{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T12:23:37Z","timestamp":1763641417781,"version":"3.38.0"},"reference-count":23,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2010,12,14]],"date-time":"2010-12-14T00:00:00Z","timestamp":1292284800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2011,4]]},"DOI":"10.1007\/s00228-010-0964-5","type":"journal-article","created":{"date-parts":[[2010,12,15]],"date-time":"2010-12-15T16:10:20Z","timestamp":1292429420000},"page":"347-353","source":"Crossref","is-referenced-by-count":18,"title":["Genistein alters caffeine exposure in healthy female volunteers"],"prefix":"10.1007","volume":"67","author":[{"given":"Yao","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Qiong","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi-Jing","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bi-Lian","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gan","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi-Rong","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li-Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong-Hao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2010,12,14]]},"reference":[{"key":"964_CR1","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/j.watres.2009.03.025","volume":"44","author":"ZH Liu","year":"2010","unstructured":"Liu ZH, Kanjo Y, Mizutani S (2010) A review of phytoestrogens: their occurrence and fate in the environment. Water Res 44:567\u2013577","journal-title":"Water Res"},{"key":"964_CR2","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1210\/jc.2008-0735","volume":"94","author":"P Villa","year":"2009","unstructured":"Villa P, Costantini B, Suriano R et al (2009) The differential effect of the phytoestrogen genistein on cardiovascular risk factors in postmenopausal women: relationship with the metabolic status. J Clin Endocrinol Metab 94:552\u2013558","journal-title":"J Clin Endocrinol Metab"},{"key":"964_CR3","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.jsbmb.2008.10.001","volume":"112","author":"LM Scott","year":"2008","unstructured":"Scott LM, Durant P, Leone-Kabler S et al (2008) Effects of prior oral contraceptive use and soy isoflavonoids on estrogen-metabolizing cytochrome P450 enzymes. J Steroid Biochem Mol Biol 112:179\u2013185","journal-title":"J Steroid Biochem Mol Biol"},{"key":"964_CR4","doi-asserted-by":"crossref","first-page":"448","DOI":"10.5483\/BMBRep.2006.39.4.448","volume":"39","author":"YH Shon","year":"2006","unstructured":"Shon YH, Park SD, Nam KS (2006) Effective chemopreventive activity of genistein against human breast cancer cells. J Biochem Mol Biol 39:448\u2013451","journal-title":"J Biochem Mol Biol"},{"key":"964_CR5","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0278-6915(97)00171-3","volume":"36","author":"NA Helsby","year":"1998","unstructured":"Helsby NA, Chipman JK, Gescher A et al (1998) Inhibition of mouse and human CYP 1A- and 2E1-dependent substrate metabolism by the isoflavonoids genistein and equol. Food Chem Toxicol 36:375\u2013382","journal-title":"Food Chem Toxicol"},{"key":"964_CR6","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.ijpharm.2007.01.002","volume":"337","author":"X Li","year":"2007","unstructured":"Li X, Choi JS (2007) Effect of genistein on the pharmacokinetics of paclitaxel administered orally or intravenously in rats. Int J Pharm 337:188\u2013193","journal-title":"Int J Pharm"},{"key":"964_CR7","doi-asserted-by":"crossref","first-page":"147","DOI":"10.7326\/0003-4819-114-2-147","volume":"114","author":"MG Myers","year":"1991","unstructured":"Myers MG (1991) Caffeine and cardiac arrhythmias. Ann Intern Med 114:147\u2013150","journal-title":"Ann Intern Med"},{"key":"964_CR8","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1097\/MCO.0b013e3282f05d81","volume":"10","author":"MC Cornelis","year":"2007","unstructured":"Cornelis MC, El-Sohemy A (2007) Coffee, caffeine, and coronary heart disease. Curr Opin Clin Nutr Metab Care 10:745\u2013751","journal-title":"Curr Opin Clin Nutr Metab Care"},{"key":"964_CR9","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1002\/cncr.23275","volume":"112","author":"SS Tworoger","year":"2008","unstructured":"Tworoger SS, Gertig DM, Gates MA et al (2008) Caffeine, alcohol, smoking, and the risk of incident epithelial ovarian cancer. Cancer 112:1169\u20131177","journal-title":"Cancer"},{"key":"964_CR10","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0731-7085(01)00546-5","volume":"27","author":"MS Caubet","year":"2002","unstructured":"Caubet MS, Elbast W, Dubuc MC et al (2002) Analysis of urinary caffeine metabolites by HPLC-DAD: the use of metabolic ratios to assess CYP1A2 enzyme activity. J Pharm Biomed Anal 27:261\u2013270","journal-title":"J Pharm Biomed Anal"},{"key":"964_CR11","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/00008571-199604000-00001","volume":"6","author":"A Rostami-Hodjegan","year":"1996","unstructured":"Rostami-Hodjegan A, Nurminen S, Jackson PR et al (1996) Caffeine urinary metabolite ratios as markers of enzyme activity: a theoretical assessment. Pharmacogenetics 6:121\u2013149","journal-title":"Pharmacogenetics"},{"key":"964_CR12","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1097\/00008571-199406000-00002","volume":"4","author":"BK Tang","year":"1994","unstructured":"Tang BK, Zhou Y, Kadar D et al (1994) Caffeine as a probe for CYP1A2 activity: potential influence of renal factors on urinary phenotypic trait measurements. Pharmacogenetics 4:117\u2013124","journal-title":"Pharmacogenetics"},{"key":"964_CR13","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/clpt.1991.82","volume":"49","author":"BK Tang","year":"1991","unstructured":"Tang BK, Kadar D, Qian L et al (1991) Caffeine as a metabolic probe: validation of its use for acetylator phenotyping. Clin Pharmacol Ther 49:648\u2013657","journal-title":"Clin Pharmacol Ther"},{"key":"964_CR14","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1038\/clpt.1991.176","volume":"50","author":"W Kalow","year":"1991","unstructured":"Kalow W, Tang BK (1991) Use of caffeine metabolite ratios to explore CYP1A2 and xanthine oxidase activities. Clin Pharmacol Ther 50:508\u2013519","journal-title":"Clin Pharmacol Ther"},{"key":"964_CR15","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0731-7085(01)00656-2","volume":"28","author":"P Wong","year":"2002","unstructured":"Wong P, Villeneuve G, Tessier V et al (2002) Stability of 5-acetamido-6-formylamino-3-methyluracil in buffers and urine. J Pharmaceut Biomed 28:693\u2013700","journal-title":"J Pharmaceut Biomed"},{"key":"964_CR16","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1038\/clpt.1983.80","volume":"33","author":"DM Grant","year":"1983","unstructured":"Grant DM, Tang BK, Kalow W (1983) Variability in caffeine metabolism. Clin Pharmacol Ther 33:591\u2013602","journal-title":"Clin Pharmacol Ther"},{"key":"964_CR17","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/00008571-199206000-00003","volume":"2","author":"MA Butler","year":"1992","unstructured":"Butler MA, Lang NP, Young JF et al (1992) Determination of CYP1A2 and NAT2 phenotypes in human populations by analysis of caffeine urinary metabolites. Pharmacogenetics 2:116\u2013127","journal-title":"Pharmacogenetics"},{"key":"964_CR18","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0022-3565(25)38136-X","volume":"265","author":"W Tassaneeyakul","year":"1993","unstructured":"Tassaneeyakul W, Birkett DJ, Veronese ME et al (1993) Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2. J Pharmacol Exp Ther 265:401\u2013407","journal-title":"J Pharmacol Exp Ther"},{"key":"964_CR19","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1016\/S0022-3565(24)36947-2","volume":"282","author":"ES Messina","year":"1997","unstructured":"Messina ES, Tyndale RF, Sellers EM (1997) A major role for CYP2A6 in nicotine C-oxidation by human liver microsomes. J Pharmacol Exp Ther 282:1608\u20131614","journal-title":"J Pharmacol Exp Ther"},{"key":"964_CR20","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0022-3565(24)38154-6","volume":"289","author":"KI Nunoya","year":"1999","unstructured":"Nunoya KI, Yokoi T, Kimura K et al (1999) A new CYP2A6 gene deletion responsible for the in vivo polymorphic metabolism of (+)-cis-3, 5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride in humans. J Pharmacol Exp Ther 289:437\u2013442","journal-title":"J Pharmacol Exp Ther"},{"key":"964_CR21","first-page":"377","volume":"11","author":"S Nowell","year":"2002","unstructured":"Nowell S, Sweeney C, Hammons G et al (2002) CYP2A6 activity determined by caffeine phenotyping: association with colorectal cancer risk. Cancer Epidemiol Biomarkers Prev 11:377\u2013383","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"964_CR22","doi-asserted-by":"crossref","first-page":"3450","DOI":"10.1016\/j.bmc.2007.03.010","volume":"15","author":"JF Hsieh","year":"2007","unstructured":"Hsieh JF, Wu SH, Yang YL et al (2007) The screening and characterization of 6-aminopurine-based xanthine oxidase inhibitors. Bioorg Med Chem 15:3450\u20133456","journal-title":"Bioorg Med Chem"},{"key":"964_CR23","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.neulet.2007.01.078","volume":"416","author":"AA Fatokun","year":"2007","unstructured":"Fatokun AA, Stone TW, Smith RA (2007) Hydrogen peroxide mediates damage by xanthine and xanthine oxidase in cerebellar granule neuronal cultures. Neurosci Lett 416:34\u201338","journal-title":"Neurosci Lett"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-010-0964-5.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00228-010-0964-5\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-010-0964-5","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T21:06:08Z","timestamp":1740776768000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00228-010-0964-5"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,12,14]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,4]]}},"alternative-id":["964"],"URL":"https:\/\/doi.org\/10.1007\/s00228-010-0964-5","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"type":"print","value":"0031-6970"},{"type":"electronic","value":"1432-1041"}],"subject":[],"published":{"date-parts":[[2010,12,14]]}}}