{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,24]],"date-time":"2025-12-24T18:14:57Z","timestamp":1766600097017,"version":"3.37.3"},"reference-count":40,"publisher":"Springer Science and Business Media LLC","issue":"5","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["22K16755","C:20K09514","C:KK230021"],"award-info":[{"award-number":["22K16755","C:20K09514","C:KK230021"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009666","name":"Salt Science Research Foundation","doi-asserted-by":"publisher","award":["22C1"],"award-info":[{"award-number":["22C1"]}],"id":[{"id":"10.13039\/100009666","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"DOI":"10.1007\/s00223-024-01193-5","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T18:01:58Z","timestamp":1710180118000},"page":"535-549","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Roles of Plasminogen Activator Inhibitor-1 in Heterotopic Ossification Induced by Achilles Tenotomy in Thermal Injured Mice"],"prefix":"10.1007","volume":"114","author":[{"given":"Yuya","family":"Mizukami","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoyuki","family":"Kawao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Ohira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daiki","family":"Hashimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyotaka","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Osamu","family":"Matsuo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7433-5135","authenticated-orcid":false,"given":"Hiroshi","family":"Kaji","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"issue":"4","key":"1193_CR1","doi-asserted-by":"publisher","first-page":"e10172","DOI":"10.1002\/jbm4.10172","volume":"3","author":"C Meyers","year":"2019","unstructured":"Meyers C, Lisiecki J, Miller S, Levin A, Fayad L, Ding C, Sono T, McCarthy E, Levi B, James AW (2019) Heterotopic ossification: a comprehensive review. JBMR Plus 3(4):e10172","journal-title":"JBMR Plus"},{"issue":"12","key":"1193_CR2","doi-asserted-by":"publisher","first-page":"611","DOI":"10.3390\/biomedicines8120611","volume":"8","author":"S Cappato","year":"2020","unstructured":"Cappato S, Gamberale R, Bocciardi R, Brunelli S (2020) Genetic and acquired heterotopic ossification: a translational tale of mice and men. Biomedicines 8(12):611","journal-title":"Biomedicines"},{"key":"1193_CR3","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.bone.2017.09.014","volume":"109","author":"RJ Pignolo","year":"2018","unstructured":"Pignolo RJ, Kaplan FS (2018) Clinical staging of fibrodysplasia ossificans progressiva (FOP). Bone 109:111\u2013114","journal-title":"Bone"},{"issue":"12","key":"1193_CR4","doi-asserted-by":"publisher","first-page":"633206","DOI":"10.3389\/fgene.2021.633206","volume":"26","author":"N Brewer","year":"2021","unstructured":"Brewer N, Fong JT, Zhang D, Ramaswamy G, Shore EM (2021) Gnas inactivation alters subcutaneous tissues in progression to heterotopic ossification. Front Genet 26(12):633206","journal-title":"Front Genet"},{"key":"1193_CR5","doi-asserted-by":"publisher","first-page":"116655","DOI":"10.1016\/j.bone.2022.116655","volume":"168","author":"G Cao","year":"2023","unstructured":"Cao G, Zhang S, Wang Y, Quan S, Yue C, Yao J, Alexander PG, Tan H (2023) Pathogenesis of acquired heterotopic ossification: risk factors, cellular mechanisms, and therapeutic implications. Bone 168:116655","journal-title":"Bone"},{"issue":"2","key":"1193_CR6","doi-asserted-by":"publisher","first-page":"365","DOI":"10.1002\/jbmr.3346","volume":"33","author":"JP Levesque","year":"2018","unstructured":"Levesque JP, Sims NA, Pettit AR, Alexander KA, Tseng HW, Torossian F, Gen\u00eat F, Lataillade JJ, Le Bousse-Kerdil\u00e8s MC (2018) Macrophages driving heterotopic ossification: convergence of genetically-driven and trauma-driven mechanisms. J Bone Miner Res 33(2):365\u2013366","journal-title":"J Bone Miner Res"},{"issue":"1","key":"1193_CR7","doi-asserted-by":"publisher","first-page":"722","DOI":"10.1038\/s41467-019-14172-4","volume":"11","author":"M Sorkin","year":"2020","unstructured":"Sorkin M, Huber AK, Hwang C, Carson WF 4th, Menon R, Li J, Vasquez K, Pagani C, Patel N, Li S, Visser ND, Niknafs Y, Loder S, Scola M, Nycz D, Gallagher K, McCauley LK, Xu J, James AW, Agarwal S, Kunkel S, Mishina Y, Levi B (2020) Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing. Nat Commun 11(1):722","journal-title":"Nat Commun"},{"issue":"9","key":"1193_CR8","doi-asserted-by":"publisher","first-page":"2845","DOI":"10.1007\/s11999-014-3694-7","volume":"472","author":"JA Forsberg","year":"2014","unstructured":"Forsberg JA, Potter BK, Polfer EM, Safford SD, Elster EA (2014) Do inflammatory markers portend heterotopic ossification and wound failure in combat wounds? Clin Orthop Relat Res 472(9):2845\u20132854","journal-title":"Clin Orthop Relat Res"},{"issue":"2","key":"1193_CR9","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1007\/s11999-013-3325-8","volume":"472","author":"KN Evans","year":"2014","unstructured":"Evans KN, Potter BK, Brown TS, Davis TA, Elster EA, Forsberg JA (2014) Osteogenic gene expression correlates with development of heterotopic ossification in war wounds. Clin Orthop Relat Res 472(2):396\u2013404","journal-title":"Clin Orthop Relat Res"},{"issue":"18","key":"1193_CR10","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1016\/j.jot.2019.06.001","volume":"5","author":"L Li","year":"2019","unstructured":"Li L, Jiang Y, Lin H, Shen H, Sohn J, Alexander PG, Tuan RS (2019) Muscle injury promotes heterotopic ossification by stimulating local bone morphogenetic protein-7 production. J Orthop Translat 5(18):142\u2013153","journal-title":"J Orthop Translat"},{"issue":"1","key":"1193_CR11","doi-asserted-by":"publisher","first-page":"551","DOI":"10.1038\/s41467-018-02988-5","volume":"9","author":"X Wang","year":"2018","unstructured":"Wang X, Li F, Xie L, Crane J, Zhen G, Mishina Y, Deng R, Gao B, Chen H, Liu S, Yang P, Gao M, Tu M, Wang Y, Wan M, Fan C, Cao X (2018) Inhibition of overactive TGF-\u03b2 attenuates progression of heterotopic ossification in mice. Nat Commun 9(1):551","journal-title":"Nat Commun"},{"issue":"669","key":"1193_CR12","doi-asserted-by":"publisher","first-page":"eabd0536","DOI":"10.1126\/scisignal.abd0536","volume":"14","author":"C Mundy","year":"2021","unstructured":"Mundy C, Yao L, Sinha S, Chung J, Rux D, Catheline SE, Koyama E, Qin L, Pacifici M (2021) Activin a promotes the development of acquired heterotopic ossification and is an effective target for disease attenuation in mice. Sci Signal 14(669):eabd0536","journal-title":"Sci Signal"},{"issue":"21","key":"1193_CR13","doi-asserted-by":"publisher","first-page":"e96034","DOI":"10.1172\/jci.insight.96034","volume":"2","author":"F Torossian","year":"2017","unstructured":"Torossian F, Guerton B, Anginot A, Alexander KA, Desterke C, Soave S, Tseng HW, Arouche N, Boutin L, Kulina I, Salga M, Jose B, Pettit AR, Clay D, Rochet N, Vlachos E, Genet G, Debaud C, Denormandie P, Genet F, Sims NA, Banzet S, Levesque JP, Lataillade JJ, Le Bousse-Kerdil\u00e8s MC (2017) Macrophage-derived oncostatin M contributes to human and mouse neurogenic heterotopic ossifications. JCI Insight 2(21):e96034","journal-title":"JCI Insight"},{"issue":"5","key":"1193_CR14","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1002\/jor.23833","volume":"36","author":"C Tuzmen","year":"2018","unstructured":"Tuzmen C, Verdelis K, Weiss L, Campbell P (2018) Crosstalk between substance P and calcitonin gene-related peptide during heterotopic ossification in murine Achilles tendon. J Orthop Res 36(5):1444\u20131455","journal-title":"J Orthop Res"},{"issue":"4","key":"1193_CR15","doi-asserted-by":"publisher","first-page":"2595","DOI":"10.1111\/jcmm.14150","volume":"23","author":"J Zhang","year":"2019","unstructured":"Zhang J, Wang L, Cao H, Chen N, Yan B, Ao X, Zhao H, Chu J, Huang M, Zhang Z (2019) Neurotrophin-3 acts on the endothelial-mesenchymal transition of heterotopic ossification in rats. J Cell Mol Med 23(4):2595\u20132609","journal-title":"J Cell Mol Med"},{"issue":"4","key":"1193_CR16","doi-asserted-by":"publisher","first-page":"1873","DOI":"10.1002\/cphy.c160004","volume":"6","author":"H Kaji","year":"2016","unstructured":"Kaji H (2016) Adipose tissue-derived plasminogen activator inhibitor-1 function and regulation. Compr Physiol 6(4):1873\u20131896","journal-title":"Compr Physiol"},{"issue":"8","key":"1193_CR17","doi-asserted-by":"publisher","first-page":"1879","DOI":"10.1111\/j.1538-7836.2005.01420.x","volume":"3","author":"DE Vaughan","year":"2005","unstructured":"Vaughan DE (2005) PAI-1 and atherothrombosis. J Thromb Haemost 3(8):1879\u20131883","journal-title":"J Thromb Haemost"},{"issue":"8","key":"1193_CR18","doi-asserted-by":"publisher","first-page":"1378","DOI":"10.1161\/hq0801.093667","volume":"21","author":"A Pandolfi","year":"2001","unstructured":"Pandolfi A, Cetrullo D, Polishuck R, Alberta MM, Calafiore A, Pellegrini G, Vitacolonna E, Capani F, Consoli A (2001) Plasminogen activator inhibitor type 1 is increased in the arterial wall of type II diabetic subjects. Arterioscler Thromb Vasc Biol 21(8):1378\u20131382","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"1","key":"1193_CR19","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1161\/01.ATV.18.1.1","volume":"18","author":"DJ Loskutoff","year":"1998","unstructured":"Loskutoff DJ, Samad F (1998) The adipocyte and hemostatic balance in obesity: studies of PAI-1. Arterioscler Thromb Vasc Biol 18(1):1\u20136","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"40","key":"1193_CR20","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1186\/s41232-020-00128-5","volume":"16","author":"K Okada","year":"2020","unstructured":"Okada K, Nishioka M, Kaji H (2020) Roles of fibrinolytic factors in the alterations in bone marrow hematopoietic stem\/progenitor cells during bone repair. Inflamm Regen 16(40):22","journal-title":"Inflamm Regen"},{"issue":"4","key":"1193_CR21","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1007\/s00223-008-9169-7","volume":"83","author":"CH Rundle","year":"2008","unstructured":"Rundle CH, Wang X, Wergedal JE, Mohan S, Lau KH (2008) Fracture healing in mice deficient in plasminogen activator inhibitor-1. Calcif Tissue Int 83(4):276\u2013284","journal-title":"Calcif Tissue Int"},{"issue":"8","key":"1193_CR22","doi-asserted-by":"publisher","first-page":"1510","DOI":"10.1359\/jbmr.2000.15.8.1510","volume":"15","author":"E Daci","year":"2000","unstructured":"Daci E, Verstuyf A, Moermans K, Bouillon R, Carmeliet G (2000) Mice lacking the plasminogen activator inhibitor 1 are protected from trabecular bone loss induced by estrogen deficiency. J Bone Miner Res 15(8):1510\u20131516","journal-title":"J Bone Miner Res"},{"issue":"3","key":"1193_CR23","doi-asserted-by":"publisher","first-page":"e92686","DOI":"10.1371\/journal.pone.0092686","volume":"9","author":"L Mao","year":"2014","unstructured":"Mao L, Kawao N, Tamura Y, Okumoto K, Okada K, Yano M, Matsuo O, Kaji H (2014) Plasminogen activator inhibitor-1 is involved in impaired bone repair associated with diabetes in female mice. PLoS ONE 9(3):e92686","journal-title":"PLoS ONE"},{"key":"1193_CR24","doi-asserted-by":"publisher","first-page":"115310","DOI":"10.1016\/j.bone.2020.115310","volume":"134","author":"K Okada","year":"2020","unstructured":"Okada K, Okamoto T, Okumoto K, Takafuji Y, Ishida M, Kawao N, Matsuo O, Kaji H (2020) PAI-1 is involved in delayed bone repair induced by glucocorticoids in mice. Bone 134:115310","journal-title":"Bone"},{"issue":"6","key":"1193_CR25","doi-asserted-by":"publisher","first-page":"9687","DOI":"10.1002\/jcp.27655","volume":"234","author":"Y Takafuji","year":"2019","unstructured":"Takafuji Y, Tatsumi K, Ishida M, Kawao N, Okada K, Matsuo O, Kaji H (2019) Plasminogen activator inhibitor-1 deficiency suppresses osteoblastic differentiation of mesenchymal stem cells in mice. J Cell Physiol 234(6):9687\u20139697","journal-title":"J Cell Physiol"},{"issue":"9","key":"1193_CR26","doi-asserted-by":"publisher","first-page":"3170","DOI":"10.2337\/db12-1552","volume":"62","author":"Y Tamura","year":"2013","unstructured":"Tamura Y, Kawao N, Okada K, Yano M, Okumoto K, Matsuo O, Kaji H (2013) Plasminogen activator inhibitor-1 is involved in streptozotocin-induced bone loss in female mice. Diabetes 62(9):3170\u20133179","journal-title":"Diabetes"},{"issue":"6","key":"1193_CR27","doi-asserted-by":"publisher","first-page":"1730","DOI":"10.1002\/stem.1981","volume":"33","author":"Y Matsumoto","year":"2015","unstructured":"Matsumoto Y, Ikeya M, Hino K, Horigome K, Fukuta M, Watanabe M, Nagata S, Yamamoto T, Otsuka T, Toguchida J (2015) New protocol to optimize iPS cells for genome analysis of fibrodysplasia ossificans progressiva. Stem Cells 33(6):1730\u20131742","journal-title":"Stem Cells"},{"issue":"3","key":"1193_CR28","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1097\/BCR.0b013e3182957768","volume":"35","author":"A Medina","year":"2014","unstructured":"Medina A, Shankowsky H, Savaryn B, Shukalak B, Tredget EE (2014) Characterization of heterotopic ossification in burn patients. J Burn Care Res 35(3):251\u2013256","journal-title":"J Burn Care Res"},{"key":"1193_CR29","first-page":"e52880","volume":"102","author":"JR Peterson","year":"2015","unstructured":"Peterson JR, Agarwal S, Brownley RC, Loder SJ, Ranganathan K, Cederna PS, Mishina Y, Wang SC, Levi B (2015) Direct mouse trauma\/burn model of heterotopic ossification. J Vis Exp 102:e52880","journal-title":"J Vis Exp"},{"issue":"4","key":"1193_CR30","doi-asserted-by":"publisher","first-page":"e0284258","DOI":"10.1371\/journal.pone.0284258","volume":"18","author":"Y Mizukami","year":"2023","unstructured":"Mizukami Y, Kawao N, Takafuji Y, Ohira T, Okada K, Jo JI, Tabata Y, Kaji H (2023) Matrix vesicles promote bone repair after a femoral bone defect in mice. PLoS ONE 18(4):e0284258","journal-title":"PLoS ONE"},{"issue":"7","key":"1193_CR31","doi-asserted-by":"publisher","first-page":"1561","DOI":"10.1002\/jbmr.1921","volume":"28","author":"N Kawao","year":"2013","unstructured":"Kawao N, Tamura Y, Okumoto K, Yano M, Okada K, Matsuo O, Kaji H (2013) Plasminogen plays a crucial role in bone repair. J Bone Miner Res 28(7):1561\u20131574","journal-title":"J Bone Miner Res"},{"issue":"7","key":"1193_CR32","doi-asserted-by":"publisher","first-page":"1294","DOI":"10.1038\/nprot.2010.81","volume":"5","author":"BT Estes","year":"2010","unstructured":"Estes BT, Diekman BO, Gimble JM, Guilak F (2010) Isolation of adipose-derived stem cells and their induction to a chondrogenic phenotype. Nat Protoc 5(7):1294\u20131311","journal-title":"Nat Protoc"},{"issue":"1","key":"1193_CR33","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1186\/s12891-017-1752-5","volume":"18","author":"A Moritake","year":"2017","unstructured":"Moritake A, Kawao N, Okada K, Tatsumi K, Ishida M, Okumoto K, Matsuo O, Akagi M, Kaji H (2017) Plasminogen activator inhibitor-1 deficiency enhances subchondral osteopenia after induction of osteoarthritis in mice. BMC Musculoskelet Disord 18(1):392","journal-title":"BMC Musculoskelet Disord"},{"issue":"12","key":"1193_CR34","doi-asserted-by":"publisher","first-page":"1421","DOI":"10.1507\/endocrj.EJ21-0142","volume":"68","author":"H Ehara","year":"2021","unstructured":"Ehara H, Takafuji Y, Tatsumi K, Okada K, Mizukami Y, Kawao N, Matsuo O, Kaji H (2021) Role of plasminogen activator inhibitor-1 in muscle wasting induced by a diabetic state in female mice. Endocr J 68(12):1421\u20131428","journal-title":"Endocr J"},{"issue":"6","key":"1193_CR35","doi-asserted-by":"publisher","first-page":"2194","DOI":"10.2337\/db14-1192","volume":"64","author":"Y Tamura","year":"2015","unstructured":"Tamura Y, Kawao N, Yano M, Okada K, Okumoto K, Chiba Y, Matsuo O, Kaji H (2015) Role of plasminogen activator inhibitor-1 in glucocorticoid-induced diabetes and osteopenia in mice. Diabetes 64(6):2194\u20132206","journal-title":"Diabetes"},{"key":"1193_CR36","doi-asserted-by":"publisher","first-page":"95","DOI":"10.1016\/j.trsl.2017.06.004","volume":"186","author":"D Dey","year":"2017","unstructured":"Dey D, Wheatley BM, Cholok D, Agarwal S, Yu PB, Levi B, Davis TA (2017) The traumatic bone: trauma-induced heterotopic ossification. Transl Res 186:95\u2013111","journal-title":"Transl Res"},{"issue":"2\u20133","key":"1193_CR37","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1016\/j.mam.2012.07.007","volume":"34","author":"IC Forster","year":"2013","unstructured":"Forster IC, Hernando N, Biber J, Murer H (2013) Phosphate transporters of the SLC20 and SLC34 families. Mol Aspects Med 34(2\u20133):386\u201395","journal-title":"Mol Aspects Med"},{"issue":"3","key":"1193_CR38","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1038\/nrrheum.2012.1","volume":"8","author":"L Claes","year":"2012","unstructured":"Claes L, Recknagel S, Ignatius A (2012) Fracture healing under healthy and inflammatory conditions. Nat Rev Rheumatol 8(3):133\u2013143","journal-title":"Nat Rev Rheumatol"},{"issue":"11","key":"1193_CR39","doi-asserted-by":"publisher","first-page":"689","DOI":"10.5435\/00124635-200911000-00003","volume":"17","author":"CA Cipriano","year":"2009","unstructured":"Cipriano CA, Pill SG, Keenan MA (2009) Heterotopic ossification following traumatic brain injury and spinal cord injury. J Am Acad Orthop Surg 17(11):689\u2013697","journal-title":"J Am Acad Orthop Surg"},{"issue":"4","key":"1193_CR40","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1080\/10790268.2017.1357104","volume":"41","author":"GJ Farkas","year":"2018","unstructured":"Farkas GJ, Gater DR (2018) Neurogenic obesity and systemic inflammation following spinal cord injury: a review. J Spinal Cord Med 41(4):378\u2013387","journal-title":"J Spinal Cord Med"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-024-01193-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00223-024-01193-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-024-01193-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,30]],"date-time":"2024-04-30T16:12:02Z","timestamp":1714493522000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00223-024-01193-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,11]]},"references-count":40,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2024,5]]}},"alternative-id":["1193"],"URL":"https:\/\/doi.org\/10.1007\/s00223-024-01193-5","relation":{},"ISSN":["1432-0827"],"issn-type":[{"type":"electronic","value":"1432-0827"}],"subject":[],"published":{"date-parts":[[2024,3,11]]},"assertion":[{"value":"16 November 2023","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"2 February 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 March 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"All mouse experiments were performed according to the Guide for the Care and Use of Laboratory Animals from the National Institutes of Health and the institutional guidelines for the use and care of laboratory animals at Kindai University. The protocol was approved by the Experimental Animal Welfare Committee of Kinki University (permit numbers: KAME-2022\u2013073).","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"The authors have no competing interests to declare that are relevant to the content of this article.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}