{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,11]],"date-time":"2026-08-11T13:51:20Z","timestamp":1786456280264,"version":"build-2736575974"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1007\/s00228-012-1284-8","type":"journal-article","created":{"date-parts":[[2012,4,30]],"date-time":"2012-04-30T07:55:19Z","timestamp":1335772519000},"page":"1465-1472","source":"Crossref","is-referenced-by-count":8,"title":["Intravenous buspirone for the prevention of postoperative nausea and vomiting"],"prefix":"10.1007","volume":"68","author":[{"given":"Peter","family":"Kranke","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerstin D.","family":"R\u00f6hm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Diemunsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tong J.","family":"Gan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian C.","family":"Apfel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leopold","family":"Eberhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold S.","family":"Minkowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Wallenborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Chassard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gilles","family":"Lebuffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriel M.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin R.","family":"Tram\u00e8r","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2012,5,1]]},"reference":[{"key":"1284_CR1","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1097\/EJA.0b013e3283435e51","volume":"28","author":"P Kranke","year":"2011","unstructured":"Kranke P (2011) Effective management of postoperative nausea and vomiting: let us practise what we preach! Eur J Anaesthesiol 28:152\u2013154","journal-title":"Eur J Anaesthesiol"},{"key":"1284_CR2","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/EJA.0b013e328342fd86","volume":"28","author":"S Pierre","year":"2011","unstructured":"Pierre S (2011) Risk scores for predicting postoperative nausea and vomiting are clinically useful tools and should be used in every patient: pro\u2013'don't throw the baby out with the bathwater'. Eur J Anaesthesiol 28:160\u2013163","journal-title":"Eur J Anaesthesiol"},{"key":"1284_CR3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.autneu.2006.07.009","volume":"129","author":"GJ Sanger","year":"2006","unstructured":"Sanger GJ, Andrews PL (2006) Treatment of nausea and vomiting: gaps in our knowledge. Auton Neurosci 129:3\u201316","journal-title":"Auton Neurosci"},{"key":"1284_CR4","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1097\/00000539-200211000-00063","volume":"95","author":"T Oshima","year":"2002","unstructured":"Oshima T, Kasuya Y, Okumura Y, Terazawa E, Dohi S (2002) Prevention of nausea and vomiting with tandospirone in adults after tympanoplasty. Anesth Analg 95:1442\u20131445","journal-title":"Anesth Analg"},{"key":"1284_CR5","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1007\/s007020050222","volume":"106","author":"NA Darmani","year":"1999","unstructured":"Darmani NA, Zhao W, Ahmad B (1999) The role of D2 and D3 dopamine receptors in the mediation of emesis in Cryptotis parva (the least shrew). J Neural Transm 106:1045\u20131061","journal-title":"J Neural Transm"},{"key":"1284_CR6","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1097\/EJA.0b013e32834a4e1e","volume":"28","author":"P Kranke","year":"2011","unstructured":"Kranke P, Eberhart LH (2011) Possibilities and limitations in the pharmacological management of postoperative nausea and vomiting. Eur J Anaesthesiol 28:758\u2013765","journal-title":"Eur J Anaesthesiol"},{"key":"1284_CR7","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1097\/EJA.0b013e32832d6a76","volume":"27","author":"FO Kooij","year":"2010","unstructured":"Kooij FO, Klok T, Hollmann MW, Kal JE (2010) Automated reminders increase adherence to guidelines for administration of prophylaxis for postoperative nausea and vomiting. Eur J Anaesthesiol 27:187\u2013191","journal-title":"Eur J Anaesthesiol"},{"key":"1284_CR8","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.jclinane.2004.04.004","volume":"17","author":"AS Habib","year":"2005","unstructured":"Habib AS, Gan TJ (2005) The effectiveness of rescue antiemetics after failure of prophylaxis with ondansetron or droperidol: a preliminary report. J Clin Anesth 17:62\u201365","journal-title":"J Clin Anesth"},{"key":"1284_CR9","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1136\/bmj.327.7418.762","volume":"327","author":"MR Tram\u00e8r","year":"2003","unstructured":"Tram\u00e8r MR (2003) Treatment of postoperative nausea and vomiting. Br Med J 327:762\u2013763","journal-title":"Br Med J"},{"key":"1284_CR10","first-page":"11","volume":"43","author":"LA Riblet","year":"1982","unstructured":"Riblet LA, Taylor DP, Eison MS, Stanton HC (1982) Pharmacology and neurochemistry of buspirone. J Clin Psychiatry 43:11\u201318","journal-title":"J Clin Psychiatry"},{"key":"1284_CR11","first-page":"463","volume":"46","author":"YK Gupta","year":"2002","unstructured":"Gupta YK, Sharma SS (2002) Involvement of 5-HT1A and 5-HT2 receptor in cisplatin induced emesis in dogs. Indian J Physiol Pharmacol 46:463\u2013467","journal-title":"Indian J Physiol Pharmacol"},{"key":"1284_CR12","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1002\/j.1552-4604.1987.tb03003.x","volume":"27","author":"JB Lucot","year":"1987","unstructured":"Lucot JB, Crampton GH (1987) Buspirone blocks cisplatin-induced emesis in cats. J Clin Pharmacol 27:817\u2013818","journal-title":"J Clin Pharmacol"},{"key":"1284_CR13","first-page":"989","volume":"58","author":"JB Lucot","year":"1987","unstructured":"Lucot JB, Crampton GH (1987) Buspirone blocks motion sickness and xylazine-induced emesis in the cat. Aviat Space Environ Med 58:989\u2013991","journal-title":"Aviat Space Environ Med"},{"key":"1284_CR14","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1254\/jjp.64.109","volume":"64","author":"F Okada","year":"1994","unstructured":"Okada F, Torii Y, Saito H, Matsuki N (1994) Antiemetic effects of serotonergic 5-HT1A-receptor agonists in Suncus murinus. Jpn J Pharmacol 64:109\u2013114","journal-title":"Jpn J Pharmacol"},{"key":"1284_CR15","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1038\/bjc.1995.452","volume":"72","author":"AB Alfieri","year":"1995","unstructured":"Alfieri AB, Cubeddu LX (1995) Comparative efficacy of a single oral dose of ondansetron and of buspirone against cisplatin-induced emesis in cancer patients. Br J Cancer 72:1013\u20131015","journal-title":"Br J Cancer"},{"key":"1284_CR16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/0002-9343(86)90331-1","volume":"80","author":"RE Gammans","year":"1986","unstructured":"Gammans RE, Mayol RF, LaBudde JA (1986) Metabolism and disposition of buspirone. Am J Med 80:41\u201351","journal-title":"Am J Med"},{"key":"1284_CR17","volume-title":"Guidance for industry: estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers","author":"Center for Drug Evaluation and Research","year":"2005","unstructured":"Center for Drug Evaluation and Research (2005) Guidance for industry: estimating the maximum safe starting dose in initial clinical trials for therapeutics in adult healthy volunteers. United States Food and Drug Administration, Rockville"},{"key":"1284_CR18","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0952-8180(94)00001-K","volume":"7","author":"JA Aldrete","year":"1995","unstructured":"Aldrete JA (1995) The post-anesthesia recovery score revisited. J Clin Anesth 7:89\u201391","journal-title":"J Clin Anesth"},{"key":"1284_CR19","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1016\/0006-3223(85)90194-5","volume":"20","author":"SJ Peroutka","year":"1985","unstructured":"Peroutka SJ (1985) Selective interaction of novel anxiolytics with 5-hydroxytryptamine1A receptors. Biol Psychiatry 20:971\u2013979","journal-title":"Biol Psychiatry"},{"key":"1284_CR20","doi-asserted-by":"crossref","first-page":"2066","DOI":"10.1021\/jm00067a003","volume":"36","author":"AG Romero","year":"1993","unstructured":"Romero AG, Leiby JA, McCall RB, Piercey MF, Smith MW, Han F (1993) Novel 2-substituted tetrahydro-3\u00a0H-benz.eindolamines: highly potent and selective agonists acting at the 5-HT1A receptor as possible anxiolytics and antidepressants. J Med Chem 36:2066\u20132074","journal-title":"J Med Chem"},{"key":"1284_CR21","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0014-2999(98)00483-X","volume":"355","author":"A Newman-Tancredi","year":"1998","unstructured":"Newman-Tancredi A, Gavaudan S, Conte C, Chaput C, Touzard M, Verri\u00e8le L, Audinot V, Millan MJ (1998) Agonist and antagonist actions of antipsychotic agents at 5-HT1A receptors: a.35SGTPgammaS binding study. Eur J Pharmacol 355:245\u2013256","journal-title":"Eur J Pharmacol"},{"key":"1284_CR22","doi-asserted-by":"crossref","first-page":"6S","DOI":"10.1097\/00004714-199006001-00003","volume":"10","author":"FD Yocca","year":"1990","unstructured":"Yocca FD (1990) Neurochemistry and neurophysiology of buspirone and gepirone: interactions at presynaptic and postsynaptic 5-HT1A receptors. J Clin Psychopharmacol 10:6S\u201312S","journal-title":"J Clin Psychopharmacol"},{"key":"1284_CR23","volume-title":"Summary basis of approval, tandospirone citrate tablets","author":"Ministry of Health Labour and Welfare (Japan)","year":"1997","unstructured":"Ministry of Health Labour and Welfare (Japan) (1997) Summary basis of approval, tandospirone citrate tablets. Ministry of Health, Labour and Welfare, Tokyo"},{"key":"1284_CR24","doi-asserted-by":"crossref","first-page":"10831","DOI":"10.1523\/JNEUROSCI.2999-05.2005","volume":"25","author":"L D\u00edaz-Mataix","year":"2005","unstructured":"D\u00edaz-Mataix L, Scorza MC, Bortolozzi A, Toth M, Celada P, Artigas F (2005) Involvement of 5-HT1A receptors in prefrontal cortex in the modulation of dopaminergic activity: role in atypical antipsychotic action. J Neurosci 25:10831\u201310843","journal-title":"J Neurosci"},{"key":"1284_CR25","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.biopha.2005.01.010","volume":"59","author":"BT Zhu","year":"2005","unstructured":"Zhu BT (2005) Mechanistic explanation for the unique pharmacologic properties of receptor partial agonists. Biomed Pharmacother 59:76\u201389","journal-title":"Biomed Pharmacother"},{"key":"1284_CR26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/0893-133X(95)00025-9","volume":"13","author":"B Seletti","year":"1995","unstructured":"Seletti B, Benkelfat C, Blier P, Annable L, Gilbert F, de Montigny C (1995) Serotonin1A receptor activation by flesinoxan in humans. Body temperature and neuroendocrine responses. Neuropsychopharmacology 13:93\u2013104","journal-title":"Neuropsychopharmacology"},{"key":"1284_CR27","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/00004850-199300830-00005","volume":"8","author":"P Grof","year":"1993","unstructured":"Grof P, Joffe R, Kennedy S, Persad E, Syrotiuk J, Bradford D (1993) An open study of oral flesinoxan, a 5-HT1A receptor agonist, in treatment-resistant depression. Int Clin Psychopharmacol 8:167\u2013172","journal-title":"Int Clin Psychopharmacol"},{"key":"1284_CR28","doi-asserted-by":"crossref","first-page":"119","DOI":"10.2174\/1568007053544165","volume":"4","author":"HL Lutsep","year":"2005","unstructured":"Lutsep HL (2005) Repinotan, A 5-HT1A agonist, in the treatment of acute ischemic stroke. Curr Drug Targets CNS Neurol Disord 4:119\u2013120","journal-title":"Curr Drug Targets CNS Neurol Disord"},{"key":"1284_CR29","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0014-2999(94)90756-0","volume":"253","author":"JB Lucot","year":"1994","unstructured":"Lucot JB (1994) Antiemetic effects of flesinoxan in cats: comparisons with 8-hydroxy-2-(di-n-propylamino)tetralin. Eur J Pharmacol 253:53\u201360","journal-title":"Eur J Pharmacol"},{"key":"1284_CR30","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bbr.2008.02.023","volume":"195","author":"SO Ogren","year":"2008","unstructured":"Ogren SO, Eriksson TM, Elvander-Tottie E, D'Addario C, Ekstr\u00f6m JC, Svenningsson P, Meister B, Kehr J, Stiedl O (2008) The role of 5-HT(1A) receptors in learning and memory. Behav Brain Res 195:54\u201377","journal-title":"Behav Brain Res"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-012-1284-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00228-012-1284-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-012-1284-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T08:48:58Z","timestamp":1558687738000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00228-012-1284-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5,1]]},"references-count":30,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["1284"],"URL":"https:\/\/doi.org\/10.1007\/s00228-012-1284-8","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,5,1]]}}}