{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T08:02:03Z","timestamp":1784620923691,"version":"3.55.0"},"reference-count":42,"publisher":"Springer Science and Business Media LLC","issue":"1","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Universit\u00e4tsklinikum Hamburg-Eppendorf (UKE)"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Distal radius fractures and proximal humerus fractures are common fractures in postmenopausal women with osteoporosis. The question of whether bone microstructural deficits are reflected in specific changes in bone microstructure at peripheral skeletal sites has not yet been investigated. In this retrospective study, treatment-na\u00efve postmenopausal women with distal radius fractures (DRF) or proximal humerus fractures (PHF) were included. Of more than 500 patients screened, 30 patients with DRF and 30 patients with PHF were included in the final analysis following propensity score matching. All participants underwent biochemical testing, dual-energy X-ray absorptiometry assessment, and bone microstructural evaluation by high-resolution peripheral quantitative computed tomography. After propensity score matching, both groups showed no significant differences in terms of age, weight, height, BMI, and lowest T-score (all\n                    <jats:italic>p<\/jats:italic>\n                    \u2009&gt;\u20090.05). Mean age was 64.4\u2009\u00b1\u200910.7\u00a0years in the DRF group and 66.7\u2009\u00b1\u20099.0\u00a0years in the PHF group (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.365). In both groups, the lowest mean T-score was \u2212\u20092.9 (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.539). Overall, both groups showed a reduction in total BMD and microarchitectural parameters compared to reference values at the distal radius and tibia. The PHF group exhibited significantly reduced bone geometry at the distal radius compared with the DRF group, including lower total area (p\u2009=\u20090.004), trabecular area (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.021), and cortical area (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.006), as well as reduced cortical thickness at both the distal radius (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.031) and tibia (\n                    <jats:italic>p<\/jats:italic>\n                    \u2009=\u20090.024). PHF are characterized by reduced cortical thickness and unfavorable bone geometry, which is independent of areal bone mineral density.\n                  <\/jats:p>","DOI":"10.1007\/s00223-026-01579-7","type":"journal-article","created":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T07:08:25Z","timestamp":1784617705000},"update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Distinct Cortical Microstructure in Postmenopausal Women with Distal Radius and Proximal Humerus Fractures"],"prefix":"10.1007","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9094-6021","authenticated-orcid":false,"given":"Mikolaj","family":"Bartosik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3325-8983","authenticated-orcid":false,"given":"Alexander","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-7522-4887","authenticated-orcid":false,"given":"Oskar","family":"Windels","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6586-6794","authenticated-orcid":false,"given":"Felix N.","family":"von Brackel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0200-8431","authenticated-orcid":false,"given":"Florian","family":"Barvencik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2382-8348","authenticated-orcid":false,"given":"Michael","family":"Amling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9449-5013","authenticated-orcid":false,"given":"Ralf","family":"Oheim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"1579_CR1","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1002\/jbmr.3666","volume":"34","author":"S Borhan","year":"2019","unstructured":"Borhan S, Papaioannou A, Gajic-Veljanoski O et al (2019) Incident fragility fractures have a long-term negative impact on health-related quality of life of older people: the Canadian Multicentre Osteoporosis Study. J Bone Miner Res 34:838\u2013848. https:\/\/doi.org\/10.1002\/jbmr.3666","journal-title":"J Bone Miner Res"},{"key":"1579_CR2","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-025-07821-6","author":"R Sund","year":"2025","unstructured":"Sund R, Rikkonen T, Kr\u00f6ger H, Sirola J (2025) Burden of accumulating fragility fractures on health service usage and costs among post-menopausal women. Osteoporos Int. https:\/\/doi.org\/10.1007\/s00198-025-07821-6","journal-title":"Osteoporos Int"},{"key":"1579_CR3","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1007\/s00198-025-07586-y","volume":"36","author":"H Wang","year":"2025","unstructured":"Wang H, Zhao Y, Liu Q et al (2025) Global burden of low bone mineral density related fractures in pre- and post-menopausal women from 1990 to 2021, with projections to 2050. Osteoporos Int 36:1593\u20131605. https:\/\/doi.org\/10.1007\/s00198-025-07586-y","journal-title":"Osteoporos Int"},{"key":"1579_CR4","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.jclinepi.2010.07.007","volume":"64","author":"AH Warriner","year":"2011","unstructured":"Warriner AH, Patkar NM, Curtis JR et al (2011) Which fractures are most attributable to osteoporosis? J Clin Epidemiol 64:46\u201353. https:\/\/doi.org\/10.1016\/j.jclinepi.2010.07.007","journal-title":"J Clin Epidemiol"},{"key":"1579_CR5","doi-asserted-by":"publisher","first-page":"894","DOI":"10.1001\/jama.2025.6003","volume":"334","author":"SN Morin","year":"2025","unstructured":"Morin SN, Leslie WD, Schousboe JT (2025) Osteoporosis: a review. JAMA 334:894\u2013907. https:\/\/doi.org\/10.1001\/jama.2025.6003","journal-title":"JAMA"},{"key":"1579_CR6","doi-asserted-by":"publisher","first-page":"1726","DOI":"10.1007\/s00198-006-0172-4","volume":"17","author":"O Johnell","year":"2006","unstructured":"Johnell O, Kanis JA (2006) An estimate of the worldwide prevalence and disability associated with osteoporotic fractures. Osteoporos Int 17:1726\u20131733. https:\/\/doi.org\/10.1007\/s00198-006-0172-4","journal-title":"Osteoporos Int"},{"key":"1579_CR7","doi-asserted-by":"publisher","first-page":"128","DOI":"10.2106\/jbjs.22.00012","volume":"105","author":"A Kadri","year":"2023","unstructured":"Kadri A, Binkley N, Daffner SD, Anderson PA (2023) Fracture in patients with normal bone mineral density: an evaluation of the American Orthopaedic Association\u2019s own the bone registry. J Bone Joint Surg Am 105:128\u2013136. https:\/\/doi.org\/10.2106\/jbjs.22.00012","journal-title":"J Bone Joint Surg Am"},{"key":"1579_CR8","doi-asserted-by":"publisher","first-page":"3514","DOI":"10.1210\/jc.2018-02614","volume":"104","author":"HT Mai","year":"2019","unstructured":"Mai HT, Tran TS, Ho-Le TP et al (2019) Two-thirds of all fractures are not attributable to osteoporosis and advancing age: implications for fracture prevention. J Clin Endocrinol Metab 104:3514\u20133520. https:\/\/doi.org\/10.1210\/jc.2018-02614","journal-title":"J Clin Endocrinol Metab"},{"key":"1579_CR9","doi-asserted-by":"publisher","first-page":"1158","DOI":"10.1002\/jbmr.2796","volume":"31","author":"S Boutroy","year":"2016","unstructured":"Boutroy S, Khosla S, Sornay-Rendu E et al (2016) Microarchitecture and peripheral BMD are impaired in postmenopausal white women with fracture independently of total hip T-score: an international multicenter study. J Bone Miner Res 31:1158\u20131166. https:\/\/doi.org\/10.1002\/jbmr.2796","journal-title":"J Bone Miner Res"},{"key":"1579_CR10","doi-asserted-by":"publisher","first-page":"425","DOI":"10.1359\/jbmr.061206","volume":"22","author":"E Sornay-Rendu","year":"2007","unstructured":"Sornay-Rendu E, Boutroy S, Munoz F, Delmas PD (2007) Alterations of cortical and trabecular architecture are associated with fractures in postmenopausal women, partially independent of decreased BMD measured by DXA: the OFELY study. J Bone Miner Res 22:425\u2013433. https:\/\/doi.org\/10.1359\/jbmr.061206","journal-title":"J Bone Miner Res"},{"key":"1579_CR11","doi-asserted-by":"publisher","first-page":"2572","DOI":"10.1002\/jbmr.152","volume":"25","author":"EM Stein","year":"2010","unstructured":"Stein EM, Liu XS, Nickolas TL et al (2010) Abnormal microarchitecture and reduced stiffness at the radius and tibia in postmenopausal women with fractures. J Bone Miner Res 25:2572\u20132581. https:\/\/doi.org\/10.1002\/jbmr.152","journal-title":"J Bone Miner Res"},{"key":"1579_CR12","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1016\/j.bone.2006.06.001","volume":"39","author":"CJ Hernandez","year":"2006","unstructured":"Hernandez CJ, Keaveny TM (2006) A biomechanical perspective on bone quality. Bone 39:1173\u20131181. https:\/\/doi.org\/10.1016\/j.bone.2006.06.001","journal-title":"Bone"},{"key":"1579_CR13","doi-asserted-by":"publisher","first-page":"587","DOI":"10.1093\/aje\/153.6.587","volume":"153","author":"TV Nguyen","year":"2001","unstructured":"Nguyen TV, Center JR, Sambrook PN, Eisman JA (2001) Risk factors for proximal humerus, forearm, and wrist fractures in elderly men and women the Dubbo osteoporosis epidemiology study. Am J Epidemiol 153:587\u2013595. https:\/\/doi.org\/10.1093\/aje\/153.6.587","journal-title":"Am J Epidemiol"},{"key":"1579_CR14","doi-asserted-by":"publisher","first-page":"348","DOI":"10.2106\/jbjs.J.00303","volume":"93","author":"J Oyen","year":"2011","unstructured":"Oyen J, Brudvik C, Gjesdal CG et al (2011) Osteoporosis as a risk factor for distal radial fractures: a case-control study. J Bone Joint Surg Am 93:348\u2013356. https:\/\/doi.org\/10.2106\/jbjs.J.00303","journal-title":"J Bone Joint Surg Am"},{"key":"1579_CR15","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-023-01143-7","author":"M Bartosik","year":"2023","unstructured":"Bartosik M, Simon A, Strahl A et al (2023) Comparison of motion grading in 1,000 patients by first- and second-generation HR-pQCT: a propensity score matched cohort study. Calcif Tissue Int. https:\/\/doi.org\/10.1007\/s00223-023-01143-7","journal-title":"Calcif Tissue Int"},{"key":"1579_CR16","doi-asserted-by":"publisher","first-page":"1607","DOI":"10.1007\/s00198-020-05438-5","volume":"31","author":"DE Whittier","year":"2020","unstructured":"Whittier DE, Boyd SK, Burghardt AJ et al (2020) Guidelines for the assessment of bone density and microarchitecture in vivo using high-resolution peripheral quantitative computed tomography. Osteoporos Int 31:1607\u20131627. https:\/\/doi.org\/10.1007\/s00198-020-05438-5","journal-title":"Osteoporos Int"},{"key":"1579_CR17","doi-asserted-by":"publisher","first-page":"2041","DOI":"10.1002\/jbmr.2873","volume":"31","author":"LA Burt","year":"2016","unstructured":"Burt LA, Liang Z, Sajobi TT, Hanley DA, Boyd SK (2016) Sex- and site-specific normative data curves for HR-pQCT. J Bone Miner Res 31:2041\u20132047. https:\/\/doi.org\/10.1002\/jbmr.2873","journal-title":"J Bone Miner Res"},{"key":"1579_CR18","doi-asserted-by":"publisher","first-page":"2151","DOI":"10.1002\/jbmr.4114","volume":"35","author":"DE Whittier","year":"2020","unstructured":"Whittier DE, Burt LA, Hanley DA, Boyd SK (2020) Sex- and site-specific reference data for bone microarchitecture in adults measured using second-generation HR-pQCT. J Bone Miner Res 35:2151\u20132158. https:\/\/doi.org\/10.1002\/jbmr.4114","journal-title":"J Bone Miner Res"},{"key":"1579_CR19","doi-asserted-by":"publisher","first-page":"1514","DOI":"10.1002\/jbmr.3128","volume":"32","author":"SL Manske","year":"2017","unstructured":"Manske SL, Davison EM, Burt LA, Raymond DA, Boyd SK (2017) The estimation of second-generation HR-pQCT from first-generation HR-pQCT using in vivo cross-calibration. J Bone Miner Res 32:1514\u20131524. https:\/\/doi.org\/10.1002\/jbmr.3128","journal-title":"J Bone Miner Res"},{"key":"1579_CR20","doi-asserted-by":"publisher","first-page":"2310","DOI":"10.1002\/jcsm.13044","volume":"13","author":"A Simon","year":"2022","unstructured":"Simon A, Sch\u00e4fer HS, Schmidt FN et al (2022) Compartment-specific effects of muscle strength on bone microarchitecture in women at high risk of osteoporosis. J Cachexia Sarcopenia Muscle 13:2310\u20132321. https:\/\/doi.org\/10.1002\/jcsm.13044","journal-title":"J Cachexia Sarcopenia Muscle"},{"key":"1579_CR21","doi-asserted-by":"publisher","first-page":"1979","DOI":"10.1056\/NEJMcp2307353","volume":"389","author":"MD Walker","year":"2023","unstructured":"Walker MD, Shane E (2023) Postmenopausal osteoporosis. N Engl J Med 389:1979\u20131991. https:\/\/doi.org\/10.1056\/NEJMcp2307353","journal-title":"N Engl J Med"},{"key":"1579_CR22","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1016\/j.mayocp.2024.01.011","volume":"99","author":"AA Khan","year":"2024","unstructured":"Khan AA, Slart RHJA, Ali DS et al (2024) Osteoporotic fractures: diagnosis, evaluation, and significance from the International Working Group on DXA Best Practices. Mayo Clin Proc 99:1127\u20131141. https:\/\/doi.org\/10.1016\/j.mayocp.2024.01.011","journal-title":"Mayo Clin Proc"},{"key":"1579_CR23","doi-asserted-by":"publisher","first-page":"263","DOI":"10.1002\/jbmr.562","volume":"27","author":"XS Liu","year":"2012","unstructured":"Liu XS, Stein EM, Zhou B et al (2012) Individual trabecula segmentation (ITS)-based morphological analyses and microfinite element analysis of HR-pQCT images discriminate postmenopausal fragility fractures independent of DXA measurements. J Bone Miner Res 27:263\u2013272. https:\/\/doi.org\/10.1002\/jbmr.562","journal-title":"J Bone Miner Res"},{"key":"1579_CR24","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1002\/jbmr.3924","volume":"35","author":"R Chapurlat","year":"2020","unstructured":"Chapurlat R, Bui M, Sornay-Rendu E et al (2020) Deterioration of cortical and trabecular microstructure identifies women with osteopenia or normal bone mineral density at imminent and long-term risk for fragility fracture: a prospective study. J Bone Miner Res 35:833\u2013844. https:\/\/doi.org\/10.1002\/jbmr.3924","journal-title":"J Bone Miner Res"},{"key":"1579_CR25","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1016\/s2213-8587(18)30308-5","volume":"7","author":"EJ Samelson","year":"2019","unstructured":"Samelson EJ, Broe KE, Xu H et al (2019) Cortical and trabecular bone microarchitecture as an independent predictor of incident fracture risk in older women and men in the Bone Microarchitecture International Consortium (BoMIC): a prospective study. Lancet Diabetes Endocrinol 7:34\u201343. https:\/\/doi.org\/10.1016\/s2213-8587(18)30308-5","journal-title":"Lancet Diabetes Endocrinol"},{"key":"1579_CR26","doi-asserted-by":"publisher","first-page":"1574","DOI":"10.1093\/jbmr\/zjae143","volume":"39","author":"M Sarfati","year":"2024","unstructured":"Sarfati M, Chapurlat R, Dufour AB et al (2024) Short-term risk of fracture is increased by deficits in cortical and trabecular bone microarchitecture independent of DXA BMD and FRAX: Bone Microarchitecture International Consortium (BoMIC) prospective cohorts. J Bone Miner Res 39:1574\u20131583. https:\/\/doi.org\/10.1093\/jbmr\/zjae143","journal-title":"J Bone Miner Res"},{"key":"1579_CR27","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1002\/jbmr.3347","volume":"33","author":"LA Burt","year":"2018","unstructured":"Burt LA, Manske SL, Hanley DA, Boyd SK (2018) Lower bone density, impaired microarchitecture, and strength predict future fragility fracture in postmenopausal women: 5-year follow-up of the Calgary CaMos cohort. J Bone Miner Res 33:589\u2013597. https:\/\/doi.org\/10.1002\/jbmr.3347","journal-title":"J Bone Miner Res"},{"key":"1579_CR28","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2024.117072","volume":"182","author":"E Sornay-Rendu","year":"2024","unstructured":"Sornay-Rendu E, Duboeuf F, Chapurlat RD (2024) Postmenopausal women with normal BMD who have fractures have deteriorated bone microarchitecture: a prospective analysis from The OFELY study. Bone 182:117072. https:\/\/doi.org\/10.1016\/j.bone.2024.117072","journal-title":"Bone"},{"key":"1579_CR29","doi-asserted-by":"publisher","first-page":"1963","DOI":"10.1002\/jbmr.4663","volume":"37","author":"DE Whittier","year":"2022","unstructured":"Whittier DE, Manske SL, Billington E et al (2022) Hip fractures in older adults are associated with the low density bone phenotype and heterogeneous deterioration of bone microarchitecture. J Bone Miner Res 37:1963\u20131972. https:\/\/doi.org\/10.1002\/jbmr.4663","journal-title":"J Bone Miner Res"},{"key":"1579_CR30","doi-asserted-by":"publisher","first-page":"1470","DOI":"10.1002\/jbmr.3451","volume":"33","author":"P Szulc","year":"2018","unstructured":"Szulc P, Boutroy S, Chapurlat R (2018) Prediction of fractures in men using bone microarchitectural parameters assessed by high-resolution peripheral quantitative computed tomography-the prospective STRAMBO study. J Bone Miner Res 33:1470\u20131479. https:\/\/doi.org\/10.1002\/jbmr.3451","journal-title":"J Bone Miner Res"},{"key":"1579_CR31","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1007\/s00223-019-00564-7","volume":"105","author":"LD Westbury","year":"2019","unstructured":"Westbury LD, Shere C, Edwards MH et al (2019) Cluster analysis of finite element analysis and bone microarchitectural parameters identifies phenotypes with high fracture risk. Calcif Tissue Int 105:252\u2013262. https:\/\/doi.org\/10.1007\/s00223-019-00564-7","journal-title":"Calcif Tissue Int"},{"key":"1579_CR32","doi-asserted-by":"publisher","first-page":"1290","DOI":"10.1002\/jbmr.1879","volume":"28","author":"KJ Jepsen","year":"2013","unstructured":"Jepsen KJ, Evans R, Negus CH et al (2013) Variation in tibial functionality and fracture susceptibility among healthy, young adults arises from the acquisition of biologically distinct sets of traits. J Bone Miner Res 28:1290\u20131300. https:\/\/doi.org\/10.1002\/jbmr.1879","journal-title":"J Bone Miner Res"},{"key":"1579_CR33","doi-asserted-by":"publisher","first-page":"825","DOI":"10.1002\/jbmr.3661","volume":"34","author":"EM Bigelow","year":"2019","unstructured":"Bigelow EM, Patton DM, Ward FS et al (2019) External bone size is a key determinant of strength-decline trajectories of aging male radii. J Bone Miner Res 34:825\u2013837. https:\/\/doi.org\/10.1002\/jbmr.3661","journal-title":"J Bone Miner Res"},{"key":"1579_CR34","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2022.116429","volume":"161","author":"S Uppuganti","year":"2022","unstructured":"Uppuganti S, Ketsiri T, Zhang Y, Does MD, Nyman JS (2022) HR-pQCT parameters of the distal radius correlate with the bending strength of the radial diaphysis. Bone 161:116429. https:\/\/doi.org\/10.1016\/j.bone.2022.116429","journal-title":"Bone"},{"key":"1579_CR35","doi-asserted-by":"publisher","first-page":"1672","DOI":"10.1002\/jbmr.3150","volume":"32","author":"A Yu","year":"2017","unstructured":"Yu A, Carballido-Gamio J, Wang L et al (2017) Spatial differences in the distribution of bone between femoral neck and trochanteric fractures. J Bone Miner Res 32:1672\u20131680. https:\/\/doi.org\/10.1002\/jbmr.3150","journal-title":"J Bone Miner Res"},{"key":"1579_CR36","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1002\/jbmr.4494","volume":"37","author":"DE Whittier","year":"2022","unstructured":"Whittier DE, Samelson EJ, Hannan MT et al (2022) Bone microarchitecture phenotypes identified in older adults are associated with different levels of osteoporotic fracture risk. J Bone Miner Res 37:428\u2013439. https:\/\/doi.org\/10.1002\/jbmr.4494","journal-title":"J Bone Miner Res"},{"key":"1579_CR37","doi-asserted-by":"publisher","first-page":"1733","DOI":"10.1007\/s00198-012-2160-1","volume":"24","author":"KK Nishiyama","year":"2013","unstructured":"Nishiyama KK, Macdonald HM, Hanley DA, Boyd SK (2013) Women with previous fragility fractures can be classified based on bone microarchitecture and finite element analysis measured with HR-pQCT. Osteoporos Int 24:1733\u20131740. https:\/\/doi.org\/10.1007\/s00198-012-2160-1","journal-title":"Osteoporos Int"},{"key":"1579_CR38","doi-asserted-by":"publisher","first-page":"2150","DOI":"10.1002\/jbmr.3556","volume":"33","author":"NC Harvey","year":"2018","unstructured":"Harvey NC, Od\u00e9n A, Orwoll E et al (2018) Measures of physical performance and muscle strength as predictors of fracture risk independent of FRAX, falls, and aBMD: a meta-analysis of the Osteoporotic Fractures in Men (MrOS) study. J Bone Miner Res 33:2150\u20132157. https:\/\/doi.org\/10.1002\/jbmr.3556","journal-title":"J Bone Miner Res"},{"key":"1579_CR39","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1016\/s0140-6736(96)01440-7","volume":"348","author":"P Dargent-Molina","year":"1996","unstructured":"Dargent-Molina P, Favier F, Grandjean H et al (1996) Fall-related factors and risk of hip fracture: the EPIDOS prospective study. Lancet 348:145\u2013149. https:\/\/doi.org\/10.1016\/s0140-6736(96)01440-7","journal-title":"Lancet"},{"key":"1579_CR40","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1007\/s00198-006-0290-z","volume":"18","author":"PN Sambrook","year":"2007","unstructured":"Sambrook PN, Cameron ID, Chen JS et al (2007) Influence of fall related factors and bone strength on fracture risk in the frail elderly. Osteoporos Int 18:603\u2013610. https:\/\/doi.org\/10.1007\/s00198-006-0290-z","journal-title":"Osteoporos Int"},{"key":"1579_CR41","doi-asserted-by":"publisher","first-page":"1741","DOI":"10.1359\/jbmr.080704","volume":"23","author":"L Vico","year":"2008","unstructured":"Vico L, Zouch M, Amirouche A et al (2008) High-resolution pQCT analysis at the distal radius and tibia discriminates patients with recent wrist and femoral neck fractures. J Bone Miner Res 23:1741\u20131750. https:\/\/doi.org\/10.1359\/jbmr.080704","journal-title":"J Bone Miner Res"},{"key":"1579_CR42","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1002\/jbmr.3901","volume":"35","author":"N Mikolajewicz","year":"2020","unstructured":"Mikolajewicz N, Bishop N, Burghardt AJ et al (2020) HR-pQCT measures of bone microarchitecture predict fracture: systematic review and meta-analysis. J Bone Miner Res 35:446\u2013459. https:\/\/doi.org\/10.1002\/jbmr.3901","journal-title":"J Bone Miner Res"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-026-01579-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00223-026-01579-7","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00223-026-01579-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T07:08:26Z","timestamp":1784617706000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00223-026-01579-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,21]]},"references-count":42,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2026,12]]}},"alternative-id":["1579"],"URL":"https:\/\/doi.org\/10.1007\/s00223-026-01579-7","relation":{},"ISSN":["1432-0827"],"issn-type":[{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,21]]},"assertion":[{"value":"1 May 2026","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"13 July 2026","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 July 2026","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"MA declares that there is no conflict of interest. MB and AS received a travel grant from Fresenius. FvB served as a speaker for UCB. OW received a travel support from Alexion, Inozyme and UCB and has served as a speaker for Alexion. RO has served as a speaker and advisory board member for Hexal Pharma, Kyowa Kirin, Inozyme, Ipsen, Mereo, Pharmacosmos, and UCB and has received institutional research grants from Kyowa Kirin, UCB, and Inozyme. FB has received speaker fees from Alexion, UCB, Blueprint Medicines (Germany), Synlab, Gedeon Richter and Diasorin and has received institutional research grants from UCB and Alexion.","order":1,"name":"Ethics","label":"Conflict of interest","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This retrospective study was performed in accordance with the Declaration of Helsinki and the local ethical guidelines.","order":2,"name":"Ethics","label":"Ethics approval","group":{"name":"EthicsHeading","label":"Declarations"}}],"article-number":"117"}}