{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:28:35Z","timestamp":1791109715414,"version":"4.1.0"},"reference-count":26,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T00:00:00Z","timestamp":1132185600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2005,12]]},"DOI":"10.1007\/s00228-005-0047-1","type":"journal-article","created":{"date-parts":[[2005,11,17]],"date-time":"2005-11-17T18:28:30Z","timestamp":1132252110000},"page":"803-809","source":"Crossref","is-referenced-by-count":24,"title":["Polymorphisms of IL\u201313 and IL\u20134\u2013IL\u201313\u2013SNPs in patients with penicillins allergy"],"prefix":"10.1007","volume":"61","author":[{"given":"Jing","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai\u2013Ling","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zi\u2013Ming","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2005,11,17]]},"reference":[{"key":"47_CR1","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1111\/j.1365-2222.1989.tb02434.x","volume":"19","author":"M Blanca","year":"1989","unstructured":"Blanca M, Vega JM, Garcia JJ, Carmona MJ, Miranda A (1989) Immediate hypersensitivity reactions to penicillin and related antibiotics. Clin Exp Allergy 19:556\u2013558","journal-title":"Clin Exp Allergy"},{"key":"47_CR2","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/0167-5699(91)90120-I","volume":"12","author":"S Romagnani","year":"1991","unstructured":"Romagnani S (1991) Human TH1 and TH2 subsets: doubt no more. Immunol Today 12:256\u2013257","journal-title":"Immunol Today"},{"key":"47_CR3","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0167-5699(94)90021-3","volume":"15","author":"G Zurawski","year":"1994","unstructured":"Zurawski G, de Vries JE (1994) Interleukin 13, an interleukin 4\u2013like cytokine that acts on monocytes and B cells, but not on T cells. Immunol Today 15:19\u201326","journal-title":"Immunol Today"},{"key":"47_CR4","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1056\/NEJM198902023200502","volume":"320","author":"B Burrows","year":"1989","unstructured":"Burrows B, Martinez FD, Halonen M, Barbee RA, Cline MG (1989) Association of asthma with serum IgE levels and skin-test reactivity to allergens. N Engl J Med 320:271\u2013277","journal-title":"N Engl J Med"},{"key":"47_CR5","first-page":"51","volume":"41","author":"DA Meyers","year":"1987","unstructured":"Meyers DA, Beaty TH, Freidhoff LR, Marsh DG (1987) Inheritance of total serum IgE (basal levels) in man. Am J Hum Genet 41:51\u201362","journal-title":"Am J Hum Genet"},{"key":"47_CR6","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1002\/gepi.1370120109","volume":"12","author":"MH Dizier","year":"1995","unstructured":"Dizier MH, Hill M, James A, Faux J, Ryan G, le Souef P, Lathrop M, Musk AW, Demenais F, Cookson W (1995) Detection of a recessive major gene for high IgE levels acting independently of specific response to allergens. Genet Epidemiol 12:93\u2013105","journal-title":"Genet Epidemiol"},{"key":"47_CR7","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1126\/science.8178175","volume":"264","author":"DG Marsh","year":"1994","unstructured":"Marsh DG, Neely JD, Breazeale DR, Ghosh B, Freidhoff LR, Ehrlich\u2013Kautzky E, Schou C, Krishnaswamy G, Beaty TH (1994) Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science 264:1152\u20131156","journal-title":"Science"},{"key":"47_CR8","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1093\/intimm\/7.9.1405","volume":"7","author":"R Waal Malefyt de","year":"1995","unstructured":"de Waal Malefyt R, Abrams JS, Zurawski SM, Lecron JC, Mohan\u2013Peterson S, Sanjanwala B, Bennett B, Silver J, de Vries JE, Yssel H (1995) Differential regulation of IL\u201313 and IL\u20134 production by human CD8+and CD4+Th0, Th1 and Th2 T cell clones and EBV\u2013transformed B cells. Int Immunol 7:1405\u20131416","journal-title":"Int Immunol"},{"key":"47_CR9","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1002\/eji.1830260311","volume":"26","author":"T Jung","year":"1996","unstructured":"Jung T, Wijdenes J, Neumann C, de Vries JE, Yssel H (1996) Interleukin\u201313 is produced by activated human CD45RA+and CD45RO+T cells: modulation by interleukin\u20134 and interleukin\u201312. Eur J Immunol 26:571\u2013577","journal-title":"Eur J Immunol"},{"key":"47_CR10","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/hmg\/9.4.549","volume":"9","author":"A Heinzmann","year":"2000","unstructured":"Heinzmann A, Mao XQ, Akaiwa M, Kreomer RT, Gao PS, Ohshima K, Umeshita R, Abe Y, Braun S, Yamashita T, Roberts MH, Sugimoto R, Arima K, Arinobu Y, Yu B, Kruse S, Enomoto T, Dake Y, Kawai M, Shimazu S, Sasaki S, Adra CN, Kitaichi M, Inoue H, Yamauchi K, Tomichi N, Kurimoto F, Hamasaki N, Hopkin JM, Izuhara K, Shirakawa T, Deichmann KA (2000) Genetic variants of IL\u201313 signalling and human asthma and atopy. Hum Mol Genet 9:549\u2013559","journal-title":"Hum Mol Genet"},{"key":"47_CR11","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1067\/mai.2000.104940","volume":"105","author":"PE Graves","year":"2000","unstructured":"Graves PE, Kabesch M, Halonen M, Holberg CJ, Baldini M, Fritzsch C, Weiland SK, Erickson RP, von Mutius E, Martinez FD (2000) A cluster of seven tightly linked polymorphisms in the IL\u201313 gene is associated with total serum IgE levels in three populations of white children.J Allergy Clin Immunol 105:506\u2013513","journal-title":"J Allergy Clin Immunol"},{"key":"47_CR12","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1126\/science.288.5463.136","volume":"288","author":"GG Loots","year":"2000","unstructured":"Loots GG, Locksley RM, Blankespoor CM, Wang ZE, Miller W, Rubin EM, Frazer KA (2000) Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons. Science 288:136\u2013140","journal-title":"Science"},{"key":"47_CR13","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1016\/S0198-8859(01)00338-X","volume":"62","author":"E Noguchi","year":"2001","unstructured":"Noguchi E, Nukaga\u2013Nishio Y, Jian Z, Yokouchi Y, Kamioka M, Yamakawa\u2013Kobayashi K, Hamaguchi H, Matsui A, Shibasaki M, Arinami T (2001) Haplotypes of the 5\u2032 region of the IL\u20134 gene and SNPs in the intergene sequence between the IL\u20134 and IL\u201313 genes are associated with atopic asthma. Hum Immunol 62:1251\u20131257","journal-title":"Hum mmunol"},{"key":"47_CR14","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/gepi.10182","volume":"23","author":"DL DeMeo","year":"2002","unstructured":"DeMeo DL, Lange C, Silverman EK, Senter JM, Drazen JM, Barth MJ, Laird N, Weiss ST (2002) Univariate and multivariate family-based association analysis of the IL\u201313 ARG130GLN polymorphism in the Childhood Asthma Management Program. Genet Epidemiol 23:335\u2013348","journal-title":"Genet Epidemiol"},{"key":"47_CR15","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0923-1811(02)00065-8","volume":"30","author":"Y Tsunemi","year":"2002","unstructured":"Tsunemi Y, Saeki H, Nakamura K, Sekiya T, Hirai K, Kakinuma T, Fujita H, Asano N, Tanida Y, Wakugawa M, Torii H, Tamaki K (2002) Interleukin\u201313 gene polymorphism G4257A is associated with atopic dermatitis in Japanese patients. J Dermatol Sci 30:100\u2013107","journal-title":"J Dermatol Sci"},{"key":"47_CR16","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/j.1398-9995.2005.00816.x","volume":"60","author":"HL Qiao","year":"2005","unstructured":"Qiao HL, Yang J, Zhang YW (2005) Relationships between specific serum IgE, cytokines, and polymorphisms in the IL\u20134, IL\u20134R in patients with penicillins allergy. Allergy 60:1053\u20131059","journal-title":"Allergy"},{"key":"47_CR17","first-page":"1904","volume":"116","author":"YX Zhao","year":"2003","unstructured":"Zhao YX, Qiao HL (2003) Detection of specific IgE antibodies to major and minor antigenic determinants in sera of penicillin allergic patients. Chin Med J (Engl) 116:1904\u20131910","journal-title":"Chin Med J(Engl)"},{"key":"47_CR18","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1111\/j.1398-9995.2004.00625.x","volume":"59","author":"HL Qiao","year":"2004","unstructured":"Qiao HL, Yang J, Zhang YW (2004) Specific serum IgE levels and Fc\u025bR\u25a1\u03b2genetic polymorphism in patients with penicillins allergy. Allergy 59:1326\u20131332","journal-title":"Allergy"},{"key":"47_CR19","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1093\/nar\/3.9.2303","volume":"3","author":"N Blin","year":"1976","unstructured":"Blin N, Stafford DW (1976) A general method for isolation of high molecular weight DNA from eukaryotes. Nucleic Acids Res 3:2303\u20132308","journal-title":"Nucleic Acids Res"},{"issue":"Suppl 2","key":"47_CR20","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1365-2222.1995.tb00428.x","volume":"25","author":"LJ Rosenwasser","year":"1995","unstructured":"Rosenwasser LJ, Klemm DJ, Dresback Jk, Inamura H, Mascali JJ, Klinnert M, Borish L (1995) Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy. Clin Exp Allergy25 (Suppl 2):74\u201378","journal-title":"Clin Exp Allergy"},{"key":"47_CR21","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1165\/ajrcmb.25.3.4483","volume":"25","author":"TD Howard","year":"2001","unstructured":"Howard TD, Whittaker PA, Zaiman AL, Koppelman GH, Xu J, Hanley MT, Meyers DA, Postma DS, Bleecker ER (2001) Identification and association of polymorphisms in the interleukin\u201313 gene with asthma and atopy in a Dutch population. Am J Respir Cell Mol Biol 25:377\u2013384","journal-title":"Am J Respir Cell Mol Biol"},{"key":"47_CR22","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/85776","volume":"27","author":"L Kruglyak","year":"2001","unstructured":"Kruglyak L, Nickerson DA (2001) Variation is the spice of life. Nat Genet 27:234\u2013236","journal-title":"Nat Genet"},{"key":"47_CR23","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/sj.gene.6363630","volume":"1","author":"TC Pouw Kraan van der","year":"1999","unstructured":"van der Pouw Kraan TC, van Veen A, Boeije LC, van Tuyl SA, de Groot ER, Stapel SO, Bakker A, Verweij CL, Aarden LA, van der Zee JS (1999) An IL\u201313 promoter polymorphism associated with increased risk of allergic asthma. Genes Immun 1:61\u201365","journal-title":"Genes Immun"},{"key":"47_CR24","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1067\/mai.2000.107935","volume":"106","author":"X Liu","year":"2000","unstructured":"Liu X, Nickel R, Beyer K, Wahn U, Ehrlich E, Freidhoff LR, Bjorksten B, Beaty TH, Huang SK (2000) An IL13 coding region variant is associated with a high total serum IgE level and atopic dermatitis in the German multicenter atopy study (MAS\u201390). J Allergy Clin Immunol 106: 167\u2013170","journal-title":"J Allergy Clin Immunol"},{"key":"47_CR25","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/S0923-1811(02)00065-8","volume":"30","author":"Y Tsunemi","year":"2002","unstructured":"Tsunemi Y, Saeki H, Nakamura K, Sekiya T, Hirai K, Kakinuma T, Fujita H, Asano N, Tanida Y, Wakugawa M, Torii H, Tamaki K (2002) Interleukin\u201313 gene polymorphism G4257A is associated with atopic dermatitis in Japanese patients.J Dermatol Sci 30:100\u2013107","journal-title":"J Dermatol Sci"},{"key":"47_CR26","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1046\/j.1365-2222.2002.01348.x","volume":"32","author":"JC Celedon","year":"2002","unstructured":"Celedon JC, Soto\u2013Quiros ME, Palmer LJ, Senter J, Mosley J, Silverman EK, Weiss ST (2002) Lack of association between a polymorphism in the interleukin\u201313 gene and total serum immunoglobulin E level among nuclear families in Costa Rica. Clin Exp Allergy 32:387\u2013390","journal-title":"Clin Exp Allergy"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-005-0047-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00228-005-0047-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-005-0047-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T12:51:18Z","timestamp":1558702278000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00228-005-0047-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,17]]},"references-count":26,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["47"],"URL":"https:\/\/doi.org\/10.1007\/s00228-005-0047-1","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,17]]}}}