{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T14:33:22Z","timestamp":1768919602756,"version":"3.49.0"},"reference-count":53,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T00:00:00Z","timestamp":1616112000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T00:00:00Z","timestamp":1616112000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01AR059781, P20GM109036, R01MH107354, R01MH104680, R01GM109068, R01AR069055, U19AG055373, R01DK115679"],"award-info":[{"award-number":["R01AR059781, P20GM109036, R01MH107354, R01MH104680, R01GM109068, R01AR069055, U19AG055373, R01DK115679"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1007\/s00223-021-00817-4","type":"journal-article","created":{"date-parts":[[2021,3,19]],"date-time":"2021-03-19T14:03:47Z","timestamp":1616162627000},"page":"17-31","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Identification of Novel Pleiotropic SNPs Associated with Osteoporosis and Rheumatoid Arthritis"],"prefix":"10.1007","volume":"109","author":[{"given":"Ying-Qi","family":"Liu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0240-6448","authenticated-orcid":false,"given":"Hong-Wen","family":"Deng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,3,19]]},"reference":[{"issue":"15","key":"817_CR1","doi-asserted-by":"publisher","first-page":"1889","DOI":"10.1001\/jama.288.15.1889","volume":"288","author":"SR Cummings","year":"2002","unstructured":"Cummings SR, Bates D, Black DM (2002) Clinical use of bone densitometry: scientific review. JAMA 288(15):1889\u20131897","journal-title":"JAMA"},{"issue":"4","key":"817_CR2","doi-asserted-by":"publisher","first-page":"1419","DOI":"10.1007\/s00198-012-2048-0","volume":"24","author":"M Tenne","year":"2013","unstructured":"Tenne M, McGuigan F, Besjakov J, Gerdhem P, Akesson K (2013) Degenerative changes at the lumbar spine\u2013implications for bone mineral density measurement in elderly women. Osteoporos Int 24(4):1419\u20131428. https:\/\/doi.org\/10.1007\/s00198-012-2048-0","journal-title":"Osteoporos Int"},{"issue":"2","key":"817_CR3","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s00223001124","volume":"67","author":"H Franck","year":"2000","unstructured":"Franck H, Munz M (2000) Total body and regional bone mineral densitometry (BMD) and soft tissue measurements: correlations of BMD parameter to lumbar spine and hip. Calcif Tissue Int 67(2):111\u2013115. https:\/\/doi.org\/10.1007\/s00223001124","journal-title":"Calcif Tissue Int"},{"issue":"1","key":"817_CR4","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1002\/1529-0131(200001)43:1<30::Aid-anr5>3.0.Co;2-b","volume":"43","author":"AJ MacGregor","year":"2000","unstructured":"MacGregor AJ, Snieder H, Rigby AS, Koskenvuo M, Kaprio J, Aho K et al (2000) Characterizing the quantitative genetic contribution to rheumatoid arthritis using data from twins. Arthritis Rheum 43(1):30\u201337. https:\/\/doi.org\/10.1002\/1529-0131(200001)43:1%3c30::Aid-anr5%3e3.0.Co;2-b","journal-title":"Arthritis Rheum"},{"issue":"2","key":"817_CR5","doi-asserted-by":"publisher","first-page":"173","DOI":"10.1359\/jbmr.060806","volume":"22","author":"JP Ioannidis","year":"2007","unstructured":"Ioannidis JP, Ng MY, Sham PC, Zintzaras E, Lewis CM, Deng HW et al (2007) Meta-analysis of genome-wide scans provides evidence for sex- and site-specific regulation of bone mass. J Bone Miner Res 22(2):173\u2013183. https:\/\/doi.org\/10.1359\/jbmr.060806","journal-title":"J Bone Miner Res"},{"issue":"4","key":"817_CR6","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1016\/0049-0172(91)90021-q","volume":"20","author":"I Joffe","year":"1991","unstructured":"Joffe I, Epstein S (1991) Osteoporosis associated with rheumatoid arthritis: pathogenesis and management. Semin Arthritis Rheum 20(4):256\u2013272. https:\/\/doi.org\/10.1016\/0049-0172(91)90021-q","journal-title":"Semin Arthritis Rheum"},{"issue":"2","key":"817_CR7","first-page":"85","volume":"9","author":"V Cagnetta","year":"2012","unstructured":"Cagnetta V, Patella V (2012) The role of the immune system in the physiopathology of osteoporosis. Clinical cases in mineral and bone metabolism\u202f: the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases 9(2):85\u201388","journal-title":"Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases"},{"issue":"9","key":"817_CR8","doi-asserted-by":"publisher","first-page":"e1001395","DOI":"10.1371\/journal.pbio.1001395","volume":"10","author":"M Corvaisier","year":"2012","unstructured":"Corvaisier M, Delneste Y, Jeanvoine H, Preisser L, Blanchard S, Garo E et al (2012) IL-26 is overexpressed in rheumatoid arthritis and induces proinflammatory cytokine production and Th17 cell generation. PLoS Biol 10(9):e1001395. https:\/\/doi.org\/10.1371\/journal.pbio.1001395","journal-title":"PLoS Biol"},{"issue":"1","key":"817_CR9","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.ajhg.2017.12.005","volume":"102","author":"C Medina-Gomez","year":"2018","unstructured":"Medina-Gomez C, Kemp JP, Trajanoska K, Luan J, Chesi A, Ahluwalia TS et al (2018) Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects. Am J Hum Genet 102(1):88\u2013102. https:\/\/doi.org\/10.1016\/j.ajhg.2017.12.005","journal-title":"Am J Hum Genet"},{"issue":"7488","key":"817_CR10","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1038\/nature12873","volume":"506","author":"Y Okada","year":"2014","unstructured":"Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K et al (2014) Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature 506(7488):376\u2013381. https:\/\/doi.org\/10.1038\/nature12873","journal-title":"Nature"},{"issue":"8","key":"817_CR11","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1038\/nrg3228","volume":"13","author":"JB Richards","year":"2012","unstructured":"Richards JB, Zheng HF, Spector TD (2012) Genetics of osteoporosis from genome-wide association studies: advances and challenges. Nat Rev Genet 13(8):576\u2013588. https:\/\/doi.org\/10.1038\/nrg3228","journal-title":"Nat Rev Genet"},{"issue":"2","key":"817_CR12","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1016\/j.ajhg.2013.01.001","volume":"92","author":"OA Andreassen","year":"2013","unstructured":"Andreassen OA, Djurovic S, Thompson WK, Schork AJ, Kendler KS, O\u2019Donovan MC et al (2013) Improved detection of common variants associated with schizophrenia by leveraging pleiotropy with cardiovascular-disease risk factors. Am J Hum Genet 92(2):197\u2013209. https:\/\/doi.org\/10.1016\/j.ajhg.2013.01.001","journal-title":"Am J Hum Genet"},{"key":"817_CR13","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1016\/j.bone.2018.08.020","volume":"117","author":"Y Hu","year":"2018","unstructured":"Hu Y, Tan LJ, Chen XD, Greenbaum J, Deng HW (2018) Identification of novel variants associated with osteoporosis, type 2 diabetes and potentially pleiotropic loci using pleiotropic cFDR method. Bone 117:6\u201314. https:\/\/doi.org\/10.1016\/j.bone.2018.08.020","journal-title":"Bone"},{"issue":"7571","key":"817_CR14","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1038\/nature15394","volume":"526","author":"PH Sudmant","year":"2015","unstructured":"Sudmant PH, Rausch T, Gardner EJ, Handsaker RE, Abyzov A, Huddleston J et al (2015) An integrated map of structural variation in 2,504 human genomes. Nature 526(7571):75\u201381. https:\/\/doi.org\/10.1038\/nature15394","journal-title":"Nature"},{"issue":"1","key":"817_CR15","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/nar\/gkn923","volume":"37","author":"DW Huang","year":"2009","unstructured":"Huang DW, Sherman BT, Lempicki RA (2009) Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists. Nucleic Acids Res 37(1):1\u201313. https:\/\/doi.org\/10.1093\/nar\/gkn923","journal-title":"Nucleic Acids Res"},{"issue":"16","key":"817_CR16","doi-asserted-by":"publisher","first-page":"e164","DOI":"10.1093\/nar\/gkq603","volume":"38","author":"K Wang","year":"2010","unstructured":"Wang K, Li M, Hakonarson H (2010) ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data. Nucleic Acids Res 38(16):e164. https:\/\/doi.org\/10.1093\/nar\/gkq603","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"817_CR17","doi-asserted-by":"publisher","first-page":"e1007371","DOI":"10.1371\/journal.pgen.1007371","volume":"14","author":"S Rueger","year":"2018","unstructured":"Rueger S, McDaid A, Kutalik Z (2018) Evaluation and application of summary statistic imputation to discover new height-associated loci. PLoS Genet 14(5):e1007371. https:\/\/doi.org\/10.1371\/journal.pgen.1007371","journal-title":"PLoS Genet"},{"issue":"2","key":"817_CR18","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1093\/bioinformatics\/btw615","volume":"33","author":"G Kichaev","year":"2017","unstructured":"Kichaev G, Roytman M, Johnson R, Eskin E, Lindstrom S, Kraft P et al (2017) Improved methods for multi-trait fine mapping of pleiotropic risk loci. Bioinformatics 33(2):248\u2013255. https:\/\/doi.org\/10.1093\/bioinformatics\/btw615","journal-title":"Bioinformatics"},{"issue":"D1","key":"817_CR19","doi-asserted-by":"publisher","first-page":"D766","DOI":"10.1093\/nar\/gky955","volume":"47","author":"A Frankish","year":"2019","unstructured":"Frankish A, Diekhans M, Ferreira AM, Johnson R, Jungreis I, Loveland J et al (2019) GENCODE reference annotation for the human and mouse genomes. Nucleic Acids Res 47(D1):D766\u2013D773. https:\/\/doi.org\/10.1093\/nar\/gky955","journal-title":"Nucleic Acids Res"},{"issue":"6099","key":"817_CR20","doi-asserted-by":"publisher","first-page":"1190","DOI":"10.1126\/science.1222794","volume":"337","author":"MT Maurano","year":"2012","unstructured":"Maurano MT, Humbert R, Rynes E, Thurman RE, Haugen E, Wang H et al (2012) Systematic localization of common disease-associated variation in regulatory DNA. Science 337(6099):1190\u20131195. https:\/\/doi.org\/10.1126\/science.1222794","journal-title":"Science"},{"issue":"4","key":"817_CR21","doi-asserted-by":"publisher","first-page":"e1008720","DOI":"10.1371\/journal.pgen.1008720","volume":"16","author":"C Wallace","year":"2020","unstructured":"Wallace C (2020) Eliciting priors and relaxing the single causal variant assumption in colocalisation analyses. PLoS Genet 16(4):e1008720. https:\/\/doi.org\/10.1371\/journal.pgen.1008720","journal-title":"PLoS Genet"},{"key":"817_CR22","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.34408","author":"G Hemani","year":"2018","unstructured":"Hemani G, Zheng J, Elsworth B, Wade KH, Haberland V, Baird D et al (2018) The MR-Base platform supports systematic causal inference across the human phenome. eLife. https:\/\/doi.org\/10.7554\/eLife.34408","journal-title":"eLife"},{"issue":"1","key":"817_CR23","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1038\/jhg.2008.5","volume":"54","author":"T Shiina","year":"2009","unstructured":"Shiina T, Hosomichi K, Inoko H, Kulski JK (2009) The HLA genomic loci map: expression, interaction, diversity and disease. J Hum Genet 54(1):15\u201339. https:\/\/doi.org\/10.1038\/jhg.2008.5","journal-title":"J Hum Genet"},{"issue":"7","key":"817_CR24","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1038\/ng.3570","volume":"48","author":"JK Pickrell","year":"2016","unstructured":"Pickrell JK, Berisa T, Liu JZ, Segurel L, Tung JY, Hinds DA (2016) Detection and interpretation of shared genetic influences on 42 human traits. Nat Genet 48(7):709\u2013717. https:\/\/doi.org\/10.1038\/ng.3570","journal-title":"Nat Genet"},{"issue":"7","key":"817_CR25","doi-asserted-by":"publisher","first-page":"820","DOI":"10.1038\/ng.395","volume":"41","author":"PK Gregersen","year":"2009","unstructured":"Gregersen PK, Amos CI, Lee AT, Lu Y, Remmers EF, Kastner DL et al (2009) REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. Nat Genet 41(7):820\u2013823. https:\/\/doi.org\/10.1038\/ng.395","journal-title":"Nat Genet"},{"issue":"10","key":"817_CR26","doi-asserted-by":"publisher","first-page":"1216","DOI":"10.1038\/ng.233","volume":"40","author":"S Raychaudhuri","year":"2008","unstructured":"Raychaudhuri S, Remmers EF, Lee AT, Hackett R, Guiducci C, Burtt NP et al (2008) Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet 40(10):1216\u20131223. https:\/\/doi.org\/10.1038\/ng.233","journal-title":"Nat Genet"},{"issue":"1","key":"817_CR27","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1038\/sj.gene.6364359","volume":"8","author":"S Steer","year":"2007","unstructured":"Steer S, Abkevich V, Gutin A, Cordell HJ, Gendall KL, Merriman ME et al (2007) Genomic DNA pooling for whole-genome association scans in complex disease: empirical demonstration of efficacy in rheumatoid arthritis. Genes Immun 8(1):57\u201368. https:\/\/doi.org\/10.1038\/sj.gene.6364359","journal-title":"Genes Immun"},{"issue":"6","key":"817_CR28","doi-asserted-by":"publisher","first-page":"e1000107","DOI":"10.1371\/journal.pgen.1000107","volume":"4","author":"M Chang","year":"2008","unstructured":"Chang M, Rowland CM, Garcia VE, Schrodi SJ, Catanese JJ, van der Helm-van Mil AH et al (2008) A large-scale rheumatoid arthritis genetic study identifies association at chromosome 9q332. PLoS Genet 4(6):e1000107. https:\/\/doi.org\/10.1371\/journal.pgen.1000107","journal-title":"PLoS Genet"},{"issue":"2","key":"817_CR29","doi-asserted-by":"publisher","first-page":"e1002004","DOI":"10.1371\/journal.pgen.1002004","volume":"7","author":"A Zhernakova","year":"2011","unstructured":"Zhernakova A, Stahl EA, Trynka G, Raychaudhuri S, Festen EA, Franke L et al (2011) Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. PLoS Genet 7(2):e1002004. https:\/\/doi.org\/10.1371\/journal.pgen.1002004","journal-title":"PLoS Genet"},{"issue":"4","key":"817_CR30","first-page":"586","volume":"35","author":"A Lenert","year":"2017","unstructured":"Lenert A, Fardo DW (2017) Detecting novel micro RNAs in rheumatoid arthritis with gene-based association testing. Clin Exp Rheumatol 35(4):586\u2013592","journal-title":"Clin Exp Rheumatol"},{"issue":"8","key":"817_CR31","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1093\/bioinformatics\/btu779","volume":"31","author":"M Arnold","year":"2015","unstructured":"Arnold M, Raffler J, Pfeufer A, Suhre K, Kastenmuller G (2015) SNiPA: an interactive, genetic variant-centered annotation browser. Bioinformatics 31(8):1334\u20131336. https:\/\/doi.org\/10.1093\/bioinformatics\/btu779","journal-title":"Bioinformatics"},{"issue":"6","key":"817_CR32","doi-asserted-by":"publisher","first-page":"1086","DOI":"10.1002\/jbmr.3681","volume":"34","author":"YF Pei","year":"2019","unstructured":"Pei YF, Liu L, Liu TL, Yang XL, Zhang H, Wei XT et al (2019) Joint Association Analysis Identified 18 New Loci for Bone Mineral Density. J Bone Miner Res 34(6):1086\u20131094. https:\/\/doi.org\/10.1002\/jbmr.3681","journal-title":"J Bone Miner Res"},{"issue":"D1","key":"817_CR33","doi-asserted-by":"publisher","first-page":"D794","DOI":"10.1093\/nar\/gkx1081","volume":"46","author":"CA Davis","year":"2018","unstructured":"Davis CA, Hitz BC, Sloan CA, Chan ET, Davidson JM, Gabdank I et al (2018) The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Res 46(D1):D794\u2013D801. https:\/\/doi.org\/10.1093\/nar\/gkx1081","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"817_CR34","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1002\/art.24138","volume":"60","author":"C Vignal","year":"2009","unstructured":"Vignal C, Bansal AT, Balding DJ, Binks MH, Dickson MC, Montgomery DS et al (2009) Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci. Arthritis Rheum 60(1):53\u201362. https:\/\/doi.org\/10.1002\/art.24138","journal-title":"Arthritis Rheum"},{"key":"817_CR35","doi-asserted-by":"publisher","first-page":"429373","DOI":"10.1155\/2013\/429373","volume":"2013","author":"ZS Buchwald","year":"2013","unstructured":"Buchwald ZS, Aurora R (2013) Osteoclasts and CD8 T cells form a negative feedback loop that contributes to homeostasis of both the skeletal and immune systems. Clin Dev Immunol 2013:429373. https:\/\/doi.org\/10.1155\/2013\/429373","journal-title":"Clin Dev Immunol"},{"key":"817_CR36","doi-asserted-by":"publisher","first-page":"1245","DOI":"10.3389\/fonc.2020.01245","volume":"10","author":"L Lyu","year":"2020","unstructured":"Lyu L, Yao J, Wang M, Zheng Y, Xu P, Wang S et al (2020) Overexpressed Pseudogene HLA-DPB2 Promotes Tumor Immune Infiltrates by Regulating HLA-DPB1 and Indicates a Better Prognosis in Breast Cancer. Front Oncol 10:1245. https:\/\/doi.org\/10.3389\/fonc.2020.01245","journal-title":"Front Oncol"},{"issue":"2","key":"817_CR37","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/s41588-018-0302-x","volume":"51","author":"JA Morris","year":"2018","unstructured":"Morris JA, Kemp JP, Youlten SE, Laurent L, Logan JG, Chai RC et al (2018) An atlas of genetic influences on osteoporosis in humans and mice. Nat Genet 51(2):258\u2013266. https:\/\/doi.org\/10.1038\/s41588-018-0302-x","journal-title":"Nat Genet"},{"issue":"6","key":"817_CR38","doi-asserted-by":"publisher","first-page":"1791","DOI":"10.1093\/hmg\/ddu583","volume":"24","author":"M He","year":"2015","unstructured":"He M, Xu M, Zhang B, Liang J, Chen P, Lee J-Y et al (2015) Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci. Hum Mol Genet 24(6):1791\u20131800. https:\/\/doi.org\/10.1093\/hmg\/ddu583","journal-title":"Hum Mol Genet"},{"issue":"D1","key":"817_CR39","doi-asserted-by":"publisher","first-page":"D801","DOI":"10.1093\/nar\/gky1056","volume":"47","author":"CJ Bult","year":"2019","unstructured":"Bult CJ, Blake JA, Smith CL, Kadin JA, Richardson JE, Mouse Genome Database G (2019) Mouse Genome Database (MGD) 2019. Nucleic Acids Res 47(D1):D801\u2013D806. https:\/\/doi.org\/10.1093\/nar\/gky1056","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"817_CR40","doi-asserted-by":"publisher","first-page":"755","DOI":"10.1007\/s00439-013-1409-x","volume":"133","author":"M Beauregard","year":"2014","unstructured":"Beauregard M, Gagnon E, Guay-Belanger S, Morissette J, Brown JP, Michou L (2014) Identification of rare genetic variants in novel loci associated with Paget\u2019s disease of bone. Hum Genet 133(6):755\u2013768. https:\/\/doi.org\/10.1007\/s00439-013-1409-x","journal-title":"Hum Genet"},{"issue":"11\u201312","key":"817_CR41","doi-asserted-by":"publisher","first-page":"1195","DOI":"10.1007\/s00439-015-1596-8","volume":"134","author":"Q Wang","year":"2015","unstructured":"Wang Q, Yang C, Gelernter J, Zhao H (2015) Pervasive pleiotropy between psychiatric disorders and immune disorders revealed by integrative analysis of multiple GWAS. Hum Genet 134(11\u201312):1195\u20131209. https:\/\/doi.org\/10.1007\/s00439-015-1596-8","journal-title":"Hum Genet"},{"issue":"4","key":"817_CR42","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1002\/art.40790","volume":"71","author":"T Mustelin","year":"2019","unstructured":"Mustelin T, Bottini N, Stanford SM (2019) The Contribution of PTPN22 to Rheumatic Disease. Arthritis Rheumatol 71(4):486\u2013495. https:\/\/doi.org\/10.1002\/art.40790","journal-title":"Arthritis Rheumatol"},{"issue":"3","key":"817_CR43","doi-asserted-by":"publisher","first-page":"266","DOI":"10.1016\/j.autrev.2013.10.011","volume":"13","author":"J Zheng","year":"2014","unstructured":"Zheng J, Petersen F, Yu X (2014) The role of PTPN22 in autoimmunity: learning from mice. Autoimmun Rev 13(3):266\u2013271. https:\/\/doi.org\/10.1016\/j.autrev.2013.10.011","journal-title":"Autoimmun Rev"},{"issue":"11","key":"817_CR44","doi-asserted-by":"publisher","first-page":"e0167212","DOI":"10.1371\/journal.pone.0167212","volume":"11","author":"H Zhu","year":"2016","unstructured":"Zhu H, Xia W, Mo XB, Lin X, Qiu YH, Yi NJ et al (2016) Gene-Based Genome-Wide Association Analysis in European and Asian Populations Identified Novel Genes for Rheumatoid Arthritis. PLoS ONE 11(11):e0167212. https:\/\/doi.org\/10.1371\/journal.pone.0167212","journal-title":"PLoS ONE"},{"issue":"49","key":"817_CR45","doi-asserted-by":"publisher","first-page":"7796","DOI":"10.1038\/sj.onc.1206965","volume":"22","author":"K Ando","year":"2003","unstructured":"Ando K, Kanazawa S, Tetsuka T, Ohta S, Jiang X, Tada T et al (2003) Induction of Notch signaling by tumor necrosis factor in rheumatoid synovial fibroblasts. Oncogene 22(49):7796\u20137803. https:\/\/doi.org\/10.1038\/sj.onc.1206965","journal-title":"Oncogene"},{"issue":"6","key":"817_CR46","doi-asserted-by":"publisher","first-page":"1653","DOI":"10.1007\/s00198-012-1909-x","volume":"23","author":"C Zuo","year":"2012","unstructured":"Zuo C, Huang Y, Bajis R, Sahih M, Li YP, Dai K et al (2012) Osteoblastogenesis regulation signals in bone remodeling. Osteoporos Int 23(6):1653\u20131663. https:\/\/doi.org\/10.1007\/s00198-012-1909-x","journal-title":"Osteoporos Int"},{"issue":"7","key":"817_CR47","doi-asserted-by":"publisher","first-page":"502","DOI":"10.3967\/bes2015.072","volume":"28","author":"Q Ma","year":"2015","unstructured":"Ma Q, Zhang Y, Meng R, Xie KM, Xiong Y, Lin S et al (2015) MAGI3 Suppresses Glioma Cell Proliferation via Upregulation of PTEN Expression. Biomed Environ Sci 28(7):502\u2013509. https:\/\/doi.org\/10.3967\/bes2015.072","journal-title":"Biomed Environ Sci"},{"issue":"1","key":"817_CR48","doi-asserted-by":"publisher","first-page":"400","DOI":"10.3892\/mmr.2017.7907","volume":"17","author":"D Zheng","year":"2018","unstructured":"Zheng D, Cui C, Yu M, Li X, Wang L, Chen X et al (2018) Coenzyme Q10 promotes osteoblast proliferation and differentiation and protects against ovariectomy-induced osteoporosis. Mol Med Rep 17(1):400\u2013407. https:\/\/doi.org\/10.3892\/mmr.2017.7907","journal-title":"Mol Med Rep"},{"issue":"D1","key":"817_CR49","doi-asserted-by":"publisher","first-page":"D643","DOI":"10.1093\/nar\/gkw1022","volume":"45","author":"Y Lu","year":"2017","unstructured":"Lu Y, Quan C, Chen H, Bo X, Zhang C (2017) 3DSNP: a database for linking human noncoding SNPs to their three-dimensional interacting genes. Nucleic Acids Res 45(D1):D643\u2013D649. https:\/\/doi.org\/10.1093\/nar\/gkw1022","journal-title":"Nucleic Acids Res"},{"issue":"23","key":"817_CR50","doi-asserted-by":"publisher","first-page":"4706","DOI":"10.1128\/mcb.05980-11","volume":"31","author":"W Wei","year":"2011","unstructured":"Wei W, Zeve D, Suh JM, Wang X, Du Y, Zerwekh JE et al (2011) Biphasic and Dosage-Dependent Regulation of Osteoclastogenesis by -Catenin. Mol Cell Biol 31(23):4706\u20134719. https:\/\/doi.org\/10.1128\/mcb.05980-11","journal-title":"Mol Cell Biol"},{"issue":"13","key":"817_CR51","doi-asserted-by":"publisher","first-page":"3458","DOI":"10.1158\/0008-5472.CAN-17-2296","volume":"78","author":"A Levin","year":"2018","unstructured":"Levin A, Minis A, Lalazar G, Rodriguez J, Steller H (2018) PSMD5 Inactivation Promotes 26S Proteasome Assembly during Colorectal Tumor Progression. Cancer Res 78(13):3458\u20133468. https:\/\/doi.org\/10.1158\/0008-5472.CAN-17-2296","journal-title":"Cancer Res"},{"key":"817_CR52","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18102054","author":"K Lee","year":"2017","unstructured":"Lee K, Kim MY, Ahn H, Kim HS, Shin HI, Jeong D (2017) Blocking of the Ubiquitin-Proteasome System Prevents Inflammation-Induced Bone Loss by Accelerating M-CSF Receptor c-Fms Degradation in Osteoclast Differentiation. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms18102054","journal-title":"Int J Mol Sci"},{"issue":"8","key":"817_CR53","doi-asserted-by":"publisher","first-page":"e0183842","DOI":"10.1371\/journal.pone.0183842","volume":"12","author":"R Zhou","year":"2017","unstructured":"Zhou R, Lin X, Li DY, Wang XF, Greenbaum J, Chen YC et al (2017) Identification of novel genetic loci for osteoporosis and\/or rheumatoid arthritis using cFDR approach. PLoS ONE 12(8):e0183842. https:\/\/doi.org\/10.1371\/journal.pone.0183842","journal-title":"PLoS ONE"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-021-00817-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00223-021-00817-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-021-00817-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,6,29]],"date-time":"2021-06-29T06:04:45Z","timestamp":1624946685000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00223-021-00817-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,19]]},"references-count":53,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["817"],"URL":"https:\/\/doi.org\/10.1007\/s00223-021-00817-4","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"value":"0171-967X","type":"print"},{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,19]]},"assertion":[{"value":"5 October 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 January 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"19 March 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Disclosure"}},{"value":"The authors declared that they have no conflicts of interest to this work.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"No human participants or animals were involved in this empirical study. We only analyzed the existing data published on public websites.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights and Informed Consent"}},{"value":"This article does not contain any studies with human participants or animals performed by any of the authors.\u00a0We only analyzed the existing data published on public websites.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}