{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T11:16:26Z","timestamp":1771067786166,"version":"3.50.1"},"reference-count":54,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T00:00:00Z","timestamp":1574985600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T00:00:00Z","timestamp":1574985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR043052-07"],"award-info":[{"award-number":["R01 AR043052-07"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 AR03043"],"award-info":[{"award-number":["P50 AR03043"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["P50 AR060752"],"award-info":[{"award-number":["P50 AR060752"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1007\/s00223-019-00634-w","type":"journal-article","created":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T06:03:13Z","timestamp":1575007393000},"page":"303-314","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Sequential Treatment of Estrogen Deficient, Osteopenic Rats with Alendronate, Parathyroid Hormone (1\u201334), or Raloxifene Alters Cortical Bone Mineral and Matrix Composition"],"prefix":"10.1007","volume":"106","author":[{"given":"Erik A.","family":"Taylor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eve","family":"Donnelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomei","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mark L.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah K.","family":"Amugongo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5463-520X","authenticated-orcid":false,"given":"Donald B.","family":"Kimmel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nancy E.","family":"Lane","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2019,11,29]]},"reference":[{"key":"634_CR1","doi-asserted-by":"publisher","first-page":"544","DOI":"10.1359\/jbmr.071207","volume":"23","author":"JA Gasser","year":"2008","unstructured":"Gasser JA, Ingold P, Venturiere A et al (2008) Long-term protective effects of zoledronic acid on cancellous and cortical bone in the ovariectomized rat. J Bone Miner Res 23:544\u2013551. https:\/\/doi.org\/10.1359\/jbmr.071207","journal-title":"J Bone Miner Res"},{"key":"634_CR2","doi-asserted-by":"publisher","first-page":"385","DOI":"10.1007\/s11914-014-0237-9","volume":"12","author":"F Cosman","year":"2014","unstructured":"Cosman F (2014) Anabolic and antiresorptive therapy for osteoporosis: combination and sequential approaches. Curr Osteoporos Rep 12:385\u2013395. https:\/\/doi.org\/10.1007\/s11914-014-0237-9","journal-title":"Curr Osteoporos Rep"},{"key":"634_CR3","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/8756-3282(94)00033-V","volume":"16","author":"L Mosekilde","year":"1995","unstructured":"Mosekilde L, Danielsen CC, S\u00f8gaard CH et al (1995) The anabolic effects of parathyroid hormone on cortical bone mass, dimensions and strength-assessed in a sexually mature, ovariectomized rat model. Bone 16:223\u2013230. https:\/\/doi.org\/10.1016\/8756-3282(94)00033-V","journal-title":"Bone"},{"key":"634_CR4","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1007\/s00198-014-2678-5","volume":"25","author":"SK Amugongo","year":"2014","unstructured":"Amugongo SK, Yao W, Jia J et al (2014) Effects of sequential osteoporosis treatments on trabecular bone in adult rats with low bone mass. Osteoporos Int 25:1735\u20131750. https:\/\/doi.org\/10.1007\/s00198-014-2678-5","journal-title":"Osteoporos Int"},{"key":"634_CR5","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1097\/OPX.0b013e3182540562","volume":"67","author":"S Amugongo","year":"2014","unstructured":"Amugongo S, Yao W, Jia J et al (2014) Effect of sequential treatments with alendronate, parathyroid hormone (1\u201334) and raloxifene on cortical bone mass and strength in ovariectomized rats. Bone 67:257\u2013268. https:\/\/doi.org\/10.1097\/OPX.0b013e3182540562","journal-title":"Bone"},{"key":"634_CR6","doi-asserted-by":"publisher","first-page":"31102","DOI":"10.1117\/1.1922927","volume":"10","author":"A Boskey","year":"2005","unstructured":"Boskey A, Mendelsohn R (2005) Infrared analysis of bone in health and disease. J Biomed Opt 10:31102. https:\/\/doi.org\/10.1117\/1.1922927","journal-title":"J Biomed Opt"},{"key":"634_CR7","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.bone.2015.08.002","volume":"81","author":"C Acevedo","year":"2015","unstructured":"Acevedo C, Bale H, Gludovatz B et al (2015) Alendronate treatment alters bone tissues at multiple structural levels in healthy canine cortical bone. Bone 81:352\u2013363. https:\/\/doi.org\/10.1016\/j.bone.2015.08.002","journal-title":"Bone"},{"key":"634_CR8","doi-asserted-by":"publisher","first-page":"701","DOI":"10.1016\/j.bone.2011.05.009","volume":"49","author":"DB Burr","year":"2011","unstructured":"Burr DB, Allen MR, Miller LM et al (2011) Bisphosphonates do not alter the rate of secondary mineralization. Bone 49:701\u2013705. https:\/\/doi.org\/10.1016\/j.bone.2011.05.009","journal-title":"Bone"},{"key":"634_CR9","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1002\/jbmr.1501","volume":"27","author":"Y Bala","year":"2012","unstructured":"Bala Y, Depalle B, Farlay D et al (2012) Bone micromechanical properties are compromised during long-term alendronate therapy independently of mineralization. J Bone Miner Res 27:825\u2013834. https:\/\/doi.org\/10.1002\/jbmr.1501","journal-title":"J Bone Miner Res"},{"key":"634_CR10","doi-asserted-by":"publisher","first-page":"326","DOI":"10.1016\/j.bone.2012.10.018","volume":"52","author":"JC Burket","year":"2013","unstructured":"Burket JC, Brooks DJ, MacLeay JM et al (2013) Variations in nanomechanical properties and tissue composition within trabeculae from an ovine model of osteoporosis and treatment. Bone 52:326\u2013336. https:\/\/doi.org\/10.1016\/j.bone.2012.10.018","journal-title":"Bone"},{"key":"634_CR11","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1359\/jbmr.2003.18.4.769","volume":"18","author":"EP Paschalis","year":"2003","unstructured":"Paschalis EP, Burr DB, Mendelsohn R et al (2003) Bone mineral and collagen quality in humeri of ovariectomized cynomolgus monkeys given rhPTH (1\u201334) for 18 months. J Bone Miner Res 18:769\u2013775. https:\/\/doi.org\/10.1359\/jbmr.2003.18.4.769","journal-title":"J Bone Miner Res"},{"key":"634_CR12","doi-asserted-by":"publisher","first-page":"2373","DOI":"10.1007\/s00198-010-1454-4","volume":"22","author":"M Saito","year":"2011","unstructured":"Saito M, Marumo K, Kida Y et al (2011) Changes in the contents of enzymatic immature, mature, and non-enzymatic senescent cross-links of collagen after once-weekly treatment with h-PTH (1\u201334) for 18 months contribute to improvement of bone strength in OVX monkeys. Osteoporos Int 22:2373\u20132383. https:\/\/doi.org\/10.1007\/s00198-010-1454-4","journal-title":"Osteoporos Int"},{"key":"634_CR13","doi-asserted-by":"publisher","first-page":"307","DOI":"10.1359\/JBMR.051027","volume":"21","author":"SK Eswaran","year":"2006","unstructured":"Eswaran SK, Gupta A, Adams MF, Keaveny TM (2006) Cortical and trabecular load sharing in the human vertebral body. J Bone Miner Res 21:307\u2013314. https:\/\/doi.org\/10.1359\/JBMR.051027","journal-title":"J Bone Miner Res"},{"key":"634_CR14","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1016\/j.bonr.2018.02.005","volume":"8","author":"A Stern","year":"2018","unstructured":"Stern A, Yao X, Wang Y et al (2018) Effect of osteoporosis treatment agents on the cortical bone osteocyte microenvironment in adult estrogen-deficient, osteopenic rats. Bone Rep 8:115\u2013124. https:\/\/doi.org\/10.1016\/j.bonr.2018.02.005","journal-title":"Bone Rep"},{"key":"634_CR15","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1007\/s00774-004-0519-x","volume":"22","author":"K Tazawa","year":"2004","unstructured":"Tazawa K, Hoshi K, Kawamoto S et al (2004) Osteocytic osteolysis observed in rats to which parathyroid hormone was continuously administered. J Bone Miner Metab 22:524\u2013529. https:\/\/doi.org\/10.1007\/s00774-004-0519-x","journal-title":"J Bone Miner Metab"},{"key":"634_CR16","doi-asserted-by":"publisher","first-page":"130","DOI":"10.1016\/j.bone.2018.09.019","volume":"117","author":"JD Gardinier","year":"2018","unstructured":"Gardinier JD, Al-Omaishi S, Rostami N et al (2018) Examining the influence of PTH (1\u201334) on tissue strength and composition. Bone 117:130\u2013137. https:\/\/doi.org\/10.1016\/j.bone.2018.09.019","journal-title":"Bone"},{"key":"634_CR17","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1002\/jbmr.1543","volume":"27","author":"AJ Roelofs","year":"2012","unstructured":"Roelofs AJ, Stewart CA, Sun S et al (2012) Influence of bone affinity on the skeletal distribution of fluorescently labeled bisphosphonates in vivo. J Bone Miner Res 27:835\u2013847. https:\/\/doi.org\/10.1002\/jbmr.1543","journal-title":"J Bone Miner Res"},{"issue":"2","key":"634_CR18","doi-asserted-by":"publisher","first-page":"230","DOI":"10.1016\/j.bone.2013.01.025","volume":"54","author":"JJ Wysolmerski","year":"2013","unstructured":"Wysolmerski JJ (2013) Osteocytes remove and replace perilacunar mineral during reproductive cycles. Bone 54(2):230\u2013236. https:\/\/doi.org\/10.1016\/j.bone.2013.01.025","journal-title":"Bone"},{"issue":"2","key":"634_CR19","doi-asserted-by":"publisher","first-page":"59","DOI":"10.4248\/ijos.09019","volume":"1","author":"H Qing","year":"2009","unstructured":"Qing H, Bonewald LF (2009) Osteocyte remodeling of the perilacunar and pericanalicular matrix. Int J Oral Sci 1(2):59\u201365. https:\/\/doi.org\/10.4248\/ijos.09019","journal-title":"Int J Oral Sci"},{"issue":"3","key":"634_CR20","first-page":"292","volume":"18","author":"E Tsourdi","year":"2018","unstructured":"Tsourdi E, J\u00e4hn K, Rauner M, Busse B, Bonewald LF (2018) Physiological and pathological osteocytic osteolysis. J Musculoskelet Neuronal Interact 18(3):292\u2013303","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"634_CR21","doi-asserted-by":"publisher","first-page":"1735","DOI":"10.1016\/j.jbiomech.2005.04.032","volume":"39","author":"DP Nicolella","year":"2006","unstructured":"Nicolella DP, Moravits DE, Gale AM et al (2006) Osteocyte lacunae tissue strain in cortical bone. J Biomech 39:1735\u20131743. https:\/\/doi.org\/10.1016\/j.jbiomech.2005.04.032","journal-title":"J Biomech"},{"key":"634_CR22","doi-asserted-by":"publisher","first-page":"162","DOI":"10.1016\/j.matbio.2016.02.010","volume":"52\u201354","author":"JD Gardinier","year":"2016","unstructured":"Gardinier JD, Al-Omaishi S, Morris MD, Kohn DH (2016) PTH signaling mediates perilacunar remodeling during exercise. Matrix Biol 52\u201354:162\u2013175. https:\/\/doi.org\/10.1016\/j.matbio.2016.02.010","journal-title":"Matrix Biol"},{"key":"634_CR23","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1038\/bonekey.2014.115","volume":"4","author":"GS Mandair","year":"2015","unstructured":"Mandair GS, Morris MD (2015) Contributions of Raman spectroscopy to the understanding of bone strength. BoneKEy 4:1\u20138. https:\/\/doi.org\/10.1038\/bonekey.2014.115","journal-title":"BoneKEy"},{"key":"634_CR24","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1016\/j.bone.2010.04.608","volume":"47","author":"S Gamsjaeger","year":"2010","unstructured":"Gamsjaeger S, Masic A, Roschger P et al (2010) Cortical bone composition and orientation as a function of animal and tissue age in mice by Raman spectroscopy. Bone 47:392\u2013399. https:\/\/doi.org\/10.1016\/j.bone.2010.04.608","journal-title":"Bone"},{"issue":"10","key":"634_CR25","doi-asserted-by":"publisher","first-page":"2404","DOI":"10.1177\/0003702817709286","volume":"71","author":"EA Taylor","year":"2017","unstructured":"Taylor EA, Lloyd AA, Salazar-Lara C, Donnelly EL (2017) Raman and FT-IR mineral to matrix ratios correlate with physical chemical properties of model compounds and native bone tissue. Appl Spectrosc 71(10):2404\u20132410. https:\/\/doi.org\/10.1177\/0003702817709286","journal-title":"Appl Spectrosc"},{"issue":"6","key":"634_CR26","doi-asserted-by":"publisher","first-page":"565","DOI":"10.1007\/s00223-016-0232-5","volume":"100","author":"S Gamsjaeger","year":"2017","unstructured":"Gamsjaeger S, Robins SP, Tatakis DN et al (2017) Identification of pyridinoline trivalent collagen cross-links by Raman microspectroscopy. Calcif Tissue Int 100(6):565\u2013574. https:\/\/doi.org\/10.1007\/s00223-016-0232-5","journal-title":"Calcif Tissue Int"},{"issue":"2","key":"634_CR27","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s10856-019-6226-x","volume":"30","author":"JR Beattie","year":"2019","unstructured":"Beattie JR, Sophocleous A, Caraher MC et al (2019) Raman spectroscopy as a predictive tool for monitoring osteoporosis therapy in a rat model of postmenopausal osteoporosis. J Mater Sci Mater Med 30(2):25. https:\/\/doi.org\/10.1007\/s10856-019-6226-x","journal-title":"J Mater Sci Mater Med"},{"issue":"2","key":"634_CR28","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1007\/s10103-011-0976-0","volume":"27","author":"RA de Souza","year":"2012","unstructured":"de Souza RA, Xavier M, da Silva FF et al (2012) Influence of creatine supplementation on bone quality in the OVX rat model: an FT-Raman spectroscopy study. Lasers Med Sci 27(2):487\u2013495. https:\/\/doi.org\/10.1007\/s10103-011-0976-0","journal-title":"Lasers Med Sci"},{"key":"634_CR29","doi-asserted-by":"publisher","first-page":"031102","DOI":"10.1117\/1.1922927","volume":"10","author":"A Boskey","year":"2005","unstructured":"Boskey A, Mendelsohn R (2005) Infrared analysis of bone in health and disease. J Biomed Opt 10:031102. https:\/\/doi.org\/10.1117\/1.1922927","journal-title":"J Biomed Opt"},{"issue":"3","key":"634_CR30","doi-asserted-by":"publisher","first-page":"242","DOI":"10.1007\/s00223-015-9985-5","volume":"97","author":"M Saito","year":"2015","unstructured":"Saito M, Marumo K (2015) Effects of collagen crosslinking on bone material properties in health and disease. Calcif Tissue Int 97(3):242\u2013261. https:\/\/doi.org\/10.1007\/s00223-015-9985-5","journal-title":"Calcif Tissue Int"},{"issue":"3","key":"634_CR31","doi-asserted-by":"publisher","first-page":"308","DOI":"10.1007\/s00223-015-9971-y","volume":"97","author":"Y Bala","year":"2015","unstructured":"Bala Y, Seeman E (2015) Bone\u2019s material constituents and their contribution to bone strength in health, disease, and treatment. Calcif Tissue Int 97(3):308\u2013326. https:\/\/doi.org\/10.1007\/s00223-015-9971-y","journal-title":"Calcif Tissue Int"},{"key":"634_CR32","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1038\/bonekey.2012.182","volume":"1","author":"P Garnero","year":"2012","unstructured":"Garnero P (2012) The contribution of collagen crosslinks to bone strength. BoneKey Rep 1:182. https:\/\/doi.org\/10.1038\/bonekey.2012.182","journal-title":"BoneKey Rep"},{"key":"634_CR33","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1016\/j.bone.2011.08.015","volume":"49","author":"S Gamsjaeger","year":"2011","unstructured":"Gamsjaeger S, Buchinger B, Zoehrer R et al (2011) Effects of one year daily teriparatide treatment on trabecular bone material properties in postmenopausal osteoporotic women previously treated with alendronate or risedronate. Bone 49:1160\u20131165. https:\/\/doi.org\/10.1016\/j.bone.2011.08.015","journal-title":"Bone"},{"key":"634_CR34","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1007\/s00198-008-0725-9","volume":"20","author":"AL Boskey","year":"2009","unstructured":"Boskey AL, Spevak L, Weinstein RS (2009) Spectroscopic markers of bone quality in alendronate-treated postmenopausal women. Osteoporos Int 20:793\u2013800. https:\/\/doi.org\/10.1007\/s00198-008-0725-9","journal-title":"Osteoporos Int"},{"key":"634_CR35","doi-asserted-by":"publisher","first-page":"1581","DOI":"10.1359\/jbmr.060701","volume":"21","author":"E Durchschlag","year":"2006","unstructured":"Durchschlag E, Paschalis EP, Zoehrer R et al (2006) Bone material properties in trabecular bone from human iliac crest biopsies after 3- and 5-year treatment with risedronate. J Bone Miner Res 21:1581\u20131590. https:\/\/doi.org\/10.1359\/jbmr.060701","journal-title":"J Bone Miner Res"},{"key":"634_CR36","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1002\/jbmr.180","volume":"26","author":"S Gamsjaeger","year":"2011","unstructured":"Gamsjaeger S, Buchinger B, Zwettler E et al (2011) Bone material properties in actively bone-forming trabeculae in postmenopausal women with osteoporosis after three years of treatment with once-yearly zoledronic acid. J Bone Miner Res 26:12\u201318. https:\/\/doi.org\/10.1002\/jbmr.180","journal-title":"J Bone Miner Res"},{"key":"634_CR37","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1016\/j.bone.2014.01.009.Bone","volume":"61","author":"MA Gallant","year":"2015","unstructured":"Gallant MA, Brown DM, Hammond M et al (2015) Bone cell-independent benefits of raloxifene on the skeleton: a novel mechanism for improving bone material properties. Bone 61:191\u2013200. https:\/\/doi.org\/10.1016\/j.bone.2014.01.009.Bone","journal-title":"Bone"},{"key":"634_CR38","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1359\/jbmr.090702","volume":"25","author":"P Roschger","year":"2010","unstructured":"Roschger P, Lombardi A, Misof BM et al (2010) Mineralization density distribution of postmenopausal osteoporotic bone is restored to normal after long-term alendronate treatment: qBEI and sSAXS data from the fracture intervention trial long-term extension (FLEX). J Bone Miner Res 25:48\u201355. https:\/\/doi.org\/10.1359\/jbmr.090702","journal-title":"J Bone Miner Res"},{"key":"634_CR39","doi-asserted-by":"publisher","first-page":"893","DOI":"10.1359\/jbmr.2001.16.5.893","volume":"16","author":"H Ou-Yang","year":"2001","unstructured":"Ou-Yang H, Paschalis EP, Mayo WE et al (2001) Infrared microscopic imaging of bone: spatial distribution of CO3(2\u2212). J Bone Miner Res 16:893\u2013900. https:\/\/doi.org\/10.1359\/jbmr.2001.16.5.893","journal-title":"J Bone Miner Res"},{"key":"634_CR40","doi-asserted-by":"publisher","first-page":"672","DOI":"10.1002\/jbmr.560","volume":"27","author":"E Donnelly","year":"2012","unstructured":"Donnelly E, Meredith DS, Nguyen JT et al (2012) Reduced cortical bone compositional heterogeneity with bisphosphonate treatment in postmenopausal women with intertrochanteric and subtrochanteric fractures. J Bone Miner Res 27:672\u2013678. https:\/\/doi.org\/10.1002\/jbmr.560","journal-title":"J Bone Miner Res"},{"issue":"4","key":"634_CR41","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1002\/jbm.a.36294","volume":"106","author":"FA Shah","year":"2017","unstructured":"Shah FA, Stoica A, Cardemil C, Palmquist A (2017) Multiscale characterisation of cortical bone composition, microstructure, and nanomechanical properties in experimentally-induced osteoporosis. J Biomed Mater Res 106(4):997\u20131007. https:\/\/doi.org\/10.1002\/jbm.a.36294","journal-title":"J Biomed Mater Res"},{"issue":"4","key":"634_CR42","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1007\/s00774-010-0241-9","volume":"29","author":"K Miyagawa","year":"2011","unstructured":"Miyagawa K, Kozai Y, Ito Y et al (2011) A novel underuse model shows that inactivity but not OVX determines the deteriorated material properties and geometry of cortical bone in the tibia of adult rats. J Bone Miner Metab 29(4):422\u2013436. https:\/\/doi.org\/10.1007\/s00774-010-0241-9","journal-title":"J Bone Miner Metab"},{"issue":"1","key":"634_CR43","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1007\/s00774-018-0903-6","volume":"37","author":"FR Paolillo","year":"2018","unstructured":"Paolillo FR, Romano RA, de Matos L et al (2018) Short-term and long-term effects of osteoporosis on incisor teeth and femoral bones evaluated by Raman spectroscopy and energy dispersive X-ray analysis in OVX rats. J Bone Miner Metab 37(1):18\u201327. https:\/\/doi.org\/10.1007\/s00774-018-0903-6","journal-title":"J Bone Miner Metab"},{"key":"634_CR44","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1016\/j.bone.2018.11.004","volume":"120","author":"EP Paschalis","year":"2019","unstructured":"Paschalis EP, Gamsjaeger S, Condon K, Klaushofer K, Burr D (2019) Estrogen depletion alters mineralization regulation mechanisms in an OVX monkey animal model. Bone 120:279\u2013284. https:\/\/doi.org\/10.1016\/j.bone.2018.11.004","journal-title":"Bone"},{"key":"634_CR45","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.bone.2016.10.029","volume":"95","author":"EP Paschalis","year":"2017","unstructured":"Paschalis EP, Gamsjaeger S, Hassler N, Klaushofer K, Burr D (2017) Ovarian hormone depletion affects cortical bone quality differently on different skeletal envelopes. Bone 95:55\u201364. https:\/\/doi.org\/10.1016\/j.bone.2016.10.029","journal-title":"Bone"},{"key":"634_CR46","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1359\/jbmr.090201","volume":"24","author":"S Gourion-Arsiquaud","year":"2009","unstructured":"Gourion-Arsiquaud S, Burket JC, Havill LM et al (2009) Spatial variation in osteonal bone properties relative to tissue and animal age. J Bone Miner Res 24:1271\u20131281. https:\/\/doi.org\/10.1359\/jbmr.090201","journal-title":"J Bone Miner Res"},{"key":"634_CR47","doi-asserted-by":"publisher","first-page":"1018","DOI":"10.1002\/jbmr.1567","volume":"27","author":"H Qing","year":"2012","unstructured":"Qing H, Ardeshirpour L, Pajevic PD et al (2012) Remodeling in mice during lactation. J Bone Miner Res 27:1018\u20131029. https:\/\/doi.org\/10.1002\/jbmr.1567","journal-title":"J Bone Miner Res"},{"key":"634_CR48","doi-asserted-by":"publisher","first-page":"676","DOI":"10.1002\/jbmr.3090","volume":"32","author":"S Kaya","year":"2017","unstructured":"Kaya S, Basta-Pljakic J, Seref-Ferlengez Z et al (2017) Lactation-induced changes in the volume of osteocyte lacunar-canalicular space alter mechanical properties in cortical bone tissue. J Bone Miner Res 32:676\u2013680. https:\/\/doi.org\/10.1002\/jbmr.3090","journal-title":"J Bone Miner Res"},{"key":"634_CR49","doi-asserted-by":"publisher","first-page":"606","DOI":"10.1016\/j.bone.2007.12.224","volume":"42","author":"LF Bonewald","year":"2008","unstructured":"Bonewald LF, Johnson ML (2008) Osteocytes, mechanosensing and Wnt signaling. Bone 42:606\u2013615. https:\/\/doi.org\/10.1016\/j.bone.2007.12.224","journal-title":"Bone"},{"key":"634_CR50","doi-asserted-by":"publisher","first-page":"2199","DOI":"10.1016\/j.jbiomech.2006.10.040","volume":"40","author":"A Rath Bonivtch","year":"2007","unstructured":"Rath Bonivtch A, Bonewald LF, Nicolella DP (2007) Tissue strain amplification at the osteocyte lacuna: a microstructural finite element analysis. J Biomech 40:2199\u20132206. https:\/\/doi.org\/10.1016\/j.jbiomech.2006.10.040","journal-title":"J Biomech"},{"key":"634_CR51","doi-asserted-by":"publisher","first-page":"466","DOI":"10.1359\/JBMR.051103","volume":"21","author":"NE Lane","year":"2006","unstructured":"Lane NE, Yao W, Balooch M et al (2006) Glucocorticoid-treated mice have localized changes in trabecular bone material properties and osteocyte lacunar size that are not observed in placebo-treated or estrogen-deficient mice. J Bone Miner Res 21:466\u2013476. https:\/\/doi.org\/10.1359\/JBMR.051103","journal-title":"J Bone Miner Res"},{"key":"634_CR52","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1152\/ajplegacy.1971.221.3.669","volume":"221","author":"DJ Baylink","year":"1971","unstructured":"Baylink DJ, Wergedal JE (1971) Bone formation by osteocytes. Am J Physiol 221:669\u2013678","journal-title":"Am J Physiol"},{"key":"634_CR53","first-page":"203","volume":"46","author":"AR Villanueva","year":"1966","unstructured":"Villanueva AR, Ramser JR, Frost HM et al (1966) Tetracycline-based quantitative measurements of the tissue and cell dynamics in 10 cases of osteoporosis. Clin Orthop Relat Res 46:203\u2013217","journal-title":"Clin Orthop Relat Res"},{"key":"634_CR54","doi-asserted-by":"publisher","first-page":"211","DOI":"10.1007\/BF02058664","volume":"3","author":"HM Frost","year":"1969","unstructured":"Frost HM (1969) Tetracycline-based histological analysis of bone remodeling. Calcif Tissue Res 3:211\u2013239","journal-title":"Calcif Tissue Res"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-019-00634-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00223-019-00634-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-019-00634-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T00:19:26Z","timestamp":1606522766000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00223-019-00634-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11,29]]},"references-count":54,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["634"],"URL":"https:\/\/doi.org\/10.1007\/s00223-019-00634-w","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"value":"0171-967X","type":"print"},{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,11,29]]},"assertion":[{"value":"29 August 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 November 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 November 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Erik A. Taylor, Eve Donnelly, Xiaomei Yao, Mark L. Johnson, Sarah K. Amugongo, Donald B. Kimmel, and Nancy E. Lane declare that they have no conflict of interest or disclosures.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"We present no data from groups of human patients or individual human participants in this study. All applicable international, national, and institutional guidelines for the care and use of animals were followed. All procedures performed during studies involving animals were in accordance with the ethical standards of practice at the University of California, Davis. This study only reports data from animal experiments for which the statement on animal welfare is included.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights and Informed Consent"}}]}}