{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T21:36:33Z","timestamp":1765056993957},"reference-count":35,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T00:00:00Z","timestamp":1531872000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2018,12]]},"DOI":"10.1007\/s00223-018-0456-7","type":"journal-article","created":{"date-parts":[[2018,7,18]],"date-time":"2018-07-18T14:37:19Z","timestamp":1531924639000},"page":"617-624","update-policy":"http:\/\/dx.doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Spatial Distribution of Microcracks in Osteoarthritic Femoral Neck: Influence of Osteophytes on Microcrack Formation"],"prefix":"10.1007","volume":"103","author":[{"given":"Gustavo D.","family":"Rabelo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathalie","family":"Portero-Muzy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Evelyne","family":"Gineyts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Paul","family":"Roux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Chapurlat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pascale","family":"Chavassieux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2018,7,18]]},"reference":[{"key":"456_CR1","doi-asserted-by":"publisher","first-page":"141118","DOI":"10.1053\/joca.2002.0873","volume":"11","author":"K Gelse","year":"2003","unstructured":"Gelse K, S\u00f6der S, Eger W, Diemtar T, Aigner T (2003) Osteophyte development\u2014molecular characterization of differentiation stages. Osteoarthr Cartil 11:141\u2013118. \n                    https:\/\/doi.org\/10.1053\/joca.2002.0873","journal-title":"Osteoarthr Cartil"},{"key":"456_CR2","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1016\/j.joca.2006.11.006","volume":"15","author":"PM Kraan van der","year":"2007","unstructured":"van der Kraan PM, van den Berg WB (2007) Osteophytes: relevance and biology. Osteoarthr Cartil 15:237\u2013244. \n                    https:\/\/doi.org\/10.1016\/j.joca.2006.11.006","journal-title":"Osteoarthr Cartil"},{"key":"456_CR3","doi-asserted-by":"publisher","DOI":"10.1109\/TBME.2011.2129519","author":"PK Saha","year":"2011","unstructured":"Saha PK, Liang G, Elkins JM, Coimbra A, Duong LT, Williams DS, Sonka M (2011) A new osteophyte segmentation algorithm using partial shape model and its applications to rabbit femur anterior cruciate ligament transection via micro-CT imaging. IEEE Trans Biomed Eng. \n                    https:\/\/doi.org\/10.1109\/TBME.2011.2129519","journal-title":"IEEE Trans Biomed Eng"},{"key":"456_CR4","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1016\/j.bone.2008.07.236","volume":"43","author":"H Blain","year":"2008","unstructured":"Blain H, Chavassieux P, Portero-Muzy N, Bonnel F, Canovas F, Chammas M, Maury P, Delmas PD (2008) Cortical and trabecular bone distribution in the femoral neck in osteoporosis and osteoarthritis. Bone 43:862\u2013868. \n                    https:\/\/doi.org\/10.1016\/j.bone.2008.07.236","journal-title":"Bone"},{"key":"456_CR5","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1016\/j.bone.2011.07.037","volume":"49","author":"S Boutroy","year":"2011","unstructured":"Boutroy S, Vilayphiou N, Roux JP, Delmas PD, Blain H, Chapurlat RD, Chavassieux P (2011) Comparison of 2D and 3D bone microarchitecture evaluation at the femoral neck, among postmenopausal women with hip fracture or hip osteoarthritis. Bone 49:1055\u20131061. \n                    https:\/\/doi.org\/10.1016\/j.bone.2011.07.037","journal-title":"Bone"},{"key":"456_CR6","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-017-0378-9","author":"GD Rabelo","year":"2017","unstructured":"Rabelo GD, Roux JP, Portero-Muzy N, Gineyts E, Chapurlat R, Chavassieux P (2018) Cortical fractal analysis and collagen crosslinks content in femoral neck after osteoporotic fracture in postmenopausal women: comparison with osteoarthritis. Calcif Tissue Int 102:644-650. \n                    https:\/\/doi.org\/10.1007\/s00223-017-0378-9","journal-title":"Calcif Tissue Int"},{"key":"456_CR7","doi-asserted-by":"publisher","first-page":"770","DOI":"10.1097\/BRS.0b013e3181df1a70","volume":"36","author":"M Al-Rawahi","year":"2011","unstructured":"Al-Rawahi M, Luo J, Pollintine P, Dolan P, Adams MA (2011) Mechanical function of vertebral body osteophytes, as revealed by experiments on cadaveric spines. Spine (Phila Pa 1976) 36:770\u2013777. \n                    https:\/\/doi.org\/10.1097\/BRS.0b013e3181df1a70","journal-title":"Spine (Phila Pa 1976)"},{"key":"456_CR8","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1002\/art.37792","volume":"65","author":"MC Casta\u00f1o-Betancourt","year":"2013","unstructured":"Casta\u00f1o-Betancourt MC, Rivadeneira F, Bierma-Zeinstra S, Kerkhof HJ, Hofman A, Uitterlinden AG, van Meurs JB (2013) Bone parameters across different types of hip osteoarthritis and their relationship to osteoporotic fracture risk. Arthritis Rheum 65:693\u2013700. \n                    https:\/\/doi.org\/10.1002\/art.37792","journal-title":"Arthritis Rheum"},{"key":"456_CR9","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1210\/er.2006-0029","volume":"28","author":"P Chavassieux","year":"2007","unstructured":"Chavassieux P, Seeman E, Delmas PD (2007) Insights into material and structural basis of bone fragility from diseases associated with fractures: how determinants of the biomechanical properties of bone are compromised by disease. Endocr Rev 28:151\u2013164. \n                    https:\/\/doi.org\/10.1210\/er.2006-0029","journal-title":"Endocr Rev"},{"key":"456_CR10","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1016\/j.bone.2005.01.023","volume":"37","author":"S Qiu","year":"2013","unstructured":"Qiu S, Rao DS, Fyhrie DP, Palnitkar S, Parfitt AM (2013) The morphological association between microcracks and osteocyte lacunae in human cortical bone. Bone 37:10\u201315. \n                    https:\/\/doi.org\/10.1016\/j.bone.2005.01.023","journal-title":"Bone"},{"key":"456_CR11","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1016\/8756-3282(93)90235-3","volume":"14","author":"S Mori","year":"1993","unstructured":"Mori S, Burr DB (1993) Increased intracortical remodeling following fatigue damage. Bone 14:103\u2013109. \n                    https:\/\/doi.org\/10.1016\/8756-3282(93)90235-3","journal-title":"Bone"},{"issue":"8","key":"456_CR12","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1016\/S0021-9290(97)00029-8","volume":"30","author":"D. Vashishth","year":"1997","unstructured":"Vashishth D, Behiri JC, Bonfield W. Crack growth resistance in cortical bone: concept of microcrack toughening. J Biomech 30:763\u2013769. \n                    https:\/\/doi.org\/10.1016\/S0021-9290(97)00029-8","journal-title":"Journal of Biomechanics"},{"key":"456_CR13","doi-asserted-by":"publisher","first-page":"1299","DOI":"10.1007\/s00198-009-0899-9","volume":"20","author":"RD Chapurlat","year":"2009","unstructured":"Chapurlat RD, Delmas PD (2009) Bone microcrack: a clinical perspective. Osteoporos Int 20:1299\u20131308. \n                    https:\/\/doi.org\/10.1007\/s00198-009-0899-9","journal-title":"Osteoporos Int"},{"key":"456_CR14","doi-asserted-by":"publisher","first-page":"917","DOI":"10.1016\/j.bone.2011.07.001","volume":"49","author":"NR Portero-Muzy","year":"2011","unstructured":"Portero-Muzy NR, Chavassieux PM, Arlot ME, Chapurlat RD (2011) Staining procedure for the detection of microcracks: application to ewe bone. Bone 49:917\u2013919. \n                    https:\/\/doi.org\/10.1016\/j.bone.2011.07.001","journal-title":"Bone"},{"key":"456_CR15","doi-asserted-by":"publisher","first-page":"515","DOI":"10.1002\/path.970","volume":"195","author":"D Chappard","year":"2001","unstructured":"Chappard D, Legrand E, Haettich B, Chales G, Auvinet B, Eschard JP, Hamelin JP, Basle MF, Audran M (2001) Fractal dimension of trabecular bone: comparison of three histomorphometric computed techniques for measuring the architectural two-dimensional complexity. J Pathol 195:515\u2013521. \n                    https:\/\/doi.org\/10.1002\/path.970","journal-title":"J Pathol"},{"key":"456_CR16","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jchromb.2008.10.043","volume":"877","author":"S Viguet-Carrin","year":"2009","unstructured":"Viguet-Carrin S, Gineyts E, Bertholon C, Delmas PD (2009) Simple and sensitive method for quantification of fluorescent enzymatic mature and senescent crosslinks of collagen in bone hydrolysate using single-column high performance liquid chromatography. J Chromatogr B 877:1\u20137. \n                    https:\/\/doi.org\/10.1016\/j.jchromb.2008.10.043","journal-title":"J Chromatogr B"},{"key":"456_CR17","doi-asserted-by":"publisher","first-page":"2250","DOI":"10.1056\/NEJMra053077","volume":"354","author":"E Seeman","year":"2006","unstructured":"Seeman E, Delmas PD (2006) Bone quality\u2014the material and structural basis of bone strength and fragility. N Engl J Med 354:2250\u20132261. \n                    https:\/\/doi.org\/10.1056\/NEJMra053077","journal-title":"N Engl J Med"},{"key":"456_CR18","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/S0021-9290(98)00016-5","volume":"31","author":"DB Burr","year":"1998","unstructured":"Burr DB, Turner CH, Naick P, Forwood MR, Ambrosius W, Hasan MS, Pidaparti R (1998) Does microdamage accumulation affect the mechanical properties of bone? J Biomech 31:337\u2013345. \n                    https:\/\/doi.org\/10.1016\/S0021-9290(98)00016-5","journal-title":"J Biomech"},{"key":"456_CR19","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.bone.2017.12.020","volume":"108","author":"T Tang","year":"2018","unstructured":"Tang T, Cripton PA, Guy P, McKay HA, Wang R (2018) Clinical hip fracture is accompanied by compression induced failure in the superior cortex of the femoral neck. Bone 108:121\u2013131. \n                    https:\/\/doi.org\/10.1016\/j.bone.2017.12.020","journal-title":"Bone"},{"key":"456_CR20","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/BF01774015","volume":"5","author":"JC Lotz","year":"1995","unstructured":"Lotz JC, Cheal EJ, Hayes WC (1995) Stress distributions within the proximal femur during gait and falls: implications for osteoporotic fracture. Osteoporos Int 5:252\u2013261","journal-title":"Osteoporos Int"},{"key":"456_CR21","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1016\/j.bone.2005.09.002","volume":"38","author":"T Diab","year":"2006","unstructured":"Diab T, Condon KW, Burr DB, Vashishth D (2006) Age-related change in the damage morphology of human cortical bone and its role in bone fragility. Bone 38:427\u2013431. \n                    https:\/\/doi.org\/10.1016\/j.bone.2005.09.002","journal-title":"Bone"},{"key":"456_CR22","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1016\/j.micron.2005.07.004","volume":"36","author":"JS Nyman","year":"2005","unstructured":"Nyman JS, Reyes M, Wang X (2005) Effect of ultrastructural changes on the toughness of bone. Micron 36:566\u2013582. \n                    https:\/\/doi.org\/10.1016\/j.micron.2005.07.004","journal-title":"Micron"},{"key":"456_CR23","doi-asserted-by":"publisher","first-page":"1463","DOI":"10.1016\/0021-9290(96)84542-8","volume":"29","author":"AC Courtney","year":"1996","unstructured":"Courtney AC, Hayes WC, Gibson LJ (1996) Age-related differences in post-yield damage in human cortical bone. Exp Model J Biomech 29:1463\u20131471","journal-title":"Exp Model J Biomech"},{"key":"456_CR24","doi-asserted-by":"publisher","first-page":"612","DOI":"10.1016\/j.bone.2006.09.027","volume":"40","author":"T Diab","year":"2007","unstructured":"Diab T, Vashishth D (2007) Morphology, localization and accumulation of in vivo microdamage in human cortical bone. Bone 40:612\u2013618. \n                    https:\/\/doi.org\/10.1016\/j.bone.2006.09.027","journal-title":"Bone"},{"key":"456_CR25","doi-asserted-by":"publisher","first-page":"2659","DOI":"10.1016\/j.jbiomech.2011.08.006","volume":"44","author":"JO Green","year":"2011","unstructured":"Green JO, Wang J, Diab T, Vidakovic B, Guldberg RE (2011) Age-related differences in the morphology of microdamage propagation in trabecular bone. J Biomech 44:2659\u20132666. \n                    https:\/\/doi.org\/10.1016\/j.jbiomech.2011.08.006","journal-title":"J Biomech"},{"key":"456_CR26","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1016\/S8756-3282(97)00298-6","volume":"22","author":"NL Fazzalari","year":"1998","unstructured":"Fazzalari NL, Forwood MR, Smith K, Manthey BA, Herreen P (1998) Assessment of cancellous bone quality in severe osteoarthrosis: bone mineral density, mechanics, and microdamage. Bone 22:381\u2013388. \n                    https:\/\/doi.org\/10.1016\/S8756-3282(97)00298-6","journal-title":"Bone"},{"key":"456_CR27","doi-asserted-by":"publisher","first-page":"1739","DOI":"10.1002\/jor.21448","volume":"29","author":"L Karim","year":"2011","unstructured":"Karim L, Vashishth D (2011) Role of trabecular microarchitecture in the formation, accumulation, and morphology of microdamage in human cancellous bone. J Orthop Res 29:1739\u20131744. \n                    https:\/\/doi.org\/10.1002\/jor.21448","journal-title":"J Orthop Res"},{"key":"456_CR28","doi-asserted-by":"publisher","first-page":"1502","DOI":"10.1359\/jbmr.070609","volume":"22","author":"RD Chapurlat","year":"2007","unstructured":"Chapurlat RD, Arlot M, Burt-Pichat B, Chavassieux P, Roux JP, Portero-Muzy N, Delmas PD (2007) Microcrack frequency and bone remodeling in postmenopausal osteoporotic women on long-term bisphosphonates: a bone biopsy study. J Bone Miner Res 22:1502\u20131509. \n                    https:\/\/doi.org\/10.1359\/jbmr.070609","journal-title":"J Bone Miner Res"},{"key":"456_CR29","doi-asserted-by":"publisher","first-page":"e55232","DOI":"10.1371\/journal.pone.0055232","volume":"8","author":"H Follet","year":"2013","unstructured":"Follet H, Farlay D, Bala Y, Viguet-Carrin S, Gineyts E, Burt-Pichat B, Wegrzyn J, Delmas P, Boivin G, Chapurlat R (2013) Determinants of microdamage in elderly human vertebral trabecular bone. PLoS ONE 8:e55232. \n                    https:\/\/doi.org\/10.1371\/journal.pone.0055232","journal-title":"PLoS ONE"},{"key":"456_CR30","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1111\/j.1469-7580.2006.00509.x","volume":"208","author":"S Mohsin","year":"2006","unstructured":"Mohsin S, O\u2019Brien FJ, Lee TC (2006) Osteonal crack barriers in ovine compact bone. J Anat 208:81\u201389. \n                    https:\/\/doi.org\/10.1111\/j.1469-7580.2006.00509.x","journal-title":"J Anat"},{"key":"456_CR31","doi-asserted-by":"publisher","first-page":"2671","DOI":"10.1007\/s00198-013-2374-x","volume":"24","author":"A Bernhard","year":"2013","unstructured":"Bernhard A, Milovanovic P, Zimmermann EA, Hahn M, Djonic D, Krause M, Breer S, P\u00fcschel K, Djuric M, Amling M, Busse B (2013) Micro-morphological properties of osteons reveal changes in cortical bone stability during aging, osteoporosis, and bisphosphonate treatment in women. Osteoporos Int 24:2671\u20132680. \n                    https:\/\/doi.org\/10.1007\/s00198-013-2374-x","journal-title":"Osteoporos Int"},{"key":"456_CR32","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1007\/s10237-011-0349-4","volume":"11","author":"C Dooley","year":"2012","unstructured":"Dooley C, Tisbo P, Lee TC, Taylor D (2012) Rupture of osteocyte processes across microcracks: the effect of crack length and stress. Biomech Model Mechanobiol 11:759\u2013766. \n                    https:\/\/doi.org\/10.1007\/s10237-011-0349-4","journal-title":"Biomech Model Mechanobiol"},{"key":"456_CR33","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1007\/s00198-005-2035-9","volume":"17","author":"S Viguet-Carrin","year":"2006","unstructured":"Viguet-Carrin S, Garnero P, Delmas PD (2006) The role of collagen in bone strength. Osteoporos Int 17:319\u2013336. \n                    https:\/\/doi.org\/10.1007\/s00198-005-2035-9","journal-title":"Osteoporos Int"},{"key":"456_CR34","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.1359\/jbmr.2002.17.9.1621","volume":"17","author":"X Banse","year":"2002","unstructured":"Banse X, Sims TJ, Bailey AJ (2002) Mechanical properties of adult vertebral cancellous bone: correlation with collagen intermolecular cross-links. J Bone Miner Res 17:1621\u20131628. \n                    https:\/\/doi.org\/10.1359\/jbmr.2002.17.9.1621","journal-title":"J Bone Miner Res"},{"key":"456_CR35","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/S0020-1383(97)00122-8","volume":"29","author":"OO Oni","year":"1998","unstructured":"Oni OO, Morrison CJ (1998) The mechanical \u2018quality\u2019 of osteophytes. Injury 29:31\u201333. \n                    https:\/\/doi.org\/10.1016\/S0020-1383(97)00122-8","journal-title":"Injury"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00223-018-0456-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-018-0456-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-018-0456-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,7,17]],"date-time":"2019-07-17T19:19:37Z","timestamp":1563391177000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00223-018-0456-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,18]]},"references-count":35,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2018,12]]}},"alternative-id":["456"],"URL":"https:\/\/doi.org\/10.1007\/s00223-018-0456-7","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"value":"0171-967X","type":"print"},{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,18]]},"assertion":[{"value":"25 April 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 July 2018","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 July 2018","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Gustavo Davi Rabelo, Nathalie Portero-Muzy, Evelyne Gineyts, Jean-Paul Roux, Roland Chapurlat, and Pascale Chavassieux declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standard of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the research ethics committee, and written informed consent to participation in the study was obtained for all women.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights and Informed Consent"}}]}}