{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T13:56:10Z","timestamp":1776347770811,"version":"3.51.2"},"reference-count":38,"publisher":"Springer Science and Business Media LLC","issue":"2","license":[{"start":{"date-parts":[[2014,11,8]],"date-time":"2014-11-08T00:00:00Z","timestamp":1415404800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2015,2]]},"DOI":"10.1007\/s00228-014-1777-8","type":"journal-article","created":{"date-parts":[[2014,11,14]],"date-time":"2014-11-14T18:15:10Z","timestamp":1415988910000},"page":"219-227","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":73,"title":["Metamizole-induced agranulocytosis revisited: results from the prospective Berlin Case\u2013Control Surveillance Study"],"prefix":"10.1007","volume":"71","author":[{"given":"Matthias","family":"Huber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Andersohn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giselle","family":"Sarganas","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Bronder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Klimpel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Thomae","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Konzen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reinhold","family":"Kreutz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edeltraut","family":"Garbe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2014,11,8]]},"reference":[{"key":"1777_CR1","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1001\/jama.1936.92770330003007b","volume":"107","author":"JE Benjamin","year":"1936","unstructured":"Benjamin JE, Bierman JB (1936) Agranulocytic leukopenia induced by a drug related to aminopyrine. JAMA 107:493\u2013494","journal-title":"JAMA"},{"key":"1777_CR2","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.1001\/jama.1986.03380130077032","volume":"256","author":"International Agranulocytosis and Aplastic Anemia Study","year":"1986","unstructured":"International Agranulocytosis and Aplastic Anemia Study (1986) Risks of agranulocytosis and aplastic anemia. A first report of their relation to drug use with special reference to analgesics. JAMA 256:1749\u20131757","journal-title":"JAMA"},{"key":"1777_CR3","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s00228-004-0836-y","volume":"60","author":"L Ibanez","year":"2005","unstructured":"Ibanez L, Vidal X, Ballarin E, Laporte JR (2005) Agranulocytosis associated with dipyrone (metamizol). Eur J Clin Pharmacol 60:821\u2013829","journal-title":"Eur J Clin Pharmacol"},{"key":"1777_CR4","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1177\/147323001003800419","volume":"38","author":"GW Basak","year":"2010","unstructured":"Basak GW, Drozd-Sokolowska J, Wiktor-Jedrzejczak W (2010) Update on the incidence of metamizole sodium-induced blood dyscrasias in Poland. J Int Med Res 38:1374\u20131380","journal-title":"J Int Med Res"},{"key":"1777_CR5","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1001\/archinte.159.4.369","volume":"159","author":"MM Klauw Van der","year":"1999","unstructured":"Van der Klauw MM, Goudsmit R, Halie MR, van\u2019t Veer MB, Herings RM, Wilson JH, Stricker BH (1999) A population-based case-cohort study of drug-associated agranulocytosis. Arch Intern Med 159:369\u2013374","journal-title":"Arch Intern Med"},{"key":"1777_CR6","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1007\/s00228-002-0465-2","volume":"58","author":"K Hedenmalm","year":"2002","unstructured":"Hedenmalm K, Spigset O (2002) Agranulocytosis and other blood dyscrasias associated with dipyrone (metamizole). Eur J Clin Pharmacol 58:265\u2013274","journal-title":"Eur J Clin Pharmacol"},{"key":"1777_CR7","doi-asserted-by":"crossref","first-page":"f4366","DOI":"10.1136\/bmj.f4366","volume":"347","author":"S Bhaumik","year":"2013","unstructured":"Bhaumik S (2013) India\u2019s health ministry bans pioglitazone, metamizole, and flupentixol-melitracen. BMJ 347:f4366","journal-title":"BMJ"},{"key":"1777_CR8","unstructured":"AbZ Pharma GmbH Ulm (2013) Metamizole-Summary of medicinal product characteristics. http:\/\/www.fachinfo.de . Accessed 16 Oct 2014"},{"key":"1777_CR9","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/j.1532-2149.2011.00029.x","volume":"16","author":"M K\u00f6lzsch","year":"2012","unstructured":"K\u00f6lzsch M, Wulff I, Ellert S, Fischer T, Kopke K, Kalinowski S, Drager D, Kreutz R (2012) Deficits in pain treatment in nursing homes in Germany: a cross-sectional study. Eur J Pain 16:439\u2013446","journal-title":"Eur J Pain"},{"key":"1777_CR10","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1016\/j.gerinurse.2013.08.002","volume":"34","author":"T Gazibara","year":"2013","unstructured":"Gazibara T, Nurkovic S, Kisic-Tepavcevic D, Kurtagic I, Kovacevic N, Gazibara T, Pekmezovic T (2013) Pharmacotherapy and over-the-counter drug use among elderly in Belgrade, Serbia. Geriatr Nurs 34:486\u2013490","journal-title":"Geriatr Nurs"},{"key":"1777_CR11","author":"FJ Abajo De","year":"2014","unstructured":"De Abajo FJ, Gil MJ, Garcia PP, Bryant V, Oliva B, Timoner J, Garcia-Rodriguez LA (2014) Risk of nonfatal acute myocardial infarction associated with non-steroidal antiinflammatory drugs, non-narcotic analgesics and other drugs used in osteoarthritis: a nested case\u2013control study. Pharmacoepidemiol Drug Saf. doi: 10.1002\/pds.3617","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"1777_CR12","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/ACO.0000000000000113","volume":"27","author":"E Pogatzki-Zahn","year":"2014","unstructured":"Pogatzki-Zahn E, Chandrasena C, Schug SA (2014) Nonopioid analgesics for postoperative pain management. Curr Opin Anaesthesiol 27:513\u2013519","journal-title":"Curr Opin Anaesthesiol"},{"key":"1777_CR13","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1002\/pds.2227","volume":"20","author":"C Varas-Lorenzo","year":"2011","unstructured":"Varas-Lorenzo C, Riera-Guardia N, Calingaert B, Castellsague J, Pariente A, Scotti L, Sturkenboom M, Perez-Gutthann S (2011) Stroke risk and NSAIDs: a systematic review of observational studies. Pharmacoepidemiol Drug Saf 20:1225\u20131236","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"1777_CR14","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s00228-014-1734-6","volume":"70","author":"M Wehling","year":"2014","unstructured":"Wehling M (2014) Non-steroidal anti-inflammatory drug use in chronic pain conditions with special emphasis on the elderly and patients with relevant comorbidities: management and mitigation of risks and adverse effects. Eur J Clin Pharmacol 70:1159\u20131172","journal-title":"Eur J Clin Pharmacol"},{"key":"1777_CR15","doi-asserted-by":"crossref","first-page":"E85","DOI":"10.36076\/ppj.2013\/16\/E85","volume":"16","author":"A Dahan","year":"2013","unstructured":"Dahan A, Overdyk F, Smith T, Aarts L, Niesters M (2013) Pharmacovigilance: a review of opioid-induced respiratory depression in chronic pain patients. Pain Physician 16:E85\u2013E94","journal-title":"Pain Physician"},{"key":"1777_CR16","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S1526-5900(03)00556-X","volume":"4","author":"E McNicol","year":"2003","unstructured":"McNicol E, Horowicz-Mehler N, Fisk RA, Bennett K, Gialeli-Goudas M, Chew PW, Lau J, Carr D (2003) Management of opioid side effects in cancer-related and chronic noncancer pain: a systematic review. J Pain 4:231\u2013256","journal-title":"J Pain"},{"key":"1777_CR17","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1111\/j.1532-5415.2012.03923.x","volume":"60","author":"American Geriatric Society","year":"2012","unstructured":"American Geriatric Society (2012) American Geriatrics Society updated beers criteria for potentially inappropriate medication use in older adults. J Am Geriatr Soc 60:616\u2013631","journal-title":"J Am Geriatr Soc"},{"key":"1777_CR18","first-page":"543","volume":"107","author":"S Holt","year":"2010","unstructured":"Holt S, Schmiedl S, Thurmann PA (2010) Potentially inappropriate medications in the elderly: the PRISCUS list. Dtsch Arztebl Int 107:543\u2013551","journal-title":"Dtsch Arztebl Int"},{"key":"1777_CR19","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/j.1365-2141.2011.08784.x","volume":"154","author":"E Garbe","year":"2011","unstructured":"Garbe E, Andersohn F, Bronder E, Klimpel A, Thomae M, Schrezenmeier H, Hildebrandt M, Spath-Schwalbe E, Gruneisen A, Mayer B, Salama A, Kurtal H (2011) Drug induced immune haemolytic anaemia in the Berlin Case\u2013Control Surveillance Study. Br J Haematol 154:644\u2013653","journal-title":"Br J Haematol"},{"key":"1777_CR20","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s00228-011-1184-3","volume":"68","author":"E Garbe","year":"2012","unstructured":"Garbe E, Andersohn F, Bronder E, Salama A, Klimpel A, Thomae M, Schrezenmeier H, Hildebrandt M, Spath-Schwalbe E, Gruneisen A, Meyer O, Kurtal H (2012) Drug-induced immune thrombocytopaenia: results from the Berlin Case\u2013Control Surveillance Study. Eur J Clin Pharmacol 68:821\u2013832","journal-title":"Eur J Clin Pharmacol"},{"key":"1777_CR21","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1111\/apt.12461","volume":"38","author":"A Douros","year":"2013","unstructured":"Douros A, Bronder E, Andersohn F, Klimpel A, Thomae M, Ockenga J, Kreutz R, Garbe E (2013) Drug-induced acute pancreatitis: results from the hospital-based Berlin Case\u2013Control Surveillance Study of 102 cases. Aliment Pharmacol Ther 38:825\u2013834","journal-title":"Aliment Pharmacol Ther"},{"key":"1777_CR22","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s00228-013-1618-1","volume":"70","author":"M Huber","year":"2014","unstructured":"Huber M, Andersohn F, Bronder E, Klimpel A, Thomae M, Konzen C, Meyer O, Salama A, Schrezenmeier H, Hildebrandt M, Spath-Schwalbe E, Gruneisen A, Kreutz R, Garbe E (2014) Drug-induced agranulocytosis in the Berlin Case\u2013Control Surveillance Study. Eur J Clin Pharmacol 70:339\u2013345","journal-title":"Eur J Clin Pharmacol"},{"key":"1777_CR23","unstructured":"The Uppsala Monitoring Centre (2012) The use of the WHO-UMC system for standardised case causality assessment. WHO-UMC web. http:\/\/who-umc.org\/Graphics\/24734.pdf . Accessed 10 Jul 2014"},{"key":"1777_CR24","unstructured":"Deutschland Regionalstatistik. Regionaldatenbank Deutschland. D\u00fcsseldorf 2010. http:\/\/www.regionalstatistik.de\/genesis\/online;jsessionid=9DE71A1700AF2182E35C5CD292700FB8?Sequenz=tabelleErgebnis&selectionname=173-21-4 . Accessed 10 Jul 2014"},{"key":"1777_CR25","unstructured":"WIdO Research Institute(\u2018Wissenschaftliches Institut der AOK\u2019), Berlin, Germany (2014) Arzneimittel. http:\/\/www.wido.de . Accessed 16 Oct 2014"},{"key":"1777_CR26","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1001\/archinte.165.8.869","volume":"165","author":"L Ibanez","year":"2005","unstructured":"Ibanez L, Vidal X, Ballarin E, Laporte JR (2005) Population-based drug-induced agranulocytosis. Arch Intern Med 165:869\u2013874","journal-title":"Arch Intern Med"},{"key":"1777_CR27","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1517\/14740338.6.3.323","volume":"6","author":"E Garbe","year":"2007","unstructured":"Garbe E (2007) Non-chemotherapy drug-induced agranulocytosis. Expert Opin Drug Saf 6:323\u2013335","journal-title":"Expert Opin Drug Saf"},{"key":"1777_CR28","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1136\/bmj.3.5875.339","volume":"3","author":"LE Bottiger","year":"1973","unstructured":"Bottiger LE, Westerholm B (1973) Drug-induced blood dyscrasias in Sweden. Br Med J 3:339\u2013343","journal-title":"Br Med J"},{"key":"1777_CR29","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1002\/pds.697","volume":"11","author":"M Backstrom","year":"2002","unstructured":"Backstrom M, Hagg S, Mjorndal T, Dahlqvist R (2002) Utilization pattern of metamizole in northern Sweden and risk estimates of agranulocytosis. Pharmacoepidemiol Drug Saf 11:239\u2013245","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"1777_CR30","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1007\/s00520-007-0327-7","volume":"15","author":"JF Duarte Souza","year":"2007","unstructured":"Duarte Souza JF, Lajolo PP, Pinczowski H, del Giglio A (2007) Adjunct dipyrone in association with oral morphine for cancer-related pain: the sooner the better. Support Care Cancer 15:1319\u20131323","journal-title":"Support Care Cancer"},{"key":"1777_CR31","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00482-011-1022-7","volume":"25","author":"EA Lux","year":"2011","unstructured":"Lux EA, Stamer U, Meissner W, Wiebalck A (2011) Postoperative pain management after ambulatory surgery. A survey of anaesthesiologists. Schmerz 25:191\u2013198","journal-title":"Schmerz"},{"key":"1777_CR32","doi-asserted-by":"crossref","first-page":"95","DOI":"10.21307\/immunohematology-2019-103","volume":"30","author":"BR Curtis","year":"2014","unstructured":"Curtis BR (2014) Drug-induced immune neutropenia\/agranulocytosis. Immunohematology 30:95\u2013101","journal-title":"Immunohematology"},{"key":"1777_CR33","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1002\/ajh.2830310314","volume":"31","author":"JB Hargis","year":"1989","unstructured":"Hargis JB, La Russa VF, Redmond J, Kessler SW, Wright DG (1989) Agranulocytosis associated with \u201cMexican aspirin\u201d (dipyrone): evidence for an autoimmune mechanism affecting multipotential hematopoietic progenitors. Am J Hematol 31:213\u2013215","journal-title":"Am J Hematol"},{"key":"1777_CR34","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/BF03259896","volume":"3","author":"H Heimpel","year":"1988","unstructured":"Heimpel H (1988) Drug-induced agranulocytosis. Med Toxicol Adverse Drug Exp 3:449\u2013462","journal-title":"Med Toxicol Adverse Drug Exp"},{"key":"1777_CR35","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1592\/phco.26.3.440","volume":"26","author":"S Garcia","year":"2006","unstructured":"Garcia S, Canionero M, Lopes G (2006) Dipyrone-induced granulocytopenia: a case for awareness. Pharmacotherapy 26:440\u2013442","journal-title":"Pharmacotherapy"},{"issue":"1","key":"1777_CR36","doi-asserted-by":"crossref","first-page":"e46","DOI":"10.1097\/MPH.0b013e31826e7d9d","volume":"36","author":"M Isk","year":"2014","unstructured":"Isk M, Kaya Z, Belen FB, Aktas AT, Tezer H, Gursel T (2014) Life-threatening agranulocytosis, anemia, and plasmacytosis after dipyrone Use for fever in a child. J Pediatr Hematol Oncol 36(1):e46\u2013e48","journal-title":"J Pediatr Hematol Oncol"},{"issue":"33","key":"1777_CR37","first-page":"A-1758 \/ B-1498","volume":"108","author":"Drug Commission of the German Physicians","year":"2011","unstructured":"Drug Commission of the German Physicians (2011) (Arzneimittelkommission der Deutschen \u00c4rzteschaft). \u201cAus der UAW-Datenbank\u201dAgranulozytose nach Metamizol \u2013 sehr selten, aber h\u00e4ufiger als gedacht. Deutsches \u00c4rzteblatt 108(33):A-1758 \/ B-1498 \/ C-1494","journal-title":"Deutsches \u00c4rzteblatt"},{"key":"1777_CR38","first-page":"9","volume":"3","author":"J Rotthauwe","year":"2011","unstructured":"Institute for Drugs and Medical Devices in Germany (Bundesinstitut f\u00fcr Arzneimittel und Medizinprodukte), Rotthauwe J (2011) Metamizol \u2013 Indikationsstellung, Gegenanzeigen, Vorsichtsma\u00dfnahmen und Warnhinweise beachten. Bull Arzneimittelsicherheit 3:9\u201311, available from: http:\/\/www.pei.de\/SharedDocs\/Downloads\/vigilanz\/bulletin-zur-arzneimittelsicherheit\/2011\/3-2011.pdf?__blob=publicationFile&v=1 . Accessed 16 Oct 2014","journal-title":"Bull Arzneimittelsicherheit"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-014-1777-8.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00228-014-1777-8\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-014-1777-8","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,4,22]],"date-time":"2022-04-22T09:08:57Z","timestamp":1650618537000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00228-014-1777-8"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,8]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,2]]}},"alternative-id":["1777"],"URL":"https:\/\/doi.org\/10.1007\/s00228-014-1777-8","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,11,8]]}}}