{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T21:04:48Z","timestamp":1784581488029,"version":"3.55.0"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T00:00:00Z","timestamp":1371513600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2013,6,18]],"date-time":"2013-06-18T00:00:00Z","timestamp":1371513600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2013,11]]},"DOI":"10.1007\/s00228-013-1549-x","type":"journal-article","created":{"date-parts":[[2013,6,17]],"date-time":"2013-06-17T08:53:59Z","timestamp":1371459239000},"page":"1909-1916","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":59,"title":["Association between CYP2B6 polymorphisms and Nevirapine-induced SJS\/TEN: a pharmacogenetics study"],"prefix":"10.1007","volume":"69","author":[{"given":"Cinzia","family":"Ciccacci","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davide","family":"Di Fusco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C.","family":"Marazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ines","family":"Zimba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fulvio","family":"Erba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Novelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo","family":"Palombi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Borgiani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Liotta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2013,6,18]]},"reference":[{"issue":"1","key":"1549_CR1","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1038\/sj.jid.5701033","volume":"128","author":"M Mockenhaupt","year":"2008","unstructured":"Mockenhaupt M, Viboud C, Dunant A, Naldi L, Halevy S, Bouwes Bavinck JN, Sidoroff A, Schneck J, Roujeau JC, Flahault A (2008) Stevens-Johnson syndrome and toxic epidermal necrolysis: assessment of medication risks with emphasis on recently marketed drugs. The EuroSCAR-study. J Investig Dermatol 128(1):35\u201344","journal-title":"J Investig Dermatol"},{"issue":"6","key":"1549_CR2","doi-asserted-by":"publisher","first-page":"803","DOI":"10.1586\/eci.11.66","volume":"7","author":"M Mockenhaupt","year":"2011","unstructured":"Mockenhaupt M (2011) The current understanding of Stevens-Johnson syndrome and toxic epidermal necrolysis. Expert Rev Clin Immunol 7(6):803\u2013813","journal-title":"Expert Rev Clin Immunol"},{"issue":"6","key":"1549_CR3","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1001\/archderm.1991.01680050083008","volume":"127","author":"E Sch\u00f6pf","year":"1991","unstructured":"Sch\u00f6pf E, St\u00fchmer A, Rzany B, Victor N, Zentgraf R, Kapp JF (1991) Toxic epidermal necrolysis and Stevens-Johnson syndrome. An epidemiologic study from West Germany. Arch Dermatol 127(6):839\u2013842","journal-title":"Arch Dermatol"},{"issue":"7","key":"1549_CR4","doi-asserted-by":"publisher","first-page":"769","DOI":"10.1016\/0895-4356(96)00035-2","volume":"49","author":"B Rzany","year":"1996","unstructured":"Rzany B, Mockenhaupt M, Baur S, Schr\u00f6der W, Stocker U, Mueller J, Holl\u00e4nder N, Bruppacher R, Sch\u00f6pf E (1996) Epidemiology of erythema exsudativum multiforme majus, Stevens-Johnson syndrome, and toxic epidermal necrolysis in Germany (1990\u20131992): structure and results of a population-based registry. J Clin Epidemiol 49(7):769\u2013773","journal-title":"J Clin Epidemiol"},{"key":"1549_CR5","doi-asserted-by":"publisher","first-page":"9","DOI":"10.2332\/allergolint.55.9","volume":"55","author":"LE French","year":"2006","unstructured":"French LE (2006) Toxic epidermal necrolysis and Stevens Johnson syndrome: our current understanding. Allergol Int 55:9\u201316","journal-title":"Allergol Int"},{"key":"1549_CR6","doi-asserted-by":"publisher","first-page":"317","DOI":"10.1097\/ACI.0b013e3282370c5f","volume":"7","author":"WH Chung","year":"2007","unstructured":"Chung WH, Hung SI, Chen YT (2007) Human leukocyte antigens and drug hypersensitivity. Curr Opin Allergy Clin Immunol 7:317\u2013323","journal-title":"Curr Opin Allergy Clin Immunol"},{"issue":"3","key":"1549_CR7","doi-asserted-by":"publisher","first-page":"190","DOI":"10.1016\/j.jdermsci.2012.04.002","volume":"66","author":"WH Chung","year":"2012","unstructured":"Chung WH, Hung SI (2012) Recent advances in the genetics and immunology of Stevens-Johnson syndrome and toxic epidermalnecrosis. J Dermatol Sci 66(3):190\u2013196","journal-title":"J Dermatol Sci"},{"issue":"5","key":"1549_CR8","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1111\/j.1468-1293.2006.00386.x","volume":"7","author":"MC Marazzi","year":"2006","unstructured":"Marazzi MC, Germano P, Liotta G, Guidotti G, Loureiro S, da Cruz GA, Valls Blazquez MC, Narciso P, Perno CF, Mancinelli S, Palombi L (2006) Safety of nevirapine-containing antiretroviral triple therapy regimens to prevent vertical transmission in an African cohort of HIV-1-infected pregnant women. HIV Med 7(5):338\u2013344","journal-title":"HIV Med"},{"issue":"7","key":"1549_CR9","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1097\/QAD.0b013e328351a521","volume":"26","author":"BJ Dong","year":"2012","unstructured":"Dong BJ, Zheng Y, Hughes MD, Frymoyer A, Verotta D, Lizak P, Sawe F, Currier JS, Lockman S, Aweeka FT, AIDS Clinical Trials Group Study 5208 Team (2012) Nevirapine pharmacokinetics and risk of rash and hepatitis among HIV-infected sub-Saharan African women. AIDS 26(7):833\u2013841","journal-title":"AIDS"},{"issue":"14","key":"1549_CR10","doi-asserted-by":"publisher","first-page":"1843","DOI":"10.1097\/00002030-200109280-00014","volume":"15","author":"JP Fagot","year":"2001","unstructured":"Fagot JP, Mockenhaupt M, Bouwes-Bavinck JN, Naldi L, Viboud C, Roujeau JC, EuroSCAR Study Group (2001) Nevirapine and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. AIDS 15(14):1843\u20131848","journal-title":"AIDS"},{"issue":"10","key":"1549_CR11","doi-asserted-by":"publisher","first-page":"1271","DOI":"10.1097\/QAD.0b013e32834779df","volume":"25","author":"J Yuan","year":"2011","unstructured":"Yuan J, Guo S, Hall D, Cammett AM, Jayadev S, Distel M, Storfer S, Huang Z, Mootsikapun P, Ruxrungtham K, Podzamczer D, Haas DW (2011) Toxicogenomics of nevirapine-associated cutaneous and hepatic adverse events among populations of African, Asian, and European descent. AIDS 25(10):1271\u20131280","journal-title":"AIDS"},{"issue":"4","key":"1549_CR12","doi-asserted-by":"publisher","first-page":"297","DOI":"10.1097\/01.fpc.0000199500.46842.4a","volume":"16","author":"SI Hung","year":"2006","unstructured":"Hung SI, Chung WH, Jee SH, Chen WC, Chang YT, Lee WR, Hu SL, Wu MT, Chen GS, Wong TW, Hsiao PF, Chen WH, Shih HY, Fang WH, Wei CY, Lou YH, Huang YL, Lin JJ, Chen YT (2006) Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions. Pharmacogenet Genomics 16(4):297\u2013306","journal-title":"Pharmacogenet Genomics"},{"issue":"9","key":"1549_CR13","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1097\/FPC.0b013e328330a3b8","volume":"19","author":"W Tassaneeyakul","year":"2009","unstructured":"Tassaneeyakul W, Jantararoungtong T, Chen P, Lin PY, Tiamkao S, Khunarkornsiri U, Chucherd P, Konyoung P, Vannaprasaht S, Choonhakarn C, Pisuttimarn P, Sangviroon A, Tassaneeyakul W (2009) Strong association between HLA-B*5801 and allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a Thai population. Pharmacogenet Genomics 19(9):704\u2013709","journal-title":"Pharmacogenet Genomics"},{"issue":"2","key":"1549_CR14","doi-asserted-by":"publisher","first-page":"99","DOI":"10.1097\/FPC.0b013e3282f3ef9c","volume":"18","author":"C Lonjou","year":"2008","unstructured":"Lonjou C, Borot N, Sekula P, Ledger N, Thomas L, Halevy S, Naldi L, Bouwes-Bavinck JN, Sidoroff A, de Toma C, Schumacher M, Roujeau JC, Hovnanian A, Mockenhaupt M, RegiSCAR study group (2008) A European study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs. Pharmacogenet Genomics 18(2):99\u2013107","journal-title":"Pharmacogenet Genomics"},{"key":"1549_CR15","doi-asserted-by":"publisher","first-page":"2087","DOI":"10.1111\/j.1528-1167.2008.01719.x","volume":"49","author":"C Locharernkul","year":"2008","unstructured":"Locharernkul C, Loplumlert J, Limotai C, Korkij W, Desudchit T, Tongkobpetch S, Kangwanshiratada O, Hirankarn N, Suphapeetiporn K, Shotelersuk V (2008) Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population. Epilepsia 49:2087\u20132091","journal-title":"Epilepsia"},{"issue":"2","key":"1549_CR16","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1111\/j.1365-4632.2010.04745.x","volume":"50","author":"CC Chang","year":"2011","unstructured":"Chang CC, Too CL, Murad S, Hussein SH (2011) Association of HLA-B*1502 allele with carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome in the multi-ethnic Malaysian population. Int J Dermatol 50(2):221\u2013224","journal-title":"Int J Dermatol"},{"issue":"12","key":"1549_CR17","doi-asserted-by":"publisher","first-page":"1126","DOI":"10.1056\/NEJMoa1009717","volume":"364","author":"P Chen","year":"2011","unstructured":"Chen P, Lin JJ, Lu CS et al (2011) Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan. N Engl J Med 364(12):1126\u20131133","journal-title":"N Engl J Med"},{"issue":"6","key":"1549_CR18","doi-asserted-by":"publisher","first-page":"813","DOI":"10.2217\/14622416.7.6.813","volume":"7","author":"A Alfirevic","year":"2006","unstructured":"Alfirevic A, Jorgensen AL, Williamson PR, Chadwick DW, Park BK, Pirmohamed M (2006) HLA-B locus in Caucasian patients with carbamazepine hypersensitivity. Pharmacogenomics 7(6):813\u2013818","journal-title":"Pharmacogenomics"},{"issue":"4","key":"1549_CR19","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1038\/sj.tpj.6500356","volume":"6","author":"C Lonjou","year":"2006","unstructured":"Lonjou C, Thomas L, Borot N, Ledger N, de Toma C, LeLouet H, Graf E, Schumacher M, Hovnanian A, Mockenhaupt M, Roujeau JC, RegiSCAR Group (2006) A marker for Stevens-Johnson syndrome \u2026: ethnicity matters. Pharmacogenomics J 6(4):265\u2013268","journal-title":"Pharmacogenomics J"},{"issue":"1","key":"1549_CR20","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1038\/tpj.2011.41","volume":"13","author":"M Tohkin","year":"2013","unstructured":"Tohkin M, Kaniwa N, Saito Y, Sugiyama E, Kurose K, Nishikawa J, Hasegawa R, Aihara M, Matsunaga K, Abe M, Furuya H, Takahashi Y, Ikeda H, Muramatsu M, Ueta M, Sotozono C, Kinoshita S, Ikezawa Z (2013) A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients. Pharmacogenomics J 13(1):60\u201369","journal-title":"Pharmacogenomics J"},{"key":"1549_CR21","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/1750-1172-6-52","volume":"6","author":"E G\u00e9nin","year":"2011","unstructured":"G\u00e9nin E, Schumacher M, Roujeau JC, Naldi L, Liss Y, Kazma R, Sekula P, Hovnanian A, Mockenhaupt M (2011) Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe. Orphanet J Rare Dis 6:52","journal-title":"Orphanet J Rare Dis"},{"issue":"4","key":"1549_CR22","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1097\/QAD.0b013e3282f37812","volume":"22","author":"ZG Vitezica","year":"2008","unstructured":"Vitezica ZG, Milpied B, Lonjou C, Borot N, Ledger TN, Lefebvre A, Hovnanian A (2008) HLA-DRB1*01 associated with cutaneous hypersensitivity induced by nevirapine and efavirenz. AIDS 22(4):540\u2013541","journal-title":"AIDS"},{"key":"1549_CR23","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1097\/FPC.0b013e32831d0faf","volume":"19","author":"S Chantarangsu","year":"2009","unstructured":"Chantarangsu S, Mushiroda T, Mahasirimongkol S, Kiertiburanakul S, Sungkanuparph S, Manosuthi W, Tantisiriwat W, Charoenyingwattana A, Sura T, Chantratita W, Nakamura Y (2009) HLA-B*3505 allele is a strong predictor for nevirapine-induced skin adverse drug reactions in HIV-infected Thai patients. Pharmacogenet Genomics 19:139\u2013146","journal-title":"Pharmacogenet Genomics"},{"issue":"1","key":"1549_CR24","doi-asserted-by":"publisher","first-page":"23","DOI":"10.2217\/pgs.09.142","volume":"11","author":"C Ciccacci","year":"2010","unstructured":"Ciccacci C, Borgiani P, Ceffa S, Sirianni E, Marazzi MC, Altan AM, Paturzo G, Bramanti P, Novelli G, Palombi L (2010) Nevirapine-induced hepatotoxicity and pharmacogenetics: a retrospective study in a population from Mozambique. Pharmacogenomics 11(1):23\u201331","journal-title":"Pharmacogenomics"},{"issue":"6","key":"1549_CR25","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1086\/507097","volume":"43","author":"DW Haas","year":"2006","unstructured":"Haas DW, Bartlett JA, Andersen JW, Sanne I, Wilkinson GR, Hinkle J, Rousseau F, Ingram CD, Shaw A, Lederman MM, Kim RB, Adult AIDS Clinical Trials Group (2006) Pharmacogenetics of nevirapine-associated hepatotoxicity: an Adult AIDS Clinical Trials Group collaboration. Clin Infect Dis 43(6):783\u2013786","journal-title":"Clin Infect Dis"},{"issue":"1","key":"1549_CR26","doi-asserted-by":"publisher","first-page":"97","DOI":"10.1097\/00002030-200501030-00014","volume":"19","author":"AM Martin","year":"2005","unstructured":"Martin AM, Nolan D, James I, Cameron P, Keller J, Moore C, Phillips E, Christiansen FT, Mallal S (2005) Predisposition to nevirapine hypersensitivity associated with HLA-DRB1*0101 and abrogated by low CD4 T-cell counts. AIDS 19(1):97\u201399","journal-title":"AIDS"},{"issue":"16","key":"1549_CR27","doi-asserted-by":"publisher","first-page":"2191","DOI":"10.1097\/QAD.0b013e3282ef9695","volume":"21","author":"A Saitoh","year":"2007","unstructured":"Saitoh A, Sarles E, Capparelli E, Aweeka F, Kovacs A, Burchett SK, Wiznia A, Nachman S, Fenton T, Spector SA (2007) CYP2B6 genetic variants are associated with nevirapine pharmacokinetics and clinical response in HIV-1-infected children. AIDS 21(16):2191\u20132199","journal-title":"AIDS"},{"key":"1549_CR28","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1097\/01.fpc.0000236338.41799.57","volume":"16","author":"A Owen","year":"2006","unstructured":"Owen A, Pirmohamed M, Khoo SH, Back DJ (2006) Pharmacogenetics of HIV therapy. Pharmacogenet Genomics 16:693\u2013703","journal-title":"Pharmacogenet Genomics"},{"issue":"1","key":"1549_CR29","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1097\/FPC.0b013e32834dd82e","volume":"22","author":"NJ Liptrott","year":"2012","unstructured":"Liptrott NJ, Pushpakom S, Wyen C, F\u00e4tkenheuer G, Hoffmann C, Mauss S, Knechten H, Brockmeyer NH, Hopper-Borge E, Siccardi M, Back DJ, Khoo SH, Pirmohamed M, Owen A, German Competence Network for HIV\/AIDS (2012) Association of ABCC10 polymorphisms with nevirapine plasma concentrations in the German Competence Network for HIV\/AIDS. Pharmacogenet Genomics 22(1):10\u201319","journal-title":"Pharmacogenet Genomics"},{"issue":"1","key":"1549_CR30","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/01213011-200501000-00001","volume":"15","author":"M Rotger","year":"2005","unstructured":"Rotger M, Colombo S, Furrer H, Bleiber G, Buclin T, Lee BL, Keiser O, Biollaz J, D\u00e9costerd L, Telenti A, Swiss HIV Cohort Study (2005) Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients. Pharmacogenet Genomics 15(1):1\u20135","journal-title":"Pharmacogenet Genomics"},{"key":"1549_CR31","first-page":"47","volume":"1","author":"LG Excoffier","year":"2005","unstructured":"Excoffier LG, Laval SS (2005) Arlequin ver. 3.0. An integrated software package for population genetics data analysis. Evol Bioinformatics Online 1:47\u201350","journal-title":"Evol Bioinformatics Online"},{"issue":"3","key":"1549_CR32","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1111\/j.1365-2125.2007.02884.x","volume":"64","author":"RK Mehlotra","year":"2007","unstructured":"Mehlotra RK, Bockarie MJ, Zimmerman PA (2007) CYP2B6 983T>C polymorphism is prevalent in West Africa but absent in Papua New Guinea: implications for HIV\/AIDS treatment. Br J Clin Pharmacol 64(3):391\u2013395","journal-title":"Br J Clin Pharmacol"},{"issue":"4","key":"1549_CR33","doi-asserted-by":"publisher","first-page":"914","DOI":"10.1093\/jac\/dkn029","volume":"61","author":"C Wyen","year":"2008","unstructured":"Wyen C, Hendra H, Vogel M, Hoffmann C, Knechten H, Brockmeyer NH, Bogner JR, Rockstroh J, Esser S, Jaeger H, Harrer T, Mauss S, van Lunzen J, Skoetz N, Jetter A, Groneuer C, F\u00e4tkenheuer G, Khoo SH, Egan D, Back DJ, Owen A, German Competence Network for HIV\/AIDS (2008) Impact of CYP2B6 983T>C polymorphism on non-nucleoside reverse transcriptase inhibitor plasma concentrations in HIV-infected patients. J Antimicrob Chemother 61(4):914\u2013918","journal-title":"J Antimicrob Chemother"},{"issue":"6","key":"1549_CR34","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1016\/j.jaci.2011.08.013","volume":"128","author":"TM Ko","year":"2011","unstructured":"Ko TM, Chung WH, Wei CY, Shih HY, Chen JK, Lin CH, Chen YT, Hung SI (2011) Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome. J Allergy Clin Immunol 128(6):1266\u20131276","journal-title":"J Allergy Clin Immunol"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-013-1549-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00228-013-1549-x\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-013-1549-x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-013-1549-x.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T15:46:55Z","timestamp":1659109615000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00228-013-1549-x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,6,18]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2013,11]]}},"alternative-id":["1549"],"URL":"https:\/\/doi.org\/10.1007\/s00228-013-1549-x","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2013,6,18]]},"assertion":[{"value":"1 March 2013","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"31 May 2013","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 June 2013","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}