{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T03:09:20Z","timestamp":1740107360978,"version":"3.37.3"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T00:00:00Z","timestamp":1574121600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T00:00:00Z","timestamp":1574121600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1007\/s00223-019-00630-0","type":"journal-article","created":{"date-parts":[[2019,11,19]],"date-time":"2019-11-19T20:01:33Z","timestamp":1574193693000},"page":"283-293","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Loss of Lgals3 Protects Against Gonadectomy-Induced Cortical Bone Loss in Mice"],"prefix":"10.1007","volume":"106","author":[{"given":"Kevin A.","family":"Maupin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Dick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5261-5301","authenticated-orcid":false,"given":"Bart O.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,11,19]]},"reference":[{"issue":"2","key":"630_CR1","first-page":"115","volume":"21","author":"SC Manolagas","year":"2000","unstructured":"Manolagas SC (2000) Birth and death of bone cells: basic regulatory mechanisms and implications for the pathogenesis and treatment of osteoporosis. Endocr Rev 21(2):115\u2013137","journal-title":"Endocr Rev"},{"issue":"3","key":"630_CR2","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1210\/edrv.23.3.0465","volume":"23","author":"BL Riggs","year":"2002","unstructured":"Riggs BL, Khosla S, Melton LJ 3rd (2002) Sex steroids and the construction and conservation of the adult skeleton. Endocr Rev 23(3):279\u2013302","journal-title":"Endocr Rev"},{"issue":"5","key":"630_CR3","doi-asserted-by":"publisher","first-page":"763","DOI":"10.1359\/jbmr.1998.13.5.763","volume":"13","author":"BL Riggs","year":"1998","unstructured":"Riggs BL, Khosla S, Melton LJ 3rd (1998) A unitary model for involutional osteoporosis: estrogen deficiency causes both type I and type II osteoporosis in postmenopausal women and contributes to bone loss in aging men. J Bone Miner Res 13(5):763\u2013773","journal-title":"J Bone Miner Res"},{"issue":"5","key":"630_CR4","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1007\/s001980050093","volume":"8","author":"AC Looker","year":"1998","unstructured":"Looker AC et al (1998) Updated data on proximal femur bone mineral levels of US adults. Osteoporos Int 8(5):468\u2013489","journal-title":"Osteoporos Int"},{"issue":"1","key":"630_CR5","doi-asserted-by":"publisher","first-page":"7","DOI":"10.3390\/cancers9010007","volume":"9","author":"MT Schweizer","year":"2017","unstructured":"MT Schweizer, EY Yu (2017) AR-signaling in human malignancies: Prostate cancer and beyond. Cancers 9(1):7","journal-title":"Cancers"},{"key":"630_CR6","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1186\/s12885-015-1843-3","volume":"15","author":"A Wang","year":"2015","unstructured":"Wang A et al (2015) Risk of fracture in men with prostate cancer on androgen deprivation therapy: a population-based cohort study in New Zealand. BMC Cancer 15:837","journal-title":"BMC Cancer"},{"issue":"4","key":"630_CR7","first-page":"276","volume":"36","author":"OA Chernichenko","year":"2014","unstructured":"Chernichenko OA et al (2014) Effect of androgen suppression on bone mineral density in patients with prostate cancer. Experimental Oncology 36(4):276\u2013278","journal-title":"Exp Oncol"},{"issue":"2","key":"630_CR8","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1002\/aja.1002030211","volume":"203","author":"D Fowlis","year":"1995","unstructured":"Fowlis D et al (1995) Galectin-3 is expressed in the notochord, developing bones, and skin of the postimplantation mouse embryo. Dev Dyn 203(2):241\u2013251","journal-title":"Dev Dyn"},{"issue":"8","key":"630_CR9","first-page":"1191","volume":"45","author":"C Colnot","year":"1999","unstructured":"Colnot C et al (1999) Cellular and subcellular distribution of galectin-3 in the epiphyseal cartilage and bone of fetal and neonatal mice. Cell Mol Biol 45(8):1191\u20131202","journal-title":"Cell Mol Biol"},{"issue":"1","key":"630_CR10","doi-asserted-by":"publisher","first-page":"R20","DOI":"10.1186\/ar2130","volume":"9","author":"A Janelle-Montcalm","year":"2007","unstructured":"Montcalm A et al (2007) Extracellular localization of galectin-3 has a deleterious role in joint tissues. Arthritis Res Ther 9(1):R20","journal-title":"Arthritis Res Ther"},{"issue":"11","key":"630_CR11","doi-asserted-by":"publisher","first-page":"939","DOI":"10.1016\/j.neo.2014.09.005","volume":"16","author":"K Nakajima","year":"2014","unstructured":"Nakajima K et al (2014) Galectin-3 inhibits osteoblast differentiation through notch signaling. Neoplasia 16(11):939\u2013949","journal-title":"Neoplasia"},{"issue":"1","key":"630_CR12","doi-asserted-by":"publisher","first-page":"16","DOI":"10.18632\/aging.100865","volume":"8","author":"S Weilner","year":"2016","unstructured":"Weilner S et al (2016) Vesicular galectin-3 levels decrease with donor age and contribute to the reduced osteo-inductive potential of human plasma derived extracellular vesicles. Aging 8(1):16\u201333","journal-title":"Aging"},{"key":"630_CR13","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1016\/j.metabol.2018.02.001","volume":"83","author":"C Iacobini","year":"2018","unstructured":"Iacobini C et al (2018) Galectin-3 is essential for proper bone cell differentiation and activity, bone remodeling and biomechanical competence in mice. Metabolism 83:149\u2013158","journal-title":"Metabolism"},{"issue":"1","key":"630_CR14","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1038\/s41413-017-0003-6","volume":"6","author":"KA Maupin","year":"2018","unstructured":"Maupin KA et al (2018) Enhanced cortical bone expansion in Lgals3-deficient mice during aging. Bone Res 6(1):7","journal-title":"Bone Res"},{"issue":"1","key":"630_CR15","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1038\/labinvest.2008.111","volume":"89","author":"YJ Li","year":"2009","unstructured":"Li YJ et al (2009) A possible suppressive role of galectin-3 in upregulated osteoclastogenesis accompanying adjuvant-induced arthritis in rats. Lab Investig 89(1):26\u201337","journal-title":"Lab Investig"},{"issue":"6","key":"630_CR16","doi-asserted-by":"publisher","first-page":"3028","DOI":"10.1091\/mbc.e04-12-1119","volume":"16","author":"N Ortega","year":"2005","unstructured":"Ortega N et al (2005) Galectin-3 is a downstream regulator of matrix metalloproteinase-9 function during endochondral bone formation. Mol Biol Cell 16(6):3028\u20133039","journal-title":"Mol Biol Cell"},{"key":"630_CR17","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1016\/j.bone.2017.08.013","volume":"105","author":"D Simon","year":"2017","unstructured":"Simon D et al (2017) Galectin-3 as a novel regulator of osteoblast-osteoclast interaction and bone homeostasis. Bone 105:35\u201341","journal-title":"Bone"},{"issue":"6","key":"630_CR18","doi-asserted-by":"publisher","first-page":"1391","DOI":"10.1158\/0008-5472.CAN-15-1793","volume":"76","author":"K Nakajima","year":"2016","unstructured":"Nakajima K et al (2016) Galectin-3 Cleavage Alters Bone Remodeling: Different Outcomes in Breast and Prostate Cancer Skeletal Metastasis. Can Res 76(6):1391\u20131402","journal-title":"Can Res"},{"issue":"47","key":"630_CR19","doi-asserted-by":"publisher","first-page":"13522","DOI":"10.1073\/pnas.1607644113","volume":"113","author":"AK Oestreich","year":"2016","unstructured":"Oestreich AK et al (2016) Decreasing maternal myostatin programs adult offspring bone strength in a mouse model of osteogenesis imperfecta. Proc Natl Acad Sci USA 113(47):13522\u201313527","journal-title":"Proc Natl Acad Sci USA"},{"issue":"4","key":"630_CR20","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/8756-3282(93)90081-K","volume":"14","author":"CH Turner","year":"1993","unstructured":"Turner CH, Burr DB (1993) Basic biomechanical measurements of bone: a tutorial. Bone 14(4):595\u2013608","journal-title":"Bone"},{"issue":"2","key":"630_CR21","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.atherosclerosis.2014.12.011","volume":"238","author":"G Pugliese","year":"2015","unstructured":"Pugliese G et al (2015) The dark and bright side of atherosclerotic calcification. Atherosclerosis 238(2):220\u2013230","journal-title":"Atherosclerosis"},{"issue":"3","key":"630_CR22","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1093\/cvr\/cvt206","volume":"100","author":"S Menini","year":"2013","unstructured":"Menini S et al (2013) The galectin-3\/RAGE dyad modulates vascular osteogenesis in atherosclerosis. Cardiovasc Res 100(3):472\u2013480","journal-title":"Cardiovasc Res"},{"issue":"11","key":"630_CR23","doi-asserted-by":"publisher","first-page":"e004360","DOI":"10.1161\/JAHA.116.004360","volume":"5","author":"JR Sadaba","year":"2016","unstructured":"Sadaba JR et al (2016) Role for galectin-3 in calcific aortic valve stenosis. J Am Heart Assoc 5(11):e004360","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"630_CR24","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1111\/j.1365-2796.2011.02476.x","volume":"272","author":"RA de Boer","year":"2012","unstructured":"de Boer RA et al (2012) The fibrosis marker galectin-3 and outcome in the general population. J Intern Med 272(1):55\u201364","journal-title":"J Intern Med"},{"issue":"1","key":"630_CR25","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1677\/JOE-10-0026","volume":"206","author":"HE MacLean","year":"2010","unstructured":"MacLean HE et al (2010) DNA-binding-dependent androgen receptor signaling contributes to gender differences and has physiological actions in males and females. J Endocrinol 206(1):93\u2013103","journal-title":"J Endocrinol"},{"issue":"10","key":"630_CR26","doi-asserted-by":"publisher","first-page":"4576","DOI":"10.1210\/jcem.86.10.7960","volume":"86","author":"E Seeman","year":"2001","unstructured":"Seeman E (2001) Clinical review 137: Sexual dimorphism in skeletal size, density, and strength. J Clin Endocrinol Metab 86(10):4576\u20134584","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"630_CR27","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1530\/JME-12-0014","volume":"49","author":"PK Russell","year":"2012","unstructured":"Russell PK et al (2012) Identification of gene pathways altered by deletion of the androgen receptor specifically in mineralizing osteoblasts and osteocytes in mice. J Mol Endocrinol 49(1):1\u201310","journal-title":"J Mol Endocrinol"},{"issue":"4","key":"630_CR28","doi-asserted-by":"publisher","first-page":"621","DOI":"10.1359\/jbmr.081217","volume":"24","author":"C Chiang","year":"2009","unstructured":"Chiang C et al (2009) Mineralization and bone resorption are regulated by the androgen receptor in male mice. J Bone Miner Res 24(4):621\u2013631","journal-title":"J Bone Miner Res"},{"issue":"1","key":"630_CR29","doi-asserted-by":"publisher","first-page":"R17","DOI":"10.1186\/ar3696","volume":"14","author":"SA Rowas","year":"2012","unstructured":"Rowas SA et al (2012) Effect of in utero exposure to diethylstilbestrol on lumbar and femoral bone, articular cartilage, and the intervertebral disc in male and female adult mice progeny with and without swimming exercise. Arthr Res Ther 14(1):R17","journal-title":"Arthr Res Ther"},{"issue":"5","key":"630_CR30","doi-asserted-by":"publisher","first-page":"2118","DOI":"10.1210\/endo.137.5.8612556","volume":"137","author":"S Migliaccio","year":"1996","unstructured":"Migliaccio S et al (1996) Alterations of maternal estrogen levels during gestation affect the skeleton of female offspring. Endocrinology 137(5):2118\u20132125","journal-title":"Endocrinology"},{"issue":"1","key":"630_CR31","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/S8756-3282(00)00286-6","volume":"27","author":"S Migliaccio","year":"2000","unstructured":"Migliaccio S et al (2000) Transient estrogen exposure of female mice during early development permanently affects osteoclastogenesis in adulthood. Bone 27(1):47\u201352","journal-title":"Bone"},{"key":"630_CR32","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1186\/s12933-015-0230-3","volume":"14","author":"AL Darrow","year":"2015","unstructured":"Darrow AL, Shohet RV (2015) Galectin-3 deficiency exacerbates hyperglycemia and the endothelial response to diabetes. Cardiovasc Diabetol 14:73","journal-title":"Cardiovasc Diabetol"},{"issue":"1","key":"630_CR33","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1016\/j.thromres.2010.01.045","volume":"126","author":"SN Tchaikovski","year":"2010","unstructured":"Tchaikovski SN, Rosing J (2010) Mechanisms of estrogen-induced venous thromboembolism. Thromb Res 126(1):5\u201311","journal-title":"Thromb Res"},{"issue":"1","key":"630_CR34","first-page":"168","volume":"120","author":"TP McDonald","year":"1992","unstructured":"McDonald TP et al (1992) Sex- and strain-related differences in megakaryocytopoiesis and platelet production in C3H and BALB\/c mice. J Lab Clin Med 120(1):168\u2013173","journal-title":"J Lab Clin Med"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-019-00630-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00223-019-00630-0\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-019-00630-0.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T04:35:47Z","timestamp":1605674147000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00223-019-00630-0"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,19]]},"references-count":34,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["630"],"URL":"https:\/\/doi.org\/10.1007\/s00223-019-00630-0","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"type":"print","value":"0171-967X"},{"type":"electronic","value":"1432-0827"}],"subject":[],"published":{"date-parts":[[2019,11,19]]},"assertion":[{"value":"23 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"1 November 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Authors Kevin A. Maupin, Daniel Dick, Johan Lee, and Bart O. Williams have declared no conflicts of interest associated with this study. BOW has served as a consultant for Amgen, is an Advisory Board member at Surrozen, and has research support from Janssen in areas unrelated to this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of Interest"}},{"value":"All animal procedures were carried out in compliance with the regulations and guidelines set by the Institutional Animal Care and Use Committee at VARI. The protocols used were approved by the Institutional Animal Care and Use Committee at VARI prior to the initiation of experiments.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights"}}]}}