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Much remains to be discovered about the phenotype and medical care needs of these patients. The purpose of this study was to examine the use of medical care among Dutch individuals identified between 2014 and 2021 with a pathogenic or suspicious rare variant in <jats:italic>LRP5<\/jats:italic>, <jats:italic>PLS3<\/jats:italic>, or <jats:italic>WNT1<\/jats:italic>. In addition, the aim was to compare their medical care utilization to both the overall Dutch population and the Dutch Osteogenesis Imperfecta (OI) population. The Amsterdam UMC Genome Database was used to match 92 patients with the Statistics Netherlands (CBS) cohort. Patients were categorized based on their harbored variants: <jats:italic>LRP5<\/jats:italic>, <jats:italic>PLS3<\/jats:italic>, or <jats:italic>WNT1<\/jats:italic>. Hospital admissions, outpatient visits, medication data, and diagnosis treatment combinations (DTCs) were compared between the variant groups and, when possible, to the total population and OI population. Compared to the total population, patients with an <jats:italic>LRP5<\/jats:italic>, <jats:italic>PLS3<\/jats:italic>, or <jats:italic>WNT1<\/jats:italic> variant had 1.63 times more hospital admissions, 2.0 times more opened DTCs, and a greater proportion using medication. Compared to OI patients, they had 0.62 times fewer admissions. Dutch patients with an <jats:italic>LRP5<\/jats:italic>, <jats:italic>PLS3<\/jats:italic>, or <jats:italic>WNT1<\/jats:italic> variant appear to require on average more medical care than the total population. As expected, they made higher use of care at the surgical and orthopedic departments. Additionally, they used more care at the audiological centers and the otorhinolaryngology (ENT) department, suggesting a higher risk of hearing-related problems.<\/jats:p>","DOI":"10.1007\/s00223-023-01101-3","type":"journal-article","created":{"date-parts":[[2023,6,6]],"date-time":"2023-06-06T03:24:19Z","timestamp":1686021859000},"page":"186-194","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Medical Care Use Among Patients with Monogenic Osteoporosis Due to Rare Variants in LRP5, PLS3, or WNT1"],"prefix":"10.1007","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5992-6789","authenticated-orcid":false,"given":"S. J. 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Verdonk, S. Storoni, L. Zhytnik, W. Zhong, G. Pals, B.J. van Royen, M.W. Elting, A. Maugeri, E.M.W. Eekhoff and D. Micha declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The study was conducted in accordance with the Declaration of Helsinki, and approved by the Institutional Review Board of The Medical Ethics Review Committee (MERC) of the Amsterdam UMC (Amsterdam, The Netherlands) (MERC study number 2021.0085). Patient consent was waived due to the retrospectively obtained and anonymized data for a non-intervention study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}]}}