{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T21:20:16Z","timestamp":1791062416222,"version":"4.1.0"},"reference-count":21,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2013,5,10]],"date-time":"2013-05-10T00:00:00Z","timestamp":1368144000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2013,9]]},"DOI":"10.1007\/s00228-013-1521-9","type":"journal-article","created":{"date-parts":[[2013,5,9]],"date-time":"2013-05-09T02:49:25Z","timestamp":1368067765000},"page":"1641-1649","source":"Crossref","is-referenced-by-count":23,"title":["Methotrexate binds to recombinant thiopurine S-methyltransferase and inhibits enzyme activity after high-dose infusions in childhood leukaemia"],"prefix":"10.1007","volume":"69","author":[{"given":"Patricia","family":"Wennerstrand","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars-G\u00f6ran","family":"M\u00e5rtensson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"S\u00f6derh\u00e4ll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Zimdahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malin Lindqvist","family":"Appell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,5,10]]},"reference":[{"issue":"2","key":"1521_CR1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/leu.2009.251","volume":"24","author":"K Schmiegelow","year":"2010","unstructured":"Schmiegelow K, Forestier E, Hellebostad M, Heyman M, Kristinsson J, Soderhall S, Taskinen M (2010) Long-term results of NOPHO ALL-92 and ALL-2000 studies of childhood acute lymphoblastic leukemia. Leukemia 24(2):345\u2013354","journal-title":"Leukemia"},{"issue":"2","key":"1521_CR2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/clpt.2008.154","volume":"85","author":"G Stocco","year":"2009","unstructured":"Stocco G, Cheok MH, Crews KR, Dervieux T, French D, Pei D, Yang W, Cheng C, Pui CH, Relling MV, Evans WE (2009) Genetic polymorphism of inosine triphosphate pyrophosphatase is a determinant of mercaptopurine metabolism and toxicity during treatment for acute lymphoblastic leukemia. Clin Pharmacol Ther 85(2):164\u2013172","journal-title":"Clin Pharmacol Ther"},{"issue":"5","key":"1521_CR3","first-page":"651","volume":"32","author":"R Weinshilboum","year":"1980","unstructured":"Weinshilboum R, Sladek SL (1980) Mercaptopurine pharmacogenetics: monogenic inheritance of erythrocyte thiopurine methyltransferase activity. Am J Hum Genet 32(5):651\u2013662","journal-title":"Am J Hum Genet"},{"issue":"23","key":"1521_CR4","doi-asserted-by":"crossref","first-page":"2001","DOI":"10.1093\/jnci\/91.23.2001","volume":"91","author":"MV Relling","year":"1999","unstructured":"Relling MV, Hancock ML, Rivera GK, Sandlund JT, Ribeiro RC, Krynetski EY, Pui CH, Evans WE (1999) Mercaptopurine therapy intolerance and heterozygosity at the thiopurine S-methyltransferase gene locus. J Natl Cancer Inst 91(23):2001\u20132008","journal-title":"J Natl Cancer Inst"},{"issue":"6","key":"1521_CR5","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1016\/S0022-3476(05)83063-X","volume":"119","author":"WE Evans","year":"1991","unstructured":"Evans WE, Horner M, Chu YQ, Kalwinsky D, Roberts WM (1991) Altered mercaptopurine metabolism, toxic effects, and dosage requirement in a thiopurine methyltransferase-deficient child with acute lymphocytic leukemia. J Pediatr 119(6):985\u2013989","journal-title":"J Pediatr"},{"issue":"5","key":"1521_CR6","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/0955-2863(90)90070-2","volume":"1","author":"JD Finkelstein","year":"1990","unstructured":"Finkelstein JD (1990) Methionine metabolism in mammals. J Nutr Biochem 1(5):228\u2013237","journal-title":"J Nutr Biochem"},{"issue":"4","key":"1521_CR7","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1182\/blood-2002-02-0495","volume":"100","author":"T Dervieux","year":"2002","unstructured":"Dervieux T, Brenner TL, Hon YY, Zhou Y, Hancock ML, Sandlund JT, Rivera GK, Ribeiro RC, Boyett JM, Pui CH, Relling MV, Evans WE (2002) De novo purine synthesis inhibition and antileukemic effects of mercaptopurine alone or in combination with methotrexate in vivo. Blood 100(4):1240\u20131247","journal-title":"Blood"},{"issue":"23","key":"1521_CR8","doi-asserted-by":"crossref","first-page":"4671","DOI":"10.1182\/blood-2010-01-256958","volume":"115","author":"J Gregers","year":"2010","unstructured":"Gregers J, Christensen IJ, Dalhoff K, Lausen B, Schroeder H, Rosthoej S, Carlsen N, Schmiegelow K, Peterson C (2010) The association of reduced folate carrier 80G>A polymorphism to outcome in childhood acute lymphoblastic leukemia interacts with chromosome 21 copy number. Blood 115(23):4671\u20134677","journal-title":"Blood"},{"issue":"4","key":"1521_CR9","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/00008571-200404000-00006","volume":"14","author":"M Lindqvist","year":"2004","unstructured":"Lindqvist M, Haglund S, Almer S, Peterson C, Taipalensu J, Hertervig E, Lyrenas E, S\u00f6derkvist P (2004) Identification of two novel sequence variants affecting thiopurine methyltransferase enzyme activity. Pharmacogenetics 14(4):261\u2013265","journal-title":"Pharmacogenetics"},{"issue":"6","key":"1521_CR10","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.crohns.2011.11.014","volume":"6","author":"U Hindorf","year":"2012","unstructured":"Hindorf U, Appell ML (2012) Genotyping should be considered the primary choice for pre-treatment evaluation of thiopurine methyltransferase function. J Crohn\u2019s Colitis 6(6):655\u2013659","journal-title":"J Crohn\u2019s Colitis"},{"issue":"3","key":"1521_CR11","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1097\/00007691-200206000-00005","volume":"24","author":"B Pettersson","year":"2002","unstructured":"Pettersson B, Almer S, Albertioni F, S\u00f6derhall S, Peterson C (2002) Differences between children and adults in thiopurine methyltransferase activity and metabolite formation during thiopurine therapy: possible role of concomitant methotrexate. Ther Drug Monit 24(3):351\u2013358","journal-title":"Ther Drug Monit"},{"issue":"11","key":"1521_CR12","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1097\/FPC.0b013e3283402ee4","volume":"20","author":"ML Appell","year":"2010","unstructured":"Appell ML, Wennerstrand P, Peterson C, Hertervig E, Martensson LG (2010) Characterization of a novel sequence variant, TPMT*28, in the human thiopurine methyltransferase gene. Pharmacogenet Genomics 20(11):700\u2013707","journal-title":"Pharmacogenet Genomics"},{"issue":"6","key":"1521_CR13","first-page":"1141","volume":"47","author":"EY Krynetski","year":"1995","unstructured":"Krynetski EY, Krynetskaia NF, Yanishevski Y, Evans WE (1995) Methylation of mercaptopurine, thioguanine, and their nucleotide metabolites by heterologously expressed human thiopurine S-methyltransferase. Mol Pharmacol 47(6):1141\u20131147","journal-title":"Mol Pharmacol"},{"issue":"5","key":"1521_CR14","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1046\/j.0306-5251.2001.01497.x","volume":"52","author":"L Lennard","year":"2001","unstructured":"Lennard L, Chew TS, Lilleyman JS (2001) Human thiopurine methyltransferase activity varies with red blood cell age. Br J Clin Pharmacol 52(5):539\u2013546","journal-title":"Br J Clin Pharmacol"},{"issue":"4","key":"1521_CR15","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1016\/j.ejca.2004.10.027","volume":"41","author":"C Brouwer","year":"2005","unstructured":"Brouwer C, De Abreu RA, Keizer-Garritsen JJ, Lambooy LH, Ament K, ter Riet PG, van Wering ER, Trijbels FJ, Veerman AJ, Hoogerbrugge PM, Bokkerink JP (2005) Thiopurine methyltransferase in acute lymphoblastic leukaemia: biochemical and molecular biological aspects. Eur J Cancer 41(4):613\u2013623","journal-title":"Eur J Cancer"},{"key":"1521_CR16","doi-asserted-by":"crossref","unstructured":"Lennard L, Cartwright CS, Wade R, Richards SM, Vora A (2012) Thiopurine methyltransferase genotype-phenotype discordance, and thiopurine active metabolite formation, in childhood acute lymphoblastic leukaemia. Br J Clin Pharmacol. doi: 10.1111\/bcp.12066","DOI":"10.1111\/bcp.12066"},{"issue":"6","key":"1521_CR17","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S0009-9236(03)00063-8","volume":"73","author":"T Dervieux","year":"2003","unstructured":"Dervieux T, Hancock ML, Pui CH, Rivera GK, Sandlund JT, Ribeiro RC, Boyett J, Evans WE, Relling MV (2003) Antagonism by methotrexate on mercaptopurine disposition in lymphoblasts during up-front treatment of acute lymphoblastic leukemia. Clin Pharmacol Ther 73(6):506\u2013516","journal-title":"Clin Pharmacol Ther"},{"issue":"5","key":"1521_CR18","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1182\/blood-2005-01-0143","volume":"106","author":"G Zaza","year":"2005","unstructured":"Zaza G, Cheok M, Yang W, Panetta JC, Pui CH, Relling MV, Evans WE (2005) Gene expression and thioguanine nucleotide disposition in acute lymphoblastic leukemia after in vivo mercaptopurine treatment. Blood 106(5):1778\u20131785","journal-title":"Blood"},{"issue":"4","key":"1521_CR19","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1365-2125.2010.03867.x","volume":"71","author":"T Adam de Beaumais","year":"2011","unstructured":"Adam de Beaumais T, Fakhoury M, Medard Y, Azougagh S, Zhang D, Yakouben K, Jacqz-Aigrain E (2011) Determinants of mercaptopurine toxicity in paediatric acute lymphoblastic leukemia maintenance therapy. Br J Clin Pharmacol 71(4):575\u2013584","journal-title":"Br J Clin Pharmacol"},{"issue":"1","key":"1521_CR20","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/prot.21272","volume":"67","author":"H Wu","year":"2007","unstructured":"Wu H, Horton JR, Battaile K, Allali-Hassani A, Martin F, Zeng H, Loppnau P, Vedadi M, Bochkarev A, Plotnikov AN, Cheng X (2007) Structural basis of allele variation of human thiopurine-S-methyltransferase. Proteins 67(1):198\u2013208","journal-title":"Proteins"},{"issue":"12","key":"1521_CR21","doi-asserted-by":"crossref","first-page":"1845","DOI":"10.1016\/j.bcp.2009.03.006","volume":"77","author":"M Milek","year":"2009","unstructured":"Milek M, Karas Kuzelicki N, Smid A, Mlinaric-Rascan I (2009) S-adenosylmethionine regulates thiopurine methyltransferase activity and decreases 6-mercaptopurine cytotoxicity in MOLT lymphoblasts. Biochem Pharmacol 77(12):1845\u20131853","journal-title":"Biochem Pharmacol"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-013-1521-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00228-013-1521-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-013-1521-9","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,5,24]],"date-time":"2019-05-24T08:49:03Z","timestamp":1558687743000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00228-013-1521-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,5,10]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2013,9]]}},"alternative-id":["1521"],"URL":"https:\/\/doi.org\/10.1007\/s00228-013-1521-9","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,5,10]]}}}