{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T13:23:49Z","timestamp":1766755429690,"version":"3.48.0"},"reference-count":46,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T00:00:00Z","timestamp":1765238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100013088","name":"Qinglan Project of Jiangsu Province of China","doi-asserted-by":"publisher","award":["JUSRP221024"],"award-info":[{"award-number":["JUSRP221024"]}],"id":[{"id":"10.13039\/501100013088","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["JUSRP202406004"],"award-info":[{"award-number":["JUSRP202406004"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"DOI":"10.1007\/s00223-025-01453-y","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T02:39:40Z","timestamp":1765247980000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Integrated Bioinformatics Analysis and Experimental Validation of the Role of Cellular Senescence in Osteoporosis"],"prefix":"10.1007","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-6225-4299","authenticated-orcid":false,"given":"Peiwen","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiping","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunqing","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanjin","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruijin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junxing","family":"Ye","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2025,12,9]]},"reference":[{"key":"1453_CR1","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1002\/jbmr.4187","volume":"36","author":"X Cheng","year":"2021","unstructured":"Cheng X, Zhao K, Zha X, Du X, Li Y, Chen S, Wu Y, Li S, Lu Y, Zhang Y, Xiao X, Li Y, Ma X, Gong X, Chen W, Yang Y, Jiao J, Chen B, Lv Y, Gao J, Hong G, Pan Y, Yan Y, Qi H, Ran L, Zhai J, Wang L, Li K, Fu H, Wu J, Liu S, Blake GM, Pickhardt PJ, Ma Y, Fu X, Dong S, Zeng Q, Guo Z, Hind K, Engelke K, Tian W (2021) Opportunistic screening using low-dose CT and the prevalence of osteoporosis in China: a nationwide, multicenter study. J Bone Miner Res 36:427\u2013435","journal-title":"J Bone Miner Res"},{"key":"1453_CR2","doi-asserted-by":"publisher","first-page":"669","DOI":"10.1186\/s13018-021-02821-8","volume":"16","author":"N Salari","year":"2021","unstructured":"Salari N, Darvishi N, Bartina Y, Larti M, Kiaei A, Hemmati M, Shohaimi S, Mohammadi M (2021) Global prevalence of osteoporosis among the world older adults: a comprehensive systematic review and meta-analysis. J Orthop Surg Res 16:669","journal-title":"J Orthop Surg Res"},{"key":"1453_CR3","doi-asserted-by":"publisher","first-page":"1715","DOI":"10.1002\/ijc.27316","volume":"130","author":"H Rayess","year":"2012","unstructured":"Rayess H, Wang MB, Srivatsan ES (2012) Cellular senescence and tumor suppressor gene p16. Int J Cancer 130:1715\u20131725","journal-title":"Int J Cancer"},{"key":"1453_CR4","doi-asserted-by":"publisher","first-page":"250","DOI":"10.1038\/s41569-021-00624-2","volume":"19","author":"M Mehdizadeh","year":"2022","unstructured":"Mehdizadeh M, Aguilar M, Thorin E, Ferbeyre G, Nattel S (2022) The role of cellular senescence in cardiac disease: basic biology and clinical relevance. Nat Rev Cardiol 19:250\u2013264","journal-title":"Nat Rev Cardiol"},{"key":"1453_CR5","doi-asserted-by":"publisher","first-page":"121","DOI":"10.1016\/j.bone.2019.01.015","volume":"121","author":"JN Farr","year":"2019","unstructured":"Farr JN, Khosla S (2019) Cellular senescence in bone. Bone 121:121\u2013133","journal-title":"Bone"},{"key":"1453_CR6","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.bone.2018.02.008","volume":"118","author":"J Paccou","year":"2019","unstructured":"Paccou J, Penel G, Chauveau C, Cortet B, Hardouin P (2019) Marrow adiposity and bone: review of clinical implications. Bone 118:8\u201315","journal-title":"Bone"},{"key":"1453_CR7","doi-asserted-by":"publisher","first-page":"1072","DOI":"10.1038\/nm.4385","volume":"23","author":"JN Farr","year":"2017","unstructured":"Farr JN, Xu M, Weivoda MM, Monroe DG, Fraser DG, Onken JL, Negley BA, Sfeir JG, Ogrodnik MB, Hachfeld CM, LeBrasseur NK, Drake MT, Pignolo RJ, Pirtskhalava T, Tchkonia T, Oursler MJ, Kirkland JL, Khosla S (2017) Targeting cellular senescence prevents age-related bone loss in mice. Nat Med 23:1072\u20131079","journal-title":"Nat Med"},{"key":"1453_CR8","first-page":"3078","volume":"12","author":"D Zhang","year":"2020","unstructured":"Zhang D, Yu K, Yang J, Xie S, Yang J, Tan L (2020) Senolytic controls bone marrow mesenchymal stem cells fate improving bone formation. Am J Transl Res 12:3078\u20133088","journal-title":"Am J Transl Res"},{"key":"1453_CR9","first-page":"13","volume":"25","author":"Y Wang","year":"2023","unstructured":"Wang Y, Che L, Chen X, He Z, Song D, Yuan Y, Liu C (2023) Repurpose dasatinib and quercetin: targeting senescent cells ameliorates postmenopausal osteoporosis and rejuvenates bone regeneration. Bioact Mater 25:13\u201328","journal-title":"Bioact Mater"},{"key":"1453_CR10","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.81480","author":"P Ding","year":"2022","unstructured":"Ding P, Gao C, Gao Y, Liu D, Li H, Xu J, Chen X, Huang Y, Zhang C, Zheng M, Gao J (2022) Osteocytes regulate senescence of bone and bone marrow. Elife. https:\/\/doi.org\/10.7554\/eLife.81480","journal-title":"Elife"},{"key":"1453_CR11","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101507","volume":"73","author":"J Lin","year":"2022","unstructured":"Lin J, Epel E (2022) Stress and telomere shortening: insights from cellular mechanisms. Ageing Res Rev 73:101507","journal-title":"Ageing Res Rev"},{"key":"1453_CR12","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1016\/j.mad.2017.08.004","volume":"170","author":"A Bielak-Zmijewska","year":"2018","unstructured":"Bielak-Zmijewska A, Mosieniak G, Sikora E (2018) Is DNA damage indispensable for stress-induced senescence? Mech Ageing Dev 170:13\u201321","journal-title":"Mech Ageing Dev"},{"key":"1453_CR13","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1007\/s00281-024-01016-7","volume":"46","author":"A Ahmad","year":"2024","unstructured":"Ahmad A, Braden A, Khan S, Xiao J, Khan MM (2024) Crosstalk between the DNA damage response and cellular senescence drives aging and age-related diseases. Semin Immunopathol 46:10","journal-title":"Semin Immunopathol"},{"key":"1453_CR14","doi-asserted-by":"publisher","first-page":"598","DOI":"10.1016\/j.tig.2022.02.010","volume":"38","author":"PL Vaddavalli","year":"2022","unstructured":"Vaddavalli PL, Schumacher B (2022) The p53 network: cellular and systemic DNA damage responses in cancer and aging. Trends Genet 38:598\u2013612","journal-title":"Trends Genet"},{"issue":"3","key":"1453_CR15","doi-asserted-by":"publisher","first-page":"490","DOI":"10.1111\/tpj.15567","volume":"109","author":"JA Pedroza-Garcia","year":"2022","unstructured":"Pedroza-Garcia JA, Xiang Y, De Veylder L (2022) Cell cycle checkpoint control in response to DNA damage by environmental stresses. Plant J 109(3):490\u2013507. https:\/\/doi.org\/10.1111\/tpj.15567","journal-title":"Plant J"},{"key":"1453_CR16","doi-asserted-by":"publisher","first-page":"2011","DOI":"10.1007\/s10565-021-09686-x","volume":"39","author":"B Sha","year":"2023","unstructured":"Sha B, Sun Y, Zhao S, Li M, Huang W, Li Z, Shi J, Han X, Li P, Hu T, Chen P (2023) USP8 inhibitor-induced DNA damage activates cell cycle arrest, apoptosis, and autophagy in esophageal squamous cell carcinoma. Cell Biol Toxicol 39:2011\u20132032","journal-title":"Cell Biol Toxicol"},{"key":"1453_CR17","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.114098","volume":"245","author":"X Chou","year":"2022","unstructured":"Chou X, Li X, Min Z, Ding F, Ma K, Shen Y, Sun D, Wu Q (2022) Sirtuin-1 attenuates cadmium-induced renal cell senescence through p53 deacetylation. Ecotoxicol Environ Saf 245:114098","journal-title":"Ecotoxicol Environ Saf"},{"key":"1453_CR18","doi-asserted-by":"publisher","first-page":"15545","DOI":"10.1073\/pnas.0506580102","volume":"102","author":"A Subramanian","year":"2005","unstructured":"Subramanian A, Tamayo P, Mootha VK, Mukherjee S, Ebert BL, Gillette MA, Paulovich A, Pomeroy SL, Golub TR, Lander ES, Mesirov JP (2005) Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles. Proc Natl Acad Sci U S A 102:15545\u201315550","journal-title":"Proc Natl Acad Sci U S A"},{"key":"1453_CR19","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1089\/omi.2011.0118","volume":"16","author":"G Yu","year":"2012","unstructured":"Yu G, Wang LG, Han Y, He QY (2012) clusterProfiler: an R package for comparing biological themes among gene clusters. OMICS 16:284\u2013287","journal-title":"OMICS"},{"key":"1453_CR20","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks1094","volume":"41","author":"A Franceschini","year":"2013","unstructured":"Franceschini A, Szklarczyk D, Frankild S, Kuhn M, Simonovic M, Roth A, Lin J, Minguez P, Bork P, von Mering C, Jensen LJ (2013) STRING v9.1: protein-protein interaction networks, with increased coverage and integration. Nucleic Acids Res 41:D808","journal-title":"Nucleic Acids Res"},{"key":"1453_CR21","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1093\/bioinformatics\/btq675","volume":"27","author":"ME Smoot","year":"2011","unstructured":"Smoot ME, Ono K, Ruscheinski J, Wang PL, Ideker T (2011) Cytoscape 2.8: new features for data integration and network visualization. Bioinformatics 27:431\u2013432","journal-title":"Bioinformatics"},{"key":"1453_CR22","doi-asserted-by":"publisher","DOI":"10.3389\/fpubh.2022.963426","volume":"10","author":"J Zou","year":"2022","unstructured":"Zou J, Zhang W, Chen X, Su W, Yu D (2022) Data mining reveal the association between diabetic foot ulcer and peripheral artery disease. Front Public Health 10:963426","journal-title":"Front Public Health"},{"key":"1453_CR23","doi-asserted-by":"publisher","first-page":"1437","DOI":"10.1016\/j.cell.2017.10.049","volume":"171","author":"A Subramanian","year":"2017","unstructured":"Subramanian A, Narayan R, Corsello SM, Peck DD, Natoli TE, Lu X, Gould J, Davis JF, Tubelli AA, Asiedu JK, Lahr DL, Hirschman JE, Liu Z, Donahue M, Julian B, Khan M, Wadden D, Smith IC, Lam D, Liberzon A, Toder C, Bagul M, Orzechowski M, Enache OM, Piccioni F, Johnson SA, Lyons NJ, Berger AH, Shamji AF, Brooks AN, Vrcic A, Flynn C, Rosains J, Takeda DY, Hu R, Davison D, Lamb J, Ardlie K, Hogstrom L, Greenside P, Gray NS, Clemons PA, Silver S, Wu X, Zhao WN, Read-Button W, Wu X, Haggarty SJ, Ronco LV, Boehm JS, Schreiber SL, Doench JG, Bittker JA, Root DE, Wong B, Golub TR (2017) A next generation connectivity map: L1000 platform and the first 1,000,000 profiles. Cell 171:1437-1452.e1417","journal-title":"Cell"},{"key":"1453_CR24","doi-asserted-by":"publisher","first-page":"W214","DOI":"10.1093\/nar\/gkq537","volume":"38","author":"D Warde-Farley","year":"2010","unstructured":"Warde-Farley D, Donaldson SL, Comes O, Zuberi K, Badrawi R, Chao P, Franz M, Grouios C, Kazi F, Lopes CT, Maitland A, Mostafavi S, Montojo J, Shao Q, Wright G, Bader GD, Morris Q (2010) The GeneMANIA prediction server: biological network integration for gene prioritization and predicting gene function. Nucleic Acids Res 38:W214-220","journal-title":"Nucleic Acids Res"},{"key":"1453_CR25","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.1038\/aps.2015.95","volume":"36","author":"W Hong","year":"2015","unstructured":"Hong W, Xu XY, Qiu ZH, Gao JJ, Wei ZY, Zhen L, Zhang XL, Ye ZB (2015) Sirt1 is involved in decreased bone formation in aged apolipoprotein E-deficient mice. Acta Pharmacol Sin 36:1487\u20131496","journal-title":"Acta Pharmacol Sin"},{"key":"1453_CR26","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20194959","author":"P Billard","year":"2019","unstructured":"Billard P, Poncet DA (2019) Replication stress at telomeric and mitochondrial DNA: common origins and consequences on ageing. Int J Mol Sci. https:\/\/doi.org\/10.3390\/ijms20194959","journal-title":"Int J Mol Sci"},{"key":"1453_CR27","doi-asserted-by":"publisher","DOI":"10.1002\/adbi.202300136","volume":"7","author":"T Tanaka","year":"2023","unstructured":"Tanaka T, Miyakoshi Y, Kobayashi Y, Xiaolong S, Daiyang Y, Ochi H, Sato S, Kato T, Yoshii T, Okawa A, Kaldis P, Inose H (2023) Regulation of osteoblast to osteocyte differentiation by cyclin-dependent kinase-1. Adv Biol (Weinh) 7:e2300136","journal-title":"Adv Biol (Weinh)"},{"key":"1453_CR28","doi-asserted-by":"publisher","first-page":"1182","DOI":"10.1083\/jcb.201808014","volume":"218","author":"D Hayward","year":"2019","unstructured":"Hayward D, Alfonso-P\u00e9rez T, Cundell MJ, Hopkins M, Holder J, Bancroft J, Hutter LH, Novak B, Barr FA, Gruneberg U (2019) CDK1-CCNB1 creates a spindle checkpoint-permissive state by enabling MPS1 kinetochore localization. J Cell Biol 218:1182\u20131199","journal-title":"J Cell Biol"},{"key":"1453_CR29","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1016\/j.ijbiomac.2018.11.032","volume":"123","author":"A Liu","year":"2019","unstructured":"Liu A, Zeng S, Lu X, Xiong Q, Xue Y, Tong L, Xu W, Sun Y, Zhang Z, Xu C (2019) Overexpression of G2 and S phase-expressed-1 contributes to cell proliferation, migration, and invasion via regulating p53\/FoxM1\/CCNB1 pathway and predicts poor prognosis in bladder cancer. Int J Biol Macromol 123:322\u2013334","journal-title":"Int J Biol Macromol"},{"key":"1453_CR30","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2023.102957","volume":"299","author":"LY Ng","year":"2023","unstructured":"Ng LY, Ma HT, Poon RYC (2023) Cyclin A-CDK1 suppresses the expression of the CDK1 activator CDC25A to safeguard timely mitotic entry. J Biol Chem 299:102957","journal-title":"J Biol Chem"},{"key":"1453_CR31","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1186\/s13046-023-02855-2","volume":"42","author":"K Wang","year":"2023","unstructured":"Wang K, Jiang X, Jiang Y, Liu J, Du Y, Zhang Z, Li Y, Zhao X, Li J, Zhang R (2023) EZH2-H3K27me3-mediated silencing of mir-139-5p inhibits cellular senescence in hepatocellular carcinoma by activating TOP2A. J Exp Clin Cancer Res 42:320","journal-title":"J Exp Clin Cancer Res"},{"key":"1453_CR32","doi-asserted-by":"publisher","DOI":"10.3390\/biom12071007","author":"F Yang","year":"2022","unstructured":"Yang F, Hu Z, Guo Z (2022) Small-molecule inhibitors targeting FEN1 for cancer therapy. Biomolecules. https:\/\/doi.org\/10.3390\/biom12071007","journal-title":"Biomolecules"},{"key":"1453_CR33","doi-asserted-by":"publisher","first-page":"812","DOI":"10.1038\/nm1599","volume":"13","author":"L Zheng","year":"2007","unstructured":"Zheng L, Dai H, Zhou M, Li M, Singh P, Qiu J, Tsark W, Huang Q, Kernstine K, Zhang X, Lin D, Shen B (2007) Fen1 mutations result in autoimmunity, chronic inflammation and cancers. Nat Med 13:812\u2013819","journal-title":"Nat Med"},{"key":"1453_CR34","doi-asserted-by":"publisher","first-page":"4901","DOI":"10.1074\/jbc.M007825200","volume":"276","author":"J Qiu","year":"2001","unstructured":"Qiu J, Li X, Frank G, Shen B (2001) Cell cycle-dependent and DNA damage-inducible nuclear localization of FEN-1 nuclease is consistent with its dual functions in DNA replication and repair. J Biol Chem 276:4901\u20134908","journal-title":"J Biol Chem"},{"key":"1453_CR35","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2024.101916","volume":"44","author":"Z Peng","year":"2024","unstructured":"Peng Z, Wang S, Wen D, Mei Z, Zhang H, Liao S, Lv L, Li C (2024) FEN1 upregulation mediated by SUMO2 via antagonizing proteasomal degradation promotes hepatocellular carcinoma stemness. Transl Oncol 44:101916","journal-title":"Transl Oncol"},{"key":"1453_CR36","doi-asserted-by":"publisher","first-page":"258","DOI":"10.21037\/atm-20-3068","volume":"9","author":"L Xu","year":"2021","unstructured":"Xu L, Shen JM, Qu JL, Song N, Che XF, Hou KZ, Shi J, Zhao L, Shi S, Liu YP, Qu XJ, Teng YE (2021) FEN1 is a prognostic biomarker for ER+ breast cancer and associated with tamoxifen resistance through the ER\u03b1\/cyclin D1\/Rb axis. Ann Transl Med 9:258","journal-title":"Ann Transl Med"},{"key":"1453_CR37","doi-asserted-by":"publisher","first-page":"476","DOI":"10.1080\/08916934.2017.1402302","volume":"50","author":"J Wang","year":"2017","unstructured":"Wang J, Cao P, Qi YY, Chen XP, Ma L, Deng RR, Zhang LL, Zhao Y (2017) The relationship between cell apoptosis dysfunction and FEN1 E160D mutation in lupus nephritis patients. Autoimmunity 50:476\u2013480","journal-title":"Autoimmunity"},{"key":"1453_CR38","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1002\/bies.950181103","volume":"18","author":"KA Heichman","year":"1996","unstructured":"Heichman KA (1996) Cdc6 and DNA replication: limited to humble origins. BioEssays 18:859\u2013862","journal-title":"BioEssays"},{"key":"1453_CR39","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1016\/j.bbrc.2023.04.092","volume":"663","author":"R Nakajima","year":"2023","unstructured":"Nakajima R, Deguchi R, Komori H, Zhao L, Zhou Y, Shirasawa M, Angelina A, Goto Y, Tohjo F, Nakahashi K, Nakata K, Iwanaga R, Bradford AP, Araki K, Warita T, Ohtani K (2023) The TFDP1 gene coding for DP1, the heterodimeric partner of the transcription factor E2F, is a target of deregulated E2F. Biochem Biophys Res Commun 663:154\u2013162","journal-title":"Biochem Biophys Res Commun"},{"key":"1453_CR40","doi-asserted-by":"publisher","first-page":"18573","DOI":"10.1074\/jbc.M112.347690","volume":"287","author":"S Niimi","year":"2012","unstructured":"Niimi S, Arakawa-Takeuchi S, Uranbileg B, Park JH, Jinno S, Okayama H (2012) Cdc6 protein obstructs apoptosome assembly and consequent cell death by forming stable complexes with activated Apaf-1 molecules. J Biol Chem 287:18573\u201318583","journal-title":"J Biol Chem"},{"key":"1453_CR41","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1093\/emboj\/18.2.396","volume":"18","author":"BO Petersen","year":"1999","unstructured":"Petersen BO, Lukas J, S\u00f8rensen CS, Bartek J, Helin K (1999) Phosphorylation of mammalian CDC6 by cyclin A\/CDK2 regulates its subcellular localization. EMBO J 18:396\u2013410","journal-title":"EMBO J"},{"key":"1453_CR42","doi-asserted-by":"publisher","first-page":"549","DOI":"10.1038\/s41388-018-0460-4","volume":"38","author":"X Yu","year":"2019","unstructured":"Yu X, Liu Y, Yin L, Peng Y, Peng Y, Gao Y, Yuan B, Zhu Q, Cao T, Xie B, Sun L, Chen Y, Gong Z, Qiu Y, Fan X, Li X (2019) Radiation-promoted CDC6 protein stability contributes to radioresistance by regulating senescence and epithelial to mesenchymal transition. Oncogene 38:549\u2013563","journal-title":"Oncogene"},{"key":"1453_CR43","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106841","volume":"194","author":"H Gao","year":"2023","unstructured":"Gao H, Nepovimova E, Heger Z, Valko M, Wu Q, Kuca K, Adam V (2023) Role of hypoxia in cellular senescence. Pharmacol Res 194:106841","journal-title":"Pharmacol Res"},{"key":"1453_CR44","doi-asserted-by":"publisher","DOI":"10.3390\/cells9092073","author":"JM Kim","year":"2020","unstructured":"Kim JM, Lin C, Stavre Z, Greenblatt MB, Shim JH (2020) Osteoblast-osteoclast communication and bone homeostasis. Cells. https:\/\/doi.org\/10.3390\/cells9092073","journal-title":"Cells"},{"key":"1453_CR45","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1080\/17474086.2025.2465456","volume":"18","author":"Y Wang","year":"2025","unstructured":"Wang Y, Liu C, Tang K, Zhang J, Liu X, Ma Y, Li X (2025) Exploring shared pathogenesis of multiple myeloma and osteoporosis via bioinformatic analysis. Expert Rev Hematol 18:167\u2013176","journal-title":"Expert Rev Hematol"},{"issue":"1","key":"1453_CR46","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-13037-9","volume":"15","author":"L Shao","year":"2025","unstructured":"Shao L, Chen S, Wu Y, Chen L, Zhang Y, Zhou Y, Zhang J, Huang G, Sun P, Min W (2025) Association of serum urea-to-creatinine and creatinine-to-cystatin C ratios with bone mineral density and osteoporosis: a cross-sectional study. Sci Rep 15(1):27774. https:\/\/doi.org\/10.1038\/s41598-025-13037-9","journal-title":"Sci Rep"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-025-01453-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00223-025-01453-y","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-025-01453-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,26]],"date-time":"2025-12-26T13:21:08Z","timestamp":1766755268000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00223-025-01453-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,9]]},"references-count":46,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2025,12]]}},"alternative-id":["1453"],"URL":"https:\/\/doi.org\/10.1007\/s00223-025-01453-y","relation":{},"ISSN":["1432-0827"],"issn-type":[{"type":"electronic","value":"1432-0827"}],"subject":[],"published":{"date-parts":[[2025,12,9]]},"assertion":[{"value":"23 July 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 November 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 December 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"Peiwen Wang, Xiping Hu, Chunqing Han, Yuanjin Chang, Ruijin Xie, Junxing Ye and Yu Wu declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}],"article-number":"150"}}