{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T13:05:19Z","timestamp":1770901519197,"version":"3.50.1"},"reference-count":70,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T00:00:00Z","timestamp":1770854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"the Basic Scientific Research Project of the Department of Education of Liaoning Province, China","award":["JYTMS20231832"],"award-info":[{"award-number":["JYTMS20231832"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"DOI":"10.1007\/s00223-026-01480-3","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T10:51:40Z","timestamp":1770893500000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The Integration of Bioinformatics with Experimental Validation Has Uncovered Shared Molecular Characteristics Between Sarcopenia and Osteoarthritis"],"prefix":"10.1007","volume":"117","author":[{"given":"Deyu","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumin","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongfei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangran","family":"Cui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongju","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-7042-5117","authenticated-orcid":false,"given":"Xuefeng","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2026,2,12]]},"reference":[{"issue":"11","key":"1480_CR1","first-page":"1050","volume":"9","author":"HY Luk","year":"2020","unstructured":"Luk HY, Appell C, Chyu MC, Chen CH, Wang CY, Yang RS, Shen CL (2020) Impacts of green tea on joint and skeletal muscle health: prospects of translational nutrition. Antioxidants (Basel, Switzerland) 9(11):1050","journal-title":"Antioxidants (Basel, Switzerland)"},{"issue":"16","key":"1480_CR2","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.192047","volume":"10","author":"K Yu","year":"2025","unstructured":"Yu K, Vyavahare S, Alhamad D, Bensreti H, Ruan L, Tuladhar A, Dai C, Shaver JC, Tripathi A, Ding K, Pacholczyk R, Cooley MA, Zhong R, Johnson MH, Chen J, Bollag WB, Isales CM, Hill WD, Hamrick MW, Fulzele S, McGee-Lawrence ME (2025) Inhibition of AhR improves cortical bone and skeletal muscle function via preservation of neuromuscular junctions. JCI Insight 10(16):e192047","journal-title":"JCI Insight"},{"issue":"10","key":"1480_CR3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0311423","volume":"19","author":"L Yan","year":"2024","unstructured":"Yan L, Ge H, Wang Z, Shen A, Xu Q, Jiang D, Cao Y (2024) Roles of low muscle strength and sarcopenic obesity on incident symptomatic knee osteoarthritis: a longitudinal cohort study. PLoS ONE 19(10):e0311423","journal-title":"PLoS ONE"},{"issue":"4","key":"1480_CR4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ocarto.2022.100310","volume":"4","author":"G Bevilacqua","year":"2022","unstructured":"Bevilacqua G, Laskou F, Patel HP, Westbury LD, Fuggle NR, Cooper C, Dennison EM (2022) What impact does osteoarthritis have on ability to self-care and receipt of care in older adults? Findings from the Hertfordshire cohort study. Osteoarthr Cartil Open 4(4):100310","journal-title":"Osteoarthr Cartil Open"},{"issue":"10","key":"1480_CR5","doi-asserted-by":"publisher","first-page":"1351","DOI":"10.1007\/s40520-019-01282-8","volume":"31","author":"W Xia","year":"2019","unstructured":"Xia W, Cooper C, Li M, Xu L, Rizzoli R, Zhu M, Lin H, Beard J, Ding Y, Yu W, Cavalier E, Zhang Z, Kanis JA, Cheng Q, Wang Q, Reginster JY (2019) East meets west: current practices and policies in the management of musculoskeletal aging. Aging Clin Exp Res 31(10):1351\u20131373","journal-title":"Aging Clin Exp Res"},{"key":"1480_CR6","doi-asserted-by":"publisher","first-page":"99","DOI":"10.15674\/0030-59872025299-109","volume":"2","author":"A Iniushyna","year":"2025","unstructured":"Iniushyna A, Zaverukha N, Grygorieva N, Protsiuk O (2025) Osteoarthritis and geriatric syndromes: features of the relationship and management opportunities (literature review). Orthop Traumatol Prosthet 2:99\u2013109","journal-title":"Orthop Traumatol Prosthet"},{"key":"1480_CR7","doi-asserted-by":"crossref","unstructured":"Ladang A, Beaudart C, Reginster J-Y, Al-Daghri N, Bruy\u00e8re O, Burlet N, Cooper C (2023) Biochemical markers of musculoskeletal health and aging to be assessed in clinical trials of drugs aiming at the treatment of sarcopenia: consensus paper from an expert group meeting organized by the European society for clinical and economic aspects of osteoporosis, osteoarthritis and musculoskeletal diseases (ESCEO) and the Centre Acad\u00e9mique de Recherche et d\u2019Exp\u00e9rimentation en Sant\u00e9 (CARES SPRL), Under the Auspices of the World health organization collaborating center for the epidemiology of . calcified tissue international, 112: 197\u2013217.","DOI":"10.1007\/s00223-022-01054-z"},{"key":"1480_CR8","doi-asserted-by":"publisher","first-page":"101","DOI":"10.15674\/0030-598720213101-106","volume":"3","author":"N Dedukh","year":"2021","unstructured":"Dedukh N, Zaverukha N, Bystrytska M, Yakovenchuk N (2021) Sarcopenia, sarcopenic obesity and osteoarthritis. Orthop Traumatol Prosthet 3:101\u2013106","journal-title":"Orthop Traumatol Prosthet"},{"key":"1480_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2018.00409","volume":"9","author":"S P\u00e9rez-Baos","year":"2018","unstructured":"P\u00e9rez-Baos S, Prieto-Potin I, Rom\u00e1n-Blas JA, S\u00e1nchez-Pernaute O, Largo R, Herrero-Beaumont G (2018) Mediators and patterns of muscle loss in chronic systemic inflammation. Front Physiol 9:409","journal-title":"Front Physiol"},{"issue":"1","key":"1480_CR10","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-023-04515-9","volume":"6","author":"C Arrigoni","year":"2023","unstructured":"Arrigoni C, Ostano P, Bersini S, Crippa M, Colombo MV, Gilardi M, Zagra L, Mello-Grand M, Gregnanin I, Ghilardi C, Bani MR, Candrian C, Chiorino G, Moretti M (2023) Differential angiogenesis of bone and muscle endothelium in aging and inflammatory processes. Commun Biol 6(1):126","journal-title":"Commun Biol"},{"issue":"1","key":"1480_CR11","doi-asserted-by":"publisher","DOI":"10.3390\/metabo15010059","volume":"15","author":"J Wang","year":"2025","unstructured":"Wang J, Jia D, Zhang Z, Wang D (2025) Exerkines and sarcopenia: unveiling the mechanism behind exercise-induced mitochondrial homeostasis. Metabolites 15(1):59","journal-title":"Metabolites"},{"key":"1480_CR12","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.724911","volume":"12","author":"L Zhang","year":"2021","unstructured":"Zhang L, Sun Y (2021) Muscle-bone crosstalk in chronic obstructive pulmonary disease. Front Endocrinol 12:724911","journal-title":"Front Endocrinol"},{"key":"1480_CR13","doi-asserted-by":"publisher","first-page":"212","DOI":"10.1016\/j.bone.2018.11.002","volume":"120","author":"L Bonewald","year":"2019","unstructured":"Bonewald L (2019) Use it or lose it to age: a review of bone and muscle communication. Bone 120:212\u2013218","journal-title":"Bone"},{"issue":"11","key":"1480_CR14","doi-asserted-by":"publisher","DOI":"10.3390\/biom15111534","volume":"15","author":"K Yu","year":"2025","unstructured":"Yu K, Tuladhar A, Dankberg S, Dai C, McGee-Lawrence ME (2025) Integrating 3D osteocyte culture, microgravity simulation, and fluid flow reveals mechanisms of osteocyte mechanosensation and calcium signaling altered by disuse. Biomolecules 15(11):1534","journal-title":"Biomolecules"},{"issue":"2","key":"1480_CR15","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1093\/toxsci\/kfaf131","volume":"208","author":"A Tuladhar","year":"2025","unstructured":"Tuladhar A, Guffroy M, Finnema SJ, Christmann R, Van Vleet TR, Mayana SAK, Fossey S (2025) Investigation of bone toxicity in drug development: review of current and emerging technologies. Toxicol Sci 208(2):207\u2013224","journal-title":"Toxicol Sci"},{"issue":"1","key":"1480_CR16","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-23-0116","volume":"259","author":"L Lu","year":"2023","unstructured":"Lu L, Tian L (2023) Postmenopausal osteoporosis coexisting with sarcopenia: the role and mechanisms of estrogen. J Endocrinol 259(1):e230116","journal-title":"J Endocrinol"},{"issue":"2","key":"1480_CR17","volume":"12","author":"CA Narasimhulu","year":"2023","unstructured":"Narasimhulu CA, Singla DK (2023) BMP-7 Attenuates sarcopenia and adverse muscle remodeling in diabetic mice via alleviation of lipids, inflammation, HMGB1, and pyroptosis. Antioxidants (Basel, Switzerland) 12(2):331","journal-title":"Antioxidants (Basel, Switzerland)"},{"issue":"5","key":"1480_CR18","first-page":"2999","volume":"16","author":"D Yang","year":"2024","unstructured":"Yang D, Chen Y, Guo J, Xu X, Yang M, Xie J, Xu K, Xu P (2024) The organ-joint axes in osteoarthritis: significant pathogenesis and therapeutic targets. Aging Dis 16(5):2999\u20133021","journal-title":"Aging Dis"},{"issue":"3","key":"1480_CR19","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1016\/j.afos.2023.08.005","volume":"9","author":"J Yang","year":"2023","unstructured":"Yang J, Jiang T, Xu G, Wang S, Liu W (2023) Exploring molecular mechanisms underlying the pathophysiological association between knee osteoarthritis and sarcopenia. Osteoporos Sarcopenia 9(3):99\u2013111","journal-title":"Osteoporos Sarcopenia"},{"key":"1480_CR20","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1380210","volume":"11","author":"J Yang","year":"2024","unstructured":"Yang J, Zhong J, Du Y, Wang Z, Jiang L, Li Z, Liu Y (2024) Bioinformatics and systems biology approaches to identify potential common pathogeneses for sarcopenia and osteoarthritis. Front Med 11:1380210","journal-title":"Front Med"},{"issue":"8","key":"1480_CR21","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0272284","volume":"17","author":"H Wang","year":"2022","unstructured":"Wang H, Wang N, Wang Y, Li H (2022) Association between sarcopenia and osteoarthritis: a protocol for meta-analysis. PLoS ONE 17(8):e0272284. https:\/\/doi.org\/10.1371\/journal.pone.0272284","journal-title":"PLoS ONE"},{"issue":"6","key":"1480_CR22","doi-asserted-by":"publisher","first-page":"2044","DOI":"10.1093\/bib\/bby067","volume":"20","author":"A McDermaid","year":"2019","unstructured":"McDermaid A, Monier B, Zhao J, Liu B, Ma Q (2019) Interpretation of differential gene expression results of RNA-seq data: review and integration. Brief Bioinform 20(6):2044\u20132054","journal-title":"Brief Bioinform"},{"key":"1480_CR23","doi-asserted-by":"publisher","first-page":"1154","DOI":"10.1016\/j.csbj.2024.02.018","volume":"23","author":"D Rosati","year":"2024","unstructured":"Rosati D, Palmieri M, Brunelli G, Morrione A, Iannelli F, Frullanti E, Giordano A (2024) Differential gene expression analysis pipelines and bioinformatic tools for the identification of specific biomarkers: a review. Comput Struct Biotechnol J 23:1154\u20131168","journal-title":"Comput Struct Biotechnol J"},{"issue":"3","key":"1480_CR24","doi-asserted-by":"publisher","first-page":"538","DOI":"10.1002\/jcsm.12709","volume":"12","author":"WQ Xie","year":"2021","unstructured":"Xie WQ, He M, Yu DJ, Wu YX, Wang XH, Lv S, Xiao WF, Li YS (2021) Mouse models of sarcopenia: classification and evaluation. J Cachexia Sarcopenia Muscle 12(3):538\u2013554","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"1480_CR25","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.jot.2022.11.005","volume":"39","author":"BY Wang","year":"2022","unstructured":"Wang BY, Hsiao AW, Wong N, Chen YF, Lee CW, Lee WYW (2022) Is dexamethasone-induced muscle atrophy an alternative model for naturally aged sarcopenia model? J Orthop Translat 39:12\u201320","journal-title":"J Orthop Translat"},{"issue":"1","key":"1480_CR26","doi-asserted-by":"publisher","DOI":"10.1186\/ar4436","volume":"16","author":"S Ad\u00e3es","year":"2014","unstructured":"Ad\u00e3es S, Mendon\u00e7a M, Santos TN, Castro-Lopes JM, Ferreira-Gomes J, Neto FL (2014) Intra-articular injection of collagenase in the knee of rats as an alternative model to study nociception associated with osteoarthritis. Arthritis Res Ther 16(1):R10","journal-title":"Arthritis Res Ther"},{"issue":"2","key":"1480_CR27","doi-asserted-by":"publisher","DOI":"10.1016\/j.ocarto.2023.100359","volume":"5","author":"Y Oka","year":"2023","unstructured":"Oka Y, Murata K, Ozone K, Minegishi Y, Kano T, Shimada N, Kanemura N (2023) Mild treadmill exercise inhibits cartilage degeneration via macrophages in an osteoarthritis mouse model. Osteoarthritis Cartilage Open 5(2):100359","journal-title":"Osteoarthritis Cartilage Open"},{"issue":"3","key":"1480_CR28","doi-asserted-by":"publisher","first-page":"305","DOI":"10.1016\/j.drudis.2013.08.004","volume":"19","author":"F De Ceuninck","year":"2014","unstructured":"De Ceuninck F, Fradin A, Pastoureau P (2014) Bearing arms against osteoarthritis and sarcopenia: when cartilage and skeletal muscle find common interest in talking together. Drug Discov Today 19(3):305\u2013311","journal-title":"Drug Discov Today"},{"key":"1480_CR29","doi-asserted-by":"publisher","first-page":"38","DOI":"10.1016\/j.cytogfr.2018.10.002","volume":"44","author":"T Wang","year":"2018","unstructured":"Wang T, He C (2018) Pro-inflammatory cytokines: the link between obesity and osteoarthritis. Cytokine Growth Factor Rev 44:38\u201350","journal-title":"Cytokine Growth Factor Rev"},{"issue":"13","key":"1480_CR30","doi-asserted-by":"publisher","first-page":"2161","DOI":"10.2174\/0929867326666181129095309","volume":"27","author":"B Sharma","year":"2020","unstructured":"Sharma B, Dabur R (2020) Role of pro-inflammatory cytokines in regulation of skeletal muscle metabolism: a systematic review. Curr Med Chem 27(13):2161\u20132188","journal-title":"Curr Med Chem"},{"issue":"5","key":"1480_CR31","doi-asserted-by":"publisher","first-page":"725","DOI":"10.1007\/s00223-024-01285-2","volume":"115","author":"ML Hagan","year":"2024","unstructured":"Hagan ML, Tuladhar A, Yu K, Alhamad DW, Bensreti H, Dorn J, Piedra VM, Cantu N, Stokes EG, Blumenthal D, Roberts RL, Balayan V, Bass SM, Dickerson T, Cartelle AL, Montesinos-Cartagena M, Awad ME, Castro AA, Garland T Jr, Cooley MA, McGee-Lawrence ME (2024) Osteocyte Sptbn1 deficiency alters cell survival and mechanotransduction following formation of plasma membrane disruptions (PMD) from mechanical loading. Calcif Tissue Int 115(5):725\u2013743","journal-title":"Calcif Tissue Int"},{"key":"1480_CR32","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2024.117147","volume":"186","author":"A Tuladhar","year":"2024","unstructured":"Tuladhar A, Shaver JC, McGee WA, Yu K, Dorn J, Horne JL, Alhamad DW, Hagan ML, Cooley MA, Zhong R, Bollag W, Johnson M, Hamrick MW, McGee-Lawrence ME (2024) Prkd1 regulates the formation and repair of plasma membrane disruptions (PMD) in osteocytes. Bone 186:117147","journal-title":"Bone"},{"issue":"12","key":"1480_CR33","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14122588","volume":"14","author":"F Bellanti","year":"2022","unstructured":"Bellanti F, Lo Buglio A, Vendemiale G (2022) Muscle delivery of mitochondria-targeted drugs for the treatment of sarcopenia: rationale and perspectives. Pharmaceutics 14(12):2588","journal-title":"Pharmaceutics"},{"issue":"2","key":"1480_CR34","doi-asserted-by":"publisher","first-page":"390","DOI":"10.1038\/s12276-025-01400-9","volume":"57","author":"J Han","year":"2025","unstructured":"Han J, Kim YH, Han S (2025) Increased oxidative phosphorylation through pyruvate dehydrogenase kinase 2 deficiency ameliorates cartilage degradation in mice with surgically induced osteoarthritis. Exp Mol Med 57(2):390\u2013401","journal-title":"Exp Mol Med"},{"issue":"2","key":"1480_CR35","doi-asserted-by":"publisher","first-page":"C308","DOI":"10.1152\/ajpcell.00560.2020","volume":"321","author":"H Sun","year":"2021","unstructured":"Sun H, Hu L, Fan Z (2021) \u03b22 integrin activation and signal transduction in leukocyte recruitment. Am J Physiol Cell Physiol 321(2):C308\u2013C316","journal-title":"Am J Physiol Cell Physiol"},{"issue":"6","key":"1480_CR36","doi-asserted-by":"publisher","first-page":"A940","DOI":"10.1096\/fasebj.21.6.A940-d","volume":"21","author":"JS Marino","year":"2007","unstructured":"Marino JS, Tausch B, Manacci M, Pizza FX (2007) CD18-Mediated Skeletal Muscle Hypertrophy. FASEB J 21(6):A940\u2013A941","journal-title":"FASEB J"},{"issue":"2","key":"1480_CR37","doi-asserted-by":"publisher","DOI":"10.1177\/10225536221147213","volume":"31","author":"W Qian","year":"2023","unstructured":"Qian W, Li Z (2023) Expression and diagnostic significance of integrin beta-2 in synovial fluid of patients with osteoarthritis. J Orthop Surg (Hong Kong) 31(2):10225536221147213","journal-title":"J Orthop Surg (Hong Kong)"},{"key":"1480_CR38","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1146\/annurev.immunol.21.120601.140946","volume":"21","author":"ML Hermiston","year":"2003","unstructured":"Hermiston ML, Xu Z, Weiss A (2003) CD45: a critical regulator of signaling thresholds in immune cells. Annu Rev Immunol 21:107\u2013137","journal-title":"Annu Rev Immunol"},{"key":"1480_CR39","doi-asserted-by":"publisher","first-page":"S434","DOI":"10.1016\/j.ymthe.2005.07.675","volume":"11","author":"S Li","year":"2005","unstructured":"Li S, Reyes M, Kimura E, Foraker J, Hagakura M (2005) Perivascular CD45-:Sca-1+:CD34-cells are derived from bone marrow cells and participate in dystrophic skeletal muscle regeneration. Mol Ther 11:S434\u2013S435","journal-title":"Mol Ther"},{"issue":"22","key":"1480_CR40","doi-asserted-by":"publisher","first-page":"12037","DOI":"10.3390\/ijms252212037","volume":"25","author":"AH Aitchison","year":"2024","unstructured":"Aitchison AH, Allen NB, O\u2019Neill CN, Droz LG, Patel P, Anastasio AT, Reilly RM, Pean CA, DeBaun MR, Nunley JA, Adams SB (2024) Synovial fluid immune cell composition following intraarticular fracture may contribute to posttraumatic osteoarthritis. Int J Mol Sci 25(22):12037","journal-title":"Int J Mol Sci"},{"issue":"4","key":"1480_CR41","doi-asserted-by":"publisher","first-page":"377","DOI":"10.5114\/ceji.2020.103411","volume":"45","author":"M Moriya","year":"2020","unstructured":"Moriya M, Uchida K, Takano S, Iwase D, Inoue G, Muaki M, Tazawa R, Aikawa J, Sekiguchi H, Takaso M (2020) Expression and regulation of macrophage-inducible C-type lectin in human synovial macrophages. Cent Eur J Immunol 45(4):377\u2013381","journal-title":"Cent Eur J Immunol"},{"key":"1480_CR42","doi-asserted-by":"publisher","DOI":"10.1016\/j.cyto.2022.155828","volume":"153","author":"K Matsushima","year":"2022","unstructured":"Matsushima K, Yang D, Oppenheim JJ (2022) Interleukin-8: an evolving chemokine. Cytokine 153:155828","journal-title":"Cytokine"},{"issue":"6","key":"1480_CR43","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1002\/JLB.3AB0220-470R","volume":"107","author":"M Metzemaekers","year":"2020","unstructured":"Metzemaekers M, Vandendriessche S, Berghmans N, Gouwy M, Proost P (2020) Truncation of CXCL8 to CXCL8(9\u201377) enhances actin polymerization and in vivo migration of neutrophils. J Leukoc Biol 107(6):1167\u20131173","journal-title":"J Leukoc Biol"},{"key":"1480_CR44","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.intimp.2016.08.005","volume":"40","author":"P Yang","year":"2016","unstructured":"Yang P, Tan J, Yuan Z, Meng G, Bi L, Liu J (2016) Expression profile of cytokines and chemokines in osteoarthritis patients: proinflammatory roles for CXCL8 and CXCL11 to chondrocytes. Int Immunopharmacol 40:16\u201323","journal-title":"Int Immunopharmacol"},{"issue":"2","key":"1480_CR45","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1002\/art.30138","volume":"63","author":"N Mor-Vaknin","year":"2011","unstructured":"Mor-Vaknin N, Kappes F, Dick AE, Legendre M, Damoc C, Teitz-Tennenbaum S, Kwok R, Ferrando-May E, Adams BS, Markovitz DM (2011) DEK in the synovium of patients with juvenile idiopathic arthritis: characterization of DEK antibodies and posttranslational modification of the DEK autoantigen. Arthritis Rheum 63(2):556\u2013567","journal-title":"Arthritis Rheum"},{"issue":"24","key":"1480_CR46","doi-asserted-by":"publisher","first-page":"9484","DOI":"10.1128\/MCB.01030-06","volume":"26","author":"N Mor-Vaknin","year":"2006","unstructured":"Mor-Vaknin N, Punturieri A, Sitwala K, Faulkner N, Legendre M, Khodadoust MS, Kappes F, Ruth JH, Koch A, Glass D, Petruzzelli L, Adams BS, Markovitz DM (2006) The DEK nuclear autoantigen is a secreted chemotactic factor. Mol Cell Biol 26(24):9484\u20139496","journal-title":"Mol Cell Biol"},{"issue":"6","key":"1480_CR47","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.devcel.2020.05.006","volume":"53","author":"L Yue","year":"2020","unstructured":"Yue L, Wan R, Luan S, Zeng W, Cheung TH (2020) Dek modulates global intron retention during muscle stem cells quiescence exit. Dev Cell 53(6):661-676.e6","journal-title":"Dev Cell"},{"issue":"10","key":"1480_CR48","doi-asserted-by":"publisher","first-page":"3245","DOI":"10.1128\/MCB.01921-07","volume":"28","author":"F Kappes","year":"2008","unstructured":"Kappes F, Fahrer J, Khodadoust MS, Tabbert A, Strasser C, Mor-Vaknin N, Moreno-Villanueva M, B\u00fcrkle A, Markovitz DM, Ferrando-May E (2008) DEK is a poly(ADP-ribose) acceptor in apoptosis and mediates resistance to genotoxic stress. Mol Cell Biol 28(10):3245\u20133257","journal-title":"Mol Cell Biol"},{"issue":"37","key":"1480_CR49","doi-asserted-by":"publisher","first-page":"26802","DOI":"10.1074\/jbc.M600915200","volume":"281","author":"M Sammons","year":"2006","unstructured":"Sammons M, Wan SS, Vogel NL, Mientjes EJ, Grosveld G, Ashburner BP (2006) Negative regulation of the RelA\/p65 transactivation function by the product of the DEK proto-oncogene. J Biol Chem 281(37):26802\u201326812","journal-title":"J Biol Chem"},{"issue":"19","key":"1480_CR50","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21197151","volume":"21","author":"YW Lim","year":"2020","unstructured":"Lim YW, James D, Huang J, Lee M (2020) The emerging role of the RNA-binding protein SFPQ in neuronal function and neurodegeneration. Int J Mol Sci 21(19):7151","journal-title":"Int J Mol Sci"},{"issue":"15","key":"1480_CR51","doi-asserted-by":"publisher","first-page":"9771","DOI":"10.1093\/nar\/gku650","volume":"42","author":"S Li","year":"2014","unstructured":"Li S, Li Z, Shu FJ, Xiong H, Phillips AC, Dynan WS (2014) Double-strand break repair deficiency in NONO knockout murine embryonic fibroblasts and compensation by spontaneous upregulation of the PSPC1 paralog. Nucleic Acids Res 42(15):9771\u20139780","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"1480_CR52","doi-asserted-by":"publisher","first-page":"81","DOI":"10.7600\/jpfsm.5.81","volume":"5","author":"N Yui","year":"2016","unstructured":"Yui N, Yudoh K, Fujiya H, Musha H (2016) Mechanical and oxidative stress in osteoarthritis. J Phys Fitness Sports Med 5(1):81\u201386","journal-title":"J Phys Fitness Sports Med"},{"issue":"1\u20132","key":"1480_CR53","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1007\/s11010-018-3361-5","volume":"449","author":"JM Dos Santos","year":"2018","unstructured":"Dos Santos JM, de Oliveira DS, Moreli ML, Benite-Ribeiro SA (2018) The role of mitochondrial DNA damage at skeletal muscle oxidative stress on the development of type 2 diabetes. Mol Cell Biochem 449(1\u20132):251\u2013255","journal-title":"Mol Cell Biochem"},{"issue":"7","key":"1480_CR54","doi-asserted-by":"publisher","first-page":"3826","DOI":"10.1093\/nar\/gkv156","volume":"43","author":"M Lee","year":"2015","unstructured":"Lee M, Sadowska A, Bekere I, Ho D, Gully BS, Lu Y, Iyer KS, Trewhella J, Fox AH, Bond CS (2015) The structure of human SFPQ reveals a coiled-coil mediated polymer essential for functional aggregation in gene regulation. Nucleic Acids Res 43(7):3826\u20133840","journal-title":"Nucleic Acids Res"},{"issue":"8","key":"1480_CR55","doi-asserted-by":"publisher","first-page":"1568","DOI":"10.4161\/cc.9.8.11298","volume":"9","author":"M Salton","year":"2010","unstructured":"Salton M, Lerenthal Y, Wang SY, Chen DJ, Shiloh Y (2010) Involvement of matrin 3 and SFPQ\/NONO in the DNA damage response. Cell Cycle 9(8):1568\u20131576","journal-title":"Cell Cycle"},{"issue":"18","key":"1480_CR56","doi-asserted-by":"publisher","first-page":"9006","DOI":"10.1093\/nar\/gkv816","volume":"43","author":"CA Yarosh","year":"2015","unstructured":"Yarosh CA, Tapescu I, Thompson MG, Qiu J, Mallory MJ, Fu XD, Lynch KW (2015) TRAP150 interacts with the RNA-binding domain of PSF and antagonizes splicing of numerous PSF-target genes in T cells. Nucleic Acids Res 43(18):9006\u20139016","journal-title":"Nucleic Acids Res"},{"issue":"3","key":"1480_CR57","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1016\/j.molcel.2014.01.009","volume":"53","author":"K Imamura","year":"2014","unstructured":"Imamura K, Imamachi N, Akizuki G, Kumakura M, Kawaguchi A, Nagata K, Kato A, Kawaguchi Y, Sato H, Yoneda M, Kai C, Yada T, Suzuki Y, Yamada T, Ozawa T, Kaneki K, Inoue T, Kobayashi M, Kodama T, Wada Y, Akimitsu N (2014) Long noncoding RNA NEAT1-dependent SFPQ relocation from promoter region to paraspeckle mediates IL8 expression upon immune stimuli. Mol Cell 53(3):393\u2013406","journal-title":"Mol Cell"},{"key":"1480_CR58","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.isci.2019.02.023","volume":"13","author":"M Hosokawa","year":"2019","unstructured":"Hosokawa M, Takeuchi A, Tanihata J, Iida K, Takeda S, Hagiwara M (2019) Loss of RNA-binding protein Sfpq causes long-gene transcriptopathy in skeletal muscle and severe muscle mass reduction with metabolic myopathy. iScience 13:229\u2013242","journal-title":"iScience"},{"issue":"1","key":"1480_CR59","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1186\/s13018-023-03658-z","volume":"18","author":"Y Li","year":"2023","unstructured":"Li Y, Nie J, Deng C, Li H (2023) P-15 promotes chondrocyte proliferation in osteoarthritis by regulating SFPQ to target the Akt-RUNX2 axis. J Orthop Surg Res 18(1):199","journal-title":"J Orthop Surg Res"},{"key":"1480_CR60","doi-asserted-by":"publisher","DOI":"10.1016\/j.exger.2025.112729","volume":"203","author":"Q Ren","year":"2025","unstructured":"Ren Q, Ding K, Jiang W, Zhu W, Gao Y (2025) Molecular crosstalk and potential causal mechanisms of rheumatoid arthritis and sarcopenia co-morbidity: a gene integration analysis. Exp Gerontol 203:112729","journal-title":"Exp Gerontol"},{"key":"1480_CR61","doi-asserted-by":"publisher","first-page":"1117713","DOI":"10.3389\/fgene.2023.1117713","volume":"14","author":"W Xu","year":"2023","unstructured":"Xu W, Wang X, Liu D, Lin X, Wang B, Xi C, Kong P, Yan J (2023) Identification and validation of hub genes and potential drugs involved in osteoarthritis through bioinformatics analysis. Front Genet 14:1117713","journal-title":"Front Genet"},{"issue":"6","key":"1480_CR62","doi-asserted-by":"publisher","first-page":"1194","DOI":"10.1016\/j.cell.2013.05.039","volume":"153","author":"C L\u00f3pez-Ot\u00edn","year":"2013","unstructured":"L\u00f3pez-Ot\u00edn C, Blasco MA, Partridge L, Serrano M, Kroemer G (2013) The hallmarks of aging. Cell 153(6):1194\u20131217","journal-title":"Cell"},{"issue":"Suppl 1","key":"1480_CR63","doi-asserted-by":"publisher","first-page":"S4","DOI":"10.1093\/gerona\/glu057","volume":"69","author":"C Franceschi","year":"2014","unstructured":"Franceschi C, Campisi J (2014) Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol Ser A Biol Sci Med Sci 69(Suppl 1):S4\u2013S9","journal-title":"J Gerontol Ser A Biol Sci Med Sci"},{"issue":"4","key":"1480_CR64","first-page":"516","volume":"55","author":"S Basat","year":"2021","unstructured":"Basat S, Sivritepe R, Ortaboz D, Sevim E, Atay S, Baygul A (2021) The relationship between osteoarthritis and sarcopenia in geriatric diabetic patients. Sisli Etfal Hast Tip Bul 55(4):516\u2013523","journal-title":"Sisli Etfal Hast Tip Bul"},{"issue":"3","key":"1480_CR65","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1038\/bjp.2008.270","volume":"155","author":"A Zarbock","year":"2008","unstructured":"Zarbock A, Allegretti M, Ley K (2008) Therapeutic inhibition of CXCR2 by reparixin attenuates acute lung injury in mice. Br J Pharmacol 155(3):357\u2013364","journal-title":"Br J Pharmacol"},{"issue":"10","key":"1480_CR66","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/nrg2825","volume":"11","author":"JT Leek","year":"2010","unstructured":"Leek JT, Scharpf RB, Bravo HC, Simcha D, Langmead B, Johnson WE, Geman D, Baggerly K, Irizarry RA (2010) Tackling the widespread and critical impact of batch effects in high-throughput data. Nat Rev Genet 11(10):733\u2013739","journal-title":"Nat Rev Genet"},{"issue":"4","key":"1480_CR67","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1093\/bib\/bbs037","volume":"14","author":"C Lazar","year":"2013","unstructured":"Lazar C, Meganck S, Taminau J, Steenhoff D, Coletta A, Molter C, Weiss-Sol\u00eds DY, Duque R, Bersini H, Now\u00e9 A (2013) Batch effect removal methods for microarray gene expression data integration: a survey. Brief Bioinform 14(4):469\u2013490","journal-title":"Brief Bioinform"},{"issue":"2","key":"1480_CR68","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1016\/j.bone.2012.02.012","volume":"51","author":"CR Scanzello","year":"2012","unstructured":"Scanzello CR, Goldring SR (2012) The role of synovitis in osteoarthritis pathogenesis. Bone 51(2):249\u2013257","journal-title":"Bone"},{"issue":"5","key":"1480_CR69","doi-asserted-by":"publisher","first-page":"258","DOI":"10.1038\/s41584-022-00749-9","volume":"18","author":"E Sanchez-Lopez","year":"2022","unstructured":"Sanchez-Lopez E, Coras R, Torres A, Lane NE, Guma M (2022) Synovial inflammation in osteoarthritis progression. Nat Rev Rheumatol 18(5):258\u2013275","journal-title":"Nat Rev Rheumatol"},{"issue":"12","key":"1480_CR70","doi-asserted-by":"publisher","first-page":"862","DOI":"10.1302\/2046-3758.1112.BJR-2022-0215.R1","volume":"11","author":"M Wang","year":"2022","unstructured":"Wang M, Tan G, Jiang H, Liu A, Wu R, Li J, Sun Z, Lv Z, Sun W, Shi D (2022) Molecular crosstalk between articular cartilage, meniscus, synovium, and subchondral bone in osteoarthritis. Bone Joint Res 11(12):862\u2013872","journal-title":"Bone Joint Res"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-026-01480-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00223-026-01480-3","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-026-01480-3.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:04:56Z","timestamp":1770897896000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00223-026-01480-3"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,12]]},"references-count":70,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1480"],"URL":"https:\/\/doi.org\/10.1007\/s00223-026-01480-3","relation":{},"ISSN":["1432-0827"],"issn-type":[{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,12]]},"assertion":[{"value":"11 November 2025","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"9 January 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 February 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflicts of interest. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"All animal experiments were conducted in accordance with institutional and national ethical guidelines for the care and use of laboratory animals. Ethical approval for this study was obtained from the Institutional Animal Care and Use Committee of Shenyang Pharmaceutical University (Approval No. SYPU-IACUC-C2024-1223-140).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval"}}],"article-number":"29"}}