{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T22:47:12Z","timestamp":1793314032367,"version":"4.5.0"},"reference-count":48,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"DOI":"10.1007\/s00223-026-01544-4","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T16:00:36Z","timestamp":1783353636000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Capsanthin Attenuates Osteoporosis by Targeting the Urotensin II Receptor Pathway to Inhibit Oxidative Stress and NLRP3 Inflammasome Activation"],"prefix":"10.1007","volume":"117","author":[{"given":"Ruonan","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Kong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,6]]},"reference":[{"key":"1544_CR1","doi-asserted-by":"publisher","first-page":"e2501164","DOI":"10.1002\/adhm.202501164","volume":"14","author":"C Yu","year":"2025","unstructured":"Yu C, Peng Y, Yu T, Ke J, Jiang Q, Li P, Yuan R, Meng T, Hu F, Wang J, Yuan H (2025) Dual-functional nanoparticles to reverse osteoblast senescence and enhance calcium supplementation for alleviating senile osteoporosis. Adv Healthc Mater 14:e2501164","journal-title":"Adv Healthc Mater"},{"key":"1544_CR2","doi-asserted-by":"crossref","unstructured":"Zhang W, Zou J, Zhang L (2025) Bidirectional interaction between the brain and bone in traumatic brain injury. In: Advanced science. Weinheim, Baden-Wurttemberg, Germany. p e03149","DOI":"10.1002\/advs.202503149"},{"key":"1544_CR3","doi-asserted-by":"publisher","first-page":"123532","DOI":"10.1016\/j.biomaterials.2025.123532","volume":"324","author":"C Ye","year":"2025","unstructured":"Ye C, Xu J, Shi L, Zong C, Ji W, Lu Y, Tao R, Han F, Ma H (2025) Injectable natural tremella-derived hydrogel for reversing ferroptosis-mediated osteoporotic microenvironment imbalance and promoting osteoregeneration. Biomaterials 324:123532","journal-title":"Biomaterials"},{"key":"1544_CR4","doi-asserted-by":"publisher","first-page":"5855","DOI":"10.2147\/DDDT.S526064","volume":"19","author":"X Gao","year":"2025","unstructured":"Gao X, Min Y, Lin R, Liang D, Zhang M, Xiao Q, Lu Y, Zhang F, Xu B, Liu Y (2025) Vitamin D alleviates osteoarthritis progression by targeting cartilage and subchondral bone via Myd88-TAK1-ERK axis suppression. Drug Des Devel Ther 19:5855\u20135870","journal-title":"Drug Des Devel Ther"},{"key":"1544_CR5","doi-asserted-by":"publisher","first-page":"2400474","DOI":"10.1002\/smsc.202400474","volume":"5","author":"H Liu","year":"2025","unstructured":"Liu H, Li R, Yang H, Situ B, Wang G, Xu K, Su J (2025) Extracellular vesicles in gut-bone axis: novel insights and therapeutic opportunities for osteoporosis. Small Sci 5:2400474","journal-title":"Small Sci"},{"key":"1544_CR6","doi-asserted-by":"publisher","DOI":"10.2174\/011570159X386374250623095520","author":"W Ma","year":"2025","unstructured":"Ma W, Chu S, Ma Y, Wang S, Ma X (2025) Targeting the cGAS-STING pathway: modulating inflammation, oxidative stress, and autophagy for novel depression therapies. Curr Neuropharmacol. https:\/\/doi.org\/10.2174\/011570159X386374250623095520","journal-title":"Curr Neuropharmacol"},{"key":"1544_CR7","doi-asserted-by":"publisher","first-page":"e70230","DOI":"10.1111\/1541-4337.70230","volume":"24","author":"A Patil","year":"2025","unstructured":"Patil A, Somvanshi SB, Sawale M, Desai K, Ozadali F, Benyathiar P, Mishra DK (2025) Advances in microbubble technologies for food sanitization: a comprehensive review. Compr Rev Food Sci Food Saf 24:e70230","journal-title":"Compr Rev Food Sci Food Saf"},{"key":"1544_CR8","doi-asserted-by":"publisher","first-page":"23222","DOI":"10.1038\/s41598-025-06118-2","volume":"15","author":"Z Liu","year":"2025","unstructured":"Liu Z, Yang X, Wang Z, Li Q, Gu H, Meng Q, Zhang Y (2025) Identification and verification of oxidative stress-related genes in the diagnosis of osteoporosis. Sci Rep 15:23222","journal-title":"Sci Rep"},{"key":"1544_CR9","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1186\/s13052-025-02079-4","volume":"51","author":"Q Jiang","year":"2025","unstructured":"Jiang Q, Wen J, Ding Y, Cui H (2025) From vulnerability to resilience: unraveling the role of oxidative stress in preterm brain injury. Ital J Pediatr 51:232","journal-title":"Ital J Pediatr"},{"key":"1544_CR10","doi-asserted-by":"publisher","first-page":"1601628","DOI":"10.3389\/fphar.2025.1601628","volume":"16","author":"MT Karadogan","year":"2025","unstructured":"Karadogan MT, Cicek B, Cinisli KT, Mendil AS, Ozkaraca M, Yilmaz F, Suleyman H (2025) Myricetin protects against doxorubicin-induced acute kidney injury in rats by mitigating oxidative damage and apoptotic response. Front Pharmacol 16:1601628","journal-title":"Front Pharmacol"},{"key":"1544_CR11","doi-asserted-by":"publisher","first-page":"e70286","DOI":"10.1111\/1750-3841.70286","volume":"90","author":"G Li","year":"2025","unstructured":"Li G, Shang L, Wang X, Zhang L, Zhao Y, Ni W, Bai X, Liu J (2025) Whey protein mitigates oxidative stress injury and improves protein synthesis in mouse skeletal muscle by regulating the SIRT1\/Nrf2\/HO-1 axis and AMPK\/TSC2\/mTOR\/4EBP1 pathway. J Food Sci 90:e70286","journal-title":"J Food Sci"},{"key":"1544_CR12","doi-asserted-by":"publisher","first-page":"4763","DOI":"10.1073\/pnas.1620458114","volume":"114","author":"N Gupta","year":"2017","unstructured":"Gupta N, Sahu A, Prabhakar A, Chatterjee T, Tyagi T, Kumari B, Khan N, Nair V, Bajaj N, Sharma M, Ashraf MZ (2017) Activation of NLRP3 inflammasome complex potentiates venous thrombosis in response to hypoxia. Proc Natl Acad Sci USA 114:4763\u20134768","journal-title":"Proc Natl Acad Sci USA"},{"key":"1544_CR13","doi-asserted-by":"publisher","first-page":"28242","DOI":"10.31083\/FBL28242","volume":"30","author":"X Zhang","year":"2025","unstructured":"Zhang X, Yang L (2025) Elucidating the pathogenic mechanism of spinal muscular atrophy through the investigation of UTS2. Front Biosci 30:28242","journal-title":"Front Biosci"},{"key":"1544_CR14","doi-asserted-by":"publisher","first-page":"2759","DOI":"10.1016\/j.csbj.2022.05.052","volume":"20","author":"M Selinger","year":"2022","unstructured":"Selinger M, V\u011bchtov\u00e1 P, Tykalov\u00e1 H, O\u0161lej\u0161kov\u00e1 P, Rumlov\u00e1 M, \u0160t\u011brba J, Grubhoffer L (2022) Integrative RNA profiling of TBEV-infected neurons and astrocytes reveals potential pathogenic effectors. Comput Struct Biotechnol J 20:2759\u20132777","journal-title":"Comput Struct Biotechnol J"},{"key":"1544_CR15","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.ydbio.2023.01.010","volume":"496","author":"AL Gaillard","year":"2023","unstructured":"Gaillard AL, Mohamad T, Quan FB, de Cian A, Mosimann C, Tostivint H, P\u00e9zeron G (2023) Urp1 and Urp2 act redundantly to maintain spine shape in zebrafish larvae. Dev Biol 496:36\u201351","journal-title":"Dev Biol"},{"key":"1544_CR16","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1016\/j.neuroscience.2010.06.070","volume":"170","author":"F Bruzzone","year":"2010","unstructured":"Bruzzone F, Cervetto C, Mazzotta MC, Bianchini P, Ronzitti E, Leprince J, Diaspro A, Maura G, Vallarino M, Vaudry H, Marcoli M (2010) Urotensin II receptor and acetylcholine release from mouse cervical spinal cord nerve terminals. Neuroscience 170:67\u201377","journal-title":"Neuroscience"},{"key":"1544_CR17","doi-asserted-by":"publisher","first-page":"1065","DOI":"10.5114\/aoms.2019.85197","volume":"15","author":"D Lu","year":"2019","unstructured":"Lu D, Peng F, Li J, Zhao J, Ye X, Li B, Ding W (2019) Urotensin II promotes secretion of LTB(4) through 5-lipoxygenase via the UT-ROS-Akt pathway in RAW264.7 macrophages. Arch Med Sci: AMS 15:1065\u20131072","journal-title":"Arch Med Sci: AMS"},{"key":"1544_CR18","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/j.peptides.2016.12.005","volume":"88","author":"YY Li","year":"2017","unstructured":"Li YY, Shi ZM, Yu XT, Feng P, Wang XJ (2017) The effects of urotensin II on migration and invasion are mediated by NADPH oxidase-derived reactive oxygen species through the c-Jun N-terminal kinase pathway in human hepatoma cells. Peptides 88:106\u2013114","journal-title":"Peptides"},{"key":"1544_CR19","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1038\/s41420-025-02368-1","volume":"11","author":"YC Chien","year":"2025","unstructured":"Chien YC, Wu JY, Liu LC, Yu YL (2025) Capsanthin inhibits migration and reduces N-linked glycosylation of PD-L1 via the EZH2-PD-L1 axis in triple-negative breast cancer brain metastasis. Cell Death Discov 11:85","journal-title":"Cell Death Discov"},{"key":"1544_CR20","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1016\/j.ymben.2025.01.005","volume":"88","author":"H Chen","year":"2025","unstructured":"Chen H, Guo G, Li Q, Liu Z (2025) Designing a microbial factory suited for plant chloroplast-derived enzymes to efficiently and green synthesize natural products: capsanthin and capsorubin as examples. Metab Eng 88:215\u2013227","journal-title":"Metab Eng"},{"key":"1544_CR21","doi-asserted-by":"publisher","first-page":"350","DOI":"10.17113\/ftb.60.03.22.7405","volume":"60","author":"V Shanmugham","year":"2022","unstructured":"Shanmugham V, Subban R (2022) Capsanthin-loaded micelles: preparation, characterization and in vitro evaluation of cytotoxicity using MDA-MB-231 breast cancer cell line. Food Technol Biotechnol 60:350\u2013360","journal-title":"Food Technol Biotechnol"},{"key":"1544_CR22","doi-asserted-by":"publisher","first-page":"103","DOI":"10.5194\/aab-66-103-2023","volume":"66","author":"B Csernus","year":"2023","unstructured":"Csernus B, Szab\u00f3 C, Knop R, Kidane RG, Ndunguru SF, Guly\u00e1s G, Ozsv\u00e1th XE, Czegl\u00e9di L (2023) Capsanthin supplementation modulates the immune response in broiler chickens under Escherichia coli lipopolysaccharide challenge. Arch Anim Breed 66:103\u2013111","journal-title":"Arch Anim Breed"},{"key":"1544_CR23","doi-asserted-by":"publisher","first-page":"10","DOI":"10.29219\/fnr.v64.4565","volume":"64","author":"N Umigai","year":"2020","unstructured":"Umigai N, Kozai Y, Saito T, Takara T (2020) Effects of paprika carotenoid supplementation on bone turnover in postmenopausal women: a randomized, double-blind, placebo-controlled, parallel-group comparison study. Food Nutr Res 64:10\u201329219","journal-title":"Food Nutr Res"},{"key":"1544_CR24","doi-asserted-by":"publisher","first-page":"272","DOI":"10.18632\/aging.203729","volume":"14","author":"Q Zhou","year":"2022","unstructured":"Zhou Q, Guan Z, Liu S, Xuan Y, Han G, Chen H, Jin X, Tao K, Guan Z (2022) The effects of metformin and alendronate in attenuating bone loss and improving glucose metabolism in diabetes mellitus mice. Aging 14:272\u2013285","journal-title":"Aging"},{"key":"1544_CR25","doi-asserted-by":"publisher","first-page":"2784","DOI":"10.3390\/ijms20112784","volume":"20","author":"E Park","year":"2019","unstructured":"Park E, Kim J, Kim MC, Yeo S, Kim J, Park S, Jo M, Choi CW, Jin HS, Lee SW, Li WY, Lee JW, Park JH, Huh D, Jeong SY (2019) Anti-osteoporotic effects of kukoamine B isolated from Lycii radicis cortex extract on osteoblast and osteoclast cells and ovariectomized osteoporosis model mice. Int J Mol Sci 20:2784","journal-title":"Int J Mol Sci"},{"key":"1544_CR26","doi-asserted-by":"publisher","first-page":"e79316","DOI":"10.1371\/journal.pone.0079316","volume":"8","author":"SA Myers","year":"2013","unstructured":"Myers SA, Nield A, Chew GS, Myers MA (2013) The zinc transporter, Slc39a7 (Zip7) is implicated in glycaemic control in skeletal muscle cells. PLoS ONE 8:e79316","journal-title":"PLoS ONE"},{"key":"1544_CR27","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1186\/1758-2946-6-13","volume":"6","author":"J Ru","year":"2014","unstructured":"Ru J, Li P, Wang J, Zhou W, Li B, Huang C, Li P, Guo Z, Tao W, Yang Y, Xu X, Li Y, Wang Y, Yang L (2014) TCMSP: a database of systems pharmacology for drug discovery from herbal medicines. J Cheminform 6:13","journal-title":"J Cheminform"},{"key":"1544_CR28","doi-asserted-by":"publisher","first-page":"1472","DOI":"10.3389\/fphar.2018.01472","volume":"9","author":"J Zuo","year":"2018","unstructured":"Zuo J, Wang X, Liu Y, Ye J, Liu Q, Li Y, Li S (2018) Integrating network pharmacology and metabolomics study on anti-rheumatic mechanisms and antagonistic effects against methotrexate-induced toxicity of Qing-Luo-Yin. Front Pharmacol 9:1472","journal-title":"Front Pharmacol"},{"key":"1544_CR29","doi-asserted-by":"publisher","first-page":"D672","DOI":"10.1093\/nar\/gkae909","volume":"53","author":"M Kanehisa","year":"2025","unstructured":"Kanehisa M, Furumichi M, Sato Y, Matsuura Y, Ishiguro-Watanabe M (2025) KEGG: biological systems database as a model of the real world. Nucleic Acids Res 53:D672\u2013d677","journal-title":"Nucleic Acids Res"},{"key":"1544_CR30","doi-asserted-by":"publisher","first-page":"1947","DOI":"10.1002\/pro.3715","volume":"28","author":"M Kanehisa","year":"2019","unstructured":"Kanehisa M (2019) Toward understanding the origin and evolution of cellular organisms. Protein Sci 28:1947\u20131951","journal-title":"Protein Sci"},{"key":"1544_CR31","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1038\/s41401-019-0228-6","volume":"41","author":"Y Liu","year":"2020","unstructured":"Liu Y, Grimm M, Dai WT, Hou MC, Xiao ZX, Cao Y (2020) CB-Dock: a web server for cavity detection-guided protein-ligand blind docking. Acta Pharmacol Sin 41:138\u2013144","journal-title":"Acta Pharmacol Sin"},{"key":"1544_CR32","doi-asserted-by":"publisher","first-page":"6473745","DOI":"10.1155\/2020\/6473745","volume":"2020","author":"YG Tao","year":"2020","unstructured":"Tao YG, Huang XF, Wang JY, Kang MR, Wang LJ, Xian SX (2020) Exploring molecular mechanism of Huangqi in treating heart failure using network pharmacology. Evidence-Based Complement Alter Med eCAM 2020:6473745","journal-title":"Evidence-Based Complement Alter Med eCAM"},{"key":"1544_CR33","doi-asserted-by":"publisher","first-page":"931","DOI":"10.3390\/molecules21080931","volume":"21","author":"AM Chapa-Oliver","year":"2016","unstructured":"Chapa-Oliver AM, Mej\u00eda-Teniente L (2016) Capsaicin: from plants to a cancer-suppressing agent. Molecules, Basel, Switzerland. 21:931","journal-title":"Molecules, Basel, Switzerland"},{"key":"1544_CR34","first-page":"837","volume":"36","author":"R Clark","year":"2016","unstructured":"Clark R, Lee SH (2016) Anticancer properties of capsaicin against human cancer. Anticancer Res 36:837\u2013843","journal-title":"Anticancer Res"},{"key":"1544_CR35","doi-asserted-by":"publisher","first-page":"e13807","DOI":"10.1111\/acel.13807","volume":"22","author":"Z Guan","year":"2023","unstructured":"Guan Z, Jin X, Guan Z, Liu S, Tao K, Luo L (2023) The gut microbiota metabolite capsiate regulate SLC2A1 expression by targeting HIF-1\u03b1 to inhibit knee osteoarthritis-induced ferroptosis. Aging Cell 22:e13807","journal-title":"Aging Cell"},{"key":"1544_CR36","doi-asserted-by":"publisher","first-page":"847","DOI":"10.1177\/0192623312444471","volume":"40","author":"K Bley","year":"2012","unstructured":"Bley K, Boorman G, Mohammad B, McKenzie D, Babbar S (2012) A comprehensive review of the carcinogenic and anticarcinogenic potential of capsaicin. Toxicol Pathol 40:847\u2013873","journal-title":"Toxicol Pathol"},{"key":"1544_CR37","doi-asserted-by":"publisher","first-page":"3995","DOI":"10.3390\/nu13113995","volume":"13","author":"A Al-Samydai","year":"2021","unstructured":"Al-Samydai A, Alshaer W, Al-Dujaili EAS, Azzam H, Aburjai T (2021) Preparation, characterization, and anticancer effects of capsaicin-loaded nanoliposomes. Nutrients 13:3995","journal-title":"Nutrients"},{"key":"1544_CR38","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1208\/s12249-021-02065-z","volume":"22","author":"LE Kennedy","year":"2021","unstructured":"Kennedy LE, Abraham A, Kulkarni G, Shettigar N, Dave T, Kulkarni M (2021) Capsanthin, a plant-derived xanthophyll: a review of pharmacology and delivery strategies. AAPS PharmSciTech 22:203","journal-title":"AAPS PharmSciTech"},{"key":"1544_CR39","first-page":"100092","volume":"6","author":"E Rodr\u00edguez-Rodr\u00edguez","year":"2020","unstructured":"Rodr\u00edguez-Rodr\u00edguez E, S\u00e1nchez-Prieto M, Olmedilla-Alonso B (2020) Assessment of carotenoid concentrations in red peppers (Capsicum annuum) under domestic refrigeration for three weeks as determined by HPLC-DAD. Food Chem: X 6:100092","journal-title":"Food Chem: X"},{"key":"1544_CR40","doi-asserted-by":"publisher","first-page":"e13776","DOI":"10.1111\/jfbc.13776","volume":"45","author":"V Shanmugham","year":"2021","unstructured":"Shanmugham V, Subban R (2021) Extraction of capsanthin from Capsicum annum L fruits and its effect on carbomer-induced intraocular pressure in Albino Wistar rats. J Food Biochem 45:e13776","journal-title":"J Food Biochem"},{"key":"1544_CR41","doi-asserted-by":"publisher","first-page":"689","DOI":"10.3390\/bios13070689","volume":"13","author":"SR de Benjamin","year":"2023","unstructured":"Benjamin SR, de Lima F, Nascimento VAD, de Andrade GM, Ori\u00e1 RB (2023) Advancement in paper-based electrochemical biosensing and emerging diagnostic methods. Biosensors 13:689","journal-title":"Biosensors"},{"key":"1544_CR42","doi-asserted-by":"publisher","first-page":"85","DOI":"10.1146\/annurev-anchem-061318-114845","volume":"13","author":"T Ozer","year":"2020","unstructured":"Ozer T, McMahon C, Henry CS (2020) Advances in paper-based analytical devices. Ann Rev Anal Chem (Palo Alto Calif) 13:85\u2013109","journal-title":"Ann Rev Anal Chem (Palo Alto Calif)"},{"key":"1544_CR43","doi-asserted-by":"publisher","first-page":"859","DOI":"10.1016\/j.peptides.2007.06.003","volume":"29","author":"KL Ong","year":"2008","unstructured":"Ong KL, Wong LY, Cheung BM (2008) The role of urotensin II in the metabolic syndrome. Peptides 29:859\u2013867","journal-title":"Peptides"},{"key":"1544_CR44","first-page":"328","volume":"55","author":"E Celik","year":"2019","unstructured":"Celik E, Taysi S, Sucu S, Ulusal H, Sevincler E, Celik A (2019) Urotensin 2 and oxidative stress levels in maternal serum in pregnancies complicated by intrauterine growth restriction. Medicine (Kaunas Lithuania) 55:328","journal-title":"Medicine (Kaunas Lithuania)"},{"key":"1544_CR45","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1007\/s00540-007-0524-z","volume":"21","author":"J McDonald","year":"2007","unstructured":"McDonald J, Batuwangala M, Lambert DG (2007) Role of urotensin II and its receptor in health and disease. J Anesth 21:378\u2013389","journal-title":"J Anesth"},{"key":"1544_CR46","doi-asserted-by":"publisher","first-page":"705","DOI":"10.47102\/annals-acadmedsg.V39N9p705","volume":"39","author":"KT Woo","year":"2010","unstructured":"Woo KT, Lau YK, Zhao Y, Puong KY, Tan HB, Fook-Chong S, Wong KS, Chan CM (2010) Urotensin 2 and retinoic acid receptor alpha (RARA) gene expression in IgA nephropathy. Ann Acad Med Singapore 39:705\u2013709","journal-title":"Ann Acad Med Singapore"},{"key":"1544_CR47","doi-asserted-by":"publisher","first-page":"3412","DOI":"10.1016\/j.bmcl.2017.05.088","volume":"27","author":"M Strack","year":"2017","unstructured":"Strack M, Billard \u00c9, Chatenet D, Lubell WD (2017) Urotensin core mimics that modulate the biological activity of urotensin-II related peptide but not urotensin-II. Bioorg Med Chem Lett 27:3412\u20133416","journal-title":"Bioorg Med Chem Lett"},{"key":"1544_CR48","doi-asserted-by":"publisher","first-page":"211","DOI":"10.9758\/cpn.2019.17.2.211","volume":"17","author":"E Oral","year":"2019","unstructured":"Oral E, Halici Z, Cinar I, Ozcan E, Kutlu Z (2019) Evaluation of endothelial dysfunction in bipolar affective disorders: serum endocan and urotensin-II levels. Clin Psychopharmacol Neurosci: Off Sci J Korean Coll Neuropsychopharmacol 17:211\u2013221","journal-title":"Clin Psychopharmacol Neurosci: Off Sci J Korean Coll Neuropsychopharmacol"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-026-01544-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00223-026-01544-4","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-026-01544-4.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T17:02:30Z","timestamp":1783357350000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00223-026-01544-4"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,6]]},"references-count":48,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1544"],"URL":"https:\/\/doi.org\/10.1007\/s00223-026-01544-4","relation":{},"ISSN":["1432-0827"],"issn-type":[{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,6]]},"assertion":[{"value":"1 February 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"6 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no conflict of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript, or in the decision to publish the results.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"The experimental protocol was approved by the Department of Laboratory Animal Science of the Xuzhou first People\u2019s Hospital (XZFS-2022-112, data:2021.5.6).","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical Approval and Consent to Participate"}},{"value":"We all agree to publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for Publication"}}],"article-number":"108"}}