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Osteoclasts of male and female cTG mutant mice each showed 3- to fivefold overexpression of\n                    <jats:italic>miR17<\/jats:italic>\n                    \u2009~\u2009\n                    <jats:italic>92<\/jats:italic>\n                    cluster genes compared to those of age- and sex-matched wildtype (WT) littermates. Male but not female cTG mutant mice had more trabecular and cortical bones as well as lower bone resorption reflected by reduction in osteoclast number and resorbing surface. Osteoclasts of male but not female cTG mutants showed decreased bone resorption activity. Consistent with suppression of osteoclast maturation, osteoclasts of male cTG mutants were smaller, contained less nuclei, showed reduced levels of mRNA of genes associated with osteoclast differentiation and fusion, and formed more diffused actin ring. Osteoclastic overexpression of\n                    <jats:italic>miR17<\/jats:italic>\n                    \u2009~\u2009\n                    <jats:italic>92<\/jats:italic>\n                    also increased bone formation, but the increase was much larger in males than in females. The increase in male mutants was due to higher mineral apposition rate, and conversely, it was caused by increasing bone-forming surface in female mutants. In summary, osteoclastic overexpression of\n                    <jats:italic>miR17<\/jats:italic>\n                    \u2009~\u2009\n                    <jats:italic>92<\/jats:italic>\n                    increased bone mass through reduction in bone resorption along with coupled increase in bone formation in male-specific manner. Although the osteoclastic overexpression of\n                    <jats:italic>miR17<\/jats:italic>\n                    \u2009~\u2009\n                    <jats:italic>92<\/jats:italic>\n                    -induced suppression of bone resorption and increases in bone formation support the feasibility of\n                    <jats:italic>miR17<\/jats:italic>\n                    \u2009~\u2009\n                    <jats:italic>92<\/jats:italic>\n                    -based antiresorptive strategies, the male-specific sexual disparity in skeletal responses to osteoclastic overexpression of\n                    <jats:italic>miR17<\/jats:italic>\n                    \u2009~\u2009\n                    <jats:italic>92<\/jats:italic>\n                    could limit its clinical utility as it may not be used in women with postmenopausal osteoporosis.\n                  <\/jats:p>","DOI":"10.1007\/s00223-024-01325-x","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T02:35:11Z","timestamp":1735871711000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Overexpression of miR17\u2009~\u200992 in Myeloid Cells in Mice Increased Bone Mass Through Reduced Bone Resorption and Increased Bone Formation in Sex-Dependent Manner"],"prefix":"10.1007","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0815-7008","authenticated-orcid":false,"given":"Matilda H.-C.","family":"Sheng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia M.","family":"Stiffel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jordan","family":"Taipia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4691-8143","authenticated-orcid":false,"given":"Charles H.","family":"Rundle","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1109-5052","authenticated-orcid":false,"given":"Kin-Hing William","family":"Lau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,1,3]]},"reference":[{"key":"1325_CR1","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1196\/annals.1365.035","volume":"1092","author":"DJ Hadjidakis","year":"2006","unstructured":"Hadjidakis DJ, Androulakis II (2006) Bone remodeling. 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