Romero MF, Chen AP, Parker MD, Boron WF (2013) The SLC4 family of bicarbonate (HCO(3)(\u2212)) transporters. Mol Aspects Med 34:159\u2013182","journal-title":"Mol Aspects Med"},{"key":"311_CR68","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1016\/0003-9969(91)90090-H","volume":"36","author":"S Sasaki","year":"1991","unstructured":"Sasaki S, Takagi T, Suzuki M (1991) Cyclical changes in pH in bovine developing enamel as sequential bands. Arch Oral Biol 36:227\u2013231","journal-title":"Arch Oral Biol"},{"key":"311_CR69","doi-asserted-by":"publisher","first-page":"244","DOI":"10.1007\/s00018-006-6429-4","volume":"64","author":"JL Shapiro","year":"2007","unstructured":"Shapiro JL, Wen X, Okamoto CT, Wang HJ, Lyngstadaas SP, Goldberg M, Snead ML, Paine ML (2007) Cellular uptake of amelogenin, and its localization to CD63, and Lamp1-positive vesicles. Cell Mol Life Sci 64:244\u2013256","journal-title":"Cell Mol Life Sci"},{"key":"311_CR70","doi-asserted-by":"publisher","first-page":"424","DOI":"10.1038\/ng0496-424","volume":"12","author":"VC Sheffield","year":"1996","unstructured":"Sheffield VC, Kraiem Z, Beck JC, Nishimura D, Stone EM, Salameh M, Sadeh O, Glaser B (1996) Pendred syndrome maps to chromosome 7q21-34 and is caused by an intrinsic defect in thyroid iodine organification. Nat Genet 12:424\u2013426","journal-title":"Nat Genet"},{"key":"311_CR71","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1177\/10454411950060020701","volume":"6","author":"JP Simmer","year":"1995","unstructured":"Simmer JP, Fincham AG (1995) Molecular mechanisms of dental enamel formation. Crit Rev Oral Biol Med 6:84\u2013108","journal-title":"Crit Rev Oral Biol Med"},{"key":"311_CR72","doi-asserted-by":"publisher","first-page":"1396","DOI":"10.1177\/00220345880670110701","volume":"67","author":"Z Skobe","year":"1988","unstructured":"Skobe Z, Prostak KS, Stern DN (1988) A scanning electron microscope study of monkey maturation-stage ameloblasts. J Dent Res 67:1396\u20131401","journal-title":"J Dent Res"},{"key":"311_CR73","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1146\/annurev.bi.64.070195.002111","volume":"64","author":"WS Sly","year":"1995","unstructured":"Sly WS, Hu PY (1995) Human carbonic anhydrases and carbonic anhydrase deficiencies. Annu Rev Biochem 64:375\u2013401","journal-title":"Annu Rev Biochem"},{"key":"311_CR74","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1177\/10454411980090020101","volume":"9","author":"CE Smith","year":"1998","unstructured":"Smith CE (1998) Cellular and chemical events during enamel maturation. Crit Rev Oral Biol Med 9:128\u2013161","journal-title":"Crit Rev Oral Biol Med"},{"key":"311_CR75","doi-asserted-by":"publisher","first-page":"159","DOI":"10.1177\/08959374960100020701","volume":"10","author":"CE Smith","year":"1996","unstructured":"Smith CE, Issid M, Margolis HC, Moreno EC (1996) Developmental changes in the pH of enamel fluid and its effects on matrix-resident proteinases. Adv Dent Res 10:159\u2013169","journal-title":"Adv Dent Res"},{"key":"311_CR76","first-page":"153","volume":"39","author":"CE Smith","year":"1995","unstructured":"Smith CE, Nanci A (1995) Overview of morphological changes in enamel organ cells associated with major events in amelogenesis. Int J Dev Biol 39:153\u2013161","journal-title":"Int J Dev Biol"},{"key":"311_CR77","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1002\/(SICI)1097-0185(199606)245:2<186::AID-AR7>3.0.CO;2-V","volume":"245","author":"CE Smith","year":"1996","unstructured":"Smith CE, Nanci A (1996) Protein dynamics of amelogenesis. Anat Rec 245:186\u2013207","journal-title":"Anat Rec"},{"issue":"Suppl 1","key":"311_CR78","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1111\/j.1600-0722.2006.00273.x","volume":"114","author":"CE Smith","year":"2006","unstructured":"Smith CE, Nanci A, Moffatt P (2006) Evidence by signal peptide trap technology for the expression of carbonic anhydrase 6 in rat incisor enamel organs. Eur J Oral Sci 114(Suppl 1):147\u2013153","journal-title":"Eur J Oral Sci"},{"key":"311_CR79","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1177\/00220345880670100501","volume":"67","author":"T Sugimoto","year":"1988","unstructured":"Sugimoto T, Ogawa Y, Kuwahara H, Shimazaki M, Yagi T, Sakai A (1988) Histochemical demonstration of carbonic anhydrase activity in the odontogenic cells of the rat incisor. J Dent Res 67:1271\u20131274","journal-title":"J Dent Res"},{"key":"311_CR80","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1177\/154405910308200512","volume":"82","author":"W Sui","year":"2003","unstructured":"Sui W, Boyd C, Wright JT (2003) Altered pH regulation during enamel development in the cystic fibrosis mouse incisor. J Dent Res 82:388\u2013392","journal-title":"J Dent Res"},{"key":"311_CR81","doi-asserted-by":"publisher","first-page":"603","DOI":"10.2174\/138161208783877884","volume":"14","author":"CT Supuran","year":"2008","unstructured":"Supuran CT (2008) Carbonic anhydrases\u2013an overview. Curr Pharm Des 14:603\u2013614","journal-title":"Curr Pharm Des"},{"key":"311_CR82","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1038\/nrd2467","volume":"7","author":"CT Supuran","year":"2008","unstructured":"Supuran CT (2008) Carbonic anhydrases: novel therapeutic applications for inhibitors and activators. Nat Rev Drug Discov 7:168\u2013181","journal-title":"Nat Rev Drug Discov"},{"key":"311_CR83","doi-asserted-by":"publisher","first-page":"127","DOI":"10.3109\/03008209509016992","volume":"33","author":"Y Takano","year":"1995","unstructured":"Takano Y (1995) Enamel mineralization and the role of ameloblasts in calcium transport. Connect Tissue Res 33:127\u2013137","journal-title":"Connect Tissue Res"},{"key":"311_CR84","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.jcf.2008.10.004","volume":"8","author":"L Tang","year":"2009","unstructured":"Tang L, Fatehi M, Linsdell P (2009) Mechanism of direct bicarbonate transport by the CFTR anion channel. J Cyst Fibros 8:115\u2013121","journal-title":"J Cyst Fibros"},{"key":"311_CR85","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1007\/s004410050639","volume":"285","author":"S Toyosawa","year":"1996","unstructured":"Toyosawa S, Ogawa Y, Inagaki T, Ijuhin N (1996) Immunohistochemical localization of carbonic anhydrase isozyme II in rat incisor epithelial cells at various stages of amelogenesis. Cell Tissue Res 285:217\u2013225","journal-title":"Cell Tissue Res"},{"key":"311_CR86","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1177\/08959374960100022501","volume":"10","author":"JT Wright","year":"1996","unstructured":"Wright JT, Hall KI, Grubb BR (1996) Enamel mineral composition of normal and cystic fibrosis transgenic mice. Adv Dent Res 10:270\u2013274","journal-title":"Adv Dent Res"},{"key":"311_CR87","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1177\/00220345960750041101","volume":"75","author":"JT Wright","year":"1996","unstructured":"Wright JT, Kiefer CL, Hall KI, Grubb BR (1996) Abnormal enamel development in a cystic fibrosis transgenic mouse model. J Dent Res 75:966\u2013973","journal-title":"J Dent Res"},{"key":"311_CR88","doi-asserted-by":"publisher","first-page":"29470","DOI":"10.1074\/jbc.M109.044396","volume":"284","author":"J Xu","year":"2009","unstructured":"Xu J, Song P, Nakamura S, Miller M, Barone S, Alper SL, Riederer B, Bonhagen J, Arend LJ, Amlal H, Seidler U, Soleimani M (2009) Deletion of the chloride transporter slc26a7 causes distal renal tubular acidosis and impairs gastric acid secretion. J Biol Chem 284:29470\u201329479","journal-title":"J Biol Chem"},{"key":"311_CR89","doi-asserted-by":"publisher","first-page":"307","DOI":"10.3389\/fphys.2017.00307","volume":"8","author":"K Yin","year":"2017","unstructured":"Yin K, Guo J, Lin W, Robertson SYT, Soleimani M, Paine ML (2017) Deletion of Slc26a1 and Slc26a7 delays enamel mineralization in mice. Front Physiol 8:307","journal-title":"Front Physiol"},{"key":"311_CR90","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1186\/1471-2164-15-998","volume":"15","author":"K Yin","year":"2014","unstructured":"Yin K, Hacia JG, Zhong Z, Paine ML (2014) Genome-wide analysis of miRNA and mRNA transcriptomes during amelogenesis. BMC Genomics 15:998","journal-title":"BMC Genomics"},{"key":"311_CR91","doi-asserted-by":"publisher","first-page":"e0144703","DOI":"10.1371\/journal.pone.0144703","volume":"10","author":"K Yin","year":"2015","unstructured":"Yin K, Lei Y, Wen X, Lacruz RS, Soleimani M, Kurtz I, Snead ML, White SN, Paine ML (2015) SLC26A gene family participate in pH regulation during enamel maturation. PLoS ONE 10:e0144703","journal-title":"PLoS ONE"},{"key":"311_CR92","doi-asserted-by":"publisher","first-page":"44118","DOI":"10.1038\/srep44118","volume":"7","author":"K Yin","year":"2017","unstructured":"Yin K, Lin W, Guo J, Sugiyama T, Snead ML, Hacia JG, Paine ML (2017) MiR-153 regulates amelogenesis by targeting endocytotic and endosomal\/lysosomal pathways-novel insight into the origins of enamel pathologies. Sci Rep 7:44118","journal-title":"Sci Rep"},{"key":"311_CR93","doi-asserted-by":"publisher","first-page":"682","DOI":"10.1007\/BF02237725","volume":"9","author":"EV Zegarelli","year":"1964","unstructured":"Zegarelli EV, Kutscher AH, Denning CR, Applebaum E, Fahn BS, Hoffman PJ, Botwick JT, Ragosta JM (1964) Discoloration of the teeth in older children with cystic fibrosis of the pancreas. Am J Dig Dis 9:682\u2013683","journal-title":"Am J Dig Dis"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00223-017-0311-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-017-0311-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-017-0311-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,17]],"date-time":"2020-05-17T01:30:45Z","timestamp":1589679045000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00223-017-0311-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,9]]},"references-count":93,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["311"],"URL":"https:\/\/doi.org\/10.1007\/s00223-017-0311-2","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"value":"0171-967X","type":"print"},{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,9]]},"assertion":[{"value":"26 June 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"27 July 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 August 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"Kaifeng Yin and Michael L. Paine declare that they have no conflicts of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}