{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T19:18:23Z","timestamp":1782587903983,"version":"3.54.5"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T00:00:00Z","timestamp":1518480000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["299831"],"award-info":[{"award-number":["299831"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["628582"],"award-info":[{"award-number":["628582"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1009367"],"award-info":[{"award-number":["1009367"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1026265"],"award-info":[{"award-number":["1026265"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1021345"],"award-info":[{"award-number":["1021345"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1104438"],"award-info":[{"award-number":["1104438"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1064272"],"award-info":[{"award-number":["1064272"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1059660"],"award-info":[{"award-number":["1059660"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2018,8]]},"DOI":"10.1007\/s00223-018-0398-0","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T11:27:52Z","timestamp":1518521272000},"page":"125-130","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Selective Serotonin Reuptake Inhibitors (SSRIs) and Markers of Bone Turnover in Men"],"prefix":"10.1007","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1377-1272","authenticated-orcid":false,"given":"Lana J.","family":"Williams","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Berk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason M.","family":"Hodge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Kotowicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda L.","family":"Stuart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vinoomika","family":"Chandrasekaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine","family":"Cleminson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Pasco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,13]]},"reference":[{"key":"398_CR1","first-page":"1","volume":"76","author":"LA Pratt","year":"2011","unstructured":"Pratt LA, Brody DJ, Gu Q (2011) Antidepressant use in persons aged 12 and over: United States, 2005\u20132008. NCHS Data Brief 76:1\u20138","journal-title":"NCHS Data Brief"},{"key":"398_CR2","doi-asserted-by":"publisher","first-page":"462","DOI":"10.1038\/nrrheum.2015.48","volume":"11","author":"G Hendrickx","year":"2015","unstructured":"Hendrickx G, Boudin E, Van Hul W (2015) A look behind the scenes: the risk and pathogenesis of primary osteoporosis. Nat Rev Rheumatol 11:462\u201374","journal-title":"Nat Rev Rheumatol"},{"key":"398_CR3","doi-asserted-by":"publisher","first-page":"321","DOI":"10.5694\/mja11.10571","volume":"195","author":"M Henry","year":"2011","unstructured":"Henry M, Pasco J, Nicholson G, Kotowicz M (2011) Prevalence of osteoporosis in Australian men and women: Geelong Osteoporosis Study. Med J Aust 195:321\u2013322","journal-title":"Med J Aust"},{"key":"398_CR4","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1007\/s00198-006-0172-4","volume":"17","author":"O Johnell","year":"2006","unstructured":"Johnell O, Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17:1726\u20131733","journal-title":"Osteoporos Int"},{"key":"398_CR5","unstructured":"Watts JJ, Abimanyi-Ochom J, Sanders KM (2012) Osteoporosis costing all Australians a new burden of disease analysis\u20142012 to 2022 report. Osteoprosis Australia, Glebe, NSW"},{"key":"398_CR6","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1007\/s00198-012-2015-9","volume":"24","author":"V Rabenda","year":"2013","unstructured":"Rabenda V, Nicolet D, Beaudart C, Bruyere O, Reginster JY (2013) Relationship between use of antidepressants and risk of fractures: a meta-analysis. Osteoporos Int 24:121\u2013137","journal-title":"Osteoporos Int"},{"key":"398_CR7","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1007\/s00198-011-1778-8","volume":"23","author":"Q Wu","year":"2012","unstructured":"Wu Q, Bencaz AF, Hentz JG, Crowell MD (2012) Selective serotonin reuptake inhibitor treatment and risk of fractures: a meta-analysis of cohort and case-control studies. Osteoporos Int 23:365\u2013375","journal-title":"Osteoporos Int"},{"key":"398_CR8","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s40266-015-0323-4","volume":"33","author":"BS Fernandes","year":"2016","unstructured":"Fernandes BS, Hodge JM, Pasco JA, Berk M, Williams LJ (2016) Effects of depression and serotonergic antidepressants on bone: mechanisms and implications for the treatment of depression. Drugs Aging 33:21\u201325","journal-title":"Drugs Aging"},{"key":"398_CR9","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1159\/000162297","volume":"78","author":"LJ Williams","year":"2009","unstructured":"Williams LJ, Pasco JA, Jacka FN, Henry MJ, Dodd S, Berk M (2009) Depression and bone metabolism. Rev Psychother Psychosom 78:16\u201325","journal-title":"Rev Psychother Psychosom"},{"key":"398_CR10","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1186\/s12888-015-0439-4","volume":"15","author":"LJ Williams","year":"2015","unstructured":"Williams LJ, Pasco JA, Stuart AL, Jacka FN, Brennan SL, Dobbins AG, Honkanen RJ, Koivumaa-Honkanen H, Rauma PH, Berk M (2015) Psychiatric disorders, psychotropic medication use and falls among women: an observational study. BMC Psychiatry 15:75","journal-title":"BMC Psychiatry"},{"key":"398_CR11","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1177\/1557988315609111","volume":"12","author":"AL Stuart","year":"2018","unstructured":"Stuart AL, Pasco JA, Jacka FN, Berk M, Williams LJ (2018) Falls and depression in men: a population-based study. Am J Mens Health 12:14\u201318","journal-title":"Am J Mens Health"},{"key":"398_CR12","unstructured":"World Health Organisation (2007) Prevention and management of osteoporosis: report of a WHO scientific group. In: World Health Organisation Scientific Group on the prevention and management of osteoporosis, Geneva"},{"key":"398_CR13","doi-asserted-by":"publisher","first-page":"1565","DOI":"10.1093\/ije\/dyr148","volume":"41","author":"JA Pasco","year":"2012","unstructured":"Pasco JA, Nicholson GC, Kotowicz MA (2012) Cohort profile: Geelong Osteoporosis Study. Int J Epidemiol 41:1565\u20131575","journal-title":"Int J Epidemiol"},{"key":"398_CR14","volume-title":"Structured clinical interview for DSM-IV-TR axis I disorders, research version, non-patient edition. (SCID-I\/NP)","author":"M First","year":"2002","unstructured":"First M, Spitzer R, Gibbon M, Williams J (2002) Structured clinical interview for DSM-IV-TR axis I disorders, research version, non-patient edition. (SCID-I\/NP). Biometrics Research, New York State Psychiatric Institute, New York"},{"key":"398_CR15","volume-title":"Dietary questionnaire for epidemiological studies (version 2)","author":"C Giles","year":"1996","unstructured":"Giles C, Ireland P (1996) Dietary questionnaire for epidemiological studies (version 2). The Cancer Council Victoria, Melbourne"},{"key":"398_CR16","doi-asserted-by":"publisher","first-page":"165","DOI":"10.1016\/j.ypmed.2009.06.021","volume":"49","author":"SL Brennan","year":"2009","unstructured":"Brennan SL, Henry MJ, Nicholson GC, Kotowicz MA, Pasco JA (2009) Socioeconomic status and risk factors for obesity and metabolic disorders in a population-based sample of adult females. Prev Med 49:165\u2013171","journal-title":"Prev Med"},{"key":"398_CR17","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.jomh.2009.10.004","volume":"7","author":"SL Brennan","year":"2010","unstructured":"Brennan SL, Henry MJ, Nicholson GC, Kotowicz MA, Pasco JA (2010) Socioeconomic status, obesity and lifestyle in men: the Geelong Osteoporosis Study. J Mens Health 7:31\u201341","journal-title":"J Mens Health"},{"key":"398_CR18","doi-asserted-by":"publisher","first-page":"1316","DOI":"10.1016\/j.jpsychires.2011.04.005","volume":"45","author":"H Aydin","year":"2011","unstructured":"Aydin H, Mutlu N, Akbas NB (2011) Treatment of a major depression episode suppresses markers of bone turnover in premenopausal women. J Psychiatr Res 45:1316\u20131320","journal-title":"J Psychiatr Res"},{"key":"398_CR19","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1007\/s00198-012-2170-z","volume":"24","author":"ML Shea","year":"2013","unstructured":"Shea ML, Garfield LD, Teitelbaum S, Civitelli R, Mulsant BH, Reynolds CF 3rd, Dixon D, Dore P, Lenze EJ (2013) Serotonin-norepinephrine reuptake inhibitor therapy in late-life depression is associated with increased marker of bone resorption. Osteoporos Int 24: 1741\u20131749","journal-title":"Osteoporos Int"},{"key":"398_CR20","doi-asserted-by":"publisher","first-page":"E1732-7","DOI":"10.1210\/jc.2014-2288","volume":"99","author":"SJ Diem","year":"2014","unstructured":"Diem SJ, Joffe H, Larson JC, Tsai JN, Guthrie KA, LaCroix AZ, Ensrud KE, Freeman EW, Leder BZ (2014) Effects of escitalopram on markers of bone turnover: a randomized clinical trial. J Clin Endocrinol Metab 99:E1732-7","journal-title":"J Clin Endocrinol Metab"},{"key":"398_CR21","doi-asserted-by":"publisher","first-page":"1170","DOI":"10.1038\/nm.4166","volume":"22","author":"MJ Ortuno","year":"2016","unstructured":"Ortuno MJ, Robinson ST, Subramanyam P, Paone R, Huang YY, Guo XE, Colecraft HM, Mann JJ, Ducy P (2016) Serotonin-reuptake inhibitors act centrally to cause bone loss in mice by counteracting a local anti-resorptive effect. Nat Med 22:1170\u20131179","journal-title":"Nat Med"},{"key":"398_CR22","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1016\/j.biopsych.2012.11.003","volume":"74","author":"JM Hodge","year":"2013","unstructured":"Hodge JM, Wang Y, Berk M, Collier FM, Fernandes TJ, Constable MJ, Pasco JA, Dodd S, Nicholson GC, Kennedy RL, Williams LJ (2013) Selective serotonin reuptake inhibitors inhibit human osteoclast and osteoblast formation and function. Biol Psychiatry 74:32\u201339","journal-title":"Biol Psychiatry"},{"key":"398_CR23","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1007\/s00223-011-9466-4","volume":"88","author":"N Fratzl-Zelman","year":"2011","unstructured":"Fratzl-Zelman N, Roschger P, Misof BM, Nawrot-Wawrzyniak K, Potter-Lang S, Muschitz C, Resch H, Klaushofer K, Zwettler E (2011) Fragility fractures in men with idiopathic osteoporosis are associated with undermineralization of the bone matrix without evidence of increased bone turnover. Calcif Tissue Int 88:378\u2013387","journal-title":"Calcif Tissue Int"},{"key":"398_CR24","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1471-2474-8-13","volume":"8","author":"TV Nguyen","year":"2007","unstructured":"Nguyen TV, Meier C, Center JR, Eisman JA, Seibel MJ (2007) Bone turnover in elderly men: relationships to change in bone mineral density. BMC Musculoskelet Disord 8:13","journal-title":"BMC Musculoskelet Disord"},{"key":"398_CR25","doi-asserted-by":"publisher","first-page":"e565","DOI":"10.3399\/bjgp11X593848","volume":"61","author":"P Lockhart","year":"2011","unstructured":"Lockhart P, Guthrie B (2011) Trends in primary care antidepressant prescribing 1995\u20132007: a longitudinal population database analysis. Br J Gen Pract 61:e565\u2013e572","journal-title":"Br J Gen Pract"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00223-018-0398-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-018-0398-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-018-0398-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,2,12]],"date-time":"2019-02-12T20:51:29Z","timestamp":1550004689000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00223-018-0398-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,13]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,8]]}},"alternative-id":["398"],"URL":"https:\/\/doi.org\/10.1007\/s00223-018-0398-0","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"value":"0171-967X","type":"print"},{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,13]]},"assertion":[{"value":"19 September 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 January 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 February 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"LJW has received grant\/research support from Eli Lilly, Pfizer, The University of Melbourne, Deakin University. MB has received Grant\/Research Support from the NIH, Cooperative Research Centre, Simons Autism Foundation, Cancer Council of Victoria, Stanley Medical Research Foundation, MBF, NHMRC, Beyond Blue, Rotary Health, Geelong Medical Research Foundation, Bristol Myers Squibb, Eli Lilly, Glaxo SmithKline, Meat and Livestock Board, Organon, Novartis, Mayne Pharma, Servier and Woolworths, has been a speaker for Astra Zeneca, Bristol Myers Squibb, Eli Lilly, Glaxo SmithKline, Janssen Cilag, Lundbeck, Merck, Pfizer, Sanofi Synthelabo, Servier, Solvay and Wyeth, and served as a consultant to Allergan, Astra Zeneca, Bioadvantex, Bionomics, Collaborative Medicinal Development, Eli Lilly, Glaxo SmithKline, Janssen Cilag, Lundbeck Merck, Pfizer and Servier. JAP has recently received grant\/research support from the National Health and Medical Research Council (NHMRC), BUPA Foundation, Amgen\/GlaxoSmithKline\/Osteoporosis Australia\/Australian and New Zealand Bone and Mineral Society, Western Alliance, Barwon Health, Deakin University and the Geelong Community Foundation. JH, MAK, ALS, VC and JC have no disclosures.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The Human Research Ethics Committee at Barwon Health approved the study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights and Informed Consent"}}]}}