{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2022,4,2]],"date-time":"2022-04-02T23:44:57Z","timestamp":1648943097282},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2011,4,5]],"date-time":"2011-04-05T00:00:00Z","timestamp":1301961600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1007\/s00228-011-1036-1","type":"journal-article","created":{"date-parts":[[2011,4,4]],"date-time":"2011-04-04T09:28:48Z","timestamp":1301909328000},"page":"563-571","source":"Crossref","is-referenced-by-count":3,"title":["Early phase drugs and biologicals clinical trials on worldwide leading causes of death: a descriptive analysis"],"prefix":"10.1007","volume":"67","author":[{"given":"Rafael","family":"Dal-R\u00e9","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,4,5]]},"reference":[{"key":"1036_CR1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.7326\/0003-4819-141-6-200409210-00109","volume":"141","author":"C Angelis De","year":"2004","unstructured":"De Angelis C, Drazen JM, Frizelle FA, Haug C, Hoey J et al International Committee of Medical Journal Editors (2004) Clinical trial registration: a statement from the International Committee of Medical Journal Editors. Ann Intern Med 141:477\u2013478","journal-title":"Ann Intern Med"},{"key":"1036_CR2","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1016\/S0140-6736(05)66589-0","volume":"365","author":"AM Gulmezoglu","year":"2005","unstructured":"Gulmezoglu AM, Pang T, Horton R, Dickersin K (2005) WHO facilitates international collaboration in setting standards for clinical trial registration. Lancet 365:1829\u20131830","journal-title":"Lancet"},{"key":"1036_CR3","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1016\/S0140-6736(06)68708-4","volume":"367","author":"I Sim","year":"2006","unstructured":"Sim I, Chan AW, Gulmezoglu AM, Evans T, Pang T (2006) Clinical trial registration: transparency is the watchword. Lancet 367:1631\u20131633","journal-title":"Lancet"},{"key":"1036_CR4","unstructured":"World Health Organization (2010) International Clinical Trials Registry Platform (ICTRP). http:\/\/www.who.int\/ictrp\/en\/ . Accessed May 10, 2010"},{"key":"1036_CR5","unstructured":"United States National Institutes of Health (2011) ClinicalTrials.gov http:\/\/Clinicaltrials.gov"},{"key":"1036_CR6","doi-asserted-by":"crossref","first-page":"2779","DOI":"10.1056\/NEJMsa053234","volume":"353","author":"DA Zarin","year":"2005","unstructured":"Zarin DA, Tre I, Ide NC (2005) Trial registration at ClinicalTrials.gov between May and October 2005. N Engl J Med 353:2779\u20132787","journal-title":"N Engl J Med"},{"key":"1036_CR7","unstructured":"World Health Organization (2008) Global burden of disease, 2004 update. http:\/\/www.who.int\/healthinfo\/global_burden_disease\/2004_report_update\/en\/index.html . Accessed May 10, 2010"},{"key":"1036_CR8","unstructured":"World Health Organization (2007) International statistical classification of diseases and related health problems, 10th revision. http:\/\/apps.who.int\/classifications\/apps\/icd\/icd10online\/ . Accessed May 10, 2010"},{"key":"1036_CR9","doi-asserted-by":"crossref","first-page":"2112","DOI":"10.1001\/jama.297.19.2112","volume":"297","author":"DA Zarin","year":"2007","unstructured":"Zarin DA, Ide NC, Tse T, Harlan WR, West JC, Lindberg DAB (2007) Issues in the registration of clinical trials. JAMA 297:2112\u20132120","journal-title":"JAMA"},{"issue":"11","key":"1036_CR10","doi-asserted-by":"crossref","first-page":"e442","DOI":"10.1371\/journal.pmed.0030442","volume":"3","author":"CD Mathers","year":"2006","unstructured":"Mathers CD, Loncar D (2006) Projections of global mortality and burden of disease from 2002 to 2030. PLoS Med 3(11):e442","journal-title":"PLoS Med"},{"key":"1036_CR11","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/PPO.0b013e3181bd0445","volume":"15","author":"DS Tan","year":"2009","unstructured":"Tan DS, Thomas GV, Garrett MD, Banerji U, de Bono JS et al (2009) Biomarker-driven early clinical trials in oncology: a paradigm shift in drug development. Cancer J 15:406\u2013420","journal-title":"Cancer J"},{"key":"1036_CR12","doi-asserted-by":"crossref","first-page":"477","DOI":"10.5414\/CPP45477","volume":"45","author":"M M\u00fcllner","year":"2007","unstructured":"M\u00fcllner M, Vamvakas S, Rietschel M, van Zwieten-Boot BJ (2007) Are women appropriately represented and assessed in clinical trials submitted for marketing authorization? A review of the database of the European Medicines Agency. Int J Clin Pharmacol Ther 45:477\u2013484","journal-title":"Int J Clin Pharmacol Ther"},{"key":"1036_CR13","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1089\/jwh.2008.0971","volume":"18","author":"Y Yang","year":"2009","unstructured":"Yang Y, Carlin AS, Faustino PJ, Motta MI, Hamad ML et al (2009) Participation of women in clinical trials for new drugs approved by the Food and Drug Administration in 2000\u20132002. J Womens Health (Larchmt) 18:303\u2013310","journal-title":"J Womens Health (Larchmt)"},{"key":"1036_CR14","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.clpt.2005.08.016","volume":"78","author":"J Fleish","year":"2005","unstructured":"Fleish J, Fleish MC, Th\u00fcrmann PA (2005) Women in early-phase clinical drug trials: have things changed over the past 20\u00a0years? Clin Pharmacol Ther 78:445\u2013452","journal-title":"Clin Pharmacol Ther"},{"key":"1036_CR15","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.whi.2008.09.009","volume":"19","author":"E Pinnow","year":"2009","unstructured":"Pinnow E, Sharma P, Parekh A, Gevorkian N, Uhl K (2009) Increasing participation of women in early phase clinical trials approved by the FDA. Womens Health Issues 19:89\u201393","journal-title":"Womens Health Issues"},{"key":"1036_CR16","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1136\/bmj.331.7524.1036","volume":"331","author":"M McMurdo","year":"2005","unstructured":"McMurdo M, Witham MD, Gillespie ND (2005) Including older people in clinical research. Benefits shown in trials in younger people may not apply to older people. BMJ 331:1036\u20131037","journal-title":"BMJ"},{"key":"1036_CR17","doi-asserted-by":"crossref","first-page":"4626","DOI":"10.1200\/JCO.2004.02.175","volume":"22","author":"L Talarico","year":"2004","unstructured":"Talarico L, Chen G, Pazdur R (2004) Enrollment of elderly patients in clinical trials for cancer drug registration: a 7-year experience by the US Food and Drug Administration. J Clin Oncol 22:4626\u20134631","journal-title":"J Clin Oncol"},{"key":"1036_CR18","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/1471-2407-6-34","volume":"6","author":"CA Townsley","year":"2006","unstructured":"Townsley CA, Chan KK, Pond GR, Marquez C, Siu LL, Straus SE (2006) Understanding the attitudes of the elderly towards enrolment into cancer clinical trials. BMC Cancer 6:34","journal-title":"BMC Cancer"},{"key":"1036_CR19","unstructured":"Best Pharmaceuticals for Children Act, January 4, 2002. Public Law No. 107\u2013109. http:\/\/www.fda.gov\/Drugs\/DevelopmentApprovalProcess\/DevelopmentResources\/ucm049867.htm . Accessed May 10, 2010"},{"key":"1036_CR20","unstructured":"Regulation (EC) No 1901\/2006 of the European Parliament and of the Council of 12 December 2006 on medicinal products for paediatric use and amending Regulation (EEC) No 1768\/92, Directive 2001\/20\/EC, Directive 2001\/83\/EC and Regulation (EC) No 728\/2004. Offic J Eur Union L378:1\u201318"},{"key":"1036_CR21","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s11892-008-0066-2","volume":"8","author":"NS Nader","year":"2008","unstructured":"Nader NS, Kumar S (2008) Type 2 diabetes mellitus in children and adolescents: where do we stand with drug treatment and behavioral management? Curr Diab Rep 8:383\u2013388","journal-title":"Curr Diab Rep"},{"key":"1036_CR22","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.ctrv.2010.02.008","volume":"36","author":"CM Zwaan","year":"2010","unstructured":"Zwaan CM, Kearns P, Caron H, Verschuur A, Riccardi R et al, \u2018Innovative Therapies for Children with Cancer\u2019 European consortium (2010) The role of the \u2018Innovative Therapies for Children with Cancer\u2019 (ITCC) European consortium. Cancer Treat Rev 36:328\u2013334","journal-title":"Cancer Treat Rev"},{"issue":"Suppl 3","key":"1036_CR23","doi-asserted-by":"crossref","first-page":"S184","DOI":"10.1086\/651490","volume":"50","author":"S Swaminathan","year":"2010","unstructured":"Swaminathan S, Rekha B (2010) Pediatric tuberculosis: global overview and challenges. Clin Infect Dis 50(Suppl 3):S184\u2013S194","journal-title":"Clin Infect Dis"},{"key":"1036_CR24","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/COH.0b013e3283339bd8","volume":"5","author":"AH Sohn","year":"2010","unstructured":"Sohn AH, Nuttall JJ, Zhang F (2010) Sequencing of antiretroviral therapy in children in low- and middle-income countries. Curr Opin HIV AIDS 5:54\u201360","journal-title":"Curr Opin HIV AIDS"},{"issue":"Suppl 1","key":"1036_CR25","doi-asserted-by":"crossref","first-page":"i155","DOI":"10.1093\/ije\/dyq032","volume":"39","author":"E Theodoratou","year":"2010","unstructured":"Theodoratou E, Al-Jilaihawi S, Woodward F et al (2010) The effect of case management on childhood pneumonia mortality in developing countries. Int J Epidemiol 39(Suppl 1):i155\u2013i171","journal-title":"Int J Epidemiol"},{"key":"1036_CR26","unstructured":"ICH (1997) International conference on harmonisation of technical requirements for registration of pharmaceuticals for human use. ICH harmonised tripartite guideline. General considerations for clinical trials. ICH topic E8. http:\/\/www.ich.org\/products\/guidelines\/efficacy\/efficacy-single\/article\/general-considerations-for-clinical-trials.html . Accessed May 10, 2010"},{"key":"1036_CR27","unstructured":"Current Controlled Trials Limited (2010) International standard randomised controlled trial number register. http:\/\/www.controlled-trials.com\/ . Accessed March 12, 2010"},{"key":"1036_CR28","first-page":"1407","volume":"345","author":"Anon","year":"2010","unstructured":"Anon (2010) Malaria 2010: more ambition and accountability please. Lancet 345:1407","journal-title":"Lancet"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-011-1036-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00228-011-1036-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-011-1036-1","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T08:48:51Z","timestamp":1558687731000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00228-011-1036-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,4,5]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["1036"],"URL":"https:\/\/doi.org\/10.1007\/s00228-011-1036-1","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4,5]]}}}