{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T15:16:56Z","timestamp":1786979816118,"version":"build-2736575974"},"reference-count":52,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T00:00:00Z","timestamp":1702598400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"DOI":"10.1007\/s00223-023-01170-4","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T14:02:22Z","timestamp":1702648942000},"page":"295-309","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The Role of Osteogenic Effect and Vascular Function in Bone Health in Hypertensive Rats: A Study of Anti-hypertensive and Hemorheologic Drugs"],"prefix":"10.1007","volume":"114","author":[{"given":"Subhashis","family":"Pal","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konica","family":"Porwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahesh C.","family":"Tiwari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasir A.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saroj","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Navin","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2473-0246","authenticated-orcid":false,"given":"Naibedya","family":"Chattopadhyay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2023,12,15]]},"reference":[{"key":"1170_CR1","doi-asserted-by":"publisher","first-page":"146","DOI":"10.1016\/j.amjhyper.2004.08.016","volume":"18","author":"JL P\u00e9rez-Castrill\u00f3n","year":"2005","unstructured":"P\u00e9rez-Castrill\u00f3n JL, Mart\u00edn-Escudero JC, Alvarez Manzanares P et al (2005) Hypertension as a risk factor for hip fracture [2]. Am J Hypertens 18:146\u2013147","journal-title":"Am J Hypertens"},{"key":"1170_CR2","doi-asserted-by":"publisher","first-page":"68916","DOI":"10.18632\/oncotarget.20325","volume":"8","author":"Z Ye","year":"2017","unstructured":"Ye Z, Lu H, Liu P (2017) Association between essential hypertension and bone mineral density: a systematic review and meta-analysis. Oncotarget 8:68916\u201368927. https:\/\/doi.org\/10.18632\/oncotarget.20325","journal-title":"Oncotarget"},{"issue":"11","key":"1170_CR3","doi-asserted-by":"publisher","first-page":"2255","DOI":"10.1161\/hypertensionaha.123.21648","volume":"80","author":"R Zhang","year":"2023","unstructured":"Zhang R, Yin H, Yang M et al (2023) Advanced progress of the relationship between antihypertensive drugs and bone metabolism. Hypertension 80(11):2255\u20132264. https:\/\/doi.org\/10.1161\/hypertensionaha.123.21648","journal-title":"Hypertension"},{"key":"1170_CR4","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1016\/j.amjhyper.2005.10.024","volume":"19","author":"A Afghani","year":"2006","unstructured":"Afghani A, Johnson CA (2006) Resting blood pressure and bone mineral content are inversely related in overweight and obese hispanic women. Am J Hypertens 19:286\u2013292. https:\/\/doi.org\/10.1016\/j.amjhyper.2005.10.024","journal-title":"Am J Hypertens"},{"key":"1170_CR5","doi-asserted-by":"publisher","first-page":"315","DOI":"10.1007\/s00198-021-06190-0","volume":"33","author":"D Canoy","year":"2022","unstructured":"Canoy D, Harvey NC, Prieto-Alhambra D et al (2022) Elevated blood pressure, antihypertensive medications and bone health in the population: revisiting old hypotheses and exploring future research directions. Osteoporos Int 33:315\u2013326. https:\/\/doi.org\/10.1007\/s00198-021-06190-0","journal-title":"Osteoporos Int"},{"key":"1170_CR6","doi-asserted-by":"publisher","first-page":"e87","DOI":"10.1161\/HYP.0000000000000090","volume":"73","author":"LO Lerman","year":"2019","unstructured":"Lerman LO, Kurtz TW, Touyz RM et al (2019) Animal models of hypertension: a scientific statement from the American Heart Association. Hypertension 73:e87\u2013e120. https:\/\/doi.org\/10.1161\/HYP.0000000000000090","journal-title":"Hypertension"},{"key":"1170_CR7","doi-asserted-by":"publisher","first-page":"S1","DOI":"10.1097\/00005344-199006167-00002","volume":"16","author":"WJ Louis","year":"1990","unstructured":"Louis WJ, Howes LG (1990) Genealogy of the spontaneously hypertensive rat and wistar-kyoto rat strains: implications for studies of inherited hypertension. J Cardiovasc Pharmacol 16:S1\u2013S5. https:\/\/doi.org\/10.1097\/00005344-199006167-00002","journal-title":"J Cardiovasc Pharmacol"},{"key":"1170_CR8","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1016\/j.sjbs.2021.08.093","volume":"29","author":"C Hawlitschek","year":"2022","unstructured":"Hawlitschek C, Brendel J, Gabriel P et al (2022) Antihypertensive and cardioprotective effects of different monotherapies and combination therapies in young spontaneously hypertensive rats\u2014A pilot study: antihypertensive and cardioprotective effects of different monotherapies and combination therapies. Saudi J Biol Sci 29:339\u2013345. https:\/\/doi.org\/10.1016\/j.sjbs.2021.08.093","journal-title":"Saudi J Biol Sci"},{"key":"1170_CR9","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1590\/S1806-83242010000200008","volume":"24","author":"MF Bastos","year":"2010","unstructured":"Bastos MF, Brilhante FV, Bezerra JP et al (2010) Trabecular bone area and bone healing in spontaneously hypertensive rats. A histometric study. Braz Oral Res 24:170\u2013176. https:\/\/doi.org\/10.1590\/S1806-83242010000200008","journal-title":"Braz Oral Res"},{"key":"1170_CR10","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.3346\/jkms.2013.28.8.1139","volume":"28","author":"KY Kang","year":"2013","unstructured":"Kang KY, Kang Y, Kim M et al (2013) The effects of antihypertensive Drugs on bone mineral density in ovariectomized mice. J Korean Med Sci 28:1139\u20131144. https:\/\/doi.org\/10.3346\/jkms.2013.28.8.1139","journal-title":"J Korean Med Sci"},{"key":"1170_CR11","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1124\/jpet.110.167643","volume":"334","author":"T Sato","year":"2010","unstructured":"Sato T, Arai M, Goto S, Togari A (2010) Effects of propranolol on bone metabolism in spontaneously hypertensive rats. J Pharmacol Exp Ther 334:99\u2013105. https:\/\/doi.org\/10.1124\/jpet.110.167643","journal-title":"J Pharmacol Exp Ther"},{"key":"1170_CR12","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1038\/hr.2011.143","volume":"35","author":"H Shimizu","year":"2012","unstructured":"Shimizu H, Nakagami H, Yasumasa N et al (2012) Cilnidipine, but not amlodipine, ameliorates osteoporosis in ovariectomized hypertensive rats through inhibition of the N-type calcium channel. Hypertens Res 35:77\u201381. https:\/\/doi.org\/10.1038\/hr.2011.143","journal-title":"Hypertens Res"},{"issue":"11","key":"1170_CR13","doi-asserted-by":"publisher","first-page":"2928","DOI":"10.3390\/biomedicines10112928","volume":"10","author":"G Castoldi","year":"2022","unstructured":"Castoldi G, Carletti R, Ippolito S et al (2022) Angiotensin II modulates calcium\/phosphate excretion in experimental model of hypertension: focus on bone. Biomedicines 10(11):2928. https:\/\/doi.org\/10.3390\/biomedicines10112928","journal-title":"Biomedicines"},{"key":"1170_CR14","doi-asserted-by":"publisher","first-page":"1139","DOI":"10.1002\/jmri.21954","volume":"30","author":"YF Zhang","year":"2009","unstructured":"Zhang YF, Wang YXJ, Griffith JF et al (2009) Proximal femur bone marrow blood perfusion indices are reduced in hypertensive rats: a dynamic contrast-enhanced MRI study. J Magn Reson Imaging 30:1139\u20131144. https:\/\/doi.org\/10.1002\/jmri.21954","journal-title":"J Magn Reson Imaging"},{"key":"1170_CR15","doi-asserted-by":"publisher","first-page":"120","DOI":"10.5371\/hp.2019.31.2.120","volume":"31","author":"JS Ha","year":"2019","unstructured":"Ha JS, Cho HM, Lee HJ, Kim S, Do (2019) Bilateral avascular necrosis of the femoral head in a patient with asymptomatic adrenal incidentaloma. Hip Pelvis 31:120\u2013123. https:\/\/doi.org\/10.5371\/hp.2019.31.2.120","journal-title":"Hip Pelvis"},{"key":"1170_CR16","doi-asserted-by":"publisher","first-page":"602","DOI":"10.1016\/j.crad.2003.12.008","volume":"59","author":"N Hong","year":"2004","unstructured":"Hong N, Du XK (2004) Avascular necrosis of bone in severe acute respiratory syndrome. Clin Radiol 59:602\u2013608. https:\/\/doi.org\/10.1016\/j.crad.2003.12.008","journal-title":"Clin Radiol"},{"key":"1170_CR17","doi-asserted-by":"publisher","first-page":"864","DOI":"10.3904\/kjim.2020.098","volume":"37","author":"H-L Tsai","year":"2022","unstructured":"Tsai H-L, Chang J-W, Lu J-H, Liu C-S (2022) Epidemiology and risk factors associated with avascular necrosis in patients with autoimmune Diseases: a nationwide study. Korean J Intern Med 37:864\u2013876. https:\/\/doi.org\/10.3904\/kjim.2020.098","journal-title":"Korean J Intern Med"},{"key":"1170_CR18","doi-asserted-by":"publisher","first-page":"247","DOI":"10.1002\/emmm.201000080","volume":"2","author":"A Benigni","year":"2010","unstructured":"Benigni A, Cassis P, Remuzzi G (2010) Angiotensin II revisited: new roles in inflammation, immunology and aging. EMBO Mol Med 2:247\u2013257","journal-title":"EMBO Mol Med"},{"key":"1170_CR19","doi-asserted-by":"publisher","first-page":"1201","DOI":"10.1002\/cphy.c130040","volume":"4","author":"MA Sparks","year":"2014","unstructured":"Sparks MA, Crowley SD, Gurley SB et al (2014) Classical renin-angiotensin system in kidney physiology. Compr Physiol 4:1201\u20131228. https:\/\/doi.org\/10.1002\/cphy.c130040","journal-title":"Compr Physiol"},{"key":"1170_CR20","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1111\/jvim.15454","volume":"33","author":"MK Ames","year":"2019","unstructured":"Ames MK, Atkins CE, Pitt B (2019) The renin-angiotensin-aldosterone system and its suppression. J Vet Intern Med 33:363\u2013382","journal-title":"J Vet Intern Med"},{"key":"1170_CR21","doi-asserted-by":"publisher","first-page":"e000365","DOI":"10.1136\/openhrt-2015-000365","volume":"3","author":"MF McCarty","year":"2016","unstructured":"McCarty MF, O\u2019Keefe JH, DiNicolantonio JJ (2016) Pentoxifylline for vascular health: a brief review of the literature. Open Hear 3:e000365. https:\/\/doi.org\/10.1136\/openhrt-2015-000365","journal-title":"Open Hear"},{"key":"1170_CR22","doi-asserted-by":"publisher","first-page":"752","DOI":"10.1177\/000331978103201103","volume":"32","author":"N Ohshima","year":"1981","unstructured":"Ohshima N, Sato M (1981) Effect of pentoxifylline on microvascular blood flow velocity. Angiology 32:752\u2013763. https:\/\/doi.org\/10.1177\/000331978103201103","journal-title":"Angiology"},{"key":"1170_CR23","doi-asserted-by":"publisher","first-page":"294","DOI":"10.1007\/s00223-019-00567-4","volume":"105","author":"S Pal","year":"2019","unstructured":"Pal S, Porwal K, Singh H et al (2019) Reversal of osteopenia in ovariectomized rats by pentoxifylline: evidence of osteogenic and osteo-angiogenic roles of the drug. Calcif Tissue Int 105:294\u2013307. https:\/\/doi.org\/10.1007\/s00223-019-00567-4","journal-title":"Calcif Tissue Int"},{"key":"1170_CR24","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.atherosclerosis.2005.03.043","volume":"184","author":"G Zaydun","year":"2006","unstructured":"Zaydun G, Tomiyama H, Hashimoto H et al (2006) Menopause is an Independent factor augmenting the age-related increase in arterial stiffness in the early postmenopausal phase. Atherosclerosis 184:137\u2013142. https:\/\/doi.org\/10.1016\/j.atherosclerosis.2005.03.043","journal-title":"Atherosclerosis"},{"key":"1170_CR25","doi-asserted-by":"publisher","first-page":"131","DOI":"10.1016\/S0378-5122(03)00252-4","volume":"47","author":"G Mercuro","year":"2004","unstructured":"Mercuro G, Zoncu S, Saiu F et al (2004) Menopause induced by oophorectomy reveals a role of ovarian estrogen on the maintenance of pressure homeostasis. Maturitas 47:131\u2013138. https:\/\/doi.org\/10.1016\/S0378-5122(03)00252-4","journal-title":"Maturitas"},{"key":"1170_CR26","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1097\/gme.0b013e3181b9b061","volume":"17","author":"A Sherwood","year":"2010","unstructured":"Sherwood A, Park SB, Hughes JW et al (2010) Cardiovascular hemodynamics during stress in premenopausal versus postmenopausal women. Menopause 17:403\u2013409. https:\/\/doi.org\/10.1097\/gme.0b013e3181b9b061","journal-title":"Menopause"},{"key":"1170_CR27","doi-asserted-by":"publisher","first-page":"158","DOI":"10.1016\/j.jobcr.2020.04.006","volume":"10","author":"S Trivedi","year":"2020","unstructured":"Trivedi S, Srivastava K, Gupta A et al (2020) A quantitative method to determine osteogenic differentiation aptness of scaffold. J Oral Biol Craniofacial Res 10:158\u2013160. https:\/\/doi.org\/10.1016\/j.jobcr.2020.04.006","journal-title":"J Oral Biol Craniofacial Res"},{"key":"1170_CR28","doi-asserted-by":"publisher","first-page":"115305","DOI":"10.1016\/j.bone.2020.115305","volume":"135","author":"S Pal","year":"2020","unstructured":"Pal S, Rashid M, Singh SK et al (2020) Skeletal restoration by phosphodiesterase 5 inhibitors in osteopenic mice: evidence of osteoanabolic and osteoangiogenic effects of the drugs. Bone 135:115305. https:\/\/doi.org\/10.1016\/j.bone.2020.115305","journal-title":"Bone"},{"key":"1170_CR29","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.1039\/d1fo03867b","volume":"13","author":"S Sharma","year":"2022","unstructured":"Sharma S, Porwal K, Kulkarni C et al (2022) Diosmin, a citrus fruit-derived phlebotonic bioflavonoid protects rats from chronic kidney disease-induced loss of bone mass and strength without deteriorating the renal function. Food Funct 13:2184\u20132199. https:\/\/doi.org\/10.1039\/d1fo03867b","journal-title":"Food Funct"},{"key":"1170_CR30","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1093\/toxsci\/kfz172","volume":"172","author":"K Porwal","year":"2019","unstructured":"Porwal K, Pal S, Tewari D et al (2019) Increased bone marrow-specific adipogenesis by clofazimine causes impaired fracture healing, osteopenia, and osteonecrosis without extraskeletal effects in rats. Toxicol Sci 172:167\u2013180. https:\/\/doi.org\/10.1093\/toxsci\/kfz172","journal-title":"Toxicol Sci"},{"key":"1170_CR31","doi-asserted-by":"publisher","first-page":"254","DOI":"10.1007\/s11906-012-0260-0","volume":"14","author":"R Lima","year":"2012","unstructured":"Lima R, Wofford M, Reckelhoff JF (2012) Hypertension in postmenopausal women. Curr Hypertens Rep 14:254\u2013260. https:\/\/doi.org\/10.1007\/s11906-012-0260-0","journal-title":"Curr Hypertens Rep"},{"key":"1170_CR32","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1016\/j.cdtm.2015.02.006","volume":"1","author":"M Ji","year":"2015","unstructured":"Ji M, Yu Q (2015) Primary osteoporosis in postmenopausal women. Chronic Dis Transl Med 1:9\u201313. https:\/\/doi.org\/10.1016\/j.cdtm.2015.02.006","journal-title":"Chronic Dis Transl Med"},{"key":"1170_CR33","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.3390\/ijms22041568","volume":"22","author":"E Noirrit-Esclassan","year":"2021","unstructured":"Noirrit-Esclassan E, Valera M-C, Tremollieres F et al (2021) Critical role of estrogens on bone homeostasis in both male and female: from physiology to medical implications. Int J Mol Sci 22:1568. https:\/\/doi.org\/10.3390\/ijms22041568","journal-title":"Int J Mol Sci"},{"key":"1170_CR34","doi-asserted-by":"publisher","first-page":"576","DOI":"10.1016\/j.tem.2012.03.008","volume":"23","author":"S Khosla","year":"2012","unstructured":"Khosla S, Oursler MJ, Monroe DG (2012) Estrogen and the skeleton. Trends Endocrinol Metab 23:576\u2013581","journal-title":"Trends Endocrinol Metab"},{"key":"1170_CR35","doi-asserted-by":"publisher","first-page":"699","DOI":"10.1038\/nrendo.2013.179","volume":"9","author":"SC Manolagas","year":"2013","unstructured":"Manolagas SC, O\u2019Brien CA, Almeida M (2013) The role of estrogen and androgen receptors in bone health and disease. Nat Rev Endocrinol 9:699\u2013712","journal-title":"Nat Rev Endocrinol"},{"issue":"1","key":"1170_CR36","doi-asserted-by":"publisher","first-page":"4990","DOI":"10.1038\/s41598-017-04150-5","volume":"7","author":"J Wang","year":"2017","unstructured":"Wang J, Gao Y, Cheng P et al (2017) CD31hiEmcnhi vessels support new trabecular bone formation at the frontier growth area in the bone defect repair process. Sci Rep 7(1):4990. https:\/\/doi.org\/10.1038\/s41598-017-04150-5","journal-title":"Sci Rep"},{"key":"1170_CR37","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s13139-016-0443-8","volume":"51","author":"S Han","year":"2017","unstructured":"Han S, Oh M, Yoon S et al (2017) Risk stratification for avascular necrosis of the femoral head after internal fixation of femoral neck fractures by post-operative bone SPECT\/CT. Nucl Med Mol Imaging 51:49\u201357. https:\/\/doi.org\/10.1007\/s13139-016-0443-8","journal-title":"Nucl Med Mol Imaging"},{"key":"1170_CR38","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1302\/0301-620X.92B6.23377","volume":"92","author":"RT Steffen","year":"2010","unstructured":"Steffen RT, Athanasou NA, Gill HS, Murray DW (2010) Avascular necrosis associated with fracture of the femoral neck after hip resurfacing: histological assessment of femoral bone from retrieval specimens. J Bone Jt Surg - Ser B 92:787\u2013793. https:\/\/doi.org\/10.1302\/0301-620X.92B6.23377","journal-title":"J Bone Jt Surg - Ser B"},{"key":"1170_CR39","volume-title":"Osteonecrosis (Avascular Necrosis)","author":"AH Matthews","year":"2020","unstructured":"Matthews AH, Stitson D (2020) Osteonecrosis (Avascular Necrosis). StatPearls Publishing, Florida"},{"key":"1170_CR40","doi-asserted-by":"publisher","first-page":"282","DOI":"10.1007\/s00223-014-9893-0","volume":"95","author":"TC Lee","year":"2014","unstructured":"Lee TC, Burghardt AJ, Yao W et al (2014) Improved trabecular bone structure of 20-month-old male spontaneously hypertensive rats. Calcif Tissue Int 95:282\u2013291. https:\/\/doi.org\/10.1007\/s00223-014-9893-0","journal-title":"Calcif Tissue Int"},{"key":"1170_CR41","doi-asserted-by":"publisher","first-page":"77","DOI":"10.1016\/S0008-6363(98)00077-7","volume":"39","author":"YM Pinto","year":"1998","unstructured":"Pinto YM, Paul M, Ganten D (1998) Lessons from rat models of hypertension: from goldblatt to genetic engineering. Cardiovasc Res 39:77\u201388","journal-title":"Cardiovasc Res"},{"key":"1170_CR42","doi-asserted-by":"publisher","first-page":"779","DOI":"10.1038\/clpt.1980.110","volume":"27","author":"DT Lowenthal","year":"1980","unstructured":"Lowenthal DT, Hobbs D, Affrime MB et al (1980) Prazosin kinetics and effectiveness in renal failure. Clin Pharmacol Ther 27:779\u2013783. https:\/\/doi.org\/10.1038\/clpt.1980.110","journal-title":"Clin Pharmacol Ther"},{"key":"1170_CR43","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1007\/BF00561948","volume":"19","author":"JB Fourtillan","year":"1981","unstructured":"Fourtillan JB, Courtois P, Lefebvre MA, Girault J (1981) Pharmacokinetics of oral timolol studied by mass fragmentography. Eur J Clin Pharmacol 19:193\u2013196. https:\/\/doi.org\/10.1007\/BF00561948","journal-title":"Eur J Clin Pharmacol"},{"key":"1170_CR44","first-page":"193","volume":"1","author":"WS Jee","year":"2001","unstructured":"Jee WS, Yao W (2001) Overview: animal models of osteopenia and osteoporosis. J Musculoskelet Neuronal Interact 1:193\u2013207","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"1170_CR45","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1111\/clr.12360","volume":"26","author":"XL Liu","year":"2015","unstructured":"Liu XL, Li CL, Lu WW et al (2015) Skeletal site-specific response to ovariectomy in a rat model: change in bone density and microarchitecture. Clin Oral Implants Res 26:392\u2013398. https:\/\/doi.org\/10.1111\/clr.12360","journal-title":"Clin Oral Implants Res"},{"key":"1170_CR46","first-page":"89","volume":"19","author":"N Yousefzadeh","year":"2020","unstructured":"Yousefzadeh N, Kashfi K, Jeddi S, Ghasemi A (2020) Ovariectomized rat model of osteoporosis: a practical guide. EXCLI J 19:89\u2013107","journal-title":"EXCLI J"},{"issue":"1","key":"1170_CR47","doi-asserted-by":"publisher","first-page":"12293","DOI":"10.1038\/s41598-019-48797-8","volume":"9","author":"W Tiyasatkulkovit","year":"2019","unstructured":"Tiyasatkulkovit W, Promruk W, Rojviriya C et al (2019) Impairment of bone microstructure and upregulation of osteoclastogenic markers in spontaneously hypertensive rats. Sci Rep 9(1):12293. https:\/\/doi.org\/10.1038\/s41598-019-48797-8","journal-title":"Sci Rep"},{"key":"1170_CR48","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1244372","author":"D Ribatti","year":"2023","unstructured":"Ribatti D, D\u2019Amati A (2023) Bone angiocrine factors. Front Cell Dev Biol. https:\/\/doi.org\/10.3389\/fcell.2023.1244372. 11:","journal-title":"Front Cell Dev Biol"},{"key":"1170_CR49","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1530\/EC-20-0446","volume":"10","author":"L Oinonen","year":"2021","unstructured":"Oinonen L, Tikkakoski A, Koskela J et al (2021) Parathyroid hormone may play a role in the pathophysiology of primary hypertension. Endocr Connect 10:54\u201365. https:\/\/doi.org\/10.1530\/EC-20-0446","journal-title":"Endocr Connect"},{"key":"1170_CR50","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s00198-002-1345-4","volume":"14","author":"P Ammann","year":"2003","unstructured":"Ammann P, Rizzoli R (2003) Bone strength and its determinants. Osteoporos Int 14:13\u201318","journal-title":"Osteoporos Int"},{"key":"1170_CR51","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1007\/BF01622738","volume":"6","author":"P Ammann","year":"1996","unstructured":"Ammann P, Rizzoli R, Meyer JM, Bonjour JP (1996) Bone density and shape as determinants of bone strength in IGF-I and\/or pamidronate-treated ovariectomized rats. Osteoporos Int 6:219\u2013227. https:\/\/doi.org\/10.1007\/BF01622738","journal-title":"Osteoporos Int"},{"key":"1170_CR52","first-page":"114","volume":"17","author":"NH Hart","year":"2017","unstructured":"Hart NH, Nimphius S, Rantalainen T et al (2017) Mechanical basis of bone strength: influence of bone material, bone structure and muscle action. J Musculoskelet Neuronal Interact 17:114\u2013139","journal-title":"J Musculoskelet Neuronal Interact"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-023-01170-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00223-023-01170-4\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-023-01170-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,28]],"date-time":"2024-02-28T08:03:52Z","timestamp":1709107432000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00223-023-01170-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,15]]},"references-count":52,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2024,3]]}},"alternative-id":["1170"],"URL":"https:\/\/doi.org\/10.1007\/s00223-023-01170-4","relation":{},"ISSN":["1432-0827"],"issn-type":[{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,15]]},"assertion":[{"value":"17 June 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"22 November 2023","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"15 December 2023","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Subhashis Pal, Shivani Sharma, Konica Porwal, Mahesh C. Tiwari, Yasir A. Khan, Saroj Kumar, Navin Kumar, Naibedya Chattopadhyay declare that they have no conflict of Interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All animal experiments were performed following the ethical standards of The International Union for Conservation of Nature (IUCN) and approved by institutional committee for control and supervision of experiments on animals [The Institutional Animal Ethics Committee (IAEC) approval number for this study is CDRI\/IAEC\/2017\/312)]. . The IAEC has been constituted by the Committee for the Control and Supervision of Experiments on Animals (CCSEA), the Government of India in which the Socially Aware Nominee of the CCSEA monitors all aspects of animal welfare and rights.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Human and Animal Rights and Informed Consent statements"}}]}}