{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:16:56Z","timestamp":1786979816423,"version":"build-2736575974"},"reference-count":19,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T00:00:00Z","timestamp":1618012800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T00:00:00Z","timestamp":1618012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100013220","name":"Ultragenyx Pharmaceutical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013220","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1007\/s00223-021-00841-4","type":"journal-article","created":{"date-parts":[[2021,4,10]],"date-time":"2021-04-10T14:02:15Z","timestamp":1618063335000},"page":"132-138","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Characterization of Oral Health Status in Chilean Patients with X-Linked Hypophosphatemia"],"prefix":"10.1007","volume":"109","author":[{"given":"Alejandro","family":"Marin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Morales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macarena","family":"Jim\u00e9nez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugenia","family":"Borja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danisa","family":"Ivanovic-Zuvic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5936-3146","authenticated-orcid":false,"given":"Pablo","family":"Florenzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,4,10]]},"reference":[{"key":"841_CR1","doi-asserted-by":"publisher","first-page":"1381","DOI":"10.1002\/jbmr.340","volume":"26","author":"TO Carpenter","year":"2011","unstructured":"Carpenter TO, Imel EA, Holm IA, Jan de Beur SM, Insogna KL (2011) A clinician\u2019s guide to X-linked hypophosphatemia. J Bone Miner Res 26:1381\u20131388","journal-title":"J Bone Miner Res"},{"key":"841_CR2","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s00774-011-0340-2","volume":"30","author":"TO Carpenter","year":"2012","unstructured":"Carpenter TO (2012) The expanding family of hypophosphatemic syndromes. J Bone Miner Metab 30:1\u20139","journal-title":"J Bone Miner Metab"},{"key":"841_CR3","doi-asserted-by":"publisher","first-page":"2369","DOI":"10.1007\/s00198-018-4618-2","volume":"29","author":"G Marcucci","year":"2018","unstructured":"Marcucci G, Masi L, Ferrar\u00ec S, Haffner D, Javaid MK, Kamenick\u00fd P, Reginster JY, Rizzoli R, Brandi ML (2018) Phosphate wasting disorders in adults. Osteoporos Int 29:2369\u20132387","journal-title":"Osteoporos Int"},{"key":"841_CR4","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1186\/s13005-019-0192-x","volume":"15","author":"M Hanisch","year":"2019","unstructured":"Hanisch M, Bohner L, Sabandal MMI, Kleinheinz J, Jung S (2019) Oral symptoms and oral health-related quality of life of individuals with x-linked hypophosphatemia. Head Face Med 15:8","journal-title":"Head Face Med"},{"key":"841_CR5","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1007\/s00784-015-1425-4","volume":"19","author":"MM Sabandal","year":"2015","unstructured":"Sabandal MM, Robotta P, B\u00fcrklein S, Sch\u00e4fer E (2015) Review of the dental implications of X-linked hypophosphataemic rickets (XLHR). Clin Oral Investig 19:759\u2013768","journal-title":"Clin Oral Investig"},{"key":"841_CR6","doi-asserted-by":"publisher","first-page":"3625","DOI":"10.1210\/JC.2015-2199","volume":"100","author":"J Connor","year":"2015","unstructured":"Connor J, Olear EA, Insogna KL, Katz L, Baker S, Kaur R, Simpson CA, Sterpka J, Dubrow R, Zhang JH, Carpenter TO (2015) Conventional therapy in adults with X-Linked hypophosphatemia: effects on enthesopathy and dental disease. J Clin Endocrinol Metab 100:3625\u20133632","journal-title":"J Clin Endocrinol Metab"},{"key":"841_CR7","doi-asserted-by":"publisher","first-page":"3622","DOI":"10.1210\/jc.2015-3229","volume":"100","author":"MJ Econs","year":"2015","unstructured":"Econs MJ (2015) Conventional therapy in adults with XLH Improves dental manifestations, but not enthesopathy. J Clin Endocrinol Metab 100:3622\u20133624","journal-title":"J Clin Endocrinol Metab"},{"key":"841_CR8","doi-asserted-by":"publisher","first-page":"456","DOI":"10.1002\/sca.21141","volume":"36","author":"I Cremonesi","year":"2014","unstructured":"Cremonesi I, Nucci C, D\u2019Alessandro G, Alkhamis N, Marchionni S, Piana G (2014) X-linked hypophosphatemic rickets: enamel abnormalities and oral clinical findings. Scanning 36:456\u2013461","journal-title":"Scanning"},{"key":"841_CR9","doi-asserted-by":"publisher","first-page":"604","DOI":"10.1007\/s12105-017-0872-4","volume":"12","author":"SEY Paredes","year":"2018","unstructured":"Paredes SEY, Segato RAB, Moreira LD, Moreira A, Serrano KVD, Rodrigues CT, Almeida LY, Le\u00f3n JE (2018) Dentoalveolar abscesses not associated with caries or trauma: a diagnostic hallmark of hypophosphatemic rickets initially misdiagnosed as hypochondroplasia. Head Neck Pathol 12:604\u2013609","journal-title":"Head Neck Pathol"},{"key":"841_CR10","doi-asserted-by":"publisher","first-page":"7S","DOI":"10.1177\/0022034514529150","volume":"93","author":"BL Foster","year":"2014","unstructured":"Foster BL, Ramnitz MS, Gafni RI, Burke AB, Boyce AM, Lee JS, Wright JT, Akintoye SO, Somerman MJ, Collins MT (2014) Rare bone diseases and their dental, oral, and craniofacial manifestations. J Dent Res 93:7S-19S","journal-title":"J Dent Res"},{"key":"841_CR11","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1111\/j.1365-2842.2011.02250.x","volume":"39","author":"MG Andersen","year":"2012","unstructured":"Andersen MG, Beck-Nielsen SS, Haubek D, Hintze H, Gj\u00f8rup H, Poulsen S (2012) Periapical and endodontic status of permanent teeth in patients with hypophosphatemic rickets. J Oral Rehabil 39:144\u2013150","journal-title":"J Oral Rehabil"},{"key":"841_CR12","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1016\/j.bone.2008.02.014","volume":"42","author":"I Endo","year":"2008","unstructured":"Endo I, Fukumoto S, Ozono K, Namba N, Tanaka H, Inoue D, Minagawa M, Sugimoto T, Yamauchi M, Michigami T, Matsumoto T (2008) Clinical usefulness of measurement of fibroblast growth factor 23 (FGF23) in hypophosphatemic patients: proposal of diagnostic criteria using FGF23 measurement. Bone 42:1235\u20131239","journal-title":"Bone"},{"key":"841_CR13","volume-title":"Oral health surveys: basic methods","author":"World Hearth Organization","year":"2013","unstructured":"World Hearth Organization (2013) Oral health surveys: basic methods. World Hearth Organization, Geneva"},{"key":"841_CR14","unstructured":"Soto L, Tapia R, Jara G, Rodr\u00edguez G, Urbina T (2007) Diagn\u00f3stico nacional de salud bucal del adolescente de 12 a\u00f1os y evaluaci\u00f3n del grado de cumplimiento de los objetivos sanitarios de salud bucal 2000\u20132010. In: Ediciones Universidad Mayor"},{"key":"841_CR15","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1177\/0022034517728497","volume":"97","author":"BR Coyac","year":"2018","unstructured":"Coyac BR, Hoac B, Chafey P, Falgayrac G, Slimani L, Rowe PS, Penel G, Linglart A, McKee MD, Chaussain C, Bardet C (2018) Defective mineralization in X-linked hypophosphatemia dental pulp cell cultures. J Dent Res 97:184\u2013191","journal-title":"J Dent Res"},{"key":"841_CR16","doi-asserted-by":"publisher","first-page":"388","DOI":"10.1177\/0022034516677528","volume":"96","author":"M Biosse Duplan","year":"2017","unstructured":"Biosse Duplan M, Coyac BR, Bardet C, Zadikian C, Rothenbuhler A, Kamenicky P, Briot K, Linglart A, Chaussain C (2017) Phosphate and vitamin D prevent periodontitis in X-linked hypophosphatemia. J Dent Res 96:388\u2013395","journal-title":"J Dent Res"},{"key":"841_CR17","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1902\/jop.2010.100148","volume":"81","author":"J Gamonal","year":"2010","unstructured":"Gamonal J, Mendoza C, Espinoza I, Mu\u00f1oz A, Urz\u00faa I, Aranda W, Carvajal P, Arteaga O (2010) Clinical attachment loss in Chilean adult population: first chilean national dental examination survey. J Periodontol 81:1403\u20131410","journal-title":"J Periodontol"},{"key":"841_CR18","unstructured":"Ministerio de Salud de Chile (2017) Plan nacional de salud bucal 2018\u20132030. In: Santiago"},{"key":"841_CR19","doi-asserted-by":"publisher","first-page":"81","DOI":"10.4067\/S0719-01072019000200081","volume":"12","author":"MC Fresno","year":"2019","unstructured":"Fresno MC, Jeldes G, Estay J, Martin J (2019) Prevalencia, severidad de caries dental y necesidad de tratamiento restaurador en escolares de 6 a 12 a\u00f1os de la provincia de Santiago, regi\u00f3n metropolitana. Rev Cl\u00edn Periodoncia Implantol Rehabil Oral 12:81\u201386","journal-title":"Rev Cl\u00edn Periodoncia Implantol Rehabil Oral"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-021-00841-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00223-021-00841-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-021-00841-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,7,11]],"date-time":"2021-07-11T23:12:01Z","timestamp":1626045121000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00223-021-00841-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4,10]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["841"],"URL":"https:\/\/doi.org\/10.1007\/s00223-021-00841-4","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"value":"0171-967X","type":"print"},{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,4,10]]},"assertion":[{"value":"24 November 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 March 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 April 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The Pontificia Universidad Cat\u00f3lica de Chile receives research support from Ultragenyx Pharmaceutical Inc for research related to hypophosphatemic rickets. PF has received research grant support from Ultragenyx Pharmaceuticals and is an Advisory Board Member of Kyowa Kirin. All other authors declare that they do not have any conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All procedures performed in studies participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Written inform consent from the participants and approval of the hospital\u2019s ethical committee were obtained.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights and Informed Consent"}}]}}