{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T00:08:31Z","timestamp":1791590911084,"version":"4.3.4"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T00:00:00Z","timestamp":1686268800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"DOI":"10.1007\/s00223-023-01107-x","type":"journal-article","created":{"date-parts":[[2023,6,9]],"date-time":"2023-06-09T11:02:29Z","timestamp":1686308549000},"page":"276-285","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Assessment of Bone Microarchitecture in Patients with Systemic Mastocytosis and its Association with Clinical and Biochemical Parameters of the Disease"],"prefix":"10.1007","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6526-0140","authenticated-orcid":false,"given":"Andre S.","family":"Franco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor H.","family":"Murai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliam","family":"Takayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria F.","family":"Caparbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luan L.","family":"Marchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvira D. R. P.","family":"Velloso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa M. R.","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,6,9]]},"reference":[{"key":"1107_CR1","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1002\/ajh.26118","volume":"96","author":"A Pardanani","year":"2021","unstructured":"Pardanani A (2021) Systemic mastocytosis in adults: 2021 Update on diagnosis, risk stratification and management. Am J Hematol 96:508\u2013525","journal-title":"Am J Hematol"},{"key":"1107_CR2","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1056\/NEJMra1409760","volume":"373","author":"TC Theoharides","year":"2015","unstructured":"Theoharides TC, Valent P, Akin C (2015) Mast cells, mastocytosis, and related disorders. N Engl J Med 373:163\u2013172","journal-title":"N Engl J Med"},{"key":"1107_CR3","doi-asserted-by":"publisher","first-page":"1069","DOI":"10.1002\/ajh.24490","volume":"91","author":"S Broesby-Olsen","year":"2016","unstructured":"Broesby-Olsen S, Farkas DK, Vestergaard H, Hermann AP, M\u00f8ller MB, Mortz CG, Kristensen TK, Bindslev-Jensen C, S\u00f8rensen HT, Frederiksen H (2016) Risk of solid cancer, cardiovascular disease, anaphylaxis, osteoporosis and fractures in patients with systemic mastocytosis: a nationwide population-based study. Am J Hematol 91:1069\u20131075","journal-title":"Am J Hematol"},{"key":"1107_CR4","doi-asserted-by":"publisher","first-page":"880","DOI":"10.1016\/j.bone.2011.07.004","volume":"49","author":"M Rossini","year":"2011","unstructured":"Rossini M, Zanotti R, Bonadonna P, Artuso A, Caruso B, Schena D, Vecchiato D, Bonifacio M, Viapiana O, Gatti D, Senna G, Riccio A, Passalacqua G, Pizzolo G, Adami S (2011) Bone mineral density, bone turnover markers and fractures in patients with indolent systemic mastocytosis. Bone 49:880\u2013885","journal-title":"Bone"},{"key":"1107_CR5","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1111\/j.1398-9995.2011.02780.x","volume":"67","author":"E van der Veer","year":"2012","unstructured":"van der Veer E, van der Goot W, de Monchy JG, Kluin-Nelemans HC, van Doormaal JJ (2012) High prevalence of fractures and osteoporosis in patients with indolent systemic mastocytosis. Allergy 67:431\u2013438","journal-title":"Allergy"},{"key":"1107_CR6","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/j.bone.2017.09.005","volume":"105","author":"Y Degbo\u00e9","year":"2017","unstructured":"Degbo\u00e9 Y, Eischen M, Nigon D, Apoil PA, Mailhol C, Tournier E, Laurent C, Hanssens K, Hermine O, Paul C, Laroche M, Bulai-Livideanu C (2017) Prevalence and risk factors for fragility fracture in systemic mastocytosis. Bone 105:219\u2013225","journal-title":"Bone"},{"key":"1107_CR7","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.iac.2018.04.013","volume":"38","author":"G Orsolini","year":"2018","unstructured":"Orsolini G, Viapiana O, Rossini M, Bonifacio M, Zanotti R (2018) Bone disease in mastocytosis. Immunol Allergy Clin North Am 38:443\u2013454","journal-title":"Immunol Allergy Clin North Am"},{"key":"1107_CR8","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1016\/j.iac.2014.01.011","volume":"34","author":"M Rossini","year":"2014","unstructured":"Rossini M, Zanotti R, Viapiana O, Tripi G, Orsolini G, Idolazzi L, Bonadonna P, Schena D, Escribano L, Adami S, Gatti D (2014) Bone involvement and osteoporosis in mastocytosis. Immunol Allergy Clin North Am 34:383\u2013396","journal-title":"Immunol Allergy Clin North Am"},{"key":"1107_CR9","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1007\/s00198-013-2305-x","volume":"24","author":"S Seitz","year":"2013","unstructured":"Seitz S, Barvencik F, Koehne T, Priemel M, Pogoda P, Semler J, Minne H, Pfeiffer M, Zustin J, P\u00fcschel K, Eulenburg C, Schinke T, Amling M (2013) Increased osteoblast and osteoclast indices in individuals with systemic mastocytosis. Osteoporos Int 24:2325\u20132334","journal-title":"Osteoporos Int"},{"key":"1107_CR10","doi-asserted-by":"publisher","first-page":"685","DOI":"10.1007\/s00223-021-00887-4","volume":"109","author":"M Gehlen","year":"2021","unstructured":"Gehlen M, Schmidt N, Pfeifer M, Balasingam S, Schwarz-Eywill M, Maier A, Werner M, Siggelkow H (2021) Osteoporosis caused by systemic mastocytosis: prevalence in a Cohort of 8392 patients with osteoporosis. Calcif Tissue Int 109:685\u2013695","journal-title":"Calcif Tissue Int"},{"key":"1107_CR11","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1016\/j.jocd.2011.05.005","volume":"14","author":"D Hans","year":"2011","unstructured":"Hans D, Barthe N, Boutroy S, Pothuaud L, Winzenrieth R, Krieg MA (2011) Correlations between trabecular bone score, measured using anteroposterior dual-energy X-ray absorptiometry acquisition, and 3-dimensional parameters of bone microarchitecture: an experimental study on human cadaver vertebrae. J Clin Densitom 14:302\u2013312","journal-title":"J Clin Densitom"},{"key":"1107_CR12","doi-asserted-by":"publisher","first-page":"2284","DOI":"10.3390\/jcm11092284","volume":"11","author":"FM Ulivieri","year":"2022","unstructured":"Ulivieri FM, Rinaudo L (2022) The bone strain index: an innovative dual X-ray absorptiometry bone strength index and its helpfulness in clinical medicine. J Clin Med 11:2284\u20132296","journal-title":"J Clin Med"},{"key":"1107_CR13","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1007\/s00223-020-00749-5","volume":"107","author":"FM Ulivieri","year":"2020","unstructured":"Ulivieri FM, Rinaudo L, Piodi LP, Barbieri V, Marotta G, Scium\u00e8 M, Grifoni FI, Cesana BM (2020) Usefulness of dual X-ray absorptiometry-derived bone geometry and structural indexes in mastocytosis. Calcif Tissue Int 107:551\u2013558","journal-title":"Calcif Tissue Int"},{"key":"1107_CR14","doi-asserted-by":"publisher","first-page":"352","DOI":"10.1016\/j.rbr.2014.07.010","volume":"55","author":"H Fuller","year":"2015","unstructured":"Fuller H, Fuller R, Pereira RM (2015) High resolution peripheral quantitative computed tomography for the assessment of morphological and mechanical bone parameters. Rev Bras Reumatol 55:352\u2013362","journal-title":"Rev Bras Reumatol"},{"key":"1107_CR15","doi-asserted-by":"publisher","first-page":"1420","DOI":"10.1182\/blood-2016-09-731893","volume":"129","author":"P Valent","year":"2017","unstructured":"Valent P, Akin C, Metcalfe DD (2017) Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts. Blood 129:1420\u20131427","journal-title":"Blood"},{"key":"1107_CR16","doi-asserted-by":"publisher","first-page":"1335","DOI":"10.1007\/s00198-016-3876-0","volume":"28","author":"JC Alvarenga","year":"2017","unstructured":"Alvarenga JC, Fuller H, Pasoto SG, Pereira RM (2017) Age-related reference curves of volumetric bone density, structure, and biomechanical parameters adjusted for weight and height in a population of healthy women: an HR-pQCT study. Osteoporos Int 28:1335\u20131346","journal-title":"Osteoporos Int"},{"key":"1107_CR17","doi-asserted-by":"publisher","first-page":"1309","DOI":"10.1007\/s00198-021-06288-5","volume":"33","author":"JC Alvarenga","year":"2022","unstructured":"Alvarenga JC, Caparbo VF, Domiciano DS, Pereira RMR (2022) Age-related reference data of bone microarchitecture, volumetric bone density, and bone strength parameters in a population of healthy Brazilian men: an HR-pQCT study. Osteoporos Int 33:1309\u20131321","journal-title":"Osteoporos Int"},{"key":"1107_CR18","doi-asserted-by":"publisher","first-page":"1137","DOI":"10.1002\/jbmr.5650080915","volume":"8","author":"HK Genant","year":"1993","unstructured":"Genant HK, Wu CY, van Kuijk C, Nevitt MC (1993) Vertebral fracture assessment using a semiquantitative technique. J Bone Miner Res 8:1137\u20131148","journal-title":"J Bone Miner Res"},{"key":"1107_CR19","doi-asserted-by":"publisher","first-page":"547","DOI":"10.1373\/clinchem.2017.277897","volume":"64","author":"G Greiner","year":"2018","unstructured":"Greiner G, Gurbisz M, Ratzinger F, Witzeneder N, Simonitsch-Klupp I, Mitterbauer-Hohendanner G, Mayerhofer M, M\u00fcllauer L, Sperr WR, Valent P, Hoermann G (2018) Digital PCR: a sensitive and precise method for KIT D816V quantification in mastocytosis. Clin Chem 64:547\u2013555","journal-title":"Clin Chem"},{"key":"1107_CR20","doi-asserted-by":"publisher","first-page":"1489","DOI":"10.1111\/all.13425","volume":"73","author":"F Siebenhaar","year":"2018","unstructured":"Siebenhaar F, Sander B, Ho LHT, Ellrich A, Maurer M, Weller K (2018) Development and validation of the mastocytosis activity score. Allergy 73:1489\u20131496","journal-title":"Allergy"},{"key":"1107_CR21","doi-asserted-by":"publisher","first-page":"75.e71","DOI":"10.1016\/j.amjmed.2012.07.018","volume":"126","author":"N Guillaume","year":"2013","unstructured":"Guillaume N, Desoutter J, Chandesris O, Merlusca L, Henry I, Georgin-Lavialle S, Barete S, Hirsch I, Bouredji D, Royer B, Gruson B, Lok C, Sevestre H, Mentaverri R, Brazier M, Meynier J, Hermine O, Marolleau JP, Kamel S, Damaj G (2013) Bone complications of mastocytosis: a link between clinical and biological characteristics. Am J Med 126:75.e71-77","journal-title":"Am J Med"},{"key":"1107_CR22","doi-asserted-by":"publisher","first-page":"6027","DOI":"10.1073\/pnas.0934373100","volume":"100","author":"LA Fitzpatrick","year":"2003","unstructured":"Fitzpatrick LA, Buzas E, Gagne TJ, Nagy A, Horvath C, Ferencz V, Mester A, Kari B, Ruan M, Falus A, Barsony J (2003) Targeted deletion of histidine decarboxylase gene in mice increases bone formation and protects against ovariectomy-induced bone loss. Proc Natl Acad Sci USA 100:6027\u20136032","journal-title":"Proc Natl Acad Sci USA"},{"key":"1107_CR23","doi-asserted-by":"publisher","first-page":"1426","DOI":"10.2353\/ajpath.2009.080871","volume":"174","author":"M Biosse-Duplan","year":"2009","unstructured":"Biosse-Duplan M, Baroukh B, Dy M, de Vernejoul MC, Saffar JL (2009) Histamine promotes osteoclastogenesis through the differential expression of histamine receptors on osteoclasts and osteoblasts. Am J Pathol 174:1426\u20131434","journal-title":"Am J Pathol"},{"key":"1107_CR24","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1002\/(SICI)1097-4652(199710)173:1<10::AID-JCP2>3.0.CO;2-M","volume":"173","author":"C Dobigny","year":"1997","unstructured":"Dobigny C, Saffar JL (1997) H1 and H2 histamine receptors modulate osteoclastic resorption by different pathways: evidence obtained by using receptor antagonists in a rat synchronized resorption model. J Cell Physiol 173:10\u201318","journal-title":"J Cell Physiol"},{"key":"1107_CR25","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1007\/s00198-019-04918-7","volume":"30","author":"Y Degbo\u00e9","year":"2019","unstructured":"Degbo\u00e9 Y, Eischen M, Apoil PA, Mailhol C, Dubreuil P, Hermine O, Paul C, Bulai Livideanu C, Laroche M (2019) Higher prevalence of vertebral fractures in systemic mastocytosis, but not in cutaneous mastocytosis and idiopathic mast cell activation syndrome. Osteoporos Int 30:1235\u20131241","journal-title":"Osteoporos Int"},{"key":"1107_CR26","doi-asserted-by":"publisher","first-page":"1038","DOI":"10.1111\/1756-185X.14376","volume":"25","author":"CP Figueiredo","year":"2022","unstructured":"Figueiredo CP, Perez MO, Sales LP, Domiciano DS, Sampaio-Barros MM, Caparbo VF, Pereira RMR (2022) Lower hand grip in rheumatoid arthritis patients is associated with low finite element analysis using high resolution peripheral quantitative computed tomography scan of the 2nd metacarpophalangeal joint. Int J Rheum Dis 25:1038\u20131045","journal-title":"Int J Rheum Dis"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-023-01107-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00223-023-01107-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-023-01107-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,24]],"date-time":"2023-08-24T18:04:13Z","timestamp":1692900253000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00223-023-01107-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,9]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["1107"],"URL":"https:\/\/doi.org\/10.1007\/s00223-023-01107-x","relation":{},"ISSN":["1432-0827"],"issn-type":[{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,6,9]]},"assertion":[{"value":"14 March 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"30 May 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 June 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Andre S. Franco, Igor H. Murai, Liliam Takayama, Valeria F. Caparbo, Luan L. Marchi, Elvira D. R. P. Velloso, and Rosa M. R. Pereira declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; and decision to submit the manuscript for publication.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Role of the Funder\/Sponsor"}},{"value":"The study was approved by the ethics committee of the Hospital das Clinicas of the School of Medicine of the University of Sao Paulo (#19821519.0.0000.0068, date of approval September 4, 2019) and all the patients provided written informed consent before participation.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights and Informed Consent"}}]}}