{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T05:38:26Z","timestamp":1787463506326,"version":"build-2736575974"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2004,12,3]],"date-time":"2004-12-03T00:00:00Z","timestamp":1102032000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2005,1]]},"DOI":"10.1007\/s00228-004-0836-y","type":"journal-article","created":{"date-parts":[[2004,12,3]],"date-time":"2004-12-03T03:43:24Z","timestamp":1102045404000},"page":"821-829","source":"Crossref","is-referenced-by-count":137,"title":["Agranulocytosis associated with dipyrone (metamizol)"],"prefix":"10.1007","volume":"60","author":[{"given":"Luisa","family":"Ib\ufffd\ufffdez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xavier","family":"Vidal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ballar\ufffdn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan-Ramon","family":"Laporte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2004,12,3]]},"reference":[{"key":"CR1","volume-title":"The drug etiology of agranulocytosis and aplastic anemia","author":"DW Kaufman","year":"1991","unstructured":"Kaufman DW, Kelly JP, Levy M, Shapiro S (1991) The drug etiology of agranulocytosis and aplastic anemia. Oxford University Press, New York"},{"key":"CR2","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1001\/jama.1986.03380160126038","volume":"256","author":"DW Kaufman","year":"1986","unstructured":"Kaufman DW, Kelly JP, Levy M, Shapiro S (1986) The drug etiology of agranulocytosis and aplastic anemia. A first report of their relation to drug use with special reference to analgesics. JAMA 256:1749?1757","journal-title":"JAMA"},{"key":"CR3","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1001\/archinte.159.4.369","volume":"159","author":"MM Klauw van der","year":"1999","unstructured":"van der Klauw MM, Goudsmit R, Halie MR, van?t Veer MB, Herings RMC, Wilson JHP, Stricker BHCh (1999) A population-based case-cohort study of drug-associated agranulocytosis. Arch Intern Med 159:369?374","journal-title":"Arch Intern Med"},{"key":"CR4","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1177\/147323000203000504","volume":"30","author":"S Maj","year":"2002","unstructured":"Maj S, Lis Y (2002) The incidence of metamizol sodium-induced agranulocytosis in Poland. J Int Med Res 30:488?495","journal-title":"J Int Med Res"},{"key":"CR5","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00228-002-0465-2","volume":"58","author":"K Hedenmalm","year":"2002","unstructured":"Hedenmalm K, Spigset O (2002) Agranulocytosis and other blood dyscrasias associated with metamizol (metamizol). Eur J Clin Pharmacol 58:265?274","journal-title":"Eur J Clin Pharmacol"},{"key":"CR6","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1093\/oxfordjournals.eurheartj.a059953","volume":"12","author":"L Ib\u00e1\u00f1ez","year":"1991","unstructured":"Ib\u00e1\u00f1ez L, Juan J, P\u00e9rez E, Carn\u00e9 X, Laporte J-R (1991) Agranulocytosis associated with aprindine and other antiarrhythmic drugs: an epidemiological approach. Eur Heart J 12:639?641","journal-title":"Eur Heart J"},{"key":"CR7","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/BF00315580","volume":"38","author":"JR Laporte","year":"1990","unstructured":"Laporte JR, Capell\u00e0 D, Juan J (1990) Agranulocytosis induced by cinepazide. Eur J Clin Pharmacol 38:387?388","journal-title":"Eur J Clin Pharmacol"},{"key":"CR8","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1007\/s002280050011","volume":"55","author":"L Ib\u00e1\u00f1ez","year":"2000","unstructured":"Ib\u00e1\u00f1ez L, Ballar\u00edn E, P\u00e9rez E, Vidal X, Capell\u00e0 D, Laporte JR (2000) Agranulocytosis induced by pyrithyldione, a sedative hypnotic drug. Eur J Clin Pharmacol 55:761?764","journal-title":"Eur J Clin Pharmacol"},{"key":"CR9","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1007\/s002280000190","volume":"56","author":"L Ib\u00e1\u00f1ez","year":"2000","unstructured":"Ib\u00e1\u00f1ez L, Ballar\u00edn E, Vidal X, Laporte JR (2000) Agranulocytosis associated with calcium dobesilate. Clinical course and risk estimation with the case-control and the case-population approaches. Eur J Clin Pharmacol 56:763?767","journal-title":"Eur J Clin Pharmacol"},{"key":"CR10","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1007\/BF00607096","volume":"24","author":"International Agranulocytosis and Aplastic Anemia Study","year":"1983","unstructured":"International Agranulocytosis and Aplastic Anemia Study (1983) The design of a study of the drug etiology of agranulocytosis and aplastic anemia. Eur J Clin Pharmacol 24:833?836","journal-title":"Eur J Clin Pharmacol"},{"key":"CR11","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1136\/bmj.1.4771.1270","volume":"i","author":"G Discombe","year":"1952","unstructured":"Discombe G (1952) Agranulocytosis caused by amidopyrine: an avoidable cause of death. BMJ i:1270?1273","journal-title":"BMJ"},{"key":"CR12","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1001\/jama.1964.03070120060014","volume":"189","author":"CM Huguley","year":"1964","unstructured":"Huguley CM (1964) Agranulocytosis induced by dipyrone, a hazardous antipyretic and analgesic. JAMA 189:938?941","journal-title":"JAMA"},{"key":"CR13","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/j.0954-6820.1970.tb02916.x","volume":"187","author":"IP Palva","year":"1970","unstructured":"Palva IP, Mustala DO (1970) Drug induced agranulocytosis with special reference to aminophenazone. Acta Med Scand 187:109?115","journal-title":"Acta Med Scand"},{"key":"CR14","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/bmj.3.5875.339","volume":"iii","author":"LE B\u00f6ttiger","year":"1973","unstructured":"B\u00f6ttiger LE, Westerholm B (1973) Drug-induced blood dyscrasias in Sweden. BMJ iii:339?343","journal-title":"BMJ"},{"key":"CR15","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1177\/030006057900700617","volume":"7","author":"DD Varonos","year":"1979","unstructured":"Varonos DD, Santamouris S, Karambali S (1979) The incidence of dipyrone induced agranulocytosis in Greece during 1975. J Int Med Res 7:564?568","journal-title":"J Int Med Res"},{"key":"CR16","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/S0140-6736(87)92836-4","volume":"i","author":"JR Laporte","year":"1987","unstructured":"Laporte JR, Carn\u00e9 X (1987) Blood dyscrasias and the relative safety of non-narcotic analgesics. Lancet i:809","journal-title":"Lancet"},{"key":"CR17","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/pds.697","volume":"11","author":"M B\u00e4ckstrom","year":"2002","unstructured":"B\u00e4ckstrom M, H\u00e4gg S, Mj\u00f6rndal T, Dahlqvist R (2002) Utilization pattern of metamizol in northern Sweden and risk estimates of agranulocytosis. Pharmacoepidemiol Drug Saf 11:239?245","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"CR18","first-page":"299","volume":"53","author":"D Capell\u00e0","year":"1999","unstructured":"Capell\u00e0 D, Laporte JR, Vidal X, Wiholm B-E, B\u00e9gaud B, Langman MJS, Rawlins M (1999) European network for the case-population surveillance of rare diseases (Euronet). A prospective feasibility study. Eur J Clin Pharmacol 53:299?302","journal-title":"Eur J Clin Pharmacol"},{"key":"CR19","unstructured":"Coordinating Centre (1999) A feasibility study of a European case-cohort surveillance network (EURONET) of serious ADRs to new pharmaceutical products. Euronet: final report. Contract n\u00b0 BMH4-CT95-0467 (DG 12 ? SSMA). DG XII, European Commission, Brussels"},{"key":"CR20","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/S0140-6736(84)92237-2","volume":"i","author":"A Herxheimer","year":"1984","unstructured":"Herxheimer A, Yudkin JS (1984) Agranulocytosis and pyrazolone analgesics. Lancet i:730","journal-title":"Lancet"},{"key":"CR21","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1016\/S0140-6736(84)91966-4","volume":"i","author":"S Shapiro","year":"1984","unstructured":"Shapiro S (1984) Agranulocytosis and pyrazolone. Lancet i:1471.","journal-title":"Lancet"},{"key":"CR22","doi-asserted-by":"crossref","first-page":"411","DOI":"10.2165\/00002018-200427060-00005","volume":"27","author":"J-R Laporte","year":"2004","unstructured":"Laporte J-R, Ib\u00e1\u00f1ez L, Vidal X, Vendrell L, Leone R (2004) Upper gastrointestinal bleeding associated with the use of NSAIDs. Newer versus older agents. Drug Saf 27:411?420","journal-title":"Drug Saf"},{"key":"CR23","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1016\/S0168-8278(02)00231-3","volume":"37","author":"L Ib\u00e1\u00f1ez","year":"2002","unstructured":"Ib\u00e1\u00f1ez L, P\u00e9rez E, Vidal X, Laporte J-R, The Grup d?Estudi Multic\u00e8ntric d?Hepatotoxicitat Aguda de Barcelona (GEMHAB) (2002) Prospective surveillance of acute serious liver disease unrelated to infectious, obstructive, or metabolic diseases: epidemiological and clinical features, and exposure to drugs. J Hepatol 37:592?600","journal-title":"J Hepatol"},{"key":"CR24","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.0954-6820.1973.tb10567.x","volume":"193","author":"LE B\u00f6ttiger","year":"1973","unstructured":"B\u00f6ttiger LE, Westerholm B (1973) Acquired hemolytic anaemia. I. Incidence and aetiology. Acta Med Scand 193:223?226","journal-title":"Acta Med Scand"},{"key":"CR25","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1365-2125.1993.tb04157.x","volume":"35","author":"MM Vander Klauw","year":"1993","unstructured":"Van der Klauw MM, Stricker B-HCh, Herings RMC, Cost WS, Valkenburg HA, Wilson JH (1993) A population based case-cohort study of drug-induced anaphylaxis. Br J Clin Pharmacol 35:400?408","journal-title":"Br J Clin Pharmacol"},{"key":"CR26","doi-asserted-by":"crossref","first-page":"1600","DOI":"10.1056\/NEJM199512143332404","volume":"333","author":"J-C Roujeau","year":"1995","unstructured":"Roujeau J-C, Kelly JP, Naldi L, Rzany B, Stern RS, Anderson T, Auquier A, Bastuji-Garin S, Correia O, Locati F, Mockenhaupt M, Paoletti C, Shapiro S, Shear N, Sch\u00f6pf E, Kaufman DW (1995) Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. N Engl J Med 333:1600?1607","journal-title":"N Engl J Med"},{"key":"CR27","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/0140-6736(91)90744-A","volume":"337","author":"JR Laporte","year":"1991","unstructured":"Laporte JR, Carn\u00e9 X, Vidal X, Moreno V, Juan J , The Catalan Countries Study on Upper Gastrointestinal Bleeding (1991) Upper gastrointestinal bleeding in relation to previous use of analgesics and non-steroidal anti-inflammatory drugs. Lancet 337:85?89","journal-title":"Lancet"},{"key":"CR28","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1016\/S0895-4356(98)00076-6","volume":"51","author":"SE Andrade","year":"1998","unstructured":"Andrade SE, Mart\u00ednez C, Walker AM (1998) Comparative safety evaluation of non-narcotic analgesics. J Clin Epidemiol 51:1357?1365","journal-title":"J Clin Epidemiol"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-004-0836-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00228-004-0836-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-004-0836-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T12:41:34Z","timestamp":1558701694000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00228-004-0836-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12,3]]},"references-count":28,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["836"],"URL":"https:\/\/doi.org\/10.1007\/s00228-004-0836-y","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,12,3]]}}}