{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T20:43:56Z","timestamp":1763585036985},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2011,6,19]],"date-time":"2011-06-19T00:00:00Z","timestamp":1308441600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2011,12]]},"DOI":"10.1007\/s00228-011-1073-9","type":"journal-article","created":{"date-parts":[[2011,6,18]],"date-time":"2011-06-18T06:52:44Z","timestamp":1308379964000},"page":"1213-1221","source":"Crossref","is-referenced-by-count":17,"title":["Determinants of pharmacodynamic trajectory of the therapeutic response to paroxetine in Japanese patients with panic disorder"],"prefix":"10.1007","volume":"67","author":[{"given":"Shin","family":"Ishiguro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mikito","family":"Ueda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Saeki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuki","family":"Hayashi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazufumi","family":"Akiyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsushi","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuko","family":"Kato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshimasa","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutaka","family":"Shimoda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2011,6,19]]},"reference":[{"key":"1073_CR1","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1001\/archpsyc.63.4.415","volume":"63","author":"RC Kessler","year":"2006","unstructured":"Kessler RC, Chiu WT, Jin R, Ruscio AM, Shear K, Walters EE (2006) The epidemiology of panic attacks, panic disorder, and agoraphobia in the National Comorbidity Survey Replication. Arch Gen Psychiatry 63:415\u2013424","journal-title":"Arch Gen Psychiatry"},{"key":"1073_CR2","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1007\/s00127-002-0542-y","volume":"37","author":"P Carlbring","year":"2002","unstructured":"Carlbring P, Gustafsson H, Ekselius L, Andersson G (2002) 12-month prevalence of panic disorder with or without agoraphobia in the Swedish general population. Soc Psychiatry Psychiatr Epidemiol 37:207\u2013211","journal-title":"Soc Psychiatry Psychiatr Epidemiol"},{"key":"1073_CR3","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1001\/archpsyc.1983.01790090027004","volume":"40","author":"RR Crowe","year":"1983","unstructured":"Crowe RR, Noyes R, Pauls DL, Slymen D (1983) A family study of panic disorder. Arch Gen Psychiatry 40:1065\u20131069","journal-title":"Arch Gen Psychiatry"},{"key":"1073_CR4","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/archpsyc.1983.01790090023003","volume":"40","author":"EL Harris","year":"1983","unstructured":"Harris EL, Noyes R Jr, Crowe RR, Chaudhry DR (1983) Family study of agoraphobia. Report of a pilot study. Arch Gen Psychiatry 40:1061\u20131064","journal-title":"Arch Gen Psychiatry"},{"key":"1073_CR5","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1600-0447.1993.tb03419.x","volume":"88","author":"I Skre","year":"1993","unstructured":"Skre I, Onstad S, Torgersen S, Lygren S, Kringlen E (1993) A twin study of DSM-III-R anxiety disorders. Acta Psychiatr Scand 88:85\u201392","journal-title":"Acta Psychiatr Scand"},{"key":"1073_CR6","doi-asserted-by":"crossref","first-page":"1568","DOI":"10.1176\/appi.ajp.158.10.1568","volume":"158","author":"JM Hettema","year":"2001","unstructured":"Hettema JM, Neale MC, Kendler KS (2001) A review and meta-analysis of the genetic epidemiology of anxiety disorders. Am J Psychiatry 158:1568\u20131578","journal-title":"Am J Psychiatry"},{"key":"1073_CR7","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1046\/j.1471-4159.1996.66062621.x","volume":"66","author":"A Heils","year":"1996","unstructured":"Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, Lesch KP (1996) Allelic variation of human serotonin transporter gene expression. J Neurochem 66:2621\u20132624","journal-title":"J Neurochem"},{"key":"1073_CR8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/00041444-199700710-00008","volume":"7","author":"J Deckert","year":"1997","unstructured":"Deckert J, Catalano M, Heils A, Di Bella D, Friess F, Politi E, Franke P, Nothen MM, Maier W, Bellodi L, Lesch KP (1997) Functional promoter polymorphism of the human serotonin transporter: lack of association with panic disorder. Psychiatr Genet 7:45\u201347","journal-title":"Psychiatr Genet"},{"key":"1073_CR9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00041444-199903000-00001","volume":"9","author":"SP Hamilton","year":"1999","unstructured":"Hamilton SP, Heiman GA, Haghighi F, Mick S, Klein DF, Hodge SE, Weissman MM, Fyer AJ, Knowles JA (1999) Lack of genetic linkage or association between a functional serotonin transporter polymorphism and panic disorder. Psychiatr Genet 9:1\u20136","journal-title":"Psychiatr Genet"},{"key":"1073_CR10","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1111\/j.1440-1819.1997.tb03208.x","volume":"51","author":"H Ishiguro","year":"1997","unstructured":"Ishiguro H, Arinami T, Yamada K, Otsuka Y, Toru M, Shibuya H (1997) An association study between a transcriptional polymorphism in the serotonin transporter gene and panic disorder in a Japanese population. Psychiatry Clin Neurosci 51:333\u2013335","journal-title":"Psychiatry Clin Neurosci"},{"key":"1073_CR11","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/00041444-200509000-00003","volume":"15","author":"OF Olesen","year":"2005","unstructured":"Olesen OF, Bennike B, Hansen ES, Koefoed P, Woldbye DP, Bolwig TG, Mellerup E (2005) The short\/long polymorphism in the serotonin transporter gene promoter is not associated with panic disorder in a Scandinavian sample. Psychiatr Genet 15:159","journal-title":"Psychiatr Genet"},{"key":"1073_CR12","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1744-9081-3-41","volume":"3","author":"C Blaya","year":"2007","unstructured":"Blaya C, Salum GA, Lima MS, Leistner-Segal S, Manfro GG (2007) Lack of association between the Serotonin Transporter Promoter Polymorphism (5-HTTLPR) and Panic Disorder: a systematic review and meta-analysis. Behav Brain Funct 3:41. doi: 10.1186\/1744-9081-3-41","journal-title":"Behav Brain Funct"},{"key":"1073_CR13","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1038\/sj.npp.1300822","volume":"30","author":"G Perna","year":"2005","unstructured":"Perna G, Favaron E, Di Bella D, Bussi R, Bellodi L (2005) Antipanic efficacy of paroxetine and polymorphism within the promoter of the serotonin transporter gene. Neuropsychopharmacology 30:2230\u20132235","journal-title":"Neuropsychopharmacology"},{"key":"1073_CR14","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1016\/j.neuropharm.2008.06.046","volume":"55","author":"B Francois Le","year":"2008","unstructured":"Le Francois B, Czesak M, Steubl D, Albert PR (2008) Transcriptional regulation at a HTR1A polymorphism associated with mental illness. Neuropharmacology 55:977\u2013985","journal-title":"Neuropharmacology"},{"key":"1073_CR15","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1017\/S1461145703004061","volume":"7","author":"C Rothe","year":"2004","unstructured":"Rothe C, Gutknecht L, Freitag C, Tauber R, Mossner R, Franke P, Fritze J, Wagner G, Peikert G, Wenda B, Sand P, Jacob C, Rietschel M, Nothen MM, Garritsen H, Fimmers R, Deckert J, Lesch KP (2004) Association of a functional 1019C>G 5-HT1A receptor gene polymorphism with panic disorder with agoraphobia. Int J Neuropsychopharmacol 7:189\u2013192","journal-title":"Int J Neuropsychopharmacol"},{"key":"1073_CR16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/00004850-199506000-00003","volume":"10","author":"B Bandelow","year":"1995","unstructured":"Bandelow B (1995) Assessing the efficacy of treatments for panic disorder and agoraphobia. II. The panic and agoraphobia scale. Int Clin Psychopharmacol 10:73\u201381","journal-title":"Int Clin Psychopharmacol"},{"key":"1073_CR17","first-page":"354","volume":"19","author":"K Hikida","year":"1990","unstructured":"Hikida K, Inoue Y, Nouchi E, Ohkura Y (1990) Determination of etizolam in human serum or plasma using automated column-switching high-performance liquid chromatography. Jpn J Clin Chem 19:354\u2013359","journal-title":"Jpn J Clin Chem"},{"key":"1073_CR18","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/FTD.0b013e31802bb194","volume":"29","author":"T Watanabe","year":"2007","unstructured":"Watanabe T, Ueda M, Saeki Y, Hirokane G, Morita S, Okawa M, Akiyama K, Shimoda K (2007) High plasma concentrations of paroxetine impede clinical response in patients with panic disorder. Ther Drug Monit 29:40\u201344","journal-title":"Ther Drug Monit"},{"key":"1073_CR19","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00228-009-0633-8","volume":"65","author":"Y Saeki","year":"2009","unstructured":"Saeki Y, Watanabe T, Ueda M, Saito A, Akiyama K, Inoue Y, Hirokane G, Morita S, Yamada N, Shimoda K (2009) Genetic and pharmacokinetic factors affecting the initial pharmacotherapeutic effect of paroxetine in Japanese patients with panic disorder. Eur J Clin Pharmacol 65:685\u2013691","journal-title":"Eur J Clin Pharmacol"},{"key":"1073_CR20","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1126\/science.274.5292.1527","volume":"274","author":"KP Lesch","year":"1996","unstructured":"Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Muller CR, Hamer DH, Murphy DL (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274:1527\u20131531","journal-title":"Science"},{"key":"1073_CR21","volume-title":"Essential psychopharmacology","author":"SM Stahl","year":"2000","unstructured":"Stahl SM (2000) Essential psychopharmacology, 2nd edn. Cambridge University Press, New York","edition":"2"},{"key":"1073_CR22","first-page":"435","volume":"54","author":"AK Louie","year":"1993","unstructured":"Louie AK, Lewis TB, Lannon RA (1993) Use of low-dose fluoxetine in major depression and panic disorder. J Clin Psychiatry 54:435\u2013438","journal-title":"J Clin Psychiatry"},{"key":"1073_CR23","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1038\/npp.2008.148","volume":"34","author":"HG Ruh\u00e9","year":"2009","unstructured":"Ruh\u00e9 HG, Booij J, Weert HCV, Reitsma JB, Fransen EJF, Michel MC, Schene AH (2009) Evidence why paroxetine dose escalation is not effective in major depressive disorder: a randomized controlled trial with assessment of serotonin transporter occupancy. Neuropsychopharmacology 34:999\u20131010","journal-title":"Neuropsychopharmacology"},{"key":"1073_CR24","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1176\/appi.ajp.158.11.1843","volume":"158","author":"JH Meyer","year":"2001","unstructured":"Meyer JH, Wilson AA, Ginovart N, Goulding V, Hussey D, Hood K, Houle S (2001) Occupancy of serotonin transporters by paroxetine and citalopram during treatment of depression: a [11C]DASB PET imaging study. Am J Psychiatry 158:1843\u20131849","journal-title":"Am J Psychiatry"},{"key":"1073_CR25","doi-asserted-by":"crossref","first-page":"854","DOI":"10.4088\/JCP.v63n1001","volume":"63","author":"SM Stahl","year":"2002","unstructured":"Stahl SM (2002) Independent actions on fear circuits may lead to therapeutic synergy for anxiety when combining serotonergic and GABAergic agents. J Clin Psychiatry 63:854\u2013855","journal-title":"J Clin Psychiatry"},{"key":"1073_CR26","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1523\/JNEUROSCI.3769-04.2005","volume":"25","author":"SP David","year":"2005","unstructured":"David SP, Murthy NV, Rabiner EA, Munafo MR, Johnstone EC, Jacob R, Walton RT, Grasby PM (2005) A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans. J Neurosci 25:2586\u20132590","journal-title":"J Neurosci"},{"key":"1073_CR27","doi-asserted-by":"crossref","first-page":"8788","DOI":"10.1523\/JNEUROSCI.23-25-08788.2003","volume":"23","author":"S Lemonde","year":"2003","unstructured":"Lemonde S, Turecki G, Bakish D, Du L, Hrdina PD, Bown CD, Sequeira A, Kushwaha N, Morris SJ, Basak A, Ou XM, Albert PR (2003) Impaired repression at a 5-hydroxytryptamine 1A receptor gene polymorphism associated with major depression and suicide. J Neurosci 23:8788\u20138799","journal-title":"J Neurosci"},{"key":"1073_CR28","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1177\/1073858404267382","volume":"10","author":"PR Albert","year":"2004","unstructured":"Albert PR, Lemonde S (2004) 5HT1A receptors, gene repression, and depression: guilt by association. Neuroscientist 10:575\u2013593","journal-title":"Neuroscientist"},{"key":"1073_CR29","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.1038\/sj.npp.1300992","volume":"31","author":"RV Parsey","year":"2006","unstructured":"Parsey RV, Olvet DM, Oquendo MA, Huang YY, Ogden RT, Mann JJ (2006) Higher 5-HT1A receptor binding potential during a major depressive episode predicts poor treatment response: preliminary data from a naturalistic study. Neuropsychopharmacology 31:1745\u20131749","journal-title":"Neuropsychopharmacology"},{"key":"1073_CR30","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.jad.2009.09.007","volume":"123","author":"OO Yevtushenko","year":"2010","unstructured":"Yevtushenko OO, Oros MM, Reynolds GP (2010) Early response to selective serotonin reuptake inhibitors in panic disorder is associated with a functional 5-HT1A receptor gene polymorphism. J Affect Disord 123:308\u2013311","journal-title":"J Affect Disord"},{"key":"1073_CR31","doi-asserted-by":"crossref","first-page":"1864","DOI":"10.1523\/JNEUROSCI.2643-05.2006","volume":"26","author":"M Czesak","year":"2006","unstructured":"Czesak M, Lemonde S, Peterson EA, Rogaeva A, Albert PR (2006) Cell-specific repressor or enhancer activities of Deaf-1 at a serotonin 1A receptor gene polymorphism. J Neurosci 26:1864\u20131871","journal-title":"J Neurosci"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-011-1073-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00228-011-1073-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-011-1073-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,6,12]],"date-time":"2019-06-12T00:06:04Z","timestamp":1560297964000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00228-011-1073-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6,19]]},"references-count":31,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2011,12]]}},"alternative-id":["1073"],"URL":"https:\/\/doi.org\/10.1007\/s00228-011-1073-9","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,6,19]]}}}