{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T18:41:37Z","timestamp":1792089697615,"version":"4.4.0"},"reference-count":114,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T00:00:00Z","timestamp":1518739200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T00:00:00Z","timestamp":1518739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000064","name":"National Center for Complementary and Alternative Medicine","doi-asserted-by":"publisher","award":["AT007695"],"award-info":[{"award-number":["AT007695"]}],"id":[{"id":"10.13039\/100000064","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"National Institute of Diabetes and Digestive and Kidney Diseases","doi-asserted-by":"publisher","award":["DK101050"],"award-info":[{"award-number":["DK101050"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2018,4]]},"DOI":"10.1007\/s00223-018-0403-7","type":"journal-article","created":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T12:20:53Z","timestamp":1518783653000},"page":"480-488","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":77,"title":["Advances in Probiotic Regulation of Bone and Mineral Metabolism"],"prefix":"10.1007","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5407-162X","authenticated-orcid":false,"given":"Laura R.","family":"McCabe","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8894-5564","authenticated-orcid":false,"given":"Narayanan","family":"Parameswaran","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2018,2,16]]},"reference":[{"key":"403_CR1","doi-asserted-by":"crossref","unstructured":"Gasbarrini G, Bonvicini F, Gramenzi A (2016) Probiotics history. J Clin Gastroenterol 50 Suppl 2, Proceedings from the 8th Probiotics, Prebiotics & New Foods for Microbiota and Human Health meeting held in Rome, Italy on September 13-15, 2015:S116\u2013S119","DOI":"10.1097\/MCG.0000000000000697"},{"key":"403_CR2","first-page":"1","volume":"1","author":"V Gogineni","year":"2013","unstructured":"Gogineni V (2013) Probiotics: history and evolution. J Anc Dis Prev Remeidies 1:1\u20137","journal-title":"J Anc Dis Prev Remeidies"},{"key":"403_CR3","first-page":"409","volume":"4","author":"K Azizpour","year":"2009","unstructured":"Azizpour K et al (2009) History and basic of probiotics. Res J Biol Sci 4:409\u2013426","journal-title":"Res J Biol Sci"},{"issue":"2","key":"403_CR4","doi-asserted-by":"publisher","first-page":"159","DOI":"10.3920\/BM2014.0103","volume":"6","author":"M Ozen","year":"2015","unstructured":"Ozen M, Dinleyici EC (2015) The history of probiotics: the untold story. Benef Microbes 6(2):159\u2013165","journal-title":"Benef Microbes"},{"issue":"Suppl 2","key":"403_CR5","doi-asserted-by":"publisher","first-page":"S35","DOI":"10.1017\/S0007114512004011","volume":"109","author":"L Fontana","year":"2013","unstructured":"Fontana L et al (2013) Sources, isolation, characterisation and evaluation of probiotics. Br J Nutr 109(Suppl 2):S35\u2013S50","journal-title":"Br J Nutr"},{"issue":"2","key":"403_CR6","first-page":"68","volume":"7","author":"KC Anukam","year":"2007","unstructured":"Anukam KC, Reid G (2007) Organisms associated with bacterial vaginosis in Nigerian women as determined by PCR-DGGE and 16S rRNA gene sequence. Afr Health Sci 7(2):68\u201372","journal-title":"Afr Health Sci"},{"issue":"2","key":"403_CR7","doi-asserted-by":"publisher","first-page":"323","DOI":"10.3920\/BM2017.x002","volume":"8","author":"GA Calatayud","year":"2017","unstructured":"Calatayud GA, Suarez JE (2017) A new contribution to the history of probiotics. Benef Microbes 8(2):323\u2013325","journal-title":"Benef Microbes"},{"issue":"8","key":"403_CR8","doi-asserted-by":"publisher","first-page":"506","DOI":"10.1038\/nrgastro.2014.66","volume":"11","author":"C Hill","year":"2014","unstructured":"Hill C et al (2014) Expert consensus document. The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic. Nat Rev Gastroenterol Hepatol 11(8):506\u2013514","journal-title":"Nat Rev Gastroenterol Hepatol"},{"issue":"Suppl 2","key":"403_CR9","doi-asserted-by":"publisher","first-page":"S85","DOI":"10.1093\/cid\/civ054","volume":"60","author":"LV McFarland","year":"2015","unstructured":"McFarland LV (2015) From yaks to yogurt: the history, development, and current use of probiotics. Clin Infect Dis 60(Suppl 2):S85\u2013S90","journal-title":"Clin Infect Dis"},{"issue":"1 Suppl","key":"403_CR10","doi-asserted-by":"publisher","first-page":"S2","DOI":"10.1016\/S0002-9270(99)00806-0","volume":"95","author":"SL Gorbach","year":"2000","unstructured":"Gorbach SL (2000) Probiotics and gastrointestinal health. Am J Gastroenterol 95(1 Suppl):S2\u2013S4","journal-title":"Am J Gastroenterol"},{"issue":"10","key":"403_CR11","doi-asserted-by":"publisher","first-page":"1229","DOI":"10.1172\/JCI11066","volume":"106","author":"S Cenci","year":"2000","unstructured":"Cenci S et al (2000) Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha. J Clin Invest 106(10):1229\u20131237","journal-title":"J Clin Invest"},{"issue":"6","key":"403_CR12","doi-asserted-by":"publisher","first-page":"2899","DOI":"10.1210\/endo-122-6-2899","volume":"122","author":"JM Hock","year":"1988","unstructured":"Hock JM et al (1988) Human parathyroid hormone-(1\u201334) increases bone mass in ovariectomized and orchidectomized rats. Endocrinology 122(6):2899\u20132904","journal-title":"Endocrinology"},{"issue":"5","key":"403_CR13","first-page":"842","volume":"69","author":"C Yamada","year":"2011","unstructured":"Yamada C (2011) [Role of incretins in the regulation of bone metabolism]. Nihon Rinsho 69(5):842\u2013847","journal-title":"Nihon Rinsho"},{"key":"403_CR14","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-3-319-66653-2_1","volume":"1033","author":"S Christakos","year":"2017","unstructured":"Christakos S et al (2017) Intestinal regulation of calcium: vitamin D and bone physiology. Adv Exp Med Biol 1033:3\u201312","journal-title":"Adv Exp Med Biol"},{"key":"403_CR15","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/978-3-319-66653-2_2","volume":"1033","author":"W Ramsey","year":"2017","unstructured":"Ramsey W, Isales CM (2017) Intestinal incretins and the regulation of bone physiology. Adv Exp Med Biol 1033:13\u201333","journal-title":"Adv Exp Med Biol"},{"key":"403_CR16","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/978-3-319-66653-2_3","volume":"1033","author":"B Lavoie","year":"2017","unstructured":"Lavoie B, Lian JB, Mawe GM (2017) Regulation of bone metabolism by serotonin. Adv Exp Med Biol 1033:35\u201346","journal-title":"Adv Exp Med Biol"},{"issue":"3","key":"403_CR17","doi-asserted-by":"publisher","first-page":"e92368","DOI":"10.1371\/journal.pone.0092368","volume":"9","author":"C Ohlsson","year":"2014","unstructured":"Ohlsson C et al (2014) Probiotics protect mice from ovariectomy-induced cortical bone loss. PLoS ONE 9(3):e92368","journal-title":"PLoS ONE"},{"key":"403_CR18","doi-asserted-by":"publisher","first-page":"897639","DOI":"10.1155\/2015\/897639","volume":"2015","author":"K Parvaneh","year":"2015","unstructured":"Parvaneh K et al. (2015) Probiotics (Bifidobacterium longum) increase bone mass density and upregulate Sparc and Bmp-2 genes in rats with bone loss resulting from ovariectomy. Biomed Res Int 2015:897639","journal-title":"Biomed Res Int"},{"key":"403_CR19","doi-asserted-by":"publisher","first-page":"1822","DOI":"10.1002\/jcp.24636","volume":"229","author":"RA Britton","year":"2014","unstructured":"Britton RA et al. (2014) Probiotic L. reuteri treatment prevents bone loss in a menopausal ovariectomized mouse model. J Cell Physiol 229:1822\u20131830","journal-title":"J Cell Physiol"},{"issue":"4","key":"403_CR20","doi-asserted-by":"publisher","first-page":"e0153180","DOI":"10.1371\/journal.pone.0153180","volume":"11","author":"FL Collins","year":"2016","unstructured":"Collins FL et al (2016) Lactobacillus reuteri 6475 increases bone density in intact females only under an inflammatory setting. PLoS ONE 11(4):e0153180","journal-title":"PLoS ONE"},{"issue":"9","key":"403_CR21","doi-asserted-by":"publisher","first-page":"3169","DOI":"10.1210\/EN.2015-1308","volume":"156","author":"J Zhang","year":"2015","unstructured":"Zhang J et al (2015) Loss of bone and Wnt10b expression in male type 1 diabetic mice is blocked by the probiotic Lactobacillus reuteri. Endocrinology 156(9):3169\u20133182","journal-title":"Endocrinology"},{"issue":"8","key":"403_CR22","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1002\/jcp.24340","volume":"228","author":"LR McCabe","year":"2013","unstructured":"McCabe LR et al (2013) Probiotic use decreases intestinal inflammation and increases bone density in healthy male but not female mice. J Cell Physiol 228(8):1793\u20131798","journal-title":"J Cell Physiol"},{"key":"403_CR23","doi-asserted-by":"publisher","first-page":"227","DOI":"10.1038\/nrmicro2974","volume":"11","author":"F Sommer","year":"2013","unstructured":"Sommer F, B\u00e4ckhed F (2013) The gut microbiota\u2014masters of host development and physiology. Nat Rev Microbiol 11:227\u2013238","journal-title":"Nat Rev Microbiol"},{"key":"403_CR24","doi-asserted-by":"publisher","first-page":"6275","DOI":"10.1126\/science.aad3311","volume":"351","author":"LV Blanton","year":"2016","unstructured":"Blanton LV, Charbonneau MR, Salih T, Barratt MJ, Venkatesh S, Ilkaveya O, Subramanian S, Manary MJ, Trehan I, Jorgensen JM, Fan Y-M, Henrissat B, Leyn SA, Rodionov DA, Osterman AL, Maleta KM, Newgard CB, Ashorn P, Dewey KG, Gordon JI (2016) Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children. Science 351:6275","journal-title":"Science"},{"issue":"6275","key":"403_CR25","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1126\/science.aad8588","volume":"351","author":"M Schwarzer","year":"2016","unstructured":"Schwarzer M, Makki K, Storelli G, Machuca-Gayet I, Srutkova D, Hermanova P, Martino ME, Balmand S, Hudcovic T, Heddi A, Rieusset J, Kozakova H, Vidal H, Leulier F (2016) Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition. Science 351(6275):854\u2013857","journal-title":"Science"},{"key":"403_CR26","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1159\/000248992","volume":"55","author":"PG Steenhout","year":"2009","unstructured":"Steenhout PG, Rochat F, Hager C (2009) The effect of Bifidobacterium lactis on the growth of infants: a pooled analysis of randomized controlled studies. Ann Nutr Metab 55:334\u2013340","journal-title":"Ann Nutr Metab"},{"key":"403_CR27","doi-asserted-by":"publisher","first-page":"631","DOI":"10.3920\/BM2016.0067","volume":"7","author":"M Lei","year":"2016","unstructured":"Lei M, Hua L-M, Wang D-W (2016) The effect of probiotic treatment on elderly patients with distal radius fracture: a prospective double-blind, placebo-controlled randomised clinical trial. Benef Microbes 7:631\u2013637","journal-title":"Benef Microbes"},{"key":"403_CR28","doi-asserted-by":"publisher","first-page":"e0144231","DOI":"10.1371\/journal.pone.0144231","volume":"10","author":"M-Y Tu","year":"2015","unstructured":"Tu M-Y, Chen H-L, Tung Y-T, Kao C-C, Hu F-C, Chen C-M (2015) Short-term effects of Kefir-fermented milk consumption on bone mineral density and bone metabolism in a randomized clinical trial of osteoporotic patients. PLoS ONE 10:e0144231","journal-title":"PLoS ONE"},{"key":"403_CR29","doi-asserted-by":"crossref","first-page":"909","DOI":"10.3945\/ajcn.117.153353","volume":"106","author":"Lambert","year":"2017","unstructured":"Lambert et al (2017) Combined bioavailable isoflavones and probiotics improve bone status and estrogen metabolism in postmenopausal osteopenic women: a randomized controlled trial. Am J Clin Nutr 106:909\u2013920","journal-title":"Am J Clin Nutr"},{"issue":"1","key":"403_CR30","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s00281-013-0399-z","volume":"36","author":"S Fukuda","year":"2014","unstructured":"Fukuda S, Ohno H (2014) Gut microbiome and metabolic diseases. Semin Immunopathol 36(1):103\u2013114","journal-title":"Semin Immunopathol"},{"issue":"7122","key":"403_CR31","doi-asserted-by":"publisher","first-page":"1022","DOI":"10.1038\/4441022a","volume":"444","author":"RE Ley","year":"2006","unstructured":"Ley RE et al (2006) Microbial ecology: human gut microbes associated with obesity. Nature 444(7122):1022\u20131023","journal-title":"Nature"},{"issue":"6","key":"403_CR32","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1016\/j.tim.2015.03.002","volume":"23","author":"M Derrien","year":"2015","unstructured":"Derrien M, van Hylckama Vlieg JE (2015) Fate, activity, and impact of ingested bacteria within the human gut microbiota. Trends Microbiol 23(6):354\u2013366","journal-title":"Trends Microbiol"},{"issue":"8","key":"403_CR33","doi-asserted-by":"publisher","first-page":"5615","DOI":"10.1128\/AEM.00722-06","volume":"72","author":"R Oozeer","year":"2006","unstructured":"Oozeer R et al (2006) Survival of Lactobacillus casei in the human digestive tract after consumption of fermented milk. Appl Environ Microbiol 72(8):5615\u20135617","journal-title":"Appl Environ Microbiol"},{"issue":"6","key":"403_CR34","doi-asserted-by":"publisher","first-page":"544","DOI":"10.4161\/gmic.22156","volume":"3","author":"G Loh","year":"2012","unstructured":"Loh G, Blaut M (2012) Role of commensal gut bacteria in inflammatory bowel diseases. Gut Microbes 3(6):544\u2013555","journal-title":"Gut Microbes"},{"issue":"1\u20133","key":"403_CR35","doi-asserted-by":"publisher","first-page":"90","DOI":"10.1159\/000106087","volume":"14","author":"O Firmesse","year":"2008","unstructured":"Firmesse O et al (2008) Lactobacillus rhamnosus R11 consumed in a food supplement survived human digestive transit without modifying microbiota equilibrium as assessed by real-time polymerase chain reaction. J Mol Microbiol Biotechnol 14(1\u20133):90\u201399","journal-title":"J Mol Microbiol Biotechnol"},{"issue":"1\u20132","key":"403_CR36","doi-asserted-by":"publisher","first-page":"210","DOI":"10.1016\/j.ijfoodmicro.2008.05.022","volume":"126","author":"J Fujimoto","year":"2008","unstructured":"Fujimoto J et al (2008) Identification and quantification of Lactobacillus casei strain Shirota in human feces with strain-specific primers derived from randomly amplified polymorphic DNA. Int J Food Microbiol 126(1\u20132):210\u2013215","journal-title":"Int J Food Microbiol"},{"issue":"2 Suppl","key":"403_CR37","doi-asserted-by":"publisher","first-page":"399S","DOI":"10.1093\/ajcn\/73.2.399s","volume":"73","author":"A Bezkorovainy","year":"2001","unstructured":"Bezkorovainy A (2001) Probiotics: determinants of survival and growth in the gut. Am J Clin Nutr 73(2 Suppl):399S\u2013405S","journal-title":"Am J Clin Nutr"},{"issue":"4","key":"403_CR38","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1128\/MMBR.00017-08","volume":"72","author":"S Lebeer","year":"2008","unstructured":"Lebeer S, Vanderleyden J, De Keersmaecker SC (2008) Genes and molecules of lactobacilli supporting probiotic action. Microbiol Mol Biol Rev 72(4):728\u2013764 (Table of Contents)","journal-title":"Microbiol Mol Biol Rev"},{"issue":"6","key":"403_CR39","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1007\/s11914-015-0292-x","volume":"13","author":"L McCabe","year":"2015","unstructured":"McCabe L, Britton RA, Parameswaran N (2015) Prebiotic and probiotic regulation of bone health: role of the intestine and its microbiome. Curr Osteoporos Rep 13(6):363\u2013371","journal-title":"Curr Osteoporos Rep"},{"key":"403_CR40","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1007\/978-3-319-66653-2_4","volume":"1033","author":"D Quach","year":"2017","unstructured":"Quach D, Britton RA (2017) Gut microbiota and bone health. Adv Exp Med Biol 1033:47\u201358","journal-title":"Adv Exp Med Biol"},{"key":"403_CR41","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a031203","author":"R Pacifici","year":"2017","unstructured":"Pacifici R (2017) Bone remodeling and the microbiome. Cold Spring Harb Perspect Med. https:\/\/doi.org\/10.1101\/cshperspect.a031203","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"6275","key":"403_CR42","doi-asserted-by":"publisher","first-page":"aad3311","DOI":"10.1126\/science.aad3311","volume":"351","author":"LV Blanton","year":"2016","unstructured":"Blanton LV et al (2016) Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children. Science 351(6275):aad3311","journal-title":"Science"},{"issue":"6275","key":"403_CR43","doi-asserted-by":"publisher","first-page":"854","DOI":"10.1126\/science.aad8588","volume":"351","author":"M Schwarzer","year":"2016","unstructured":"Schwarzer M et al (2016) Lactobacillus plantarum strain maintains growth of infant mice during chronic undernutrition. Science 351(6275):854\u2013857","journal-title":"Science"},{"issue":"47","key":"403_CR44","doi-asserted-by":"publisher","first-page":"E7554","DOI":"10.1073\/pnas.1607235113","volume":"113","author":"J Yan","year":"2016","unstructured":"Yan J et al (2016) Gut microbiota induce IGF-1 and promote bone formation and growth. Proc Natl Acad Sci USA 113(47):E7554\u2013E7563","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"403_CR45","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/j.cmet.2011.07.012","volume":"14","author":"G Storelli","year":"2011","unstructured":"Storelli G et al (2011) Lactobacillus plantarum promotes Drosophila systemic growth by modulating hormonal signals through TOR-dependent nutrient sensing. Cell Metab 14(3):403\u2013414","journal-title":"Cell Metab"},{"issue":"13","key":"403_CR46","doi-asserted-by":"publisher","first-page":"2351","DOI":"10.1007\/s00018-013-1313-5","volume":"70","author":"S Hyun","year":"2013","unstructured":"Hyun S (2013) Body size regulation and insulin-like growth factor signaling. Cell Mol Life Sci 70(13):2351\u20132365","journal-title":"Cell Mol Life Sci"},{"issue":"4","key":"403_CR47","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1159\/000248992","volume":"55","author":"PG Steenhout","year":"2009","unstructured":"Steenhout PG, Rochat F, Hager C (2009) The effect of Bifidobacterium lactis on the growth of infants: a pooled analysis of randomized controlled studies. Ann Nutr Metab 55(4):334\u2013340","journal-title":"Ann Nutr Metab"},{"key":"403_CR48","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1007\/978-3-319-66653-2_7","volume":"1033","author":"FA Sylvester","year":"2017","unstructured":"Sylvester FA (2017) Inflammatory bowel disease: effects on bone and mechanisms. Adv Exp Med Biol 1033:133\u2013150","journal-title":"Adv Exp Med Biol"},{"key":"403_CR49","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1007\/978-3-319-66653-2_10","volume":"1033","author":"CM Whisner","year":"2017","unstructured":"Whisner CM, Weaver CM (2017) Prebiotics and bone. Adv Exp Med Biol 1033:201\u2013224","journal-title":"Adv Exp Med Biol"},{"issue":"6","key":"403_CR50","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1172\/JCI86062","volume":"126","author":"JY Li","year":"2016","unstructured":"Li JY et al (2016) Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics. J Clin Invest 126(6):2049\u20132063","journal-title":"J Clin Invest"},{"issue":"1","key":"403_CR51","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1016\/j.chom.2017.06.014","volume":"22","author":"E Xiao","year":"2017","unstructured":"Xiao E et al (2017) Diabetes enhances IL-17 expression and alters the oral microbiome to increase its pathogenicity. Cell Host Microbe 22(1):120\u2013128 e4","journal-title":"Cell Host Microbe"},{"key":"403_CR52","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1111\/jcpe.12838","volume":"45","author":"SM Gatej","year":"2017","unstructured":"Gatej SM et al (2017) Probiotic Lactobacillus rhamnosus GG prevents alveolar bone loss in a mouse model of experimental periodontitis. J Clin Periodontol 45:204\u2013212","journal-title":"J Clin Periodontol"},{"issue":"6","key":"403_CR53","doi-asserted-by":"publisher","first-page":"e0179946","DOI":"10.1371\/journal.pone.0179946","volume":"12","author":"MST Ricoldi","year":"2017","unstructured":"Ricoldi MST et al (2017) Effects of the probiotic Bifidobacterium animalis subsp. lactis on the non-surgical treatment of periodontitis. A histomorphometric, microtomographic and immunohistochemical study in rats. PLoS ONE 12(6):e0179946","journal-title":"PLoS ONE"},{"issue":"1","key":"403_CR54","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1038\/s41598-017-00623-9","volume":"7","author":"R Kobayashi","year":"2017","unstructured":"Kobayashi R et al (2017) Oral administration of Lactobacillus gasseri SBT2055 is effective in preventing Porphyromonas gingivalis-accelerated periodontal disease. Sci Rep 7(1):545","journal-title":"Sci Rep"},{"issue":"2","key":"403_CR55","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1242\/jcs.193482","volume":"130","author":"MM France","year":"2017","unstructured":"France MM, Turner JR (2017) The mucosal barrier at a glance. J Cell Sci 130(2):307\u2013314","journal-title":"J Cell Sci"},{"issue":"10","key":"403_CR56","doi-asserted-by":"publisher","first-page":"e196","DOI":"10.1038\/ctg.2016.54","volume":"7","author":"J Konig","year":"2016","unstructured":"Konig J et al (2016) Human intestinal barrier function in health and disease. Clin Transl Gastroenterol 7(10):e196","journal-title":"Clin Transl Gastroenterol"},{"issue":"2","key":"403_CR57","doi-asserted-by":"publisher","first-page":"127","DOI":"10.5217\/ir.2016.14.2.127","volume":"14","author":"H Nagao-Kitamoto","year":"2016","unstructured":"Nagao-Kitamoto H et al (2016) Pathogenic role of the gut microbiota in gastrointestinal diseases. Intest Res 14(2):127\u2013138","journal-title":"Intest Res"},{"key":"403_CR58","doi-asserted-by":"publisher","DOI":"10.14814\/phs2.13263","author":"F Collins","year":"2017","unstructured":"Collins F et al. (2017) Temporal and regional intestinal change in permeability, tight junction and cytokine gene expression following ovariectomy-induced estrogen deficiency. Physiol Rep. https:\/\/doi.org\/10.14814\/phy2.13263","journal-title":"Physiol Rep"},{"issue":"6","key":"403_CR59","doi-asserted-by":"publisher","first-page":"R1149","DOI":"10.1152\/ajpregu.00051.2016","volume":"311","author":"R Irwin","year":"2016","unstructured":"Irwin R et al (2016) Intestinal inflammation without weight loss decreases bone density and growth. Am J Physiol Regul Integr Comp Physiol 311(6):R1149\u2013R1157","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"issue":"8","key":"403_CR60","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1097\/MIB.0b013e318289e17b","volume":"19","author":"R Irwin","year":"2013","unstructured":"Irwin R et al (2013) Colitis-induced bone loss is gender dependent and associated with increased inflammation. Inflamm Bowel Dis 19(8):1586\u20131597","journal-title":"Inflamm Bowel Dis"},{"issue":"5","key":"403_CR61","doi-asserted-by":"publisher","first-page":"G1020","DOI":"10.1152\/ajpgi.90696.2008","volume":"296","author":"L Harris","year":"2009","unstructured":"Harris L et al (2009) Inflammatory bowel disease causes reversible suppression of osteoblast and chondrocyte function in mice. Am J Physiol Gastrointest Liver Physiol 296(5):G1020\u2013G1029","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"1","key":"403_CR62","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.mehy.2012.04.016","volume":"79","author":"K Tremellen","year":"2012","unstructured":"Tremellen K, Pearce K (2012) Dysbiosis of gut microbiota (DOGMA)\u2014a novel theory for the development of Polycystic Ovarian Syndrome. Med Hypotheses 79(1):104\u2013112","journal-title":"Med Hypotheses"},{"issue":"6","key":"403_CR63","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1007\/s00774-006-0708-x","volume":"24","author":"K Maruyama","year":"2006","unstructured":"Maruyama K, Sano G, Matsuo K (2006) Murine osteoblasts respond to LPS and IFN-gamma similarly to macrophages. J Bone Miner Metab 24(6):454\u2013460","journal-title":"J Bone Miner Metab"},{"issue":"1","key":"403_CR64","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s00223-001-1018-x","volume":"71","author":"H Moriyama","year":"2002","unstructured":"Moriyama H, Ukai T, Hara Y (2002) Interferon-gamma production changes in parallel with bacterial lipopolysaccharide induced bone resorption in mice: an immunohistometrical study. Calcif Tissue Int 71(1):53\u201358","journal-title":"Calcif Tissue Int"},{"issue":"Pt 13","key":"403_CR65","doi-asserted-by":"publisher","first-page":"3317","DOI":"10.1113\/jphysiol.2009.169300","volume":"587","author":"V Braniste","year":"2009","unstructured":"Braniste V et al (2009) Oestradiol decreases colonic permeability through oestrogen receptor beta-mediated up-regulation of occludin and junctional adhesion molecule-A in epithelial cells. J Physiol 587(Pt 13):3317\u20133328","journal-title":"J Physiol"},{"issue":"5","key":"403_CR66","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.jpeds.2004.06.068","volume":"145","author":"V Rosenfeldt","year":"2004","unstructured":"Rosenfeldt V et al (2004) Effect of probiotics on gastrointestinal symptoms and small intestinal permeability in children with atopic dermatitis. J Pediatr 145(5):612\u2013616","journal-title":"J Pediatr"},{"issue":"9","key":"403_CR67","doi-asserted-by":"publisher","first-page":"575","DOI":"10.1016\/j.earlhumdev.2006.12.002","volume":"83","author":"Z Stratiki","year":"2007","unstructured":"Stratiki Z et al (2007) The effect of a bifidobacter supplemented bovine milk on intestinal permeability of preterm infants. Early Hum Dev 83(9):575\u2013579","journal-title":"Early Hum Dev"},{"issue":"3","key":"403_CR68","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1053\/gast.2001.27224","volume":"121","author":"K Madsen","year":"2001","unstructured":"Madsen K et al (2001) Probiotic bacteria enhance murine and human intestinal epithelial barrier function. Gastroenterology 121(3):580\u2013591","journal-title":"Gastroenterology"},{"issue":"11","key":"403_CR69","doi-asserted-by":"publisher","first-page":"1553","DOI":"10.1136\/gut.2005.080739","volume":"55","author":"M Zareie","year":"2006","unstructured":"Zareie M et al (2006) Probiotics prevent bacterial translocation and improve intestinal barrier function in rats following chronic psychological stress. Gut 55(11):1553\u20131560","journal-title":"Gut"},{"issue":"1","key":"403_CR70","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1017\/S0007114516004037","volume":"117","author":"PA Bron","year":"2017","unstructured":"Bron PA et al (2017) Can probiotics modulate human disease by impacting intestinal barrier function? Br J Nutr 117(1):93\u2013107","journal-title":"Br J Nutr"},{"issue":"3","key":"403_CR71","doi-asserted-by":"publisher","first-page":"804","DOI":"10.1111\/j.1462-5822.2006.00836.x","volume":"9","author":"AA Zyrek","year":"2007","unstructured":"Zyrek AA et al (2007) Molecular mechanisms underlying the probiotic effects of Escherichia coli Nissle 1917 involve ZO-2 and PKCzeta redistribution resulting in tight junction and epithelial barrier repair. Cell Microbiol 9(3):804\u2013816","journal-title":"Cell Microbiol"},{"issue":"2","key":"403_CR72","first-page":"184","volume":"309","author":"RC Anderson","year":"2010","unstructured":"Anderson RC et al (2010) Lactobacillus plantarum DSM 2648 is a potential probiotic that enhances intestinal barrier function. FEMS Microbiol Lett 309(2):184\u2013192","journal-title":"FEMS Microbiol Lett"},{"issue":"3","key":"403_CR73","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1053\/j.gastro.2005.12.015","volume":"130","author":"S Resta-Lenert","year":"2006","unstructured":"Resta-Lenert S, Barrett KE (2006) Probiotics and commensals reverse TNF-alpha- and IFN-gamma-induced dysfunction in human intestinal epithelial cells. Gastroenterology 130(3):731\u2013746","journal-title":"Gastroenterology"},{"key":"403_CR74","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1186\/1471-2180-9-63","volume":"9","author":"H Qin","year":"2009","unstructured":"Qin H et al (2009) L. plantarum prevents enteroinvasive Escherichia coli-induced tight junction proteins changes in intestinal epithelial cells. BMC Microbiol 9:63","journal-title":"BMC Microbiol"},{"issue":"3","key":"403_CR75","doi-asserted-by":"publisher","first-page":"350","DOI":"10.1016\/j.nut.2008.09.004","volume":"25","author":"G Moorthy","year":"2009","unstructured":"Moorthy G, Murali MR, Devaraj SN (2009) Lactobacilli facilitate maintenance of intestinal membrane integrity during Shigella dysenteriae 1 infection in rats. Nutrition 25(3):350\u2013358","journal-title":"Nutrition"},{"issue":"10","key":"403_CR76","doi-asserted-by":"publisher","first-page":"667","DOI":"10.1038\/nri3738","volume":"14","author":"AM Mowat","year":"2014","unstructured":"Mowat AM, Agace WW (2014) Regional specialization within the intestinal immune system. Nat Rev Immunol 14(10):667\u2013685","journal-title":"Nat Rev Immunol"},{"issue":"7","key":"403_CR77","doi-asserted-by":"publisher","first-page":"1481","DOI":"10.1016\/j.cell.2017.11.024","volume":"171","author":"P Kundu","year":"2017","unstructured":"Kundu P et al (2017) Our gut microbiome: the evolving inner self. Cell 171(7):1481\u20131493","journal-title":"Cell"},{"key":"403_CR78","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1038\/nri3661","volume":"14","author":"MF Neurath","year":"2014","unstructured":"Neurath MF (2014) Cytokines in inflammatory bowel disease. Nat Rev Immunol 14:329\u2013342","journal-title":"Nat Rev Immunol"},{"key":"403_CR79","doi-asserted-by":"publisher","first-page":"1756","DOI":"10.1053\/j.gastro.2011.02.016","volume":"140","author":"W Strober","year":"2011","unstructured":"Strober W, Fuss IJ (2011) Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology 140:1756\u20131767","journal-title":"Gastroenterology"},{"key":"403_CR80","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1136\/gut.40.2.228","volume":"40","author":"I Bjarnason","year":"1997","unstructured":"Bjarnason I et al (1997) Reduced bone density in patients with inflammatory bowel disease. Gut 40:228\u2013233","journal-title":"Gut"},{"key":"403_CR81","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1007\/s11914-016-0304-5","volume":"14","author":"MB Zanchetta","year":"2016","unstructured":"Zanchetta MB, Longobardi V, Bai JC (2016) Bone and celiac disease. Curr Osteoporos Rep 14:43\u201348","journal-title":"Curr Osteoporos Rep"},{"issue":"41","key":"403_CR82","doi-asserted-by":"publisher","first-page":"16594","DOI":"10.1073\/pnas.1213854109","volume":"109","author":"MD Trottier","year":"2012","unstructured":"Trottier MD et al (2012) Enhanced production of early lineages of monocytic and granulocytic cells in mice with colitis. Proc Natl Acad Sci USA 109(41):16594\u201316599","journal-title":"Proc Natl Acad Sci USA"},{"key":"403_CR83","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1016\/j.amjmed.2009.01.022","volume":"122","author":"T Ali","year":"2009","unstructured":"Ali T et al (2009) Osteoporosis in inflammatory bowel disease. Am J Med 122:599\u2013604","journal-title":"Am J Med"},{"key":"403_CR84","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1136\/gutjnl-2014-306947","volume":"64","author":"T Ciucci","year":"2015","unstructured":"Ciucci T et al (2015) Bone marrow Th17 TNF\u03b1 cells induce osteoclast differentiation, and link bone destruction to IBD. Gut 64:1072\u20131081","journal-title":"Gut"},{"key":"403_CR85","first-page":"G1020","volume":"296","author":"L Harris","year":"2009","unstructured":"Harris L et al (2009) Inflammatory bowel disease causes reversible suppression of osteoblast and chondrocyte function in mice. Am J Physiol 296:G1020\u2013G1029","journal-title":"Am J Physiol"},{"key":"403_CR86","doi-asserted-by":"publisher","first-page":"1586","DOI":"10.1097\/MIB.0b013e318289e17b","volume":"19","author":"R Irwin","year":"2013","unstructured":"Irwin R et al (2013) Colitis induced bone loss is gender dependent and associated with increased inflammation. Inflamm Bowel Dis 19:1586","journal-title":"Inflamm Bowel Dis"},{"key":"403_CR87","doi-asserted-by":"publisher","first-page":"802","DOI":"10.1002\/jbmr.3027","volume":"32","author":"CE Metzger","year":"2017","unstructured":"Metzger CE et al (2017) Inflammatory bowel disease in a rodent model alters osteocyte protein levels controlling bone turnover. J Bone Miner Res 32:802\u2013813","journal-title":"J Bone Miner Res"},{"key":"403_CR88","doi-asserted-by":"publisher","first-page":"1357","DOI":"10.1002\/jbmr.1588","volume":"27","author":"K Sjogren","year":"2012","unstructured":"Sjogren K et al (2012) The gut microbiota regulates bone mass in mice. J Bone Miner Res 27:1357\u20131367","journal-title":"J Bone Miner Res"},{"key":"403_CR89","doi-asserted-by":"publisher","first-page":"2049","DOI":"10.1172\/JCI86062","volume":"126","author":"J-Y Li","year":"2016","unstructured":"Li J-Y et al (2016) Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics. J Clin Invest 126:2049\u20132063","journal-title":"J Clin Invest"},{"key":"403_CR90","doi-asserted-by":"publisher","first-page":"E7554","DOI":"10.1073\/pnas.1607235113","volume":"113","author":"J Yan","year":"2016","unstructured":"Yan J et al (2016) Gut microbiota induce IGF-1 and promote bone formation and growth. Proc Natl Acad Sci USA 113:E7554\u2013E7563","journal-title":"Proc Natl Acad Sci USA"},{"key":"403_CR91","doi-asserted-by":"publisher","unstructured":"Quach D et al. (2018) Microbiota reconstitution does not cause bone loss in germ-free mice. mSphere. https:\/\/doi.org\/10.1128\/mSphereDirect.00545-17","DOI":"10.1128\/mSphereDirect.00545-17"},{"issue":"10","key":"403_CR92","doi-asserted-by":"publisher","first-page":"728","DOI":"10.1038\/nri3312","volume":"12","author":"TR Klaenhammer","year":"2012","unstructured":"Klaenhammer TR et al (2012) The impact of probiotics and prebiotics on the immune system. Nat Rev Immunol 12(10):728\u2013734","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"403_CR93","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1097\/MOG.0000000000000151","volume":"31","author":"R Frei","year":"2015","unstructured":"Frei R, Akdis M, O\u2019Mahony L (2015) Prebiotics, probiotics, synbiotics, and the immune system: experimental data and clinical evidence. Curr Opin Gastroenterol 31(2):153\u2013158","journal-title":"Curr Opin Gastroenterol"},{"key":"403_CR94","doi-asserted-by":"publisher","first-page":"1793","DOI":"10.1002\/jcp.24340","volume":"228","author":"LR McCabe","year":"2013","unstructured":"McCabe LR et al (2013) Probiotic use decreases intestinal inflammation and increases bone density in healthy male but not female mice. J Cell Physiol 228:1793\u20131798","journal-title":"J Cell Physiol"},{"key":"403_CR95","doi-asserted-by":"publisher","first-page":"e0153180","DOI":"10.1371\/journal.pone.0153180","volume":"11","author":"FL Collins","year":"2016","unstructured":"Collins FL et al (2016) Lactobacillus reuteri 6475 increases bone density in intact females only under an inflammatory setting. PLoS ONE 11:e0153180","journal-title":"PLoS ONE"},{"key":"403_CR96","doi-asserted-by":"publisher","first-page":"e31951","DOI":"10.1371\/journal.pone.0031951","volume":"7","author":"CM Thomas","year":"2012","unstructured":"Thomas CM et al (2012) Histamine derived from probiotic Lactobacillus reuteri suppresses TNF via modulation of PKA and ERK signaling. PLoS ONE 7:e31951","journal-title":"PLoS ONE"},{"key":"403_CR97","doi-asserted-by":"publisher","first-page":"e92368","DOI":"10.1371\/journal.pone.0092368","volume":"9","author":"C Ohlsson","year":"2014","unstructured":"Ohlsson C et al (2014) Probiotics protect mice from ovariectomy-induced cortical bone loss. PLoS ONE 9:e92368","journal-title":"PLoS ONE"},{"key":"403_CR98","doi-asserted-by":"publisher","first-page":"5387","DOI":"10.2147\/IJN.S130485","volume":"12","author":"Z Wang","year":"2017","unstructured":"Wang Z et al (2017) Probiotics protect mice from CoCrMo particles-induced osteolysis. Int J Nanomed 12:5387\u20135397","journal-title":"Int J Nanomed"},{"issue":"2","key":"403_CR99","doi-asserted-by":"publisher","first-page":"e31171","DOI":"10.1371\/journal.pone.0031171","volume":"7","author":"S Salva","year":"2012","unstructured":"Salva S et al (2012) Dietary supplementation with probiotics improves hematopoiesis in malnourished mice. PLoS ONE 7(2):e31171","journal-title":"PLoS ONE"},{"key":"403_CR100","doi-asserted-by":"publisher","first-page":"7734","DOI":"10.1021\/jf2013716","volume":"59","author":"SS Chiang","year":"2011","unstructured":"Chiang SS, Pan TM (2011) Antiosteoporotic effects of lactobacillus-fermented soy skim milk on bone mineral density and the microstructure of femoral bone in ovariectomized mice. J Agric Food Chem 59:7734\u20137742. https:\/\/doi.org\/10.1021\/jf2013716","journal-title":"J Agric Food Chem"},{"key":"403_CR101","doi-asserted-by":"publisher","first-page":"785","DOI":"10.1111\/jre.12164","volume":"49","author":"T Maekawa","year":"2014","unstructured":"Maekawa T, Hajishengallis G (2014) Topical treatment with probiotic Lactobacillus brevis CD2 inhibits experimental periodontal inflammation and bone loss. J Periodontal Res 49:785\u2013791. https:\/\/doi.org\/10.1111\/jre.12164","journal-title":"J Periodontal Res"},{"key":"403_CR102","doi-asserted-by":"publisher","first-page":"1818","DOI":"10.1902\/jop.2013.120644","volume":"84","author":"MR Messora","year":"2013","unstructured":"Messora MR, Oliveira LFF, Foureaux RC et al (2013) Probiotic therapy reduces periodontal tissue destruction and improves the intestinal morphology in rats with ligature-induced periodontitis. J Periodontol 84:1818\u20131826. https:\/\/doi.org\/10.1902\/jop.2013.120644","journal-title":"J Periodontol"},{"key":"403_CR103","doi-asserted-by":"publisher","DOI":"10.1902\/jop.2016.160217","author":"LFF Oliveira","year":"2016","unstructured":"Oliveira LFF, Salvador SL, Silva PHF et al (2016) Benefits of Bifidobacterium animalis subsp. lactis probiotic in experimental periodontitis. J Periodontol. https:\/\/doi.org\/10.1902\/jop.2016.160217","journal-title":"J Periodontol"},{"key":"403_CR104","first-page":"472","volume":"59","author":"KZ Ghanem","year":"2004","unstructured":"Ghanem KZ, Badawy IH, ABDEL-SALAM AM (2004) Influence of yoghurt and probiotic yoghurt on the absorption of calcium, magnesium, iron and bone mineralization in rats. Milchwissenschaft 59:472\u2013475","journal-title":"Milchwissenschaft"},{"key":"403_CR105","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/j.nutres.2012.03.006","volume":"32","author":"T Tomofuji","year":"2012","unstructured":"Tomofuji T, Ekuni D, Azuma T et al (2012) Supplementation of broccoli or Bifidobacterium longum-fermented broccoli suppresses serum lipid peroxidation and osteoclast differentiation on alveolar bone surface in rats fed a high-cholesterol diet. Nutr Res 32:301\u2013307. https:\/\/doi.org\/10.1016\/j.nutres.2012.03.006","journal-title":"Nutr Res"},{"key":"403_CR106","doi-asserted-by":"publisher","first-page":"664","DOI":"10.1089\/jmf.2011.0296","volume":"15","author":"FC Rodrigues","year":"2012","unstructured":"Rodrigues FC, Castro ASB, Rodrigues VC et al (2012) Yacon flour and Bifidobacterium longum modulate bone health in rats. J Med Food 15:664\u2013670. https:\/\/doi.org\/10.1089\/jmf.2011.0296","journal-title":"J Med Food"},{"key":"403_CR107","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1051\/dst\/2009012","volume":"89","author":"MC Kruger","year":"2009","unstructured":"Kruger MC, Fear A, Chua W-H et al (2009) The effect of Lactobacillus rhamnosus HN001 on mineral absorption and bone health in growing male and ovariectomised female rats. Dairy Sci Technol 89:219\u2013231. https:\/\/doi.org\/10.1051\/dst\/2009012","journal-title":"Dairy Sci Technol"},{"key":"403_CR108","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1016\/j.idairyj.2009.06.009","volume":"19","author":"JG Kim","year":"2009","unstructured":"Kim JG, Lee E, Kim SH et al (2009) Effects of a Lactobacillus casei 393 fermented milk product on bone metabolism in ovariectomised rats. Int Dairy J 19:690\u2013695. https:\/\/doi.org\/10.1016\/j.idairyj.2009.06.009","journal-title":"Int Dairy J"},{"key":"403_CR109","doi-asserted-by":"publisher","first-page":"228","DOI":"10.1159\/000080455","volume":"48","author":"M Narva","year":"2004","unstructured":"Narva M, Collin M, Lamberg-Allardt C et al (2004) Effects of long-term intervention with Lactobacillus helveticus-fermented milk on bone mineral density and bone mineral content in growing rats. Ann Nutr Metab 48:228\u2013234. https:\/\/doi.org\/10.1159\/000080455","journal-title":"Ann Nutr Metab"},{"key":"403_CR110","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/s11010-012-1354-3","volume":"368","author":"S Amdekar","year":"2012","unstructured":"Amdekar S, Kumar A, Sharma P et al (2012) Lactobacillus protected bone damage and maintained the antioxidant status of liver and kidney homogenates in female wistar rats. Mol Cell Biochem 368:155\u2013165. https:\/\/doi.org\/10.1007\/s11010-012-1354-3","journal-title":"Mol Cell Biochem"},{"key":"403_CR111","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1080\/17402520400001660","volume":"11","author":"J Rovensk\u00fd","year":"2004","unstructured":"Rovensk\u00fd J, \u0160v\u00edk K, Ma\u0165ha V et al (2004) The effects of Enterococcus faecium and selenium on methotrexate treatment in rat adjuvant-induced arthritis. Clin Dev Immunol 11:267\u2013273. https:\/\/doi.org\/10.1080\/17402520400001660","journal-title":"Clin Dev Immunol"},{"key":"403_CR112","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1093\/ps\/85.9.1621","volume":"85","author":"R Mutu\u015f","year":"2006","unstructured":"Mutu\u015f R, Kocabagli N, Alp M et al (2006) The effect of dietary probiotic supplementation on tibial bone characteristics and strength in broilers. Poult Sci 85:1621\u20131625","journal-title":"Poult Sci"},{"key":"403_CR113","doi-asserted-by":"publisher","first-page":"459","DOI":"10.3382\/ps.0590459","volume":"59","author":"I Plavnik","year":"1980","unstructured":"Plavnik I, Scott ML (1980) Effects of additional vitamins, minerals, or brewer\u2019s yeast upon leg weaknesses in broiler chickens. Poult Sci 59:459\u2013467","journal-title":"Poult Sci"},{"key":"403_CR114","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.3382\/ps.0731699","volume":"73","author":"SN Nahashon","year":"1994","unstructured":"Nahashon SN, Nakaue HS, Mirosh LW (1994) Production variables and nutrient retention in single comb White Leghorn laying pullets fed diets supplemented with direct-fed microbials. Poult Sci 73:1699\u20131711","journal-title":"Poult Sci"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00223-018-0403-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-018-0403-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-018-0403-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T01:18:19Z","timestamp":1693531099000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00223-018-0403-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2,16]]},"references-count":114,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,4]]}},"alternative-id":["403"],"URL":"https:\/\/doi.org\/10.1007\/s00223-018-0403-7","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"value":"0171-967X","type":"print"},{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,16]]},"assertion":[{"value":"27 December 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 February 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"16 February 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"LRM and NP have no conflict of interest.","order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}