{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T01:20:30Z","timestamp":1789003230083,"version":"build-2803163510"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"name":"Health Labour Sciences Research Grants, The Ministry of Health, Labour and Welfare, Japan"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2019,4]]},"DOI":"10.1007\/s00223-019-00518-z","type":"journal-article","created":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:43:06Z","timestamp":1548981786000},"page":"364-372","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Physical, Mental, and Social Problems of Adolescent and Adult Patients with Achondroplasia"],"prefix":"10.1007","volume":"104","author":[{"given":"Masaki","family":"Matsushita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kitoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenichi","family":"Mishima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuhiko","family":"Haga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sayaka","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keiichi","family":"Ozono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuo","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taichi","family":"Kitaoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Ishiguro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,2,1]]},"reference":[{"issue":"18","key":"518_CR1","doi-asserted-by":"publisher","first-page":"2385","DOI":"10.1002\/ajmg.a.32485","volume":"146A","author":"DK Waller","year":"2008","unstructured":"Waller DK, Correa A, Vo TM, Wang Y, Hobbs C, Langlois PH, Pearson K, Romitti PA, Shaw GM, Hecht JT (2008) The population-based prevalence of achondroplasia and thanatophoric dysplasia in selected regions of the US. Am J Med Genet A 146A (18):2385\u20132389. \n                    https:\/\/doi.org\/10.1002\/ajmg.a.32485","journal-title":"Am J Med Genet A"},{"issue":"9582","key":"518_CR2","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/S0140-6736(07)61090-3","volume":"370","author":"WA Horton","year":"2007","unstructured":"Horton WA, Hall JG, Hecht JT (2007) Achondroplasia Lancet 370(9582):162\u2013172. \n                    https:\/\/doi.org\/10.1016\/S0140-6736(07)61090-3","journal-title":"AchondroplasiaLancet"},{"issue":"6494","key":"518_CR3","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1038\/371252a0","volume":"371","author":"F Rousseau","year":"1994","unstructured":"Rousseau F, Bonaventure J, Legeai-Mallet L, Pelet A, Rozet JM, Maroteaux P, Le Merrer M, Munnich A (1994) Mutations in the gene encoding fibroblast growth factor receptor-3 in achondroplasia. Nature 371(6494):252\u2013254. \n                    https:\/\/doi.org\/10.1038\/371252a0","journal-title":"Nature"},{"issue":"2","key":"518_CR4","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1016\/0092-8674(94)90302-6","volume":"78","author":"R Shiang","year":"1994","unstructured":"Shiang R, Thompson LM, Zhu YZ, Church DM, Fielder TJ, Bocian M, Winokur ST, Wasmuth JJ (1994) Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia. Cell 78(2):335\u2013342","journal-title":"Cell"},{"issue":"5 Suppl","key":"518_CR5","doi-asserted-by":"publisher","first-page":"372","DOI":"10.3171\/ped.2007.106.5.372","volume":"106","author":"DM Sciubba","year":"2007","unstructured":"Sciubba DM, Noggle JC, Marupudi NI, Bagley CA, Bookland MJ, Carson BS, Ain MC, Jallo GI (2007) Spinal stenosis surgery in pediatric patients with achondroplasia. J Neurosurg 106(5 Suppl):372\u2013378. \n                    https:\/\/doi.org\/10.3171\/ped.2007.106.5.372","journal-title":"J Neurosurg"},{"issue":"7","key":"518_CR6","doi-asserted-by":"publisher","first-page":"873","DOI":"10.1007\/s00431-017-2923-y","volume":"176","author":"D Harada","year":"2017","unstructured":"Harada D, Namba N, Hanioka Y, Ueyama K, Sakamoto N, Nakano Y, Izui M, Nagamatsu Y, Kashiwagi H, Yamamuro M, Ishiura Y, Ogitani A, Seino Y (2017) Final adult height in long-term growth hormone-treated achondroplasia patients. Eur J Pediatr 176(7):873\u2013879. \n                    https:\/\/doi.org\/10.1007\/s00431-017-2923-y","journal-title":"Eur J Pediatr"},{"issue":"1","key":"518_CR7","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1515\/JPEM.2001.14.1.17","volume":"14","author":"C Kanaka-Gantenbein","year":"2001","unstructured":"Kanaka-Gantenbein C (2001) Present status of the use of growth hormone in short children with bone diseases (diseases of the skeleton). J Pediatr Endocrinol Metab 14(1):17\u201326","journal-title":"J Pediatr Endocrinol Metab"},{"issue":"9","key":"518_CR8","doi-asserted-by":"publisher","first-page":"1269","DOI":"10.1302\/0301-620X.96B9.33840","volume":"96-B","author":"H Kitoh","year":"2014","unstructured":"Kitoh H, Mishima K, Matsushita M, Nishida Y, Ishiguro N (2014) Early and late fracture following extensive limb lengthening in patients with achondroplasia and hypochondroplasia. Bone Joint J 96-B(9):1269\u20131273. \n                    https:\/\/doi.org\/10.1302\/0301-620X.96B9.33840","journal-title":"Bone Joint J"},{"issue":"6","key":"518_CR9","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1097\/BPO.0b013e318093f523","volume":"27","author":"H Kitoh","year":"2007","unstructured":"Kitoh H, Kitakoji T, Tsuchiya H, Katoh M, Ishiguro N (2007) Distraction osteogenesis of the lower extremity in patients with achondroplasia\/hypochondroplasia treated with transplantation of culture-expanded bone marrow cells and platelet-rich plasma. J Pediatr Orthop 27(6):629\u2013634. \n                    https:\/\/doi.org\/10.1097\/BPO.0b013e318093f523","journal-title":"J Pediatr Orthop"},{"issue":"6","key":"518_CR10","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1097\/00005650-199206000-00002","volume":"30","author":"JE Ware Jr","year":"1992","unstructured":"Ware JE Jr, Sherbourne CD (1992) The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care 30(6):473\u2013483","journal-title":"Med Care"},{"issue":"1","key":"518_CR11","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1002\/(SICI)1096-8628(19980616)78:1<30::AID-AJMG7>3.0.CO;2-P","volume":"78","author":"NN Mahomed","year":"1998","unstructured":"Mahomed NN, Spellmann M, Goldberg MJ (1998) Functional health status of adults with achondroplasia. Am J Med Genet 78(1):30\u201335","journal-title":"Am J Med Genet"},{"issue":"4","key":"518_CR12","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1002\/ajmg.a.20127","volume":"120A","author":"SE Gollust","year":"2003","unstructured":"Gollust SE, Thompson RE, Gooding HC, Biesecker BB (2003) Living with achondroplasia in an average-sized world: an assessment of quality of life. Am J Med Genet A 120A(4):447\u2013458. \n                    https:\/\/doi.org\/10.1002\/ajmg.a.20127","journal-title":"Am J Med Genet A"},{"issue":"3","key":"518_CR13","doi-asserted-by":"publisher","first-page":"237","DOI":"10.1111\/cge.12045","volume":"84","author":"Y Alade","year":"2013","unstructured":"Alade Y, Tunkel D, Schulze K, McGready J, Jallo G, Ain M, Yost T, Hoover-Fong J (2013) Cross-sectional assessment of pain and physical function in skeletal dysplasia patients. Clin Genet 84(3):237\u2013243. \n                    https:\/\/doi.org\/10.1111\/cge.12045","journal-title":"Clin Genet"},{"issue":"5","key":"518_CR14","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1007\/s11136-016-1455-7","volume":"26","author":"N Dhiman","year":"2017","unstructured":"Dhiman N, Albaghdadi A, Zogg CK, Sharma M, Hoover-Fong JE, Ain MC, Haider AH (2017) Factors associated with health-related quality of life (HRQOL) in adults with short stature skeletal dysplasias. Qual Life Res 26(5):1337\u20131348. \n                    https:\/\/doi.org\/10.1007\/s11136-016-1455-7","journal-title":"Qual Life Res"},{"issue":"11","key":"518_CR15","doi-asserted-by":"publisher","first-page":"1037","DOI":"10.1016\/S0895-4356(98)00095-X","volume":"51","author":"S Fukuhara","year":"1998","unstructured":"Fukuhara S, Bito S, Green J, Hsiao A, Kurokawa K (1998) Translation, adaptation, and validation of the SF-36 Health Survey for use in Japan. J Clin Epidemiol 51(11):1037\u20131044","journal-title":"J Clin Epidemiol"},{"issue":"11","key":"518_CR16","doi-asserted-by":"publisher","first-page":"1045","DOI":"10.1016\/S0895-4356(98)00096-1","volume":"51","author":"S Fukuhara","year":"1998","unstructured":"Fukuhara S, Ware JE Jr, Kosinski M, Wada S, Gandek B (1998) Psychometric and clinical tests of validity of the Japanese SF-36 Health Survey. J Clin Epidemiol 51(11):1045\u20131053","journal-title":"J Clin Epidemiol"},{"issue":"4","key":"518_CR17","doi-asserted-by":"publisher","first-page":"435","DOI":"10.1203\/00006450-199910000-00012","volume":"46","author":"U Ramaswami","year":"1999","unstructured":"Ramaswami U, Rumsby G, Spoudeas HA, Hindmarsh PC, Brook CG (1999) Treatment of achondroplasia with growth hormone: six years of experience. Pediatr Res 46(4):435\u2013439. \n                    https:\/\/doi.org\/10.1203\/00006450-199910000-00012","journal-title":"Pediatr Res"},{"issue":"10","key":"518_CR18","doi-asserted-by":"publisher","first-page":"1402","DOI":"10.1080\/08035250510039982","volume":"94","author":"NT Hertel","year":"2005","unstructured":"Hertel NT, Eklof O, Ivarsson S, Aronson S, Westphal O, Sipila I, Kaitila I, Bland J, Veimo D, Muller J, Mohnike K, Neumeyer L, Ritzen M, Hagenas L (2005) Growth hormone treatment in 35 prepubertal children with achondroplasia: a five-year dose-response trial. Acta Paediatr 94(10):1402\u20131410","journal-title":"Acta Paediatr"},{"issue":"12","key":"518_CR19","doi-asserted-by":"publisher","first-page":"1612","DOI":"10.1302\/0301-620X.91B12.22418","volume":"91","author":"KP Venkatesh","year":"2009","unstructured":"Venkatesh KP, Modi HN, Devmurari K, Yoon JY, Anupama BR, Song HR (2009) Femoral lengthening in achondroplasia: magnitude of lengthening in relation to patterns of callus, stiffness of adjacent joints and fracture. J Bone Joint Surg Br 91(12):1612\u20131617. \n                    https:\/\/doi.org\/10.1302\/0301-620X.91B12.22418","journal-title":"J Bone Joint Surg Br"},{"issue":"1","key":"518_CR20","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1302\/0301-620X.94B1.27567","volume":"94","author":"SJ Kim","year":"2012","unstructured":"Kim SJ, Agashe MV, Song SH, Choi HJ, Lee H, Song HR (2012) Comparison between upper and lower limb lengthening in patients with achondroplasia: a retrospective study. J Bone Joint Surg Br 94(1):128\u2013133. \n                    https:\/\/doi.org\/10.1302\/0301-620X.94B1.27567","journal-title":"J Bone Joint Surg Br"},{"issue":"1","key":"518_CR21","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1016\/j.jor.2015.01.001","volume":"12","author":"J Donaldson","year":"2015","unstructured":"Donaldson J, Aftab S, Bradish C (2015) Achondroplasia and limb lengthening: results in a UK cohort and review of the literature. J Orthop 12(1):31\u201334. \n                    https:\/\/doi.org\/10.1016\/j.jor.2015.01.001","journal-title":"J Orthop"},{"issue":"5","key":"518_CR22","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1007\/s00223-017-0301-4","volume":"101","author":"JD Hald","year":"2017","unstructured":"Hald JD, Folkestad L, Harslof T, Brixen K, Langdahl B (2017) Health-related quality of life in adults with osteogenesis imperfecta. Calcif Tissue Int 101(5):473\u2013478. \n                    https:\/\/doi.org\/10.1007\/s00223-017-0301-4","journal-title":"Calcif Tissue Int"},{"issue":"3","key":"518_CR23","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1002\/ajmg.a.20257","volume":"122A","author":"J Ablon","year":"2003","unstructured":"Ablon J (2003) Personality and stereotype in osteogenesis imperfecta: behavioral phenotype or response to life\u2019s hard challenges? Am J Med Genet A 122A(3):201\u2013214. \n                    https:\/\/doi.org\/10.1002\/ajmg.a.20257","journal-title":"Am J Med Genet A"},{"issue":"3","key":"518_CR24","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1080\/135952201317080715","volume":"6","author":"G Kodraliu","year":"2001","unstructured":"Kodraliu G, Mosconi P, Groth N, Carmosino G, Perilli A, Gianicolo EA, Rossi C, Apolone G (2001) Subjective health status assessment: evaluation of the Italian version of the SF-12 Health Survey. Results from the MiOS project. J Epidemiol Biostat 6(3):305\u2013316","journal-title":"J Epidemiol Biostat"},{"issue":"2","key":"518_CR25","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1007\/s00402-016-2608-4","volume":"137","author":"R D\u2019Ambrosi","year":"2017","unstructured":"D\u2019Ambrosi R, Ragone V, Caldarini C, Serra N, Usuelli FG, Facchini RM (2017) The impact of hereditary multiple exostoses on quality of life, satisfaction, global health status, and pain. Arch Orthop Trauma Surg 137(2):209\u2013215. \n                    https:\/\/doi.org\/10.1007\/s00402-016-2608-4","journal-title":"Arch Orthop Trauma Surg"},{"issue":"8","key":"518_CR26","doi-asserted-by":"publisher","first-page":"879","DOI":"10.1016\/0277-9536(90)90215-E","volume":"30","author":"J Ablon","year":"1990","unstructured":"Ablon J (1990) Ambiguity and difference: families with dwarf children. Soc Sci Med 30(8):879\u2013887","journal-title":"Soc Sci Med"},{"issue":"3","key":"518_CR27","doi-asserted-by":"publisher","first-page":"280","DOI":"10.3109\/17453674.2013.786636","volume":"84","author":"R Malot","year":"2013","unstructured":"Malot R, Park KW, Song SH, Kwon HN, Song HR (2013) Role of hybrid monolateral fixators in managing humeral length and deformity correction. Acta Orthop 84(3):280\u2013285. \n                    https:\/\/doi.org\/10.3109\/17453674.2013.786636","journal-title":"Acta Orthop"},{"key":"518_CR28","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1097\/00003086-200110000-00029","volume":"391","author":"N Kashiwagi","year":"2001","unstructured":"Kashiwagi N, Suzuki S, Seto Y, Futami T (2001) Bilateral humeral lengthening in achondroplasia. Clin Orthop Relat Res 391:251\u2013257","journal-title":"Clin Orthop Relat Res"},{"issue":"1","key":"518_CR29","doi-asserted-by":"publisher","first-page":"72","DOI":"10.1142\/S2424835516500119","volume":"21","author":"T Oda","year":"2016","unstructured":"Oda T, Abe Y, Katsumi Y, Ohi H, Nakamura T, Inagaki K (2016) Reliability and validity of the japanese version of the Michigan hand outcomes questionnaire: a comparison with the DASH and SF-36 questionnaires. J Hand Surg Asian Pac 21(1):72\u201377. \n                    https:\/\/doi.org\/10.1142\/S2424835516500119","journal-title":"J Hand Surg Asian Pac"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00223-019-00518-z\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-019-00518-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-019-00518-z.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T19:07:32Z","timestamp":1580497652000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00223-019-00518-z"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2,1]]},"references-count":29,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2019,4]]}},"alternative-id":["518"],"URL":"https:\/\/doi.org\/10.1007\/s00223-019-00518-z","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"value":"0171-967X","type":"print"},{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,2,1]]},"assertion":[{"value":"4 November 2018","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 January 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 February 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Masaki Matsushita, Hiroshi Kitoh, Kenichi Mishima, Satoshi Yamashita, Nobuhiko Haga, Sayaka Fujiwara, Keiichi Ozono, Takuo Kubota, Taichi Kitaoka, and Naoki Ishiguro have no commercial associations that might pose a conflict of interest in connection with the submitted article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This study complied with ethical standards of research involving human participants and was approved by the Ethics Review Committee of Nagoya University Graduate School of Medicine (Reference Number: 2015-0412). Informed consent was obtained from all patients.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights and Informed Consent"}}]}}