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PTHrP-mediated hypercalcemia has been reported in benign conditions such as systemic lupus erythematous (SLE) and sarcoidosis and appears to be responsive to glucocorticoids. We report a case of PTHrP-induced hypercalcemia due to a malignancy\u2014low grade fibromyxoid sarcoma\u2014that responded to glucocorticoid treatment. This is the first report of glucocorticoids controlling PTHrP-mediated hypercalcemia of malignancy. Immunohistochemistry of the surgical pathology localized PTHrP staining to the vascular endothelial cells within the tumor. Further studies are needed to elucidate the mechanism of glucocorticoid action in the treatment of PTHrP-mediated hypercalcemia of malignancy.<\/jats:p>","DOI":"10.1007\/s00223-023-01099-8","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T07:02:36Z","timestamp":1687762956000},"page":"246-253","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A Case of Hypercalcemia from PTHrP-Producing Fibromyxoid Sarcoma Responsive to Glucocorticoid Therapy"],"prefix":"10.1007","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7190-079X","authenticated-orcid":false,"given":"Isabella","family":"Niu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8924-106X","authenticated-orcid":false,"given":"Edward C.","family":"Hsiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8512-5344","authenticated-orcid":false,"given":"Rosanna","family":"Wustrack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3037-1008","authenticated-orcid":false,"given":"John J.","family":"Wysolmerski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pamela","family":"Dann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3269-804X","authenticated-orcid":false,"given":"Umesh","family":"Masharani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2023,6,26]]},"reference":[{"issue":"5","key":"1099_CR1","doi-asserted-by":"publisher","first-page":"2024","DOI":"10.1210\/jc.2014-4250","volume":"100","author":"PJ Donovan","year":"2015","unstructured":"Donovan PJ, Achong N, Griffin K, Galligan J, Pretorius CJ, McLeod DS (2015) PTHrP-mediated hypercalcemia: causes and survival in 138 patients. 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UM receives clinical trial support from Clementia Pharmaceuticals. All authors declare that there are no conflicts of interest regarding the publication of this article.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"This retrospective chart review\u00a0 study\u00a0involving a human participant was in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.\u00a0The study was\u00a0conducted with approval from the UCSF Committee for Human Research, as part of the UCSF Biospecimens and Skeletal Tissues for Rare and Orphan Disease Genetics (BSTROnG) Biobank, approved by the Human Investigation Committee (IRB) of University of California, San Francisco (UCSF IRB#10-03053). The participant was consented prior to use of specimens or clinical data for research, and has consented to the publication of the case.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"ECH serves in a volunteer capacity on the Medical Registry Advisory Board of the International Fibrodysplasia Ossificans Progressiva Association. ECH also serves in a volunteer capacity on the Fibrous Dysplasia Foundation Medical Advisory Board. ECH is a member of the International Clinical Council on FOP.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Non-financial interest"}}]}}