{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T15:51:08Z","timestamp":1762098668780,"version":"3.37.3"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T00:00:00Z","timestamp":1629763200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01AT008754"],"award-info":[{"award-number":["R01AT008754"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1007\/s00223-021-00905-5","type":"journal-article","created":{"date-parts":[[2021,8,24]],"date-time":"2021-08-24T08:02:48Z","timestamp":1629792168000},"page":"260-265","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Blueberry Polyphenols do not Improve Bone Mineral Density or Mechanical Properties in Ovariectomized Rats"],"prefix":"10.1007","volume":"110","author":[{"given":"Dennis P.","family":"Cladis","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth A.","family":"Swallow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew R.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen M.","family":"Hill Gallant","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5450-9609","authenticated-orcid":false,"given":"Connie M.","family":"Weaver","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2021,8,24]]},"reference":[{"key":"905_CR1","doi-asserted-by":"publisher","first-page":"1837","DOI":"10.1016\/j.clinthera.2015.06.006","volume":"37","author":"MT Drake","year":"2015","unstructured":"Drake MT, Clarke BL, Lewiecki EM (2015) The pathophysiology and treatment of osteoporosis. Clin Ther 37:1837\u20131850. https:\/\/doi.org\/10.1016\/j.clinthera.2015.06.006","journal-title":"Clin Ther"},{"key":"905_CR2","first-page":"92","volume":"43","author":"KN Tu","year":"2018","unstructured":"Tu KN, Lie JD, Wan CKV, Cameron M, Austel AG, Nguyen JK, Van K, Hyun D (2018) Osteoporosis: a review of treatment options. P T 43:92\u2013104","journal-title":"P T"},{"key":"905_CR3","doi-asserted-by":"publisher","first-page":"6279","DOI":"10.2174\/1381612823666170714122714","volume":"23","author":"S Ivanova","year":"2017","unstructured":"Ivanova S, Vasileva L (2017) Current and emerging strategies in osteoporosis management. Curr Pharm Des 23:6279\u20136287. https:\/\/doi.org\/10.2174\/1381612823666170714122714","journal-title":"Curr Pharm Des"},{"key":"905_CR4","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/j.foodres.2015.10.017","volume":"77","author":"L Dudaric","year":"2015","unstructured":"Dudaric L, Fuzinac-Smojver A, Muhvic D, Giacometti J (2015) The role of polyphenols on bone metabolism in osteoporosis. Food Res Int 77:290\u2013298. https:\/\/doi.org\/10.1016\/j.foodres.2015.10.017","journal-title":"Food Res Int"},{"key":"905_CR5","doi-asserted-by":"publisher","first-page":"697","DOI":"10.1111\/bcp.12033","volume":"75","author":"SM Sacco","year":"2013","unstructured":"Sacco SM, Horcajada MN, Offord E (2013) Phytonutrients for bone health during ageing. Br J Clin Pharmacol 75:697\u2013707. https:\/\/doi.org\/10.1111\/bcp.12033","journal-title":"Br J Clin Pharmacol"},{"unstructured":"Gahche J, Bailey R, Burt V, Hughes J, Yetley E, Dwyer J, Frances Picciano M, McDowell M, Sempos C (2011) Dietary supplement use among U.S. adults has increased since NHANES III (1988\u20131994). NCHS Data Brief, 2011, No. 61. National Center for Health Statistics, Hyattsville, MD","key":"905_CR6"},{"key":"905_CR7","doi-asserted-by":"publisher","first-page":"261","DOI":"10.3945\/jn.110.133025","volume":"141","author":"RL Bailey","year":"2011","unstructured":"Bailey RL, Gahche JJ, Lentino CV, Dwyer JT, Engel JS, Thomas PR, Betz JM, Sempos CT, Picciano MF (2011) Dietary supplement use in the United States, 2003\u20132006. J Nutr 141:261\u2013266. https:\/\/doi.org\/10.3945\/jn.110.133025","journal-title":"J Nutr"},{"unstructured":"CRN (2019) 2019 CRN consumer survey on dietary supplements. www.crnusa.org\/2019survey. Accessed 2 Aug 2020","key":"905_CR8"},{"key":"905_CR9","doi-asserted-by":"publisher","first-page":"20200031","DOI":"10.1002\/mnfr.202000031","volume":"64","author":"D Cladis","year":"2020","unstructured":"Cladis D, Debelo H, Lachcik P, Ferruzzi M, Weaver C (2020) Increasing doses of blueberry polyphenols alters colonic metabolism and calcium absorption in ovariectomized rats. Molec Nutr Food Res 64:20200031. https:\/\/doi.org\/10.1002\/mnfr.202000031","journal-title":"Molec Nutr Food Res"},{"issue":"S1","key":"905_CR10","doi-asserted-by":"publisher","first-page":"793.20","DOI":"10.1096\/fasebj.31.1_supplement.793.20","volume":"31","author":"MM Rodriguez","year":"2018","unstructured":"Rodriguez MM, Henry C, Lachcik PJ, Ferruzzi M, McCabe G, Lila MA, Weaver CM (2018) Dose response effects of a blueberry-enriched diet on net bone calcium retention in ovariectomized rats. FASEB J 31(S1):793.20. https:\/\/doi.org\/10.1096\/fasebj.31.1_supplement.793.20","journal-title":"FASEB J"},{"unstructured":"Maiz Rodrigues M (2019) A blueberry-enriched diet may aid in the amelioration of bone loss in the ovariectomized rat model. Dissertation, Purdue University","key":"905_CR11"},{"issue":"S2","key":"905_CR12","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1093\/cdn\/nzaa040_032","volume":"4","author":"J Hodges","year":"2020","unstructured":"Hodges J, Cao S, Lachcik P et al (2020) Moderate consumption of freeze-dried blueberry powder increased net bone calcium retention in healthy postmenopausal women: a randomized crossover trial. Curr Dev Nutr 4(S2):32. https:\/\/doi.org\/10.1093\/cdn\/nzaa040_032","journal-title":"Curr Dev Nutr"},{"key":"905_CR13","doi-asserted-by":"publisher","first-page":"768","DOI":"10.1002\/jbmr.4231","volume":"36","author":"AY Sato","year":"2021","unstructured":"Sato AY, Pellegrini GG, Cregor M et al (2021) Skeletal protection and promotion of microbiome diversity by dietary boosting of the endogenous antioxidant response. J Bone Min Res 36:768\u2013778. https:\/\/doi.org\/10.1002\/jbmr.4231","journal-title":"J Bone Min Res"},{"key":"905_CR14","doi-asserted-by":"publisher","first-page":"89","DOI":"10.17179\/excli2019-1990","volume":"19","author":"N Yousefzadeh","year":"2021","unstructured":"Yousefzadeh N, Kashfi K, Jeddi S, Ghasemi A (2020) Ovariectomized rat model of osteoporosis: a practical guide. EXCLI J 19:89\u2013107. https:\/\/doi.org\/10.17179\/excli2019-1990","journal-title":"EXCLI J"},{"key":"905_CR15","doi-asserted-by":"publisher","first-page":"111254","DOI":"10.1016\/j.fct.2020.111254","volume":"139","author":"DP Cladis","year":"2020","unstructured":"Cladis DP, Li SY, Reddivari L, Cox A, Ferruzzi MG, Weaver CM (2020) A 90 day oral toxicity study of blueberry polyphenols in ovariectomized sprague-dawley rats. Food Chem Toxicol 139:111254. https:\/\/doi.org\/10.1016\/j.fct.2020.111254","journal-title":"Food Chem Toxicol"},{"key":"905_CR16","doi-asserted-by":"publisher","first-page":"2442","DOI":"10.1039\/D0FO03457F","volume":"12","author":"DP Cladis","year":"2021","unstructured":"Cladis DP, Simpson AMR, Cooper K, Nakatsu C, Ferruzzi MG, Weaver CM (2021) Blueberry polyphenols alter gut microbiota and phenolic metabolism in rats. Food Funct 12:2442\u20132456. https:\/\/doi.org\/10.1039\/D0FO03457F","journal-title":"Food Funct"},{"key":"905_CR17","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1016\/B978-0-12-802147-7.00034-6","volume-title":"Nutraceuticals: efficacy, safety, and toxicity","author":"H Esch","year":"2016","unstructured":"Esch H, Kleider C, Scheffler A, Lehmann L (2016) Isoflavones: toxicological aspects and efficacy. In: Gupta R (ed) Nutraceuticals: efficacy, safety, and toxicity, 1st edn. Elsevier, Amsterdam, pp 465\u2013487","edition":"1"},{"key":"905_CR18","doi-asserted-by":"publisher","first-page":"1468","DOI":"10.1002\/jbmr.141","volume":"25","author":"ML Bouxsein","year":"2010","unstructured":"Bouxsein ML, Boyd SK, Christiansen BA, Guldberg RE, Jepsen KJ, Muller R (2010) Guidelines for assessment of bone microstructure in rodents using micro-computed tomography. J Bone Min Res 25:1468\u20131486. https:\/\/doi.org\/10.1002\/jbmr.141","journal-title":"J Bone Min Res"},{"key":"905_CR19","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1016\/8756-3282(93)90081-k","volume":"14","author":"CH Turner","year":"1993","unstructured":"Turner CH, Burr DB (1993) Basic biomechanical measurements of bone: A tutorial. Bone 14:595\u2013608. https:\/\/doi.org\/10.1016\/8756-3282(93)90081-k","journal-title":"Bone"},{"key":"905_CR20","doi-asserted-by":"publisher","first-page":"1471","DOI":"10.1007\/s00198-012-2103-x","volume":"24","author":"MR Allen","year":"2013","unstructured":"Allen MR, Chen NX, Gattone VH, Chen X, Carr AJ, LeBlanc P, Brown D, Moe SM (2013) Skeletal effects of zoledronic acid in an animal model of chronic kidney disease. Osteoporos Int 24:1471\u20131481. https:\/\/doi.org\/10.1007\/s00198-012-2103-x","journal-title":"Osteoporos Int"},{"key":"905_CR21","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2020.115632","volume":"143","author":"CE Metzger","year":"2021","unstructured":"Metzger CE, Swallow EA, Stacy AJ, Tippen SP, Hammond MA, Chen NX, Moe SM, Allen MR (2021) Reversing cortical porosity: cortical pore infilling in preclinical models of chronic kidney disease. Bone 143:115632. https:\/\/doi.org\/10.1016\/j.bone.2020.115632","journal-title":"Bone"},{"key":"905_CR22","doi-asserted-by":"publisher","first-page":"694","DOI":"10.1016\/j.jnutbio.2007.09.004","volume":"19","author":"L Devareddy","year":"2008","unstructured":"Devareddy L, Hooshmand S, Collins JK, Lucas EA, Chai SC, Arjmandi BH (2008) Blueberry prevents bone loss in ovariectomized rat model of postmenopausal osteoporosis. J Nutr Biochem 19:694\u2013699. https:\/\/doi.org\/10.1016\/j.jnutbio.2007.09.004","journal-title":"J Nutr Biochem"},{"key":"905_CR23","doi-asserted-by":"publisher","first-page":"253","DOI":"10.3945\/jn.114.198598","volume":"145","author":"EE Hohman","year":"2015","unstructured":"Hohman EE, Weaver CM (2015) A grape-enriched diet increases bone calcium retention and cortical bone properties in ovariectomized rats. J Nutr 145:253\u2013259. https:\/\/doi.org\/10.3945\/jn.114.198598","journal-title":"J Nutr"},{"key":"905_CR24","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1079\/BJN20041181","volume":"92","author":"C Puel","year":"2004","unstructured":"Puel C, Quintin A, Agalias A, Mathey J, Obled C, Mazur A, Davicco MJ, Lebecque P, Skaltsounis AL, Coxam V (2004) Olive oil and its main phenolic micronutrient (oleuropein) prevent inflammation-induced bone loss in the ovariectomised rat. Brit J Nutr 92:119\u2013127. https:\/\/doi.org\/10.1079\/BJN20041181","journal-title":"Brit J Nutr"},{"key":"905_CR25","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.jnutbio.2010.10.010","volume":"23","author":"E Rendina","year":"2012","unstructured":"Rendina E, Lim YF, Marlow D, Wang Y, Clarke SL, Kuvibidila S, Lucas EA, Smith BJ (2012) Dietary supplementation with dried plum prevents ovariectomy-induced bone loss while modulating the immune response in C57BL\/6J mice. J Nutr Biochem 23:60\u201368. https:\/\/doi.org\/10.1016\/j.jnutbio.2010.10.010","journal-title":"J Nutr Biochem"},{"key":"905_CR26","doi-asserted-by":"publisher","first-page":"527","DOI":"10.1007\/s00223-015-0043-0","volume":"97","author":"LR Brun","year":"2015","unstructured":"Brun LR, Brance ML, Lombarte M, Maher MC, Di Loreto VE, Rigalli A (2015) Effect of yerba mate (Ilex paraguariensis) on bone in ovariectomized rats. Calci Tissue Int 97:527\u2013534. https:\/\/doi.org\/10.1007\/s00223-015-0043-0","journal-title":"Calci Tissue Int"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-021-00905-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00223-021-00905-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-021-00905-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,1,23]],"date-time":"2022-01-23T16:03:20Z","timestamp":1642953800000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00223-021-00905-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,24]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["905"],"URL":"https:\/\/doi.org\/10.1007\/s00223-021-00905-5","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"type":"print","value":"0171-967X"},{"type":"electronic","value":"1432-0827"}],"subject":[],"published":{"date-parts":[[2021,8,24]]},"assertion":[{"value":"14 March 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 August 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"24 August 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Dennis Cladis, Elizabeth Swallow, Matthew Allen, Kathleen Hill Gallant, and Connie Weaver declare that they have no conflicts of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"Animal experiments were conducted in adherence to Purdue University Animal Care and Use Committee (PACUC) guidelines, following an approved protocol (1808001790).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}