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The running protocol consisted of 8\u2009\u00d7\u20093min treadmill runs at 85% of maximal aerobic speed. 17\u03b2-oestradiol concentrations (pg\u00b7ml<jats:sup>\u22121<\/jats:sup>) were lower in early-follicular (47.22\u2009\u00b1\u200939.75) compared to late-follicular (304.95\u2009\u00b1\u2009235.85;<jats:italic>p<\/jats:italic>\u2009=\u2009\u2009&lt;\u20090.001) and mid-luteal phase (165.56\u2009\u00b1\u200980.6;<jats:italic>p<\/jats:italic>\u2009=\u20090.003) and higher in withdrawal (46.51\u2009\u00b1\u200944.09) compared to active pill-taking phase (10.88\u2009\u00b1\u200911.24;<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Progesterone (ng\u00b7ml<jats:sup>\u22121<\/jats:sup>) was higher in mid-luteal (13.214\u2009\u00b1\u20094.926) compared to early-follicular (0.521\u2009\u00b1\u20090.365; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and late-follicular phase (1.677\u2009\u00b1\u20092.586;<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). In eumenorrheic females, P1NP concentrations (ng\u00b7ml<jats:sup>\u22121<\/jats:sup>) were higher in late-follicular (69.97\u2009\u00b1\u200917.84) compared to early-follicular (60.96\u2009\u00b1\u200916.64;<jats:italic>p<\/jats:italic>\u2009=\u20090.006;) and mid-luteal phase (59.122\u2009\u00b1\u200911.77;<jats:italic>p<\/jats:italic>\u2009=\u20090.002). \u03b2-CTX-1 concentrations (ng\u00b7ml<jats:sup>\u22121<\/jats:sup>) were lower in mid-luteal (0.376\u2009\u00b1\u20090.098) compared to late-follicular (0.496\u2009\u00b1\u20090.166; <jats:italic>p<\/jats:italic>\u2009=\u20090.001) and early-follicular phase (0.452\u2009\u00b1\u20090.148; <jats:italic>p<\/jats:italic>\u2009=\u20090.039). OC users showed higher post-exercise P1NP concentrations in withdrawal phase (61.75\u2009\u00b1\u20098.32) compared to post-exercise in active pill-taking phase (45.45\u2009\u00b1\u20096;<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Comparing hormonal profiles, post-exercise P1NP concentrations were higher in early-follicular (66.91\u2009\u00b1\u200916.26;<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), late-follicular (80.66\u2009\u00b1\u200916.35;<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and mid-luteal phases (64.57\u2009\u00b1\u20099.68;<jats:italic>p<\/jats:italic>\u2009=\u20090.002) to active pill-taking phase. These findings underscore the importance of studying exercising females with different ovarian hormone profiles, as changes in sex hormone concentrations affect bone metabolism in response to running, showing a higher post-exercise P1NP concentrations in all menstrual cycle phases compared with active pill-taking phase of the OC cycle.<\/jats:p>","DOI":"10.1007\/s00223-024-01259-4","type":"journal-article","created":{"date-parts":[[2024,7,27]],"date-time":"2024-07-27T11:02:03Z","timestamp":1722078123000},"page":"382-392","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Influence of Menstrual Cycle and Oral Contraceptive Phases on Bone (re)modelling Markers in Response to Interval Running"],"prefix":"10.1007","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1767-5341","authenticated-orcid":false,"given":"Isabel","family":"Guisado-Cuadrado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9754-5565","authenticated-orcid":false,"given":"Nuria","family":"Romero-Parra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1122-5099","authenticated-orcid":false,"given":"Kirsty J.","family":"Elliott-Sale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5816-4169","authenticated-orcid":false,"given":"Craig","family":"Sale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6215-0093","authenticated-orcid":false,"given":"\u00c1ngel E.","family":"D\u00edaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4871-8682","authenticated-orcid":false,"given":"Ana B.","family":"Peinado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,7,27]]},"reference":[{"issue":"9","key":"1259_CR1","doi-asserted-by":"publisher","first-page":"1709","DOI":"10.1002\/jbmr.2499","volume":"30","author":"SJ Allison","year":"2015","unstructured":"Allison SJ et al (2015) The influence of high-impact exercise on cortical and trabecular bone mineral content and 3D distribution across the proximal femur in older men: a randomized controlled unilateral intervention. 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