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The aim of the present study was to determine detraining effects on musculoskeletal outcomes after a 3-month detraining period in early post-menopausal, osteopenic women. Due to the COVID-19 pandemic, we terminated the 18-month randomized controlled ACTLIFE exercise intervention immediately after the 13-month follow-up assessment. This put an abrupt stop to the high-intensity aerobic and resistance group exercise sessions undertaken three times per week by the exercise group (EG: <jats:italic>n<\/jats:italic>\u2009=\u200927) and the gentle exercise program performed once per week for the attention control group (CG: <jats:italic>n<\/jats:italic>\u2009=\u200927); but both groups were permitted to conduct individual outdoor activity for the 3-month lock-down period. Study endpoints were lean body mass (LBM), bone mineral density (BMD) at the lumbar spine (LS), maximum hip-\/leg extension strength and power. Detraining-induced reductions of LBM, hip\/leg strength and power (but not BMD-LS) were significantly greater (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001 to <jats:italic>p<\/jats:italic>\u2009=\u20090.044) compared with the CG. Significant exercise effects, i.e. differences between EG and CG, present after 13\u00a0months of exercise, were lost after 3\u00a0months of detraining for LBM (<jats:italic>p<\/jats:italic>\u2009=\u20090.157) and BMD-LS (<jats:italic>p<\/jats:italic>\u2009=\u20090.065), but not for strength (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and power (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Of note, self-reported individual outdoor activities and exercise increased by about 40% in both groups during the lock-down period. Three months' absence from a supervised group exercise protocol resulted in considerable detraining effects for musculoskeletal parameters. Thus, exercise programs for adults should be continuous rather than intermittent.<\/jats:p><jats:p>Trial registration number: ClinicalTrials.gov: NCT04420806, 06.05.2020.<\/jats:p>","DOI":"10.1007\/s00223-021-00829-0","type":"journal-article","created":{"date-parts":[[2021,3,12]],"date-time":"2021-03-12T21:02:55Z","timestamp":1615582975000},"page":"1-11","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Detraining Effects on Musculoskeletal Parameters in Early Postmenopausal Osteopenic Women: 3-Month Follow-Up of the Randomized Controlled ACTLIFE Study"],"prefix":"10.1007","volume":"109","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3515-0669","authenticated-orcid":false,"given":"Wolfgang","family":"Kemmler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Hettchen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Kohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bragonzoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikko","family":"Julin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tapani","family":"Risto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"von Stengel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,3,12]]},"reference":[{"key":"829_CR1","doi-asserted-by":"publisher","first-page":"83","DOI":"10.2147\/CIA.S283177","volume":"16","author":"M Hettchen","year":"2021","unstructured":"Hettchen M, Kohl M, von Stengel S et al (2021) Changes of menopausal risk factors under specific regard of bone mineral density in early postmenopausal osteopenic women after 13\u00a0months of high-intensity exercise. 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