{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,25]],"date-time":"2026-01-25T13:42:45Z","timestamp":1769348565888,"version":"3.49.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"8","license":[{"start":{"date-parts":[[2006,6,22]],"date-time":"2006-06-22T00:00:00Z","timestamp":1150934400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1007\/s00228-006-0151-x","type":"journal-article","created":{"date-parts":[[2006,6,21]],"date-time":"2006-06-21T13:14:57Z","timestamp":1150895697000},"page":"667-674","source":"Crossref","is-referenced-by-count":29,"title":["Patterns and utilization of isotretinoin for acne from 1984 to 2003: is there need for concern?"],"prefix":"10.1007","volume":"62","author":[{"given":"Laurent","family":"Azoulay","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Driss","family":"Oraichi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anick","family":"B\u00e9rard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2006,6,22]]},"reference":[{"key":"151_CR1","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1067\/S0190-9622(03)01584-6","volume":"49","author":"AB Fleischer Jr","year":"2003","unstructured":"Fleischer AB Jr, Simpson JK, McMichael A, Feldman SR (2003) Are there racial and sex differences in the use of oral isotretinoin for acne management in the United States? J Am Acad Dermatol 49:662\u2013666","journal-title":"J Am Acad Dermatol"},{"key":"151_CR2","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1067\/mjd.2002.120529","volume":"46","author":"DK Wysowski","year":"2002","unstructured":"Wysowski DK, Swann J, Vega A (2002) Use of isotretinoin (Accutane) in the United States: rapid increase from 1992 through 2000. J Am Acad Dermatol 46:505\u2013509","journal-title":"J Am Acad Dermatol"},{"key":"151_CR3","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S0140-6736(83)90538-X","volume":"2","author":"FW Rosa","year":"1983","unstructured":"Rosa FW (1983) Teratogenicity of isotretinoin. Lancet 2:513","journal-title":"Lancet"},{"key":"151_CR4","doi-asserted-by":"crossref","first-page":"3267","DOI":"10.1001\/jama.1984.03340480049027","volume":"251","author":"PJ Benke","year":"1984","unstructured":"Benke PJ (1984) The isotretinoin teratogen syndrome. JAMA 251:3267\u20133269","journal-title":"JAMA"},{"key":"151_CR5","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1542\/peds.74.3.428","volume":"74","author":"E Cruz de la","year":"1984","unstructured":"de la Cruz E, Sun S, Vangvanichyakorn K, Desposito F (1984) Multiple congenital malformations associated with maternal isotretinoin therapy. Pediatrics 74:428\u2013430","journal-title":"Pediatrics"},{"key":"151_CR6","first-page":"273","volume":"131","author":"DP Zarowny","year":"1984","unstructured":"Zarowny DP (1984) Accutane Roche: risk of teratogenic effects. Can Med Assoc J 131:273","journal-title":"Can Med Assoc J"},{"key":"151_CR7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1056\/NEJM199507133330206","volume":"333","author":"AA Mitchell","year":"1995","unstructured":"Mitchell AA, Van Bennekom CM, Louik C (1995) A pregnancy-prevention program in women of childbearing age receiving isotretinoin. N Engl J Med 333:101\u2013106","journal-title":"N Engl J Med"},{"key":"151_CR8","first-page":"1719","volume":"160","author":"G Atanackovic","year":"1999","unstructured":"Atanackovic G, Koren G (1999) Fetal exposure to oral isotretinoin: failure to comply with the Pregnancy Prevention Program. CMAJ 160:1719\u20131720","journal-title":"CMAJ"},{"key":"151_CR9","doi-asserted-by":"crossref","first-page":"S150","DOI":"10.1067\/mjd.2001.113717","volume":"45","author":"CN Ellis","year":"2001","unstructured":"Ellis CN, Krach KJ (2001) Uses and complications of isotretinoin therapy. J Am Acad Dermatol 45:S150\u2013S157","journal-title":"J Am Acad Dermatol"},{"key":"151_CR10","first-page":"41","volume":"16","author":"S Wert","year":"2003","unstructured":"Wert S (2003) Identification and management of oral isotretinoin use inconsistent with product labeling. Manag Care Interface 16:41\u201343, 55","journal-title":"Manag Care Interface"},{"key":"151_CR11","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1503\/cmaj.1040317","volume":"170","author":"G Koren","year":"2004","unstructured":"Koren G, Avner M, Shear N (2004) Generic isotretinoin: a new risk for unborn children. CMAJ 170:1567\u20131568","journal-title":"CMAJ"},{"issue":"suppl","key":"151_CR12","first-page":"1","volume":"12","author":"V Ho","year":"1995","unstructured":"Ho V, Schachter D, Miller R (1995) Acne management for the 90s: Current treatment guidelines. Can J Diagnosis 12(suppl):1\u201325","journal-title":"Can J Diagnosis"},{"key":"151_CR13","first-page":"1","volume":"6","author":"JK Tan","year":"2000","unstructured":"Tan JK (2000) Perspectives on isotretinoin and the Canadian Consensus Guidelines on treatment of acne. Skin Therapy Lett 6:1\u20134","journal-title":"Skin Therapy Lett"},{"issue":"Suppl 1","key":"151_CR14","first-page":"S2","volume":"4","author":"WS Madden","year":"2000","unstructured":"Madden WS, Landells ID, Poulin Y, Searles GE, Smith KC, Tan JK, Toole J, Zip CM, Degreef H (2000) Treatment of acne vulgaris and prevention of acne scarring: Canadian consensus guidelines. J Cutan Med Surg 4(Suppl 1):S2\u2013S13","journal-title":"J Cutan Med Surg"},{"key":"151_CR15","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S0190-9622(08)80509-9","volume":"25","author":"S Gatti","year":"1991","unstructured":"Gatti S, Serri F (1991) Acute depression from isotretinoin. J Am Acad Dermatol 25:132","journal-title":"J Am Acad Dermatol"},{"key":"151_CR16","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3810\/pgm.1998.10.1768","volume":"104","author":"L Citrome","year":"1998","unstructured":"Citrome L (1998) Safety of Accutane with possible depression. Postgrad Med 104:38","journal-title":"Postgrad Med"},{"key":"151_CR17","first-page":"7290","volume":"160","author":"JB Jensen","year":"1998","unstructured":"Jensen JB (1998) [Isotretinoin (Roaccutan) and depression]. Ugeskr Laeger 160:7290\u20137291","journal-title":"Ugeskr Laeger"},{"key":"151_CR18","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1067\/mjd.2001.117730","volume":"45","author":"DK Wysowski","year":"2001","unstructured":"Wysowski DK, Pitts M, Beitz J (2001) An analysis of reports of depression and suicide in patients treated with isotretinoin. J Am Acad Dermatol 45:515\u2013519","journal-title":"J Am Acad Dermatol"},{"key":"151_CR19","unstructured":"Important safety information on Accutane [Dear Healthcare Professional Letter]. Hoffman-La Roche Limited. Mississauga (ON), 2001. (Health Canada)"},{"key":"151_CR20","first-page":"47","volume":"138","author":"DJ Hogan","year":"1988","unstructured":"Hogan DJ, Strand LM, Lane PR (1988) Isotretinoin therapy for acne: a population-based study. CMAJ 138:47\u201350","journal-title":"CMAJ"},{"key":"151_CR21","first-page":"1231","volume":"136","author":"SS Jick","year":"2000","unstructured":"Jick SS, Kremers HM, Vasilakis-Scaramozza C (2000) Isotretinoin use and risk of depression, psychotic symptoms, suicide, and attempted suicide. Arch Dermatol 136:1231\u20131236","journal-title":"Arch Dermatol"},{"key":"151_CR22","unstructured":"R\u00e9gie de l\u2019assurance maladie du Qu\u00e9bec. Statistiques annuelles. Government of Quebec, 1997"},{"key":"151_CR23","unstructured":"World Health Organization. International Classification of Diseases, Ninth Revision (ICD-9). World Health Organization, 1977"},{"key":"151_CR24","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1016\/0895-4356(94)00234-H","volume":"48","author":"R Tamblyn","year":"1995","unstructured":"Tamblyn R, Lavoie G, Petrella L, Monette J (1995) The use of prescription claims databases in pharmacoepidemiological research: the accuracy and comprehensiveness of the prescription claims database in Quebec. J Clin Epidemiol 48:999\u20131009","journal-title":"J Clin Epidemiol"},{"key":"151_CR25","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0895-4356(99)00136-5","volume":"53","author":"R Tamblyn","year":"2000","unstructured":"Tamblyn R, Reid T, Mayo N, McLeod P, Churchill-Smith M (2000) Using medical services claims to assess injuries in the elderly: sensitivity of diagnostic and procedure codes for injury ascertainment. J Clin Epidemiol 53:183\u2013194","journal-title":"J Clin Epidemiol"},{"key":"151_CR26","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1093\/oxfordjournals.aje.a117651","volume":"142","author":"AR Levy","year":"1995","unstructured":"Levy AR, Mayo NE, Grimard G (1995) Rates of transcervical and pertrochanteric hip fractures in the province of Quebec, Canada, 1981\u20131992. Am J Epidemiol 142:428\u2013436","journal-title":"Am J Epidemiol"},{"key":"151_CR27","volume-title":"Product labeling for isotretinoin","author":"Physicians Desk Reference","year":"2001","unstructured":"Physicians Desk Reference (2001) Product labeling for isotretinoin. Medical Economics, Montvale, N.J."},{"key":"151_CR28","first-page":"1","volume":"9","author":"RA Kunynetz","year":"2004","unstructured":"Kunynetz RA (2004) A review of systemic retinoid therapy for acne and related conditions. Skin Therapy Lett 9:1\u20134","journal-title":"Skin Therapy Lett"},{"key":"151_CR29","unstructured":"R\u00e9gie de l\u2019assurance maladie du Qu\u00e9bec. Statistiques annuelles. Government of Quebec, 2003"},{"key":"151_CR30","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1080\/01621459.1975.10480264","volume":"70","author":"GEP Box","year":"1975","unstructured":"Box GEP, Tiao GC (1975) Intervention analysis with applications to economic and environmental problems. J Am Stat Assoc 70:70\u201379","journal-title":"J Am Stat Assoc"},{"key":"151_CR31","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1067\/mjd.2000.110901","volume":"43","author":"RS Stern","year":"2000","unstructured":"Stern RS (2000) Medication and medical service utilization for acne 1995\u20131998. J Am Acad Dermatol 43:1042\u20131048","journal-title":"J Am Acad Dermatol"},{"key":"151_CR32","doi-asserted-by":"crossref","first-page":"272","DOI":"10.18553\/jmcp.2002.8.4.272","volume":"8","author":"K Chen","year":"2002","unstructured":"Chen K, White TJ, Juzba M, Chang E (2002) Oral isotretinoin: an analysis of its utilization in a managed care organization. J Manag Care Pharm 8:272\u2013277","journal-title":"J Manag Care Pharm"},{"key":"151_CR33","first-page":"871","volume":"45","author":"L Hatcher","year":"1999","unstructured":"Hatcher L (1999) Who\u2019s heard of the Pregnancy Prevention Program? Can Fam Physician 45:871\u2013872","journal-title":"Can Fam Physician"},{"key":"151_CR34","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1001\/jama.282.15.1458","volume":"282","author":"MD Cabana","year":"1999","unstructured":"Cabana MD, Rand CS, Powe NR, Wu AW, Wilson MH, Abboud PA, Rubin HR (1999) Why don\u2019t physicians follow clinical practice guidelines? A framework for improvement. JAMA 282:1458\u20131465","journal-title":"JAMA"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-006-0151-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00228-006-0151-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-006-0151-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,5,7]],"date-time":"2023-05-07T20:06:45Z","timestamp":1683490005000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00228-006-0151-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6,22]]},"references-count":34,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["151"],"URL":"https:\/\/doi.org\/10.1007\/s00228-006-0151-x","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6,22]]}}}