{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T15:58:17Z","timestamp":1788883097714,"version":"build-2803163510"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T00:00:00Z","timestamp":1575331200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T00:00:00Z","timestamp":1575331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1007\/s00223-019-00637-7","type":"journal-article","created":{"date-parts":[[2019,12,3]],"date-time":"2019-12-03T01:02:59Z","timestamp":1575334979000},"page":"315-324","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Long Term Ovariectomy-Induced Osteoporosis is Associated with High Stearoyl-CoA Desaturase Indexes in Rat Femur"],"prefix":"10.1007","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6878-0870","authenticated-orcid":false,"given":"Alexandrine","family":"During","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Coutel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Bertheaume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Penel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Olejnik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,3]]},"reference":[{"key":"637_CR1","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1007\/s11657-013-0136-1","volume":"8","author":"E Hernlund","year":"2013","unstructured":"Hernlund E, Svedbom A, Ivergard M, Compston J, Cooper C, Stenmark J, McCloskey EV, Jonsson B, Kanis JA (2013) Osteoporosis in the European Union: medical management, epidemiology and economic burden A report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA). Arch Osteoporos 8:136. https:\/\/doi.org\/10.1007\/s11657-013-0136-1","journal-title":"Arch Osteoporos"},{"key":"637_CR2","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/ncprheum0070","volume":"2","author":"CJ Rosen","year":"2006","unstructured":"Rosen CJ, Bouxsein ML (2006) Mechanisms of disease: is osteoporosis the obesity of bone? Nat Clin Pract Rheumatol 2:35\u201343","journal-title":"Nat Clin Pract Rheumatol"},{"key":"637_CR3","doi-asserted-by":"publisher","first-page":"20","DOI":"10.1016\/j.abb.2010.06.027","volume":"503","author":"IR Reid","year":"2010","unstructured":"Reid IR (2010) Fat and bone. Arch Biochem Biophys 503:20\u201327. https:\/\/doi.org\/10.1016\/j.abb.2010.06.027","journal-title":"Arch Biochem Biophys"},{"key":"637_CR4","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.bone.2018.02.008","volume":"118","author":"J Paccou","year":"2019","unstructured":"Paccou J, Penel G, Chauveau C, Cortet B, Hardouin P (2019) Marrow adiposity and bone: review of clinical implications. Bone 118:8\u201315. https:\/\/doi.org\/10.1016\/j.bone.2018.02.008","journal-title":"Bone"},{"key":"637_CR5","doi-asserted-by":"publisher","first-page":"40","DOI":"10.3389\/fendo.2015.00040","volume":"6","author":"AV Schwartz","year":"2015","unstructured":"Schwartz AV (2015) Marrow fat and bone: review of clinical findings. Front Endocrinol 6:40. https:\/\/doi.org\/10.3389\/fendo.2015.00040","journal-title":"Front Endocrinol"},{"key":"637_CR6","doi-asserted-by":"publisher","first-page":"279","DOI":"10.1002\/jmri.20367","volume":"22","author":"DK Yeung","year":"2005","unstructured":"Yeung DK, Griffith JF, Antonio GE, Lee FK, Woo J, Leung PC (2005) Osteoporosis is associated with increased marrow fat content and decreased marrow fat unsaturation: a proton MR spectroscopy study. J Magn Reson Imaging 22:279\u2013285","journal-title":"J Magn Reson Imaging"},{"key":"637_CR7","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1148\/radiol.2363041425","volume":"236","author":"JF Griffith","year":"2005","unstructured":"Griffith JF, Yeung DK, Antonio GE, Lee FK, Hong AW, Wong SY, Lau EM, Leung PC (2005) Vertebral bone mineral density, marrow perfusion, and fat content in healthy men and men with osteoporosis: dynamic contrast-enhanced MR imaging and MR spectroscopy. Radiology 236:945\u2013951. https:\/\/doi.org\/10.1148\/radiol.2363041425","journal-title":"Radiology"},{"key":"637_CR8","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1136\/jcp.55.9.693","volume":"55","author":"S Verma","year":"2002","unstructured":"Verma S, Rajaratnam JH, Denton J, Hoyland JA, Byers RJ (2002) Adipocytic proportion of bone marrow is inversely related to bone formation in osteoporosis. J Clin Pathol 55:693\u2013698","journal-title":"J Clin Pathol"},{"key":"637_CR9","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/S8756-3282(97)00229-9","volume":"22","author":"A Houghton","year":"1998","unstructured":"Houghton A, Oyajobi BO, Foster GA, Russell RG, Stringer BM (1998) Immortalization of human marrow stromal cells by retroviral transduction with a temperature sensitive oncogene: identification of bipotential precursor cells capable of directed differentiation to either an osteoblast or adipocyte phenotype. Bone 22:7\u201316","journal-title":"Bone"},{"key":"637_CR10","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.coph.2004.03.002","volume":"4","author":"ME Nuttall","year":"2004","unstructured":"Nuttall ME, Gimble JM (2004) Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications. Curr Opin Pharmacol 4:290\u2013294. https:\/\/doi.org\/10.1016\/j.coph.2004.03.002","journal-title":"Curr Opin Pharmacol"},{"key":"637_CR11","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1038\/bonekey.2012.183","volume":"1","author":"T Negishi-Koga","year":"2012","unstructured":"Negishi-Koga T, Takayanagi H (2012) Bone cell communication factors and semaphorins. NBoneKEy Rep 1:183","journal-title":"NBoneKEy Rep"},{"key":"637_CR12","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1002\/iub.1254","volume":"66","author":"S Muruganandan","year":"2014","unstructured":"Muruganandan S, Sinal CJ (2014) The impact of bone marrow adipocytes on osteoblast and osteoclast differentiation. IUBMB Life 66:147\u2013155. https:\/\/doi.org\/10.1002\/iub.1254","journal-title":"IUBMB Life"},{"key":"637_CR13","doi-asserted-by":"publisher","first-page":"467","DOI":"10.1016\/j.semcdb.2008.08.003","volume":"19","author":"NL Fazzalari","year":"2008","unstructured":"Fazzalari NL (2008) Bone remodeling: a review of the bone microenvironment perspective for fragility fracture (osteoporosis) of the hip. Semin Cell Dev Biol 19:467\u2013472. https:\/\/doi.org\/10.1016\/j.semcdb.2008.08.003","journal-title":"Semin Cell Dev Biol"},{"key":"637_CR14","doi-asserted-by":"publisher","first-page":"126","DOI":"10.1016\/j.plipres.2015.06.002","volume":"59","author":"A During","year":"2015","unstructured":"During A, Penel G, Hardouin P (2015) Understanding the local actions of lipids in bone physiology. Prog Lipid Res 59:126\u2013146. https:\/\/doi.org\/10.1016\/j.plipres.2015.06.002","journal-title":"Prog Lipid Res"},{"key":"637_CR15","doi-asserted-by":"publisher","first-page":"1721","DOI":"10.1002\/jbmr.1950","volume":"28","author":"JM Patsch","year":"2013","unstructured":"Patsch JM, Li X, Baum T, Yap SP, Karampinos DC, Schwartz AV, Link TM (2013) Bone marrow fat composition as a novel imaging biomarker in postmenopausal women with prevalent fragility fractures. J Bone Miner Res 28:1721\u20131728. https:\/\/doi.org\/10.1002\/jbmr.1950","journal-title":"J Bone Miner Res"},{"key":"637_CR16","first-page":"9","volume-title":"34th annual conference of American Society of Bone Mineral Research (ASBMR)","author":"X Li","year":"2012","unstructured":"Li X, Shet K, Rodriguez J, Pino A, Kurhanewicz J, Swartz A, Rosen C (2012) Unsaturation level decreased in bone marrow lipids pf postmenopausal women with low bone density using high resolution HRMAS NMR. 34th annual conference of American Society of Bone Mineral Research (ASBMR). Mineapolis, MN, USA, pp 9\u201312"},{"key":"637_CR17","doi-asserted-by":"publisher","first-page":"1092","DOI":"10.1016\/j.bone.2009.02.022","volume":"44","author":"JF Griffith","year":"2009","unstructured":"Griffith JF, Yeung DK, Ahuja AT, Choy CW, Mei WY, Lam SS, Lam TP, Chen ZY, Leung PC (2009) A study of bone marrow and subcutaneous fatty acid composition in subjects of varying bone mineral density. Bone 44:1092\u20131096. https:\/\/doi.org\/10.1016\/j.bone.2009.02.022","journal-title":"Bone"},{"key":"637_CR18","doi-asserted-by":"publisher","first-page":"2370","DOI":"10.1002\/jcb.25534","volume":"117","author":"M Miranda","year":"2016","unstructured":"Miranda M, Pino AM, Fuenzalida K, Rosen CJ, Seitz G, Rodriguez JP (2016) Characterization of fatty acid composition in bone marrow fluid from postmenopausal women: modification after hip fracture. J Cell Biochem 117:2370\u20132376. https:\/\/doi.org\/10.1002\/jcb.25534","journal-title":"J Cell Biochem"},{"key":"637_CR19","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.chroma.2017.08.004","volume":"1515","author":"A During","year":"2017","unstructured":"During A (2017) Lipid determination in bone marrow and mineralized bone tissue: from sample preparation to improved high-performance thin-layer and liquid chromatographic approaches. J Chromatogr A 1515:232\u2013244. https:\/\/doi.org\/10.1016\/j.chroma.2017.08.004","journal-title":"J Chromatogr A"},{"key":"637_CR20","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1016\/j.bone.2019.06.031","volume":"127","author":"X Coutel","year":"2019","unstructured":"Coutel X, Delattre J, Marchandise P, Falgayrac G, Behal H, Kerckhofs G, Penel G, Olejnik C (2019) Mandibular bone is protected against microarchitectural alterations and bone marrow adipose conversion in ovariectomized rats. Bone 127:343\u2013352. https:\/\/doi.org\/10.1016\/j.bone.2019.06.031","journal-title":"Bone"},{"key":"637_CR21","first-page":"186","volume":"27","author":"V Rioux","year":"1999","unstructured":"Rioux V, Catheline D, Bouriel M, Legrand P (1999) High performance liquid chromatography of fatty acids as naphthacyl derivatives. Analysis 27:186\u2013193","journal-title":"Analysis"},{"key":"637_CR22","doi-asserted-by":"publisher","first-page":"775","DOI":"10.1016\/j.nut.2005.04.002","volume":"21","author":"R Quinn","year":"2005","unstructured":"Quinn R (2005) Comparing rat's to human's age: how old is my rat in people years? Nutrition 21:775\u2013777. https:\/\/doi.org\/10.1016\/j.nut.2005.04.002","journal-title":"Nutrition"},{"key":"637_CR23","doi-asserted-by":"publisher","first-page":"16904","DOI":"10.1074\/jbc.M010955200","volume":"276","author":"S Le Lay","year":"2001","unstructured":"Le Lay S, Krief S, Farnier C, Lefrere I, Le Liepvre X, Bazin R, Ferre P, Dugail I (2001) Cholesterol, a cell size-dependent signal that regulates glucose metabolism and gene expression in adipocytes. J Biol Chem 276:16904\u201316910. https:\/\/doi.org\/10.1074\/jbc.M010955200","journal-title":"J Biol Chem"},{"key":"637_CR24","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1111\/j.1467-789X.2009.00699.x","volume":"11","author":"BL Yu","year":"2010","unstructured":"Yu BL, Zhao SP, Hu JR (2010) Cholesterol imbalance in adipocytes: a possible mechanism of adipocytes dysfunction in obesity. Obes Rev 11:560\u2013567. https:\/\/doi.org\/10.1111\/j.1467-789X.2009.00699.x","journal-title":"Obes Rev"},{"key":"637_CR25","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1097\/01.blo.0000063602.67412.83","volume":"410","author":"Y Wang","year":"2003","unstructured":"Wang Y, Li Y, Mao K, Li J, Cui Q, Wang GJ (2003) Alcohol-induced adipogenesis in bone and marrow: a possible mechanism for osteonecrosis. Clin Orthop Relat Res 410:213\u2013224","journal-title":"Clin Orthop Relat Res"},{"key":"637_CR26","doi-asserted-by":"publisher","first-page":"413","DOI":"10.1093\/alcalc\/ags057","volume":"47","author":"DB Maurel","year":"2012","unstructured":"Maurel DB, Pallu S, Jaffre C, Fazzalari NL, Boisseau N, Uzbekov R, Benhamou CL, Rochefort GY (2012) Osteocyte apoptosis and lipid infiltration as mechanisms of alcohol-induced bone loss. Alcohol Alcohol 47:413\u2013422. https:\/\/doi.org\/10.1093\/alcalc\/ags057","journal-title":"Alcohol Alcohol"},{"key":"637_CR27","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1161\/CIRCGENETICS.110.959098","volume":"4","author":"C Stegemann","year":"2011","unstructured":"Stegemann C, Drozdov I, Shalhoub J, Humphries J, Ladroue C, Didangelos A, Baumert M, Allen M, Davies AH, Monaco C, Smith A, Xu Q, Mayr M (2011) Comparative lipidomics profiling of human atherosclerotic plaques. Circ Cardiovasc Genet 4:232\u2013242. https:\/\/doi.org\/10.1161\/CIRCGENETICS.110.959098","journal-title":"Circ Cardiovasc Genet"},{"key":"637_CR28","doi-asserted-by":"publisher","first-page":"1569","DOI":"10.1194\/jlr.M026088","volume":"53","author":"DG Reid","year":"2012","unstructured":"Reid DG, Shanahan CM, Duer MJ, Arroyo LG, Schoppet M, Brooks RA, Murray RC (2012) Lipids in biocalcification: contrasts and similarities between intimal and medial vascular calcification and bone by NMR. J Lipid Res 53:1569\u20131575","journal-title":"J Lipid Res"},{"key":"637_CR29","doi-asserted-by":"publisher","first-page":"16456","DOI":"10.1038\/s41598-018-34574-6","volume":"8","author":"H Zhao","year":"2018","unstructured":"Zhao H, Li X, Zhang D, Chen H, Chao Y, Wu K, Dong X, Su J (2018) Integrative bone metabolomics-lipidomics strategy for pathological mechanism of postmenopausal osteoporosis mouse model. Sci Rep 8:16456. https:\/\/doi.org\/10.1038\/s41598-018-34574-6","journal-title":"Sci Rep"},{"key":"637_CR30","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.126180","author":"M Pekkinen","year":"2019","unstructured":"Pekkinen M, Terhal PA, Botto LD, Henning P, Makitie RE, Roschger P, Jain A, Kol M, Kjellberg MA, Paschalis EP, van Gassen K, Murray M, Bayrak-Toydemir P, Magnusson MK, Jans J, Kausar M, Carey JC, Somerharju P, Lerner UH, Olkkonen VM, Klaushofer K, Holthuis JC, Makitie O (2019) Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2. JCI Insight. https:\/\/doi.org\/10.1172\/jci.insight.126180","journal-title":"JCI Insight"},{"key":"637_CR31","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1111\/j.1600-0609.1977.tb01476.x","volume":"18","author":"M Tavassoli","year":"1977","unstructured":"Tavassoli M, Houchin DN, Jacobs P (1977) Fatty acid composition of adipose cells in red and yellow marrow: a possible determinant of haematopoietic potential. Scand J Haematol 18:47\u201353","journal-title":"Scand J Haematol"},{"key":"637_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/nu9050441","author":"B van Heerden","year":"2017","unstructured":"van Heerden B, Kasonga A, Kruger MC, Coetzee M (2017) Palmitoleic acid inhibits RANKL-induced osteoclastogenesis and bone resorption by suppressing NF-kappaB and MAPK signalling pathways. Nutrients. https:\/\/doi.org\/10.3390\/nu9050441","journal-title":"Nutrients"},{"issue":"B","key":"637_CR33","doi-asserted-by":"publisher","first-page":"185","DOI":"10.3945\/jn.110.133728","volume":"63","author":"S Dekel","year":"1981","unstructured":"Dekel S, Lenthall G, Francis MJ (1981) Release of prostaglandins from bone and muscle after tibial fracture: an experimental study in rabbits. J Bone Joint Surg Br 63(B):185\u2013189.","journal-title":"J Bone Joint Surg Br"},{"key":"637_CR34","first-page":"317","volume":"43","author":"J Keller","year":"1996","unstructured":"Keller J (1996) Effects of indomethacin and local prostaglandin E2 on fracture healing in rabbits. Dan Med Bull 43:317\u2013329","journal-title":"Dan Med Bull"},{"key":"637_CR35","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.3945\/jn.110.133728","volume":"141","author":"EK Farina","year":"2011","unstructured":"Farina EK, Kiel DP, Roubenoff R, Schaefer EJ, Cupples LA, Tucker KL (2011) Dietary intakes of arachidonic acid and alpha-linolenic acid are associated with reduced risk of hip fracture in older adults. J Nutr 141:1146\u20131153. https:\/\/doi.org\/10.3945\/jn.110.133728","journal-title":"J Nutr"},{"key":"637_CR36","doi-asserted-by":"publisher","first-page":"2615","DOI":"10.1007\/s00198-012-1903-3","volume":"23","author":"JK Virtanen","year":"2012","unstructured":"Virtanen JK, Mozaffarian D, Willett WC, Feskanich D (2012) Dietary intake of polyunsaturated fatty acids and risk of hip fracture in men and women. Osteoporos Int 23:2615\u20132624. https:\/\/doi.org\/10.1007\/s00198-012-1903-3","journal-title":"Osteoporos Int"},{"key":"637_CR37","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1097\/MOL.0b013e3282f9b54d","volume":"19","author":"MT Flowers","year":"2008","unstructured":"Flowers MT, Ntambi JM (2008) Role of stearoyl-coenzyme A desaturase in regulating lipid metabolism. Curr Opin Lipidol 19:248\u2013256. https:\/\/doi.org\/10.1097\/MOL.0b013e3282f9b54d","journal-title":"Curr Opin Lipidol"},{"key":"637_CR38","doi-asserted-by":"publisher","first-page":"929","DOI":"10.1007\/s00198-007-0521-y","volume":"19","author":"H Melhus","year":"2008","unstructured":"Melhus H, Riserus U, Warensjo E, Wernroth L, Jensevik K, Berglund L, Vessby B, Michaelsson K (2008) A high activity index of stearoyl-CoA desaturase is associated with increased risk of fracture in men. Osteoporos Int 19:929\u2013934. https:\/\/doi.org\/10.1007\/s00198-007-0521-y","journal-title":"Osteoporos Int"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-019-00637-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00223-019-00637-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-019-00637-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T19:10:41Z","timestamp":1606849841000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00223-019-00637-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,3]]},"references-count":38,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["637"],"URL":"https:\/\/doi.org\/10.1007\/s00223-019-00637-7","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"value":"0171-967X","type":"print"},{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,3]]},"assertion":[{"value":"23 September 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 November 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"3 December 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with Ethical Standards"}},{"value":"Alexandrine During, Xavier Coutel, Nicolas Bertheaume, Guillaume Penel, and C\u00e9cile Olejnik declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies involving animals were in accordance with the ethical standards of the institution or practice at which the studies were conducted (Animal Ethic Committee of the University of Lille; permit authorization B5935010).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights and Informed Consent"}}]}}