{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:04:14Z","timestamp":1791227054407,"version":"4.1.0"},"reference-count":18,"publisher":"Springer Science and Business Media LLC","issue":"4","license":[{"start":{"date-parts":[[2017,1,7]],"date-time":"2017-01-07T00:00:00Z","timestamp":1483747200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"funder":[{"DOI":"10.13039\/501100006739","name":"Capital Foundation of Medical Development","doi-asserted-by":"publisher","award":["2009-2021"],"award-info":[{"award-number":["2009-2021"]}],"id":[{"id":"10.13039\/501100006739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2017,4]]},"DOI":"10.1007\/s00228-016-2190-2","type":"journal-article","created":{"date-parts":[[2017,1,7]],"date-time":"2017-01-07T05:44:47Z","timestamp":1483767887000},"page":"445-453","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Population pharmacokinetic models of lamotrigine in different age groups of Chinese children with epilepsy"],"prefix":"10.1007","volume":"73","author":[{"given":"Zhong-bin","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang-min","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-li","family":"Zang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying-hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2017,1,7]]},"reference":[{"issue":"5","key":"2190_CR1","doi-asserted-by":"crossref","first-page":"387","DOI":"10.2165\/00003088-198611050-00004","volume":"11","author":"B Whiting","year":"1986","unstructured":"Whiting B, Kelman AW, Grevel J (1986) Population pharmacokinetics. Theory and clinical application. Clin Pharmacokinet 11(5):387\u2013401","journal-title":"Clin Pharmacokinet"},{"issue":"1","key":"2190_CR2","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1046\/j.1365-2710.1999.00202.x","volume":"24","author":"BB Serrano","year":"1999","unstructured":"Serrano BB, Garcia SMJ, Otero MJ et al (1999) Valproate population pharmacokinetics in children. J Clin Pharm Ther 24(1):73\u201380","journal-title":"J Clin Pharm Ther"},{"issue":"9","key":"2190_CR3","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/bdd.636","volume":"29","author":"T Correa","year":"2008","unstructured":"Correa T, Rodriguez I, Romano S (2008) Population pharmacokinetics of valproate in Mexican children with epilepsy. Biopharm Drug Dispos 29(9):511\u2013520","journal-title":"Biopharm Drug Dispos"},{"issue":"6","key":"2190_CR4","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1038\/aps.2012.57","volume":"33","author":"YH Wang","year":"2012","unstructured":"Wang YH, Wang L, Lu W et al (2012) Population pharmacokinetics modeling of levetiracetam in Chinese children with epilepsy. Acta Pharmacol Sin 33(6):845\u2013851","journal-title":"Acta Pharmacol Sin"},{"issue":"10","key":"2190_CR5","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1038\/aps.2014.76","volume":"35","author":"Y Wang","year":"2014","unstructured":"Wang Y, Zhang HN, Niu CH et al (2014) Population pharmacokinetics modeling of oxcarbazepine to characterize drug interactions in Chinese children with epilepsy. Acta Pharmacol Sin 35(10):1342\u20131350","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"2190_CR6","doi-asserted-by":"crossref","first-page":"152","DOI":"10.2165\/00003495-199346010-00009","volume":"46","author":"KL Goa","year":"1993","unstructured":"Goa KL, Ross SR, Chrisp P (1993) Lamotrigine. A review of its pharmacological properties and clinical efficacy in epilepsy. Drugs 46(1):152\u2013176","journal-title":"Drugs"},{"issue":"6","key":"2190_CR7","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1046\/j.1365-2125.1998.00835.x","volume":"46","author":"RG Morris","year":"1998","unstructured":"Morris RG, Black AB, Harris AL et al (1998) Lamotrigine and therapeutic drug monitoring: retrospective survey following the introduction of a routine service. Br J Clin Pharmacol 46(6):547\u2013551","journal-title":"Br J Clin Pharmacol"},{"issue":"5","key":"2190_CR8","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1345\/aph.1A252","volume":"36","author":"E Chong","year":"2002","unstructured":"Chong E, Dupuis LL (2002) Therapeutic drug monitoring of lamotrigine. Ann Pharmacother 36(5):917\u2013920","journal-title":"Ann Pharmacother"},{"issue":"2","key":"2190_CR9","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1046\/j.1365-2125.2000.00237.x","volume":"50","author":"C Chen","year":"2000","unstructured":"Chen C (2000) Validation of a population pharmacokinetic model for adjunctive lamotrigine therapy in children. Br J Clin Pharmacol 50(2):135\u2013145","journal-title":"Br J Clin Pharmacol"},{"issue":"12","key":"2190_CR10","doi-asserted-by":"crossref","first-page":"752","DOI":"10.5414\/CPP47752","volume":"47","author":"JR Milovanovic","year":"2009","unstructured":"Milovanovic JR, Jankovic SM (2009) Population pharmacokinetics of lamotrigine in patients with epilepsy. Int J Clin Pharmacol Ther 47(12):752\u2013760","journal-title":"Int J Clin Pharmacol Ther"},{"issue":"2","key":"2190_CR11","first-page":"105","volume":"10","author":"S Zhang","year":"2008","unstructured":"Zhang S, Wang L, Lu W (2008) Population pharmacokinetics of lamotrigine in Chinese children with epilepsy. Zhongguo Dang Dai Er Ke Za Zhi 10(2):105\u2013109","journal-title":"Zhongguo Dang Dai Er Ke Za Zhi"},{"issue":"11","key":"2190_CR12","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1038\/aps.2012.118","volume":"33","author":"DK He","year":"2012","unstructured":"He DK, Wang L, Qin J et al (2012) Population pharmacokinetics of lamotrigine in Chinese children with epilepsy. Acta Pharmacol Sin 33(11):1417\u20131423","journal-title":"Acta Pharmacol Sin"},{"issue":"1","key":"2190_CR13","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00228-012-1311-9","volume":"69","author":"S Mallaysamy","year":"2013","unstructured":"Mallaysamy S, Johnson MG, Rao PG et al (2013) Population pharmacokinetics of lamotrigine in Indian epileptic patients. Eur J Clin Pharmacol 69(1):43\u201352","journal-title":"Eur J Clin Pharmacol"},{"issue":"2","key":"2190_CR14","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s00228-013-1606-5","volume":"70","author":"B Brzakovic","year":"2014","unstructured":"Brzakovic B, Vucicevic K, Kovacevic SV et al (2014) Pharmacokinetics of lamotrigine in paediatric and young adult epileptic patients\u2014nonlinear mixed effects modelling approach. Eur J Clin Pharmacol 70(2):179\u2013185","journal-title":"Eur J Clin Pharmacol"},{"issue":"4","key":"2190_CR15","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1177\/00912709922007949","volume":"39","author":"TH Grasela","year":"1999","unstructured":"Grasela TH, Fiedler-Kelly J, Cox E et al (1999) Population pharmacokinetics of lamotrigine adjunctive therapy in adults with epilepsy. J Clin Pharmacol 39(4):373\u2013384","journal-title":"J Clin Pharmacol"},{"issue":"12","key":"2190_CR16","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1007\/s00431-006-0189-x","volume":"165","author":"BJ Anderson","year":"2006","unstructured":"Anderson BJ, Allegaert K, Holford NH (2006) Population clinical pharmacology of children: modelling covariate effects. Eur J Pediatr 165(12):819\u2013829","journal-title":"Eur J Pediatr"},{"issue":"1","key":"2190_CR17","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0920-1211(00)00160-1","volume":"42","author":"BE Gidal","year":"2000","unstructured":"Gidal BE, Anderson GD, Rutecki PR et al (2000) Lack of an effect of valproate concentration on lamotrigine pharmacokinetics in developmentally disabled patients with epilepsy. Epilepsy Res 42(1):23\u201331","journal-title":"Epilepsy Res"},{"issue":"12","key":"2190_CR18","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1056\/NEJMra035092","volume":"349","author":"GL Kearns","year":"2003","unstructured":"Kearns GL, Abdel-Rahman SM, Alander SW et al (2003) Developmental pharmacology\u2014drug disposition, action, and therapy in infants and children. N Engl J Med 349(12):1157\u20131167","journal-title":"N Engl J Med"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-016-2190-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00228-016-2190-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-016-2190-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,6,25]],"date-time":"2017-06-25T03:33:27Z","timestamp":1498361607000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00228-016-2190-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,7]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,4]]}},"alternative-id":["2190"],"URL":"https:\/\/doi.org\/10.1007\/s00228-016-2190-2","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,7]]}}}