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Functionalizing biomaterials with bioactive molecules, such as soy-derived isoflavone, could enhance their osteoconductive potential.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Investigate the performance of genistein in the functionalization of bioactive glass and deproteinized bovine bone by sonochemistry on peri-implant bone repair in ovariectomized rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      In total, 50 female rats were divided into five groups (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200910): blood clot (CLOT); bioactive glass (BG); bioactive glass functionalized with genistein (BG\u2009+\u2009GEN); deproteinized bovine bone (BO); and deproteinized bovine bone functionalized with genistein (BO\u2009+\u2009GEN). Thirty days after ovariectomy, implants were placed in the tibia of the rats. Calcein and alizarin were administered at 14 and 24 days post-surgery, respectively. The rats were euthanized 28 days after implant placement for analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      BO\u2009+\u2009GEN showed the highest removal torque (5.4 Ncm), significantly higher than BO (2.3 Ncm;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05), followed by BG\u2009+\u2009GEN (4.2 Ncm), BG (3.3 Ncm), and CLOT (2.1 Ncm). BG\u2009+\u2009GEN and BO\u2009+\u2009GEN upregulated the bone markers (RANKL, OPG, OCN, IBSP) (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Micro-CT revealed higher bone volume percentage (BV\/TV) in BO\u2009+\u2009GEN (11.67%) and BG\u2009+\u2009GEN (10.51%) versus their controls (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). Trabecular separation (Tb.Sp) was significantly reduced in BO\u2009+\u2009GEN compared to BG (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings suggest that genistein can potentiate the osteoconductive properties of clinically used biomaterials, enhancing peri-implant bone repair in ovariectomized rats.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00223-026-01496-9","type":"journal-article","created":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T16:24:43Z","timestamp":1771345483000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Local Delivery of Genistein in Peri-Implant Defects Enhances Osseointegration in Ovariectomized Rats"],"prefix":"10.1007","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5207-6360","authenticated-orcid":false,"given":"Nath\u00e1lia Dantas","family":"Duarte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5105-7686","authenticated-orcid":false,"given":"F\u00e1bio Roberto","family":"de Souza Batista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-8443-4739","authenticated-orcid":false,"given":"Marcelly Braga","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8308-1499","authenticated-orcid":false,"given":"Laura Gabriela","family":"Macedo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2857-9195","authenticated-orcid":false,"given":"Naara Gabriela","family":"Monteiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4489-6868","authenticated-orcid":false,"given":"Gabriel","family":"Mulinari-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8936-3662","authenticated-orcid":false,"given":"Pedro Henrique Silva","family":"Gomes-Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7734-4069","authenticated-orcid":false,"given":"Paulo Noronha","family":"Lisboa-Filho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6840-5210","authenticated-orcid":false,"given":"Luiz","family":"Meirelles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6773-6966","authenticated-orcid":false,"given":"Roberta","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,2,17]]},"reference":[{"issue":"6","key":"1496_CR1","doi-asserted-by":"publisher","first-page":"2483","DOI":"10.1007\/s00784-023-05005-2","volume":"27","author":"CAA Lemos","year":"2023","unstructured":"Lemos CAA, de Oliveira AS, Fa\u00e9 DS, Oliveira HFFE, Del Rei Daltro Rosa CD, Bento VAA, Verri FR, Pellizzer EP (2023) Do dental implants placed in patients with osteoporosis have higher risks of failure and marginal bone loss compared to those in healthy patients? 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