{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T12:31:06Z","timestamp":1789648266508,"version":"4.0.0"},"reference-count":92,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T00:00:00Z","timestamp":1512345600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100000341","name":"Arthritis Research UK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000341","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DFG","award":["HA 8163\/1-1"],"award-info":[{"award-number":["HA 8163\/1-1"]}]},{"name":"IMI-BTCure","award":["115142"],"award-info":[{"award-number":["115142"]}]},{"name":"Elsbeth-Bonhoff Stiftung","award":["Projekt 170"],"award-info":[{"award-number":["Projekt 170"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1007\/s00223-017-0370-4","type":"journal-article","created":{"date-parts":[[2017,12,4]],"date-time":"2017-12-04T16:01:24Z","timestamp":1512403284000},"page":"522-532","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The Role of Autoantibodies in Bone Metabolism and Bone Loss"],"prefix":"10.1007","volume":"102","author":[{"given":"Barbara","family":"Hauser","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2934-3202","authenticated-orcid":false,"given":"Ulrike","family":"Harre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,12,4]]},"reference":[{"key":"370_CR1","doi-asserted-by":"crossref","DOI":"10.1002\/9781118453926","volume-title":"Primer on the metabolic bone diseases and disorders of mineral metabolism","author":"C Rosen","year":"2013","unstructured":"Rosen C, Bouillon R, Compston JE, Rosen V (2013) Primer on the metabolic bone diseases and disorders of mineral metabolism. 8th\u00a0edn, Wiley, Hoboken","edition":"8"},{"key":"370_CR2","doi-asserted-by":"crossref","first-page":"234250","DOI":"10.1038\/nrd3669","volume":"11","author":"K Redlich","year":"2012","unstructured":"Redlich K, Smolen JS (2012) Inflammatory bone loss: pathogenesis and therapeutic intervention. Nat Rev Drug Discov 11 234\u2013250","journal-title":"Nat Rev Drug Discov"},{"key":"370_CR3","doi-asserted-by":"crossref","first-page":"224230","DOI":"10.1007\/s11926-012-0252-8","volume":"14","author":"IE Bultink","year":"2012","unstructured":"Bultink IE, Vis M, van der Horst-Bruinsma IE, Lems WF (2012) Inflammatory rheumatic disorders and bone. Curr Rheumatol Rep 14:224\u2013230","journal-title":"Curr Rheumatol Rep"},{"key":"370_CR4","doi-asserted-by":"crossref","first-page":"465471","DOI":"10.1007\/s00223-001-2131-6","volume":"71","author":"ML Bianchi","year":"2002","unstructured":"Bianchi ML, Bardella MT (2002) Bone and celiac disease. Calcif Tissue Int 71:465\u2013471","journal-title":"Calcif Tissue Int"},{"key":"370_CR5","first-page":"160171","volume":"15","author":"SL Nutt","year":"2015","unstructured":"Nutt SL, Hodgkin PD, Tarlinton DM, Corcoran LM (2015) The generation of antibody-secreting plasma cells. Nat Rev Immunol 15:160\u2013171","journal-title":"Nat Rev Immunol"},{"key":"370_CR6","volume-title":"Davidson\u2019s principles and practice of medicine","author":"R Brian","year":"2014","unstructured":"Brian R, Walker NRC, Stuart H, Ralston, Penman I (2014) Davidson\u2019s principles and practice of medicine. 22 edn Elsevier, Amsterdam","edition":"22"},{"key":"370_CR7","doi-asserted-by":"crossref","first-page":"201206","DOI":"10.1097\/00002281-199805000-00008","volume":"10","author":"JS Smolen","year":"1998","unstructured":"Smolen JS, Steiner G (1998) Are autoantibodies active players or epiphenomena? Curr Opin Rheumatol 10:201\u2013206","journal-title":"Curr Opin Rheumatol"},{"key":"370_CR8","doi-asserted-by":"crossref","first-page":"22052219","DOI":"10.1056\/NEJMra1004965","volume":"365","author":"IB McInnes","year":"2011","unstructured":"McInnes IB, Schett G (2011) The pathogenesis of rheumatoid arthritis. N Engl J Med 365:2205\u20132219","journal-title":"N Engl J Med"},{"key":"370_CR9","first-page":"522530","volume":"43","author":"G Haugeberg","year":"2000","unstructured":"Haugeberg G, Uhlig T, Falch JA, Halse JI, Kvien TK (2000) Bone mineral density and frequency of osteoporosis in female patients with rheumatoid arthritis: results from 394 patients in the Oslo County Rheumatoid Arthritis register. Arthritis Rheum 43:522\u2013530","journal-title":"Arthritis Rheum"},{"key":"370_CR10","doi-asserted-by":"crossref","first-page":"17591766","DOI":"10.1093\/rheumatology\/keu162","volume":"53","author":"B Hauser","year":"2014","unstructured":"Hauser B, Riches PL, Wilson JF, Horne AE, Ralston SH (2014) Prevalence and clinical prediction of osteoporosis in a contemporary cohort of patients with rheumatoid arthritis. Rheumatology 53:1759\u20131766","journal-title":"Rheumatology"},{"key":"370_CR11","first-page":"31043112","volume":"54","author":"TP Staa van","year":"2006","unstructured":"van Staa TP, Geusens P, Bijlsma JW, Leufkens HG, Cooper C (2006) Clinical assessment of the long-term risk of fracture in patients with rheumatoid arthritis. Arthritis Rheum 54:3104\u20133112","journal-title":"Arthritis Rheum"},{"key":"370_CR12","first-page":"3946","volume":"70","author":"PP Tak","year":"2011","unstructured":"Tak PP, Rigby WF, Rubbert-Roth A, Peterfy CG, van Vollenhoven RF, Stohl W, Hessey E, Chen A, Tyrrell H, Shaw TM (2011) Inhibition of joint damage and improved clinical outcomes with rituximab plus methotrexate in early active rheumatoid arthritis: the IMAGE trial. Ann Rheum Dis 70:39\u201346","journal-title":"Ann Rheum Dis"},{"key":"370_CR13","doi-asserted-by":"crossref","first-page":"351358","DOI":"10.1097\/BOR.0b013e3283534df4","volume":"24","author":"C Ambarus","year":"2012","unstructured":"Ambarus C, Yeremenko N, Tak PP, Baeten D (2012) Pathogenesis of spondyloarthritis: autoimmune or autoinflammatory? Curr Opin Rheumatol 24:351\u2013358","journal-title":"Curr Opin Rheumatol"},{"key":"370_CR14","doi-asserted-by":"crossref","first-page":"12111214","DOI":"10.1136\/annrheumdis-2012-202208","volume":"73","author":"NT Baerlecken","year":"2014","unstructured":"Baerlecken NT, Nothdorft S, Stummvoll GH, Sieper J, Rudwaleit M, Reuter S, Matthias T, Schmidt RE, Witte T (2014) Autoantibodies against CD74 in spondyloarthritis. Ann Rheum Dis 73:1211\u20131214","journal-title":"Ann Rheum Dis"},{"key":"370_CR15","first-page":"18731879","volume":"73","author":"FW Tsui","year":"2014","unstructured":"Tsui FW, Tsui HW, Las Heras F, Pritzker KP, Inman RD (2014) Serum levels of novel noggin and sclerostin-immune complexes are elevated in ankylosing spondylitis. Ann Rheum Dis 73:1873\u20131879","journal-title":"Ann Rheum Dis"},{"key":"370_CR16","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-017-0291-2","author":"B Hauser","year":"2017","unstructured":"Hauser B, Zhao S, Visconti MR, Riches PL, Fraser WD, Piec I, Goodson NJ, Ralston SH (2017) Autoantibodies to osteoprotegerin are associated with low hip bone mineral density and history of fractures in axial spondyloarthritis: a cross-sectional observational study. Calcif Tissue Int. https:\/\/doi.org\/10.1007\/s00223-017-0291-2","journal-title":"Calcif Tissue Int"},{"key":"370_CR17","doi-asserted-by":"crossref","first-page":"13791390","DOI":"10.1016\/S0140-6736(07)60635-7","volume":"369","author":"J Braun","year":"2007","unstructured":"Braun J, Sieper J (2007) Ankylosing spondylitis. Lancet 369:1379\u20131390","journal-title":"Lancet"},{"key":"370_CR18","doi-asserted-by":"crossref","first-page":"117121","DOI":"10.1136\/ard.53.2.117","volume":"53","author":"S Donnelly","year":"1994","unstructured":"Donnelly S, Doyle DV, Denton A, Rolfe I, McCloskey EV, Spector TD (1994) Bone mineral density and vertebral compression fracture rates in ankylosing spondylitis. Ann Rheum Dis 53:117\u2013121","journal-title":"Ann Rheum Dis"},{"key":"370_CR19","doi-asserted-by":"crossref","first-page":"563565","DOI":"10.1136\/bmj.300.6724.563","volume":"300","author":"SH Ralston","year":"1990","unstructured":"Ralston SH, Urquhart GD, Brzeski M, Sturrock RD (1990) Prevalence of vertebral compression fractures due to osteoporosis in ankylosing spondylitis. BMJ 300:563\u2013565","journal-title":"BMJ"},{"key":"370_CR20","first-page":"16831690","volume":"23","author":"MA Weijden van der","year":"2012","unstructured":"van der Weijden MA, van der Horst-Bruinsma IE, van Denderen JC, Dijkmans BA, Heymans MW, Lems WF (2012) High frequency of vertebral fractures in early spondylarthropathies. Osteoporos Int 23:1683\u20131690","journal-title":"Osteoporos Int"},{"key":"370_CR21","first-page":"304305","volume":"74","author":"D Wendling","year":"2007","unstructured":"Wendling D, Cedoz JP, Racadot E, Dumoulin G (2007) Serum IL-17, BMP-7, and bone turnover markers in patients with ankylosing spondylitis. Joint Bone Spine 74:304\u2013305","journal-title":"Joint Bone Spine"},{"key":"370_CR22","doi-asserted-by":"crossref","first-page":"24192426","DOI":"10.1056\/NEJMcp1113994","volume":"367","author":"A Fasano","year":"2012","unstructured":"Fasano A, Catassi C (2012) Clinical practice. Celiac disease. N Engl J Med 367:2419\u20132426","journal-title":"N Engl J Med"},{"key":"370_CR23","doi-asserted-by":"crossref","first-page":"5663","DOI":"10.1007\/s00198-004-1641-2","volume":"16","author":"M Pazianas","year":"2005","unstructured":"Pazianas M, Butcher GP, Subhani JM, Finch PJ, Ang L, Collins C, Heaney RP, Zaidi M, Maxwell JD (2005) Calcium absorption and bone mineral density in celiacs after long term treatment with gluten-free diet and adequate calcium intake. Osteoporos Int 16:56\u201363","journal-title":"Osteoporos Int"},{"key":"370_CR24","doi-asserted-by":"crossref","first-page":"125133","DOI":"10.1007\/s00223-015-0023-4","volume":"97","author":"A Real","year":"2015","unstructured":"Real A, Gilbert N, Hauser B, Kennedy N, Shand A, Gillett H, Gillett P, Goddard C, Cebolla A, Sousa C, Fraser WD, Satsangi J, Ralston SH, Riches PL (2015) Characterisation of osteoprotegerin autoantibodies in coeliac disease. Calcif Tissue Int 97:125\u2013133","journal-title":"Calcif Tissue Int"},{"key":"370_CR25","doi-asserted-by":"crossref","first-page":"14591465","DOI":"10.1056\/NEJMoa0810925","volume":"361","author":"PL Riches","year":"2009","unstructured":"Riches PL, McRorie E, Fraser WD, Determann C, van\u2019t Hof R, Ralston SH (2009) Osteoporosis associated with neutralizing autoantibodies against osteoprotegerin. N Engl J Med 361:1459\u20131465","journal-title":"N Engl J Med"},{"key":"370_CR26","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1016\/j.imlet.2017.05.010","volume":"189","author":"B Nakken","year":"2017","unstructured":"Nakken B, Papp G, Bosnes V, Zeher M, Nagy G, Szodoray P (2017) Biomarkers for rheumatoid arthritis: from molecular processes to diagnostic applications-current concepts and future perspectives. Immunol Lett 189:13\u201318","journal-title":"Immunol Lett"},{"key":"370_CR27","doi-asserted-by":"crossref","first-page":"431436","DOI":"10.1016\/j.jbspin.2012.01.008","volume":"79","author":"Z Baka","year":"2012","unstructured":"Baka Z, Gyorgy B, Geher P, Buzas EI, Falus A, Nagy G (2012) Citrullination under physiological and pathological conditions. Joint Bone Spine 79:431\u2013436","journal-title":"Joint Bone Spine"},{"key":"370_CR28","doi-asserted-by":"crossref","first-page":"302305","DOI":"10.1136\/ard.23.4.302","volume":"23","author":"RL Nienhuis","year":"1964","unstructured":"Nienhuis RL, Mandema E (1964) A new serum factor in patients with rheumatoid arthritis; the antiperinuclear factor. Ann Rheum Dis 23:302\u2013305","journal-title":"Ann Rheum Dis"},{"key":"370_CR29","doi-asserted-by":"crossref","first-page":"493502","DOI":"10.1016\/j.jbspin.2004.07.004","volume":"71","author":"M Sebbag","year":"2004","unstructured":"Sebbag M, Chapuy-Regaud S, Auger I, Petit-Texeira E, Clavel C, Nogueira L, Vincent C, Cornelis F, Roudier J, Serre G (2004) Clinical and pathophysiological significance of the autoimmune response to citrullinated proteins in rheumatoid arthritis. Joint Bone Spine 71:493\u2013502","journal-title":"Joint Bone Spine"},{"key":"370_CR30","first-page":"492873","volume":"2014","author":"AN Burska","year":"2014","unstructured":"Burska AN, Hunt L, Boissinot M, Strollo R, Ryan BJ, Vital E, Nissim A, Winyard PG, Emery P, Ponchel F (2014) Autoantibodies to posttranslational modifications in rheumatoid arthritis. Mediat Inflamm 2014:492873","journal-title":"Mediat Inflamm"},{"key":"370_CR31","doi-asserted-by":"crossref","first-page":"15801588","DOI":"10.1136\/ard.2010.138461","volume":"69","author":"D Aletaha","year":"2010","unstructured":"Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO, 3rd, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD, Combe B, Costenbader KH, Dougados M, Emery P, Ferraccioli G, Hazes JM, Hobbs K, Huizinga TW, Kavanaugh A, Kay J, Kvien TK, Laing T, Mease P, Menard HA, Moreland LW, Naden RL, Pincus T, Smolen JS, Stanislawska-Biernat E, Symmons D, Tak PP, Upchurch KS, Vencovsky J, Wolfe F, Hawker G (2010) 2010 rheumatoid arthritis classification criteria: an American College of Rheumatology\/European League Against Rheumatism collaborative initiative. Ann Rheum Dis 69:1580\u20131588","journal-title":"Ann Rheum Dis"},{"key":"370_CR32","doi-asserted-by":"crossref","first-page":"155163","DOI":"10.1002\/1529-0131(200001)43:1<155::AID-ANR20>3.0.CO;2-3","volume":"43","author":"GA Schellekens","year":"2000","unstructured":"Schellekens GA, Visser H, de Jong BA, van den Hoogen FH, Hazes JM, Breedveld FC, van Venrooij WJ (2000) The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide. Arthritis Rheum 43:155\u2013163","journal-title":"Arthritis Rheum"},{"key":"370_CR33","doi-asserted-by":"crossref","first-page":"728610","DOI":"10.1155\/2015\/728610","volume":"2015","author":"AA Jilani","year":"2015","unstructured":"Jilani AA, Mackworth-Young CG (2015) The role of citrullinated protein antibodies in predicting erosive disease in rheumatoid arthritis: a systematic literature review and meta-analysis. Int J Rheumatol 2015:728610","journal-title":"Int J Rheumatol"},{"key":"370_CR34","doi-asserted-by":"crossref","first-page":"3846","DOI":"10.1002\/art.21575","volume":"54","author":"L Klareskog","year":"2006","unstructured":"Klareskog L, Stolt P, Lundberg K, Kallberg H, Bengtsson C, Grunewald J, Ronnelid J, Harris HE, Ulfgren AK, Rantapaa-Dahlqvist S, Eklund A, Padyukov L, Alfredsson L (2006) A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope)-restricted immune reactions to autoantigens modified by citrullination. Arthritis Rheum 54:38\u201346","journal-title":"Arthritis Rheum"},{"key":"370_CR35","doi-asserted-by":"crossref","first-page":"15871593","DOI":"10.1136\/ard.2003.017574","volume":"63","author":"L Rycke De","year":"2004","unstructured":"De Rycke L, Peene I, Hoffman IE, Kruithof E, Union A, Meheus L, Lebeer K, Wyns B, Vincent C, Mielants H, Boullart L, Serre G, Veys EM, De Keyser F (2004) Rheumatoid factor and anticitrullinated protein antibodies in rheumatoid arthritis: diagnostic value, associations with radiological progression rate, and extra-articular manifestations. Ann Rheum Dis 63:1587\u20131593","journal-title":"Ann Rheum Dis"},{"key":"370_CR36","first-page":"342349","volume":"46","author":"KP Machold","year":"2007","unstructured":"Machold KP, Stamm TA, Nell VP, Pflugbeil S, Aletaha D, Steiner G, Uffmann M, Smolen JS (2007) Very recent onset rheumatoid arthritis: clinical and serological patient characteristics associated with radiographic progression over the first years of disease. Rheumatology 46:342\u2013349","journal-title":"Rheumatology"},{"key":"370_CR37","first-page":"15541561","volume":"69","author":"D Woude van der","year":"2010","unstructured":"van der Woude D, Rantapaa-Dahlqvist S, Ioan-Facsinay A, Onnekink C, Schwarte CM, Verpoort KN, Drijfhout JW, Huizinga TW, Toes RE, Pruijn GJ (2010) Epitope spreading of the anti-citrullinated protein antibody response occurs before disease onset and is associated with the disease course of early arthritis. Ann Rheum Dis 69:1554\u20131561","journal-title":"Ann Rheum Dis"},{"key":"370_CR38","doi-asserted-by":"crossref","first-page":"899910","DOI":"10.1002\/art.37835","volume":"65","author":"M Brink","year":"2013","unstructured":"Brink M, Hansson M, Mathsson L, Jakobsson PJ, Holmdahl R, Hallmans G, Stenlund H, Ronnelid J, Klareskog L, Rantapaa-Dahlqvist S (2013) Multiplex analyses of antibodies against citrullinated peptides in individuals prior to development of rheumatoid arthritis. Arthritis Rheum 65:899\u2013910","journal-title":"Arthritis Rheum"},{"key":"370_CR39","doi-asserted-by":"crossref","first-page":"234241","DOI":"10.1136\/annrheumdis-2013-203565","volume":"74","author":"Y Rombouts","year":"2015","unstructured":"Rombouts Y, Ewing E, van de Stadt LA, Selman MH, Trouw LA, Deelder AM, Huizinga TW, Wuhrer M, van Schaardenburg D, Toes RE, Scherer HU (2015) Anti-citrullinated protein antibodies acquire a pro-inflammatory Fc glycosylation phenotype prior to the onset of rheumatoid arthritis. Ann Rheum Dis 74:234\u2013241","journal-title":"Ann Rheum Dis"},{"key":"370_CR40","doi-asserted-by":"crossref","first-page":"14611464","DOI":"10.1136\/ard.2010.146506","volume":"70","author":"HU Scherer","year":"2011","unstructured":"Scherer HU, van der Woude D, Willemze A, Trouw LA, Knevel R, Syversen SW, van der Linden MP, Lie B, Huizinga TW, van der Heijde DM, van der Helm-van Mil AH, Kvien TK, Toes RE (2011) Distinct ACPA fine specificities, formed under the influence of HLA shared epitope alleles, have no effect on radiographic joint damage in rheumatoid arthritis. Ann Rheum Dis 70:1461\u20131464","journal-title":"Ann Rheum Dis"},{"key":"370_CR41","doi-asserted-by":"crossref","first-page":"R140","DOI":"10.1186\/ar4322","volume":"15","author":"JJ Beers van","year":"2013","unstructured":"van Beers JJ, Willemze A, Jansen JJ, Engbers GH, Salden M, Raats J, Drijfhout JW, van der Helm-van Mil AH, Toes RE, Pruijn GJ (2013) ACPA fine-specificity profiles in early rheumatoid arthritis patients do not correlate with clinical features at baseline or with disease progression. Arthritis Res Ther 15:R140","journal-title":"Arthritis Res Ther"},{"key":"370_CR42","doi-asserted-by":"crossref","first-page":"356361","DOI":"10.1136\/annrheumdis-2014-205698","volume":"75","author":"A Kastbom","year":"2016","unstructured":"Kastbom A, Forslind K, Ernestam S, Geborek P, Karlsson JA, Petersson IF, Saevarsdottir S, Klareskog L, van Vollenhoven RF, Lundberg K (2016) Changes in the anticitrullinated peptide antibody response in relation to therapeutic outcome in early rheumatoid arthritis: results from the SWEFOT trial. Ann Rheum Dis 75:356\u2013361","journal-title":"Ann Rheum Dis"},{"key":"370_CR43","first-page":"1737217377","volume":"108","author":"J Shi","year":"2011","unstructured":"Shi J, Knevel R, Suwannalai P, van der Linden MP, Janssen GM, van Veelen PA, Levarht NE, van der Helm-van Mil AH, Cerami A, Huizinga TW, Toes RE, Trouw LA (2011) Autoantibodies recognizing carbamylated proteins are present in sera of patients with rheumatoid arthritis and predict joint damage. Proc Natl Acad Sci USA 108:17372\u201317377","journal-title":"Proc Natl Acad Sci USA"},{"key":"370_CR44","doi-asserted-by":"crossref","first-page":"823827","DOI":"10.1056\/NEJM198104023041406","volume":"304","author":"R Fluckiger","year":"1981","unstructured":"Fluckiger R, Harmon W, Meier W, Loo S, Gabbay KH (1981) Hemoglobin carbamylation in uremia. N Engl J Med 304:823\u2013827","journal-title":"N Engl J Med"},{"key":"370_CR45","doi-asserted-by":"crossref","first-page":"11761183","DOI":"10.1136\/annrheumdis-2016-210059","volume":"76","author":"C Ospelt","year":"2017","unstructured":"Ospelt C, Bang H, Feist E, Camici GG, Keller S, Detert J, Kramer A, Gay S, Ghannam K, Burmester GR (2017) Carbamylation of vimentin is inducible by smoking and represents an independent autoantigen in rheumatoid arthritis. Ann Rheum Dis 76:1176\u20131183","journal-title":"Ann Rheum Dis"},{"key":"370_CR46","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1700502","author":"JS Dekkers","year":"2017","unstructured":"Dekkers JS, Verheul MK, Stoop JN, Liu B, Ioan-Facsinay A, van Veelen PA, de Ru AH, Janssen GMC, Hegen M, Rapecki S, Huizinga TWJ, Trouw LA, Toes REM (2017) Breach of autoreactive B cell tolerance by post-translationally modified proteins. Ann Rheum Dis. https:\/\/doi.org\/10.4049\/jimmunol.1700502","journal-title":"Ann Rheum Dis"},{"key":"370_CR47","doi-asserted-by":"crossref","first-page":"49","DOI":"10.5114\/reum.2017.66680","volume":"55","author":"S Kumar","year":"2017","unstructured":"Kumar S, Pangtey G, Gupta R, Rehan HS, Gupta LK (2017) Assessment of anti-CarP antibodies, disease activity and quality of life in rheumatoid arthritis patients on conventional and biological disease-modifying antirheumatic drugs. Reumatologia 55:4\u20139","journal-title":"Reumatologia"},{"key":"370_CR48","doi-asserted-by":"crossref","first-page":"17911802","DOI":"10.1172\/JCI60975","volume":"122","author":"U Harre","year":"2012","unstructured":"Harre U, Georgess D, Bang H, Bozec A, Axmann R, Ossipova E, Jakobsson PJ, Baum W, Nimmerjahn F, Szarka E, Sarmay G, Krumbholz G, Neumann E, Toes R, Scherer HU, Catrina AI, Klareskog L, Jurdic P, Schett G (2012) Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin. J Clin Invest 122:1791\u20131802","journal-title":"J Clin Invest"},{"key":"370_CR49","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1007\/s00223-017-0253-8","volume":"101","author":"G Orsolini","year":"2017","unstructured":"Orsolini G, Caimmi C, Viapiana O, Idolazzi L, Fracassi E, Gatti D, Adami G, Rossini M (2017) Titer-dependent effect of anti-citrullinated protein antibodies on systemic bone mass in rheumatoid arthritis patients. Calcif Tissue Int 101:17\u201323","journal-title":"Calcif Tissue Int"},{"key":"370_CR50","doi-asserted-by":"crossref","first-page":"799806","DOI":"10.1007\/s00296-017-3674-9","volume":"37","author":"I Llorente","year":"2017","unstructured":"Llorente I, Merino L, Ortiz AM, Escolano E, Gonzalez-Ortega S, Garcia-Vicuna R, Garcia-Vadillo JA, Castaneda S, Gonzalez-Alvaro I (2017) Anti-citrullinated protein antibodies are associated with decreased bone mineral density: baseline data from a register of early arthritis patients. Rheumatol Int 37:799\u2013806","journal-title":"Rheumatol Int"},{"key":"370_CR51","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1186\/s13075-016-1116-9","volume":"18","author":"S Bugatti","year":"2016","unstructured":"Bugatti S, Bogliolo L, Vitolo B, Manzo A, Montecucco C, Caporali R (2016) Anti-citrullinated protein antibodies and high levels of rheumatoid factor are associated with systemic bone loss in patients with early untreated rheumatoid arthritis. Arthritis Res Ther 18:226","journal-title":"Arthritis Res Ther"},{"key":"370_CR52","first-page":"854860","volume":"73","author":"A Kleyer","year":"2014","unstructured":"Kleyer A, Finzel S, Rech J, Manger B, Krieter M, Faustini F, Araujo E, Hueber AJ, Harre U, Engelke K, Schett G (2014) Bone loss before the clinical onset of rheumatoid arthritis in subjects with anticitrullinated protein antibodies. Ann Rheum Dis 73:854\u2013860","journal-title":"Ann Rheum Dis"},{"key":"370_CR53","doi-asserted-by":"crossref","first-page":"21512156","DOI":"10.1136\/annrheumdis-2014-205428","volume":"74","author":"C Hecht","year":"2015","unstructured":"Hecht C, Englbrecht M, Rech J, Schmidt S, Araujo E, Engelke K, Finzel S, Schett G (2015) Additive effect of anti-citrullinated protein antibodies and rheumatoid factor on bone erosions in patients with RA. Ann Rheum Dis 74:2151\u20132156","journal-title":"Ann Rheum Dis"},{"key":"370_CR54","doi-asserted-by":"crossref","first-page":"16811691","DOI":"10.1002\/jbmr.3158","volume":"32","author":"C Engdahl","year":"2017","unstructured":"Engdahl C, Bang H, Dietel K, Lang SC, Harre U, Schett G (2017) Periarticular bone loss in arthritis is induced by autoantibodies against citrullinated vimentin. J Bone Miner Res 32:1681\u20131691","journal-title":"J Bone Miner Res"},{"key":"370_CR55","first-page":"721729","volume":"75","author":"A Krishnamurthy","year":"2016","unstructured":"Krishnamurthy A, Joshua V, Haj Hensvold A, Jin T, Sun M, Vivar N, Ytterberg AJ, Engstrom M, Fernandes-Cerqueira C, Amara K, Magnusson M, Wigerblad G, Kato J, Jimenez-Andrade JM, Tyson K, Rapecki S, Lundberg K, Catrina SB, Jakobsson PJ, Svensson C, Malmstrom V, Klareskog L, Wahamaa H, Catrina AI (2016) Identification of a novel chemokine-dependent molecular mechanism underlying rheumatoid arthritis-associated autoantibody-mediated bone loss. Ann Rheum Dis 75:721\u2013729","journal-title":"Ann Rheum Dis"},{"key":"370_CR56","doi-asserted-by":"crossref","first-page":"R132","DOI":"10.1186\/ar3070","volume":"12","author":"K Steendam Van","year":"2010","unstructured":"Van Steendam K, Tilleman K, De Ceuleneer M, De Keyser F, Elewaut D, Deforce D (2010) Citrullinated vimentin as an important antigen in immune complexes from synovial fluid of rheumatoid arthritis patients with antibodies against citrullinated proteins. Arthritis Res Ther 12:R132","journal-title":"Arthritis Res Ther"},{"key":"370_CR57","doi-asserted-by":"crossref","first-page":"R64","DOI":"10.1186\/ar1926","volume":"8","author":"L Mathsson","year":"2006","unstructured":"Mathsson L, Lampa J, Mullazehi M, Ronnelid J (2006) Immune complexes from rheumatoid arthritis synovial fluid induce FcgammaRIIa dependent and rheumatoid factor correlated production of tumour necrosis factor-alpha by peripheral blood mononuclear cells. Arthritis Res Ther 8:R64","journal-title":"Arthritis Res Ther"},{"key":"370_CR58","doi-asserted-by":"crossref","first-page":"678688","DOI":"10.1002\/art.23284","volume":"58","author":"C Clavel","year":"2008","unstructured":"Clavel C, Nogueira L, Laurent L, Iobagiu C, Vincent C, Sebbag M, Serre G (2008) Induction of macrophage secretion of tumor necrosis factor alpha through Fcgamma receptor IIa engagement by rheumatoid arthritis-specific autoantibodies to citrullinated proteins complexed with fibrinogen. Arthritis Rheum 58:678\u2013688","journal-title":"Arthritis Rheum"},{"key":"370_CR59","doi-asserted-by":"crossref","first-page":"656664","DOI":"10.1038\/nrrheum.2012.153","volume":"8","author":"G Schett","year":"2012","unstructured":"Schett G, Gravallese E (2012) Bone erosion in rheumatoid arthritis: mechanisms, diagnosis and treatment. Nat Rev Rheumatol 8:656\u2013664","journal-title":"Nat Rev Rheumatol"},{"key":"370_CR60","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1186\/ar3380","volume":"13","author":"T Braun","year":"2011","unstructured":"Braun T, Zwerina J (2011) Positive regulators of osteoclastogenesis and bone resorption in rheumatoid arthritis. Arthritis Res Ther 13:235","journal-title":"Arthritis Res Ther"},{"key":"370_CR61","doi-asserted-by":"crossref","first-page":"355363","DOI":"10.1007\/s00281-017-0634-0","volume":"39","author":"U Harre","year":"2017","unstructured":"Harre U, Schett G (2017) Cellular and molecular pathways of structural damage in rheumatoid arthritis. Semin Immunopathol 39:355\u2013363","journal-title":"Semin Immunopathol"},{"key":"370_CR62","doi-asserted-by":"crossref","first-page":"612619","DOI":"10.3109\/08916934.2012.719950","volume":"45","author":"U Harre","year":"2012","unstructured":"Harre U, Keppeler H, Ipseiz N, Derer A, Poller K, Aigner M, Schett G, Herrmann M, Lauber K (2012) Moonlighting osteoclasts as undertakers of apoptotic cells. Autoimmunity 45:612\u2013619","journal-title":"Autoimmunity"},{"key":"370_CR63","doi-asserted-by":"crossref","first-page":"1072910734","DOI":"10.1073\/pnas.1301001110","volume":"110","author":"M Seeling","year":"2013","unstructured":"Seeling M, Hillenhoff U, David JP, Schett G, Tuckermann J, Lux A, Nimmerjahn F (2013) Inflammatory monocytes and Fcgamma receptor IV on osteoclasts are critical for bone destruction during inflammatory arthritis in mice. Proc Natl Acad Sci USA 110:10729\u201310734","journal-title":"Proc Natl Acad Sci USA"},{"key":"370_CR64","doi-asserted-by":"crossref","first-page":"3447","DOI":"10.1038\/nri2206","volume":"8","author":"F Nimmerjahn","year":"2008","unstructured":"Nimmerjahn F, Ravetch JV (2008) Fcgamma receptors as regulators of immune responses. Nat Rev Immunol 8:34\u201347","journal-title":"Nat Rev Immunol"},{"key":"370_CR65","doi-asserted-by":"crossref","first-page":"117123","DOI":"10.1111\/j.1749-6632.2009.05303.x","volume":"1192","author":"H Takayanagi","year":"2010","unstructured":"Takayanagi H (2010) New immune connections in osteoclast formation. Ann N Y Acad Sci 1192:117\u2013123","journal-title":"Ann N Y Acad Sci"},{"key":"370_CR66","doi-asserted-by":"crossref","first-page":"6651","DOI":"10.1038\/ncomms7651","volume":"6","author":"U Harre","year":"2015","unstructured":"Harre U, Lang SC, Pfeifle R, Rombouts Y, Fruhbeisser S, Amara K, Bang H, Lux A, Koeleman CA, Baum W, Dietel K, Grohn F, Malmstrom V, Klareskog L, Kronke G, Kocijan R, Nimmerjahn F, Toes RE, Herrmann M, Scherer HU, Schett G (2015) Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss. Nat Commun 6:6651","journal-title":"Nat Commun"},{"key":"370_CR67","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1146\/annurev.immunol.25.022106.141702","volume":"25","author":"JN Arnold","year":"2007","unstructured":"Arnold JN, Wormald MR, Sim RB, Rudd PM, Dwek RA (2007) The impact of glycosylation on the biological function and structure of human immunoglobulins. Annu Rev Immunol 25:21\u201350","journal-title":"Annu Rev Immunol"},{"key":"370_CR68","doi-asserted-by":"crossref","first-page":"443453","DOI":"10.1007\/s00281-012-0308-x","volume":"34","author":"S Bohm","year":"2012","unstructured":"Bohm S, Schwab I, Lux A, Nimmerjahn F (2012) The role of sialic acid as a modulator of the anti-inflammatory activity of IgG. Semin Immunopathol 34:443\u2013453","journal-title":"Semin Immunopathol"},{"key":"370_CR69","first-page":"1957119578","volume":"105","author":"RM Anthony","year":"2008","unstructured":"Anthony RM, Wermeling F, Karlsson MC, Ravetch JV (2008) Identification of a receptor required for the anti-inflammatory activity of IVIG. Proc Natl Acad Sci USA 105:19571\u201319578","journal-title":"Proc Natl Acad Sci USA"},{"key":"370_CR70","doi-asserted-by":"crossref","first-page":"853863","DOI":"10.1016\/j.jaci.2013.09.029","volume":"133","author":"AH Massoud","year":"2014","unstructured":"Massoud AH, Yona M, Xue D, Chouiali F, Alturaihi H, Ablona A, Mourad W, Piccirillo CA, Mazer BD (2014) Dendritic cell immunoreceptor: a novel receptor for intravenous immunoglobulin mediates induction of regulatory T cells. J Allergy Clin Immunol 133:853\u2013863","journal-title":"J Allergy Clin Immunol"},{"key":"370_CR71","doi-asserted-by":"crossref","first-page":"15241534","DOI":"10.1016\/j.molimm.2006.09.005","volume":"44","author":"BJ Scallon","year":"2007","unstructured":"Scallon BJ, Tam SH, McCarthy SG, Cai AN, Raju TS (2007) Higher levels of sialylated Fc glycans in immunoglobulin G molecules can adversely impact functionality. Mol Immunol 44:1524\u20131534","journal-title":"Mol Immunol"},{"key":"370_CR72","doi-asserted-by":"crossref","first-page":"16201629","DOI":"10.1002\/art.27414","volume":"62","author":"HU Scherer","year":"2010","unstructured":"Scherer HU, van der Woude D, Ioan-Facsinay A, el Bannoudi H, Trouw LA, Wang J, Haupl T, Burmester GR, Deelder AM, Huizinga TW, Wuhrer M, Toes RE (2010) Glycan profiling of anti-citrullinated protein antibodies isolated from human serum and synovial fluid. Arthritis Rheum 62:1620\u20131629","journal-title":"Arthritis Rheum"},{"key":"370_CR73","doi-asserted-by":"crossref","first-page":"R13","DOI":"10.1186\/ar3237","volume":"13","author":"H Kokkonen","year":"2011","unstructured":"Kokkonen H, Mullazehi M, Berglin E, Hallmans G, Wadell G, Ronnelid J, Rantapaa-Dahlqvist S (2011) Antibodies of IgG, IgA and IgM isotypes against cyclic citrullinated peptide precede the development of rheumatoid arthritis. Arthritis Res Ther 13:R13","journal-title":"Arthritis Res Ther"},{"key":"370_CR74","doi-asserted-by":"crossref","first-page":"13231328","DOI":"10.1002\/art.33489","volume":"64","author":"P Suwannalai","year":"2012","unstructured":"Suwannalai P, van de Stadt LA, Radner H, Steiner G, El-Gabalawy HS, Jol-van der Zijde CM, van Tol MJ, van Schaardenburg D, Huizinga TWJ, Toes REM, Trouw LA (2012) Avidity maturation of anti-citrullinated protein antibodies in rheumatoid arthritis. Arthritis Rheum 64:1323\u20131328","journal-title":"Arthritis Rheum"},{"key":"370_CR75","doi-asserted-by":"crossref","first-page":"104113","DOI":"10.1038\/ni.3579","volume":"18","author":"R Pfeifle","year":"2017","unstructured":"Pfeifle R, Rothe T, Ipseiz N, Scherer HU, Culemann S, Harre U, Ackermann JA, Seefried M, Kleyer A, Uderhardt S, Haugg B, Hueber AJ, Daum P, Heidkamp GF, Ge C, Bohm S, Lux A, Schuh W, Magorivska I, Nandakumar KS, Lonnblom E, Becker C, Dudziak D, Wuhrer M, Rombouts Y, Koeleman CA, Toes R, Winkler TH, Holmdahl R, Herrmann M, Bluml S, Nimmerjahn F, Schett G, Kronke G (2017) Regulation of autoantibody activity by the IL-23-TH17 axis determines the onset of autoimmune disease. Nat Immunol 18:104\u2013113","journal-title":"Nat Immunol"},{"key":"370_CR76","doi-asserted-by":"crossref","first-page":"36643674","DOI":"10.4049\/jimmunol.1402334","volume":"194","author":"F Anquetil","year":"2015","unstructured":"Anquetil F, Clavel C, Offer G, Serre G, Sebbag M (2015) IgM and IgA rheumatoid factors purified from rheumatoid arthritis sera boost the Fc receptor- and complement-dependent effector functions of the disease-specific anti-citrullinated protein autoantibodies. J Immunol 194:3664\u20133674","journal-title":"J Immunol"},{"key":"370_CR77","first-page":"813821","volume":"66","author":"J Sokolove","year":"2014","unstructured":"Sokolove J, Johnson DS, Lahey LJ, Wagner CA, Cheng D, Thiele GM, Michaud K, Sayles H, Reimold AM, Caplan L, Cannon GW, Kerr G, Mikuls TR, Robinson WH (2014) Rheumatoid factor as a potentiator of anti-citrullinated protein antibody-mediated inflammation in rheumatoid arthritis. Arthritis Rheum 66:813\u2013821","journal-title":"Arthritis Rheum"},{"key":"370_CR78","doi-asserted-by":"crossref","first-page":"401419","DOI":"10.1038\/nrd3705","volume":"11","author":"DL Lacey","year":"2012","unstructured":"Lacey DL, Boyle WJ, Simonet WS, Kostenuik PJ, Dougall WC, Sullivan JK, San Martin J, Dansey R (2012) Bench to bedside: elucidation of the OPG-RANK-RANKL pathway and the development of denosumab. Nat Rev Drug Discov 11:401\u2013419","journal-title":"Nat Rev Drug Discov"},{"key":"370_CR79","doi-asserted-by":"crossref","first-page":"309319","DOI":"10.1016\/S0092-8674(00)80209-3","volume":"89","author":"WS Simonet","year":"1997","unstructured":"Simonet WS, Lacey DL, Dunstan CR, Kelley M, Chang MS, Luthy R, Nguyen HQ, Wooden S, Bennett L, Boone T, Shimamoto G, DeRose M, Elliott R, Colombero A, Tan HL, Trail G, Sullivan J, Davy E, Bucay N, Renshaw-Gegg L, Hughes TM, Hill D, Pattison W, Campbell P, Sander S, Van G, Tarpley J, Derby P, Lee R, Boyle WJ (1997) Osteoprotegerin: a novel secreted protein involved in the regulation of bone density. Cell 89:309\u2013319","journal-title":"Cell"},{"key":"370_CR80","doi-asserted-by":"crossref","first-page":"137142","DOI":"10.1006\/bbrc.1997.6603","volume":"234","author":"E Tsuda","year":"1997","unstructured":"Tsuda E, Goto M, Mochizuki S, Yano K, Kobayashi F, Morinaga T, Higashio K (1997) Isolation of a novel cytokine from human fibroblasts that specifically inhibits osteoclastogenesis. Biochem Biophys Res Commun 234:137\u2013142","journal-title":"Biochem Biophys Res Commun"},{"key":"370_CR81","doi-asserted-by":"crossref","first-page":"35973602","DOI":"10.1073\/pnas.95.7.3597","volume":"95","author":"H Yasuda","year":"1998","unstructured":"Yasuda H, Shima N, Nakagawa N, Yamaguchi K, Kinosaki M, Mochizuki S, Tomoyasu A, Yano K, Goto M, Murakami A, Tsuda E, Morinaga T, Higashio K, Udagawa N, Takahashi N, Suda T (1998) Osteoclast differentiation factor is a ligand for osteoprotegerin\/osteoclastogenesis-inhibitory factor and is identical to TRANCE\/RANKL. Proc Natl Acad Sci USA 95:3597\u20133602","journal-title":"Proc Natl Acad Sci USA"},{"key":"370_CR82","doi-asserted-by":"crossref","first-page":"12601268","DOI":"10.1101\/gad.12.9.1260","volume":"12","author":"N Bucay","year":"1998","unstructured":"Bucay N, Sarosi I, Dunstan CR, Morony S, Tarpley J, Capparelli C, Scully S, Tan HL, Xu W, Lacey DL, Boyle WJ, Simonet WS (1998) Osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification. Genes Dev 12:1260\u20131268","journal-title":"Genes Dev"},{"key":"370_CR83","doi-asserted-by":"crossref","first-page":"165176","DOI":"10.1016\/S0092-8674(00)81569-X","volume":"93","author":"DL Lacey","year":"1998","unstructured":"Lacey DL, Timms E, Tan HL, Kelley MJ, Dunstan CR, Burgess T, Elliott R, Colombero A, Elliott G, Scully S, Hsu H, Sullivan J, Hawkins N, Davy E, Capparelli C, Eli A, Qian YX, Kaufman S, Sarosi I, Shalhoub V, Senaldi G, Guo J, Delaney J, Boyle WJ (1998) Osteoprotegerin ligand is a cytokine that regulates osteoclast differentiation and activation. Cell 93:165\u2013176","journal-title":"Cell"},{"key":"370_CR84","first-page":"2519025194","volume":"272","author":"BR Wong","year":"1997","unstructured":"Wong BR, Rho J, Arron J, Robinson E, Orlinick J, Chao M, Kalachikov S, Cayani E, Bartlett FS 3rd, Frankel WN, Lee SY, Choi Y (1997) TRANCE is a novel ligand of the tumor necrosis factor receptor family that activates c-Jun N-terminal kinase in T cells. J Biol Chem 272:25190\u201325194","journal-title":"J Biol Chem"},{"key":"370_CR85","volume-title":"Hiroshi takayanagi. Osteoimmunology 1","author":"MH Joseph Lorenzo","year":"2010","unstructured":"Joseph Lorenzo MH, Yongwon, Choi (2010) Hiroshi takayanagi. Osteoimmunology 1. Elsevier, Amsterdam"},{"key":"370_CR86","doi-asserted-by":"crossref","first-page":"821831","DOI":"10.1056\/NEJMoa044459","volume":"354","author":"MR McClung","year":"2006","unstructured":"McClung MR, Lewiecki EM, Cohen SB, Bolognese MA, Woodson GC, Moffett AH, Peacock M, Miller PD, Lederman SN, Chesnut CH, Lain D, Kivitz AJ, Holloway DL, Zhang C, Peterson MC, Bekker PJ (2006) Denosumab in postmenopausal women with low bone mineral density. N Engl J Med 354:821\u2013831","journal-title":"N Engl J Med"},{"key":"370_CR87","doi-asserted-by":"crossref","first-page":"756765","DOI":"10.1056\/NEJMoa0809493","volume":"361","author":"SR Cummings","year":"2009","unstructured":"Cummings SR, San Martin J, McClung MR, Siris ES, Eastell R, Reid IR, Delmas P, Zoog HB, Austin M, Wang A, Kutilek S, Adami S, Zanchetta J, Libanati C, Siddhanti S, Christiansen C (2009) Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med 361:756\u2013765","journal-title":"N Engl J Med"},{"key":"370_CR88","doi-asserted-by":"crossref","first-page":"16221627","DOI":"10.3748\/wjg.v18.i14.1622","volume":"18","author":"T Larussa","year":"2012","unstructured":"Larussa T, Suraci E, Nazionale I, Leone I, Montalcini T, Abenavoli L, Imeneo M, Pujia A, Luzza F (2012) No evidence of circulating autoantibodies against osteoprotegerin in patients with celiac disease. World J Gastroenterol 18:1622\u20131627","journal-title":"World J Gastroenterol"},{"key":"370_CR89","doi-asserted-by":"crossref","first-page":"16311632","DOI":"10.1136\/annrheumdis-2014-207219","volume":"74","author":"B Hauser","year":"2015","unstructured":"Hauser B, Riches PL, Gilchrist T, Visconti MR, Wilson JF, Ralston SH (2015) Autoantibodies to osteoprotegerin are associated with increased bone resorption in rheumatoid arthritis. Ann Rheum Dis 74:1631\u20131632","journal-title":"Ann Rheum Dis"},{"key":"370_CR90","doi-asserted-by":"crossref","first-page":"112125","DOI":"10.1111\/j.0105-2896.2009.00856.x","volume":"233","author":"A Duskin","year":"2010","unstructured":"Duskin A, Eisenberg RA (2010) The role of antibodies in inflammatory arthritis. Immunol Rev 233:112\u2013125","journal-title":"Immunol Rev"},{"key":"370_CR91","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-017-0322-z","author":"IEM Bultink","year":"2017","unstructured":"Bultink IEM (2017) Bone disease in connective tissue disease\/systemic lupus erythematosus. Calcif Tissue Int. https:\/\/doi.org\/10.1007\/s00223-017-0322-z","journal-title":"Calcif Tissue Int"},{"issue":"Suppl 1","key":"370_CR92","doi-asserted-by":"crossref","first-page":"i77i84","DOI":"10.1136\/ard.2010.140582","volume":"70","author":"PJ Mease","year":"2011","unstructured":"Mease PJ (2011) Psoriatic arthritis: update on pathophysiology, assessment and management. Ann Rheum Dis 70(Suppl 1):i77\u2013i84","journal-title":"Ann Rheum Dis"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00223-017-0370-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-017-0370-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-017-0370-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T16:54:26Z","timestamp":1693328066000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00223-017-0370-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12,4]]},"references-count":92,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["370"],"URL":"https:\/\/doi.org\/10.1007\/s00223-017-0370-4","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"value":"0171-967X","type":"print"},{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,12,4]]}}}