{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T10:27:15Z","timestamp":1790936835956,"version":"4.1.0"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[1996,9,1]],"date-time":"1996-09-01T00:00:00Z","timestamp":841536000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Calcif Tissue Int"],"published-print":{"date-parts":[[1996,9]]},"DOI":"10.1007\/s002239900104","type":"journal-article","created":{"date-parts":[[2002,7,25]],"date-time":"2002-07-25T06:08:57Z","timestamp":1027577337000},"page":"168-173","source":"Crossref","is-referenced-by-count":34,"title":["Effect of 17\u03b2-estradiol-bisphosphonate conjugates, potential bone-seeking estrogen pro-drugs, on 17\u03b2-estradiol serum kinetics and bone mass in rats"],"prefix":"10.1007","volume":"59","author":[{"given":"F.","family":"Bauss","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Esswein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Reiff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Sponer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"M\u00fcller-Beckmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","reference":[{"key":"590300168_CR1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.7326\/0003-4819-98-2-195","volume":"98","author":"HL Judd","year":"1983","unstructured":"Judd HL, Meldrum DR, Deftos LJ, Henderson BE (1983) Estrogen replacement therapy: indications and complications. Ann Int Med 98:195\u2013205","journal-title":"Ann Int Med"},{"key":"590300168_CR2","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1056\/NEJM198908033210505","volume":"321","author":"L Bergkvist","year":"1989","unstructured":"Bergkvist L, Adami H-O, Persson I, Hoover R, Schairer C (1989) The risk of breast cancer after estrogen and estrogen-progestin replacement. N Engl J Med 321:293\u2013297","journal-title":"N Engl J Med"},{"issue":"6","key":"590300168_CR3","first-page":"5B","volume":"91","author":"SR Cummings","year":"1991","unstructured":"Cummings SR (1991) Evaluating the benefits and risks of postmenopausal hormone therapy. Am J Med 91(suppl 6):5B-14S","journal-title":"Am J Med"},{"key":"590300168_CR4","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1056\/NEJM199506153322401","volume":"332","author":"GA Colditz","year":"1995","unstructured":"Colditz GA, Hankinson SE, Hunter DJ, Willet WC, Manson JE, Stampfer MJ, Hennekens C, Rosner B, Speizer FE (1995) The use of estrogens and progestins and the risk of breast cancer in postmenopausal women. N Engl J Med 332:1589\u20131593","journal-title":"N Engl J Med"},{"key":"590300168_CR5","unstructured":"Saari W, Rodan GA, Fisher TE, Anderson PS (1992) Novel bone-acting agents. EP 0 496 520"},{"key":"590300168_CR6","unstructured":"Sugioka T, Inazu M (1993) New bisphosphonate derivatives. EP 0 548 884"},{"key":"590300168_CR7","unstructured":"Ueno H, Kadowaki S, Kamizono A, Morioka M, Mori A (1993) Steroid derivatives. EP 0 555 845"},{"key":"590300168_CR8","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1016\/S0960-894X(01)80365-6","volume":"4","author":"MW Orme","year":"1995","unstructured":"Orme MW, Labroo VM (1995) Synthesis of \u03b2-estradiol-3-benzoate-17-(succinyl-12A-Tetracycline): a potential boneseeking estrogen. Bioorg Med Chem Lett 4:1375\u20131380","journal-title":"Bioorg Med Chem Lett"},{"key":"590300168_CR9","unstructured":"Bosies E, Esswein A, Bauss F (1992) Preparation of estradiol diphosphonate derivatives for treatment of osteoporosis. DE-A-4029499"},{"key":"590300168_CR10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/BF02407166","volume":"31","author":"E Hefti","year":"1980","unstructured":"Hefti E, Trechsel U, R\u00fcfenacht H, Fleisch H (1980) Use of dermestid beetles for cleaning bones. Calcif Tissue Int 31:45\u201347","journal-title":"Calcif Tissue Int"},{"key":"590300168_CR11","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1007\/BF02557838","volume":"37","author":"F Bauss","year":"1985","unstructured":"Bauss F, Minne HW, Sterz H, Weng U, Wesch H, Ziegler R (1985) Comparative bone analysis via inflammation-mediated osteopenia (IMO) in the rat. Calcif Tissue Int 37:539\u2013546","journal-title":"Calcif Tissue Int"},{"key":"590300168_CR12","volume-title":"TOPFIT version 2.0. Pharmacokinetic and pharmacodynamic data analysis system for the PC","author":"G Heinzel","year":"1993","unstructured":"Heinzel G, Woloszczak R, Thomann P (1993) TOPFIT version 2.0. Pharmacokinetic and pharmacodynamic data analysis system for the PC. Gustav Fischer, Stuttgart, Jena, New York"},{"key":"590300168_CR13","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1210\/endo-123-2-681","volume":"123","author":"TJ Wronski","year":"1988","unstructured":"Wronski TJ, Cintron M, Doherty AL, Dann LM (1988) Estrogen treatment prevents osteopenia and depresses bone turnover in ovariectomized rats. Endocrinology 123:681\u2013686","journal-title":"Endocrinology"},{"key":"590300168_CR14","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/0169-6009(91)90021-Q","volume":"14","author":"DN Kalu","year":"1991","unstructured":"Kalu DN, Liu CC, Salerno E, Hollis B, Echon R, Ray M (1991) Skeletal response of ovariectomized rats to low and high doses of 17\u03b2-estradiol. Bone Miner 14:175\u2013187","journal-title":"Bone Miner"},{"key":"590300168_CR15","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1007\/BF00316876","volume":"51","author":"JY Reginster","year":"1992","unstructured":"Reginster JY, Sarlet N, Deroisy R, Albert A, Gaspard U, Franchimont P (1992) Minimal levels of serum estradiol prevent postmenopausal bone loss. Calcif Tissue Int 51:340\u2013343","journal-title":"Calcif Tissue Int"},{"key":"590300168_CR16","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1016\/S0002-9343(88)80033-0","volume":"85","author":"US Barzel","year":"1988","unstructured":"Barzel US (1988) Estrogens in the prevention and treatment of postmenopausal osteoporosis: a review. Am J Med 85:847\u2013850","journal-title":"Am J Med"},{"key":"590300168_CR17","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/S0140-6736(76)92217-0","volume":"I","author":"R Lindsay","year":"1976","unstructured":"Lindsay R, Aitken JM, Anderson JB, Hart DM, MacDonald EB, Clarke AC (1976) Long-term prevention of postmenopausal osteoporosis by oestrogen: evidence for an increased bone mass after delayed onset of oestrogen treatment. Lancet I: 1038\u20131040","journal-title":"Lancet"},{"key":"590300168_CR18","doi-asserted-by":"crossref","unstructured":"Lindsay R (1993) Criteria for successful estrogen therapy in osteoporosis. Osteoporosis Int (suppl 2):S9\u2013S13","DOI":"10.1007\/BF01623221"},{"key":"590300168_CR19","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1056\/NEJM199310143291601","volume":"329","author":"DT Felson","year":"1993","unstructured":"Felson DT, Zhang Y, Hannan MT, Kiel DP, Wilson PWF, Anderson JJ (1993) The effect of postmenopausal estrogen therapy on bone density in elderly women. N Engl J Med 329:1141\u20131146","journal-title":"N Engl J Med"},{"key":"590300168_CR20","first-page":"238","volume":"82","author":"B Riis","year":"1987","unstructured":"Riis B, Christiansen C (1987) Prevention of postmenopausal osteoporosis by estrogen\/gestagen substitution therapy. Med Klin 82:238\u2013241","journal-title":"Med Klin"},{"key":"590300168_CR21","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1002\/jbmr.5650071122","volume":"7","author":"CW Marx","year":"1992","unstructured":"Marx CW, Daily GE III, Cheney C, Vint VC II, Muchmore DB (1992) Do estrogens improve bone mineral density in osteoporotic women over age 65? J Bone Miner Res 7:1275\u20131279","journal-title":"J Bone Miner Res"},{"key":"590300168_CR22","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1210\/endo-128-1-408","volume":"128","author":"JH Tobias","year":"1991","unstructured":"Tobias JH, Chow J, Colston KW, Chambers TJ (1991) High concentrations of 17\u03b2-estradiol stimulate trabecular bone formation in adult female rats. Endocrinology 128:408\u2013412","journal-title":"Endocrinology"},{"key":"590300168_CR23","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1677\/joe.0.1390267","volume":"139","author":"JH Tobias","year":"1993","unstructured":"Tobias JH, Gallagher A, Chambers TJ (1993) Prolonged intermittent but not continuous administration of oestradiol-17\u03b2 increases bone volume in the rat. J Endocrinol 139:267\u2013273","journal-title":"J Endocrinol"},{"key":"590300168_CR24","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1002\/jbmr.5650080407","volume":"8","author":"SD Bain","year":"1993","unstructured":"Bain SD, Bailey MC, Celino DL, Lantry MM, Edwards MW (1993) High-dose estrogen inhibits bone resorption and stimulates bone formation in the ovariectomized mouse. J Bone Miner Res 8:435\u2013142","journal-title":"J Bone Miner Res"},{"key":"590300168_CR25","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1210\/endo.130.5.1572310","volume":"130","author":"JWM Chow","year":"1992","unstructured":"Chow JWM, Lean JM, Chambers TJ (1992) 17\u03b2-Estradiol stimulates cancellous bone formation in female rats. Endocrinology 130:3025\u20133032","journal-title":"Endocrinology"},{"key":"590300168_CR26","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1172\/JCI115588","volume":"89","author":"J Chow","year":"1992","unstructured":"Chow J, Tobias JH, Colston KW, Chambers TJ (1992) Estrogen maintains trabecular bone volume in rats not only by suppression of bone resorption but also by stimulation of bone formation. J Clin Invest 89:74\u201378","journal-title":"J Clin Invest"},{"key":"590300168_CR27","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/8756-3282(92)90358-4","volume":"13","author":"MW Edwards","year":"1992","unstructured":"Edwards MW, Bain SD, Bailey MC, Lantry MM, Howard GA (1992) 17\u03b2-Estradiol stimulation of endosteal bone formation in the ovariectomized mouse: an animal model for the evaluation of bone-targeted estrogens. Bone 13:29\u201334","journal-title":"Bone"},{"key":"590300168_CR28","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1210\/endo.133.6.8243320","volume":"133","author":"KC Westerlind","year":"1993","unstructured":"Westerlind KC, Wakley GK, Evans GL, Turner RT (1993) Estrogen does not increase bone formation in growing rats. Endocrinology 133:2924\u20132934","journal-title":"Endocrinology"},{"key":"590300168_CR29","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/jbmr.5650080709","volume":"8","author":"T Abe","year":"1993","unstructured":"Abe T, Chow JWM, Lean JM, Chambers TJ (1993) Estrogen does not restore bone lost after ovariectomy in the rat. J Bone Miner Res 8:831\u2013838","journal-title":"J Bone Miner Res"},{"key":"590300168_CR30","doi-asserted-by":"crossref","first-page":"2172","DOI":"10.1073\/pnas.87.6.2172","volume":"87","author":"T Takano-Yamamoto","year":"1990","unstructured":"Takano-Yamamoto T, Rodan GA (1990) Direct effects of 17\u03b2-estradiol on trabecular bone in ovariectomized rats. Proc Natl Acad Sci USA 87:2172\u20132176","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Calcified Tissue International"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002239900104.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s002239900104\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s002239900104","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T11:41:20Z","timestamp":1558698080000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s002239900104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1996,9]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1996,9]]}},"alternative-id":["590300168"],"URL":"https:\/\/doi.org\/10.1007\/s002239900104","relation":{},"ISSN":["0171-967X","1432-0827"],"issn-type":[{"value":"0171-967X","type":"print"},{"value":"1432-0827","type":"electronic"}],"subject":[],"published":{"date-parts":[[1996,9]]}}}