{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,6]],"date-time":"2026-09-06T18:21:56Z","timestamp":1788718916206,"version":"build-2803163510"},"reference-count":27,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2009,2,28]],"date-time":"2009-02-28T00:00:00Z","timestamp":1235779200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2009,4]]},"DOI":"10.1007\/s00228-009-0614-y","type":"journal-article","created":{"date-parts":[[2009,2,27]],"date-time":"2009-02-27T06:13:14Z","timestamp":1235715194000},"page":"343-353","source":"Crossref","is-referenced-by-count":22,"title":["Onset of analgesia with sodium ibuprofen, ibuprofen acid incorporating poloxamer and acetaminophen\u2014a single-dose, double-blind, placebo-controlled study in patients with post-operative dental pain"],"prefix":"10.1007","volume":"65","author":[{"given":"Stephen","family":"Daniels","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandie","family":"Reader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phillip","family":"Berry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Goulder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2009,2,28]]},"reference":[{"key":"614_CR1","unstructured":"Sweetman SC (ed) (2002) Ibuprofen. In: Martindale: the complete drug reference, 33rd edn. Pharmaceutical Press, London"},{"key":"614_CR2","doi-asserted-by":"crossref","first-page":"257","DOI":"10.14219\/jada.archive.1990.0237","volume":"121","author":"DR Mehlisch","year":"1990","unstructured":"Mehlisch DR, Sollecito WA, Helfrick JF et al (1990) Multicenter clinical trial of ibuprofen and acetaminophen in the treatment of postoperative dental pain. J Am Dent Assoc 121:257\u2013263","journal-title":"J Am Dent Assoc"},{"key":"614_CR3","first-page":"628","volume":"61","author":"S Roy","year":"1983","unstructured":"Roy S (1983) A double-blind comparison of propionic acid derivative (ibuprofen) and a fenamate (mefanamic acid) in the treatment of dysmenorrhoea. Obstet Gynecol 61:628\u2013632","journal-title":"Obstet Gynecol"},{"key":"614_CR4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1177\/030006059101900205","volume":"19","author":"M Moran","year":"1991","unstructured":"Moran M (1991) Double-blind comparison of diclofenac potassium, ibuprofen and placebo in the treatment of ankle sprain. J Int Med Res 19:121\u2013130","journal-title":"J Int Med Res"},{"key":"614_CR5","first-page":"685","volume":"34","author":"CB Goswick","year":"1983","unstructured":"Goswick CB (1983) Ibuprofen versus propoxyphene hydrochloride and placebo in acute musculoskeletal trauma. Curr Ther Res Clin Exp 34:685\u2013692","journal-title":"Curr Ther Res Clin Exp"},{"key":"614_CR6","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1111\/j.1526-4610.1988.hed2807471.x","volume":"28","author":"BP Schachtel","year":"1988","unstructured":"Schachtel BP, Thoden WR (1988) Onset of action of ibuprofen in the treatment of muscle-contraction headache. Headache 28:471\u2013474","journal-title":"Headache"},{"key":"614_CR7","first-page":"465","volume":"227","author":"I Pearce","year":"1983","unstructured":"Pearce I, Frank GJ, Pearce JMS (1983) Ibuprofen compared with acetaminophen in migraine. Practitioner 227:465\u2013467","journal-title":"Practitioner"},{"key":"614_CR8","doi-asserted-by":"crossref","unstructured":"Dewland P, Reader S, Berry P (2008) Bioavailability of ibuprofen following oral administration of standard ibuprofen, sodium ibuprofen or ibuprofen acid incorporating poloxamer in healthy volunteers. Eur J Clin Pharmacol (submitted)","DOI":"10.1186\/1472-6904-9-19"},{"key":"614_CR9","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/BF03258452","volume":"5","author":"G Geisslinger","year":"1993","unstructured":"Geisslinger G, Menzel S, Wissel K, Brune K (1993) Single dose pharmacokinetics of different formulations of ibuprofen and aspirin. Drug Invest 5:238\u2013242","journal-title":"Drug Invest"},{"key":"614_CR10","doi-asserted-by":"crossref","first-page":"89","DOI":"10.5414\/CPP45089","volume":"45","author":"P Schleier","year":"2007","unstructured":"Schleier P, Prochnau A, Schmidt-Westhausen AM et al (2007) Ibuprofen sodium dihydrate, an ibuprofen formulation with improved absorption characteristics, provides faster and greater pain relief than ibuprofen acid. Int J Clin Pharmacol Ther 45:89\u201397","journal-title":"Int J Clin Pharmacol Ther"},{"key":"614_CR11","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/S0149-2918(02)80020-0","volume":"24","author":"P Black","year":"2002","unstructured":"Black P, Max MB, Desjardins P et al (2002) A randomized, double-blind, placebo-controlled comparison of the analgesic efficacy, onset of action, and tolerability of ibuprofen arginate and ibuprofen in postoperative dental pain. Clin Ther 24:1072\u20131089","journal-title":"Clin Ther"},{"key":"614_CR12","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s00228-002-0491-0","volume":"58","author":"P Desjardins","year":"2002","unstructured":"Desjardins P, Black P, Papageorge M et al (2002) Ibuprofen arginate provides effective relief from postoperative dental pain with a more rapid onset of action than ibuprofen. Eur J Clin Pharmacol 58:387\u2013394","journal-title":"Eur J Clin Pharmacol"},{"key":"614_CR13","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/S0002-9343(84)80017-0","volume":"77","author":"KS Albert","year":"1984","unstructured":"Albert KS, Gernaat CM (1984) Pharmacokinetics of ibuprofen. Am J Med 77:40\u201346","journal-title":"Am J Med"},{"key":"614_CR14","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2165\/00003088-199834020-00002","volume":"34","author":"NM Davies","year":"1998","unstructured":"Davies NM (1998) Clinical pharmacokinetics of ibuprofen. The first 30\u00a0years. Clin Pharmacokinet 34:101\u2013114","journal-title":"Clin Pharmacokinet"},{"key":"614_CR15","first-page":"232","volume":"35","author":"SA Cooper","year":"1984","unstructured":"Cooper SA, Precheur H, Rauch D et al (1984) The analgesic efficacy of ibuprofen compared to acetaminophen with codeine (abstract). Clin Pharmacol Ther 35:232","journal-title":"Clin Pharmacol Ther"},{"key":"614_CR16","first-page":"89","volume":"7","author":"D Mehlisch","year":"1984","unstructured":"Mehlisch D, Frakes L (1984) A controlled comparative evaluation of acetaminophen and aspirin in the treatment of post-operative pain. Clin Ther Exerpta Med 7:89\u201397","journal-title":"Clin Ther Exerpta Med"},{"key":"614_CR17","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/107327489900602S01","volume":"6","author":"D Mehlisch","year":"1999","unstructured":"Mehlisch D, Markenson J Schnitzer T (1999) The efficacy of nonsteroidal anti-inflammatory drugs for acute pain. Cancer Control 6:5\u20139","journal-title":"Cancer Control"},{"key":"614_CR18","doi-asserted-by":"crossref","first-page":"611","DOI":"10.14219\/jada.archive.2002.0237","volume":"133","author":"SE Daniels","year":"2002","unstructured":"Daniels SE, Desjardins PJ, Talwalker S et al (2002) The analgesic efficacy of valdecoxib vs. oxycodone\/acetaminophen after oral surgery. J Am Dental Assoc 133:611\u2013621","journal-title":"J Am Dental Assoc"},{"key":"614_CR19","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1177\/009127002401102821","volume":"42","author":"DR Mehlisch","year":"2002","unstructured":"Mehlisch DR, Ardia A, Pallotta T (2002) A controlled comparative study of ibuprofen arginate versus conventional ibuprofen in the treatment of postoperative dental pain. J Clin Pharmacol 42:904\u2013911","journal-title":"J Clin Pharmacol"},{"key":"614_CR20","unstructured":"World Medical Association (1964) Declaration of Helsinki: Ethical principles for medical research involving human patients. Adopted by the 18th WMA General Assembly 1964 and amended by the 29th, 35th, 41st and 48th WMA General Assemblies"},{"key":"614_CR21","unstructured":"European Parliament and Council of 4 April 2001 (2001) Directive 2001\/20\/EC of the approximation of the laws, regulations and administrative provisions of the Member States relating to the implementation of good clinical practice in the conduct of clinical trials on medicinal products for human use. Official Journal of the European Communities, Brussels"},{"key":"614_CR22","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1016\/0149-2918(95)80063-8","volume":"17","author":"DR Mehlisch","year":"1995","unstructured":"Mehlisch DR, Jasper RD, Brown P et al (1995) Comparative study of ibuprofen lysine and acetaminophen in patients with postoperative dental pain. Clin Ther 17:852\u2013860","journal-title":"Clin Ther"},{"key":"614_CR23","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1177\/00912700122012797","volume":"41","author":"NZ Olson","year":"2001","unstructured":"Olson NZ, Otero AM, Marrero I et al (2001) Onset of analgesia for liquigel ibuprofen 400\u00a0mg, acetaminophen 1000\u00a0mg, ketoprofen 25\u00a0mg, and placebo in the treatment of postoperative dental pain. J Clin Pharmacol 41:1238\u20131247","journal-title":"J Clin Pharmacol"},{"key":"614_CR24","first-page":"913","volume":"71","author":"C Sachs","year":"2005","unstructured":"Sachs C (2005) Oral analgesics for acute nonspecific pain. Am Fam Physician 71:913\u2013918","journal-title":"Am Fam Physician"},{"key":"614_CR25","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1046\/j.1365-2036.1999.00539.x","volume":"13","author":"G Doyle","year":"1999","unstructured":"Doyle G, Furey S, Berlin R et al (1999) Gastrointestinal safety and tolerance of ibuprofen at maximum over-the-counter dose. Aliment Pharmacol Ther 13:897\u2013906","journal-title":"Aliment Pharmacol Ther"},{"key":"614_CR26","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1136\/bmj.312.7046.1563","volume":"312","author":"D Henry","year":"1996","unstructured":"Henry D, Lim LL, Garcia Rodriguez LA et al (1996) Variability in risk of gastrointestinal complications with individual non-steroidal anti-inflammatory drugs: results of collaborative met-analysis. Br Med J 312:1563\u20131566","journal-title":"Br Med J"},{"key":"614_CR27","first-page":"43","volume":"135","author":"D Henry","year":"2003","unstructured":"Henry D, McGettigan P (2003) Epidemiology overview of gastrointestinal and renal toxicity of NSAIDs. Int J Clin Pract 135:43\u201349","journal-title":"Int J Clin Pract"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-009-0614-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00228-009-0614-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-009-0614-y","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T12:51:56Z","timestamp":1558702316000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00228-009-0614-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,2,28]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2009,4]]}},"alternative-id":["614"],"URL":"https:\/\/doi.org\/10.1007\/s00228-009-0614-y","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,2,28]]}}}