{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T22:31:46Z","timestamp":1792621906813,"version":"4.5.0"},"reference-count":62,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2010,2,26]],"date-time":"2010-02-26T00:00:00Z","timestamp":1267142400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1007\/s00228-010-0794-5","type":"journal-article","created":{"date-parts":[[2010,2,25]],"date-time":"2010-02-25T12:16:09Z","timestamp":1267100169000},"page":"359-368","source":"Crossref","is-referenced-by-count":83,"title":["Synergy of fosfomycin with other antibiotics for Gram-positive and Gram-negative bacteria"],"prefix":"10.1007","volume":"66","author":[{"given":"Antonia C.","family":"Kastoris","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Petros I.","family":"Rafailidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evridiki K.","family":"Vouloumanou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis D.","family":"Gkegkes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew E.","family":"Falagas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2010,2,26]]},"reference":[{"key":"794_CR1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1586\/14787210.6.5.593","volume":"6","author":"ME Falagas","year":"2008","unstructured":"Falagas ME, Grammatikos AP, Michalopoulos A (2008) Potential of old-generation antibiotics to address current need for new antibiotics. Expert Rev Anti Infect Ther 6:593\u2013600","journal-title":"Expert Rev Anti Infect Ther"},{"key":"794_CR2","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1086\/429323","volume":"40","author":"ME Falagas","year":"2005","unstructured":"Falagas ME, Kasiakou SK (2005) Colistin: the revival of polymyxins for the management of multidrug-resistant gram-negative bacterial infections. Clin Infect Dis 40:1333\u20131341","journal-title":"Clin Infect Dis"},{"key":"794_CR3","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1093\/jac\/dkn177","volume":"62","author":"BJ Knottnerus","year":"2008","unstructured":"Knottnerus BJ, Nys S, Ter Riet G, Donker G, Geerlings SE, Stobberingh E (2008) Fosfomycin tromethamine as second agent for the treatment of acute, uncomplicated urinary tract infections in adult female patients in the Netherlands? J Antimicrob Chemother 62:356\u2013359","journal-title":"J Antimicrob Chemother"},{"key":"794_CR4","doi-asserted-by":"crossref","first-page":"637","DOI":"10.2165\/00003495-199753040-00007","volume":"53","author":"SS Patel","year":"1997","unstructured":"Patel SS, Balfour JA, Bryson HM (1997) Fosfomycin tromethamine. A review of its antibacterial activity, pharmacokinetic properties and therapeutic efficacy as a single-dose oral treatment for acute uncomplicated lower urinary tract infections. Drugs 53:637\u2013656","journal-title":"Drugs"},{"key":"794_CR5","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1086\/527442","volume":"46","author":"ME Falagas","year":"2008","unstructured":"Falagas ME, Giannopoulou KP, Kokolakis GN, Rafailidis PI (2008) Fosfomycin: use beyond urinary tract and gastrointestinal infections. Clin Infect Dis 46:1069\u20131077","journal-title":"Clin Infect Dis"},{"key":"794_CR6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.ijantimicag.2009.03.009","volume":"34","author":"ME Falagas","year":"2009","unstructured":"Falagas ME, Kastoris AC, Karageorgopoulos DE, Rafailidis PI (2009) Fosfomycin for the treatment of infections caused by multidrug-resistant non-fermenting Gram-negative bacilli: a systematic review of microbiological, animal and clinical studies. Int J Antimicrob Agents 34:111\u2013120","journal-title":"Int J Antimicrob Agents"},{"key":"794_CR7","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1128\/AAC.01519-08","volume":"53","author":"V Prakash","year":"2009","unstructured":"Prakash V, Lewis JS 2nd, Herrera ML, Wickes BL, Jorgensen JH (2009) Oral and parenteral therapeutic options for outpatient urinary infections caused by enterobacteriaceae producing CTX-M extended-spectrum beta-lactamases. Antimicrob Agents Chemother 53:1278\u20131280","journal-title":"Antimicrob Agents Chemother"},{"key":"794_CR8","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.1001\/archinte.168.17.1897","volume":"168","author":"J Rodriguez-Bano","year":"2008","unstructured":"Rodriguez-Bano J, Alcala JC, Cisneros JM et al (2008) Community infections caused by extended-spectrum beta-lactamase-producing Escherichia coli. Arch Intern Med 168:1897\u20131902","journal-title":"Arch Intern Med"},{"key":"794_CR9","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1159\/000100811","volume":"53","author":"S Yamada","year":"2007","unstructured":"Yamada S, Hyo Y, Ohmori S, Ohuchi M (2007) Role of ciprofloxacin in its synergistic effect with fosfomycin on drug-resistant strains of Pseudomonas aeruginosa. Chemotherapy 53:202\u2013209","journal-title":"Chemotherapy"},{"key":"794_CR10","first-page":"252","volume":"19","author":"JM Sahuquillo Arce","year":"2006","unstructured":"Sahuquillo Arce JM, Colombo Gainza E, Gil Brusola A, Ortiz Estevez R, Canton E, Gobernado M (2006) In vitro activity of linezolid in combination with doxycycline, fosfomycin, levofloxacin, rifampicin and vancomycin against methicillin-susceptible Staphylococcus aureus. Rev Esp Quimioter 19:252\u2013257","journal-title":"Rev Esp Quimioter"},{"key":"794_CR11","first-page":"209","volume":"59","author":"T Mikuniya","year":"2005","unstructured":"Mikuniya T, Kato Y, Kariyama R, Monden K, Hikida M, Kumon H (2005) Synergistic effect of fosfomycin and fluoroquinolones against Pseudomonas aeruginosa growing in a biofilm. Acta Med Okayama 59:209\u2013216","journal-title":"Acta Med Okayama"},{"key":"794_CR12","first-page":"1239","volume":"36","author":"P Pruekprasert","year":"2005","unstructured":"Pruekprasert P, Tunyapanit W (2005) In vitro activity of fosfomycin-gentamicin, fosfomycin-ceftazidime, fosfomycin-imipenem and ceftazidime-gentamicin combinations against ceftazidime-resistant Pseudomonas aeruginosa. SE Asian J Trop Med Public Health 36:1239\u20131242","journal-title":"SE Asian J Trop Med Public Health"},{"key":"794_CR13","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1007\/s10156-003-0266-2","volume":"9","author":"H Nakazawa","year":"2003","unstructured":"Nakazawa H, Kikuchi Y, Honda T, Isago T, Nozaki M (2003) Enhancement of antimicrobial effects of various antibiotics against methicillin-resistant Staphylococcus aureus (MRSA) by combination with fosfomycin. J Infect Chemother 9:304\u2013309","journal-title":"J Infect Chemother"},{"key":"794_CR14","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s101560200004","volume":"8","author":"M Okazaki","year":"2002","unstructured":"Okazaki M, Suzuki K, Asano N et al (2002) Effectiveness of fosfomycin combined with other antimicrobial agents against multidrug-resistant Pseudomonas aeruginosa isolates using the efficacy time index assay. J Infect Chemother 8:37\u201342","journal-title":"J Infect Chemother"},{"key":"794_CR15","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1093\/jac\/48.2.209","volume":"48","author":"K Grif","year":"2001","unstructured":"Grif K, Dierich MP, Pfaller K, Miglioli PA, Allerberger F (2001) In vitro activity of fosfomycin in combination with various antistaphylococcal substances. J Antimicrob Chemother 48:209\u2013217","journal-title":"J Antimicrob Chemother"},{"key":"794_CR16","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1007\/s101560050022","volume":"5","author":"H Hayami","year":"1999","unstructured":"Hayami H, Goto T, Kawahara M, Ohi Y (1999) Activities of beta-lactams, fluoroquinolones, amikacin and fosfomycin alone and in combination against Pseudomonas aeruginosa isolated from complicated urinary tract infections. J Infect Chemother 5:130\u2013138","journal-title":"J Infect Chemother"},{"key":"794_CR17","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1159\/000007121","volume":"44","author":"WH Traub","year":"1998","unstructured":"Traub WH, Scheidhauer R, Leonhard B, Bauer D (1998) Surveillance of Pseudomonas aeruginosa in intensive care units: clusters of nosocomial cross-infection and encounter of a multiple-antibiotic resistant strain. Chemotherapy 44:243\u2013259","journal-title":"Chemotherapy"},{"key":"794_CR18","first-page":"472","volume":"45","author":"P Dubrous","year":"1997","unstructured":"Dubrous P, Cavallo JD, Buisson Y (1997) Sensitivity to fosfomycin of multiresistant serotype 012 Pseudomonas aeruginosa. Multicenter study. Pathol Biol (Paris) 45:472\u2013478","journal-title":"Pathol Biol (Paris)"},{"key":"794_CR19","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1007\/BF01708239","volume":"16","author":"A Ferrara","year":"1997","unstructured":"Ferrara A, Dos Santos C, Cimbro M, Gialdroni Grassi G (1997) Effect of different combinations of sparfloxacin, oxacillin, and fosfomycin against methicillin-resistant staphylococci. Eur J Clin Microbiol Infect Dis 16:535\u2013537","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"794_CR20","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/BF01709477","volume":"16","author":"F Tessier","year":"1997","unstructured":"Tessier F, Quentin C (1997) In vitro activity of fosfomycin combined with ceftazidime, imipenem, amikacin, and ciprofloxacin against Pseudomonas aeruginosa. Eur J Clin Microbiol Infect Dis 16:159\u2013162","journal-title":"Eur J Clin Microbiol Infect Dis"},{"key":"794_CR21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/BF02489184","volume":"3","author":"K Totsuka","year":"1997","unstructured":"Totsuka K, Uchiyama T, Shimizu K, Kanno Y, Takata T, Yoshida T (1997) In vitro combined effects of fosfomycin and \u03b2-lactam antibiotics against penicillin-resistant Streptococcus pneumoniae. J Infect Chemother 3:49\u201354","journal-title":"J Infect Chemother"},{"key":"794_CR22","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/jac\/38.6.1107","volume":"38","author":"L Martinez-Martinez","year":"1996","unstructured":"Martinez-Martinez L, Rodriguez G, Pascual A, Suarez AI, Perea EJ (1996) In-vitro activity of antimicrobial agent combinations against multiresistant Acinetobacter baumannii. J Antimicrob Chemother 38:1107\u20131108","journal-title":"J Antimicrob Chemother"},{"key":"794_CR23","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1089\/mdr.1995.1.185","volume":"1","author":"K Kikuchi","year":"1995","unstructured":"Kikuchi K, Totsuka K, Shimizu K, Ishii T, Yoshida T, Orikasa Y (1995) Effects of combination of benzylpenicillin and fosfomycin on penicillin-resistant Streptococcus pneumoniae. Microb Drug Resist 1:185\u2013189","journal-title":"Microb Drug Resist"},{"key":"794_CR24","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1128\/AAC.39.10.2341","volume":"39","author":"M Pestel","year":"1995","unstructured":"Pestel M, Martin E, Aucouturier C, Lemeland JF, Caron F (1995) In vitro interactions between different beta-lactam antibiotics and fosfomycin against bloodstream isolates of enterococci. Antimicrob Agents Chemother 39:2341\u20132344","journal-title":"Antimicrob Agents Chemother"},{"key":"794_CR25","doi-asserted-by":"crossref","first-page":"2655","DOI":"10.1128\/AAC.38.11.2655","volume":"38","author":"CP Doit","year":"1994","unstructured":"Doit CP, Bonacorsi SP, Fremaux AJ et al (1994) In vitro killing activities of antibiotics at clinically achievable concentrations in cerebrospinal fluid against penicillin-resistant Streptococcus pneumoniae isolated from children with meningitis. Antimicrob Agents Chemother 38:2655\u20132659","journal-title":"Antimicrob Agents Chemother"},{"key":"794_CR26","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1093\/jac\/34.6.899","volume":"34","author":"HB Drugeon","year":"1994","unstructured":"Drugeon HB, Caillon J, Juvin ME (1994) In-vitro antibacterial activity of fusidic acid alone and in combination with other antibiotics against methicillin-sensitive and -resistant Staphylococcus aureus. J Antimicrob Chemother 34:899\u2013907","journal-title":"J Antimicrob Chemother"},{"key":"794_CR27","first-page":"293","volume":"42","author":"J Watine","year":"1994","unstructured":"Watine J, Bourrel C, Dubourdieu B et al (1994) Susceptibility of multiresistant serotype 012 Pseudomonas aeruginosa to fosfomycin in combination with other antibiotics. Pathol Biol (Paris) 42:293\u2013295","journal-title":"Pathol Biol (Paris)"},{"key":"794_CR28","first-page":"483","volume":"40","author":"V Barakett","year":"1992","unstructured":"Barakett V, Lesage D, Delisle F et al (1992) Bacteriostatic activity and killing curves of eight antibiotics against seven strains of penicillin G-resistant pneumococci. Pathol Biol (Paris) 40:483\u2013491","journal-title":"Pathol Biol (Paris)"},{"key":"794_CR29","first-page":"95","volume":"71","author":"JM Hamilton-Miller","year":"1992","unstructured":"Hamilton-Miller JM (1992) In vitro activity of fosfomycin against \u2018problem\u2019 gram-positive cocci. Microbios 71:95\u2013103","journal-title":"Microbios"},{"key":"794_CR30","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1093\/jac\/27.6.809","volume":"27","author":"K Matsuda","year":"1991","unstructured":"Matsuda K, Asahi Y, Sanada M, Nakagawa S, Tanaka N, Inoue M (1991) In-vitro activity of imipenem combined with beta-lactam antibiotics for methicillin-resistant Staphylococcus aureus. J Antimicrob Chemother 27:809\u2013815","journal-title":"J Antimicrob Chemother"},{"key":"794_CR31","first-page":"488","volume":"88","author":"SC Chang","year":"1989","unstructured":"Chang SC, Hsieh WC, Luh KT, Ho SW (1989) Effects of antibiotic combinations on methicillin-resistant Staphylococcus aureus in vitro. Taiwan Yi Xue Hui Za Zhi 88:488\u2013492","journal-title":"Taiwan Yi Xue Hui Za Zhi"},{"key":"794_CR32","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/BF01643498","volume":"17","author":"S Gatermann","year":"1989","unstructured":"Gatermann S, Schulz E, Marre R (1989) The microbiological efficacy of the combination of fosfomycin and vancomycin against clinically relevant staphylococci. Infection 17:35\u201337","journal-title":"Infection"},{"key":"794_CR33","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1128\/AAC.33.4.470","volume":"33","author":"LB Rice","year":"1989","unstructured":"Rice LB, Eliopoulos GM, Moellering RC Jr (1989) In vitro synergism between daptomycin and fosfomycin against Enterococcus faecalis isolates with high-level gentamicin resistance. Antimicrob Agents Chemother 33:470\u2013473","journal-title":"Antimicrob Agents Chemother"},{"key":"794_CR34","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/jac\/22.1.41","volume":"22","author":"VM Figueredo","year":"1988","unstructured":"Figueredo VM, Neu HC (1988) Synergy of ciprofloxacin with fosfomycin in vitro against Pseudomonas isolates from patients with cystic fibrosis. J Antimicrob Chemother 22:41\u201350","journal-title":"J Antimicrob Chemother"},{"key":"794_CR35","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1093\/jac\/19.2.276","volume":"19","author":"RJ Courcol","year":"1987","unstructured":"Courcol RJ, Martin GR (1987) In-vitro activity of the combination of ceftriaxone and fosfomycin against staphylococci. J Antimicrob Chemother 19:276\u2013278","journal-title":"J Antimicrob Chemother"},{"key":"794_CR36","first-page":"507","volume":"35","author":"C David","year":"1987","unstructured":"David C, Combremont AG (1987) In vitro study of a ceftriaxone-fosfomycin combination on 55 strains of methicillin-sensitive and heterogeneous methicillin-resistant Staphylococcus aureus. Pathol Biol (Paris) 35:507\u2013509","journal-title":"Pathol Biol (Paris)"},{"key":"794_CR37","first-page":"839","volume":"35","author":"T May","year":"1987","unstructured":"May T, Weber M, Gerard A et al (1987) Treatment of post-traumatic and post-neurosurgical bacterial meningitis with ceftriaxone alone or in combination with fosfomycin. Pathol Biol (Paris) 35:839\u2013842","journal-title":"Pathol Biol (Paris)"},{"key":"794_CR38","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1007\/BF01644132","volume":"15","author":"U Ullmann","year":"1987","unstructured":"Ullmann U (1987) Synergism between ciprofloxacin and fosfomycin in vitro. Infection 15:264","journal-title":"Infection"},{"key":"794_CR39","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1128\/AAC.30.5.813","volume":"30","author":"E Debbia","year":"1986","unstructured":"Debbia E, Varaldo PE, Schito GC (1986) In vitro activity of imipenem against enterococci and staphylococci and evidence for high rates of synergism with teicoplanin, fosfomycin, and rifampin. Antimicrob Agents Chemother 30:813\u2013815","journal-title":"Antimicrob Agents Chemother"},{"key":"794_CR40","first-page":"479","volume":"34","author":"JP Stahl","year":"1986","unstructured":"Stahl JP, Croize J, Baud A et al (1986) Treatment of neurosurgical bacterial meningitis using the combination of ceftriaxone-fosfomycin. Pathol Biol (Paris) 34:479\u2013482","journal-title":"Pathol Biol (Paris)"},{"key":"794_CR41","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1128\/AAC.30.6.917","volume":"30","author":"Y Utsui","year":"1986","unstructured":"Utsui Y, Ohya S, Magaribuchi T, Tajima M, Yokota T (1986) Antibacterial activity of cefmetazole alone and in combination with fosfomycin against methicillin- and cephem-resistant Staphylococcus aureus. Antimicrob Agents Chemother 30:917\u2013922","journal-title":"Antimicrob Agents Chemother"},{"key":"794_CR42","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1128\/AAC.28.5.689","volume":"28","author":"S Alvarez","year":"1985","unstructured":"Alvarez S, Jones M, Berk SL (1985) In vitro activity of fosfomycin, alone and in combination, against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother 28:689\u2013690","journal-title":"Antimicrob Agents Chemother"},{"issue":"Suppl 1","key":"794_CR43","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.1007\/BF01644232","volume":"13","author":"H Portier","year":"1985","unstructured":"Portier H, Kazmierczak A, Lucht F, Tremeaux JC, Chavanet P, Duez JM (1985) Cefotaxime in combination with other antibiotics for the treatment of severe methicillin-resistant staphylococcal infections. Infection 13(Suppl 1):S123\u2013S128","journal-title":"Infection"},{"key":"794_CR44","first-page":"528","volume":"32","author":"T Fosse","year":"1984","unstructured":"Fosse T, David MF, Duluc F, Darmusey D, Tamalet C, Toga B (1984) In vitro study of the cefamandole-fosfomycin combination against methicillin-resistant staphylococci. Pathol Biol (Paris) 32:528\u2013531","journal-title":"Pathol Biol (Paris)"},{"key":"794_CR45","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1128\/AAC.26.5.789","volume":"26","author":"K Takahashi","year":"1984","unstructured":"Takahashi K, Kanno H (1984) Synergistic activities of combinations of beta-lactams, fosfomycin, and tobramycin against Pseudomonas aeruginosa. Antimicrob Agents Chemother 26:789\u2013791","journal-title":"Antimicrob Agents Chemother"},{"key":"794_CR46","first-page":"169","volume":"24","author":"JC Tremeaux","year":"1983","unstructured":"Tremeaux JC, Duez JM, Pechinot A, Sautreaux JL, Thierry A, Kazmierczak A (1983) [Importance of the cefotaxime-fosfomycin combination. Apropos of a case of meningitis due to heterogeneously resistant Staphylococcus aureus]. Agressologie 24:169\u2013171","journal-title":"Agressologie"},{"key":"794_CR47","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1093\/jac\/4.6.569","volume":"4","author":"T Olay","year":"1978","unstructured":"Olay T, Rodriguez A, Oliver LE, Vicente MV, Quecedo MC (1978) Interaction of fosfomycin with other antimicrobial agents: in vitro and in vivo studies. J Antimicrob Chemother 4:569\u2013576","journal-title":"J Antimicrob Chemother"},{"key":"794_CR48","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1128\/AAC.13.5.705","volume":"13","author":"EJ Perea","year":"1978","unstructured":"Perea EJ, Torres MA, Borobio MV (1978) Synergism of fosfomycin-ampicillin and fosfomycin-chloramphenicol against Salmonella and Shigella. Antimicrob Agents Chemother 13:705\u2013709","journal-title":"Antimicrob Agents Chemother"},{"issue":"Suppl 1","key":"794_CR49","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1159\/000222084","volume":"23","author":"F Baquero","year":"1977","unstructured":"Baquero F, Hortelano JG, Navarro M et al (1977) Antibiotherapy of Serratia marcescens septicemia in children. Chemotherapy 23(Suppl 1):416\u2013422","journal-title":"Chemotherapy"},{"key":"794_CR50","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1086\/520427","volume":"29","author":"JW Warren","year":"1999","unstructured":"Warren JW, Abrutyn E, Hebel JR, Johnson JR, Schaeffer AJ, Stamm WE (1999) Guidelines for antimicrobial treatment of uncomplicated acute bacterial cystitis and acute pyelonephritis in women. Infectious Diseases Society of America (IDSA). Clin Infect Dis 29:745\u2013758","journal-title":"Clin Infect Dis"},{"key":"794_CR51","first-page":"25","volume":"22","author":"M Hernandez","year":"2009","unstructured":"Hernandez M, Garcia J, Munoz J (2009) [In vitro activity of fosfomycin against ESBL-producing enterobacteria of urinary origin.]. Rev Esp Quimioter 22:25\u201329","journal-title":"Rev Esp Quimioter"},{"key":"794_CR52","first-page":"172","volume":"10","author":"JR Zahar","year":"2009","unstructured":"Zahar JR, Lortholary O, Martin C, Potel G, Plesiat P, Nordmann P (2009) Addressing the challenge of extended-spectrum beta-lactamases. Curr Opin Investig Drugs 10:172\u2013180","journal-title":"Curr Opin Investig Drugs"},{"key":"794_CR53","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1093\/jac\/dkl315","volume":"58","author":"MJ Ellington","year":"2006","unstructured":"Ellington MJ, Livermore DM, Pitt TL, Hall LM, Woodford N (2006) Mutators among CTX-M beta-lactamase-producing Escherichia coli and risk for the emergence of fosfomycin resistance. J Antimicrob Chemother 58:848\u2013852","journal-title":"J Antimicrob Chemother"},{"key":"794_CR54","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1128\/AAC.43.4.789","volume":"43","author":"T Horii","year":"1999","unstructured":"Horii T, Kimura T, Sato K, Shibayama K, Ohta M (1999) Emergence of fosfomycin-resistant isolates of Shiga-like toxin-producing Escherichia coli O26. Antimicrob Agents Chemother 43:789\u2013793","journal-title":"Antimicrob Agents Chemother"},{"key":"794_CR55","doi-asserted-by":"crossref","first-page":"2850","DOI":"10.1128\/AAC.47.9.2850-2858.2003","volume":"47","author":"AI Nilsson","year":"2003","unstructured":"Nilsson AI, Berg OG, Aspevall O, Kahlmeter G, Andersson DI (2003) Biological costs and mechanisms of fosfomycin resistance in Escherichia coli. Antimicrob Agents Chemother 47:2850\u20132858","journal-title":"Antimicrob Agents Chemother"},{"key":"794_CR56","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.ijantimicag.2009.08.013","volume":"34","author":"N Roussos","year":"2009","unstructured":"Roussos N, Karageorgopoulos DE, Samonis G, Falagas ME (2009) Clinical significance of the pharmacokinetic and pharmacodynamic characteristics of fosfomycin for the treatment of patients with systemic infections. Int J Antimicrob Agents 34:506\u2013515","journal-title":"Int J Antimicrob Agents."},{"key":"794_CR57","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s10156-002-0186-6","volume":"8","author":"K Monden","year":"2002","unstructured":"Monden K, Ando E, Iida M, Kumon H (2002) Role of fosfomycin in a synergistic combination with ofloxacin against Pseudomonas aeruginosa growing in a biofilm. J Infect Chemother 8:218\u2013226","journal-title":"J Infect Chemother"},{"issue":"Suppl 2","key":"794_CR58","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0924-8579(03)00232-2","volume":"22","author":"A Marchese","year":"2003","unstructured":"Marchese A, Bozzolasco M, Gualco L, Debbia EA, Schito GC, Schito AM (2003) Effect of fosfomycin alone and in combination with N-acetylcysteine on E. coli biofilms. Int J Antimicrob Agents 22(Suppl 2):95\u2013100","journal-title":"Int J Antimicrob Agents"},{"key":"794_CR59","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1248\/bpb1978.5.941","volume":"5","author":"S Inouye","year":"1982","unstructured":"Inouye S, Niizato T, Komiya I, Yuda Y, Yamada Y (1982) Mode of protective action of fosfomycin against dibekacin-induced nephrotoxicity in the dehydrated rats. J Pharmacobiodyn 5:941\u2013950","journal-title":"J Pharmacobiodyn"},{"key":"794_CR60","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s101560170020","volume":"7","author":"Y Yoshiyama","year":"2001","unstructured":"Yoshiyama Y, Yazaki T, Wong PC, Beauchamp D, Kanke M (2001) The effect of fosfomycin on glycopeptide antibiotic-induced nephrotoxicity in rats. J Infect Chemother 7:243\u2013246","journal-title":"J Infect Chemother"},{"key":"794_CR61","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1001\/archotol.1990.01870010053016","volume":"116","author":"JL Leach","year":"1990","unstructured":"Leach JL, Wright CG, Edwards LB, Meyerhoff WL (1990) Effect of topical fosfomycin on polymyxin B ototoxicity. Arch Otolaryngol Head Neck Surg 116:49\u201353","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"794_CR62","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s10096-005-1307-9","volume":"24","author":"A Blacky","year":"2005","unstructured":"Blacky A, Makristathis A, Apfalter P, Willinger B, Rotter ML, Hirschl AM (2005) In vitro activity of fosfomycin alone and in combination with amoxicillin, clarithromycin and metronidazole against Helicobacter pylori compared with combined clarithromycin and metronidazole. Eur J Clin Microbiol Infect Dis 24:276\u2013279","journal-title":"Eur J Clin Microbiol Infect Dis"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-010-0794-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00228-010-0794-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-010-0794-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T12:52:06Z","timestamp":1558702326000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00228-010-0794-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2,26]]},"references-count":62,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["794"],"URL":"https:\/\/doi.org\/10.1007\/s00228-010-0794-5","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,2,26]]}}}