{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T05:41:44Z","timestamp":1775886104463,"version":"3.50.1"},"reference-count":44,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2017,7,8]],"date-time":"2017-07-08T00:00:00Z","timestamp":1499472000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2017,7,8]],"date-time":"2017-07-08T00:00:00Z","timestamp":1499472000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1007\/s00228-017-2295-2","type":"journal-article","created":{"date-parts":[[2017,7,8]],"date-time":"2017-07-08T17:08:30Z","timestamp":1499533710000},"page":"1253-1259","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Impact of glutathione transferases genes polymorphisms in nevirapine adverse reactions: a possible role for GSTM1 in SJS\/TEN susceptibility"],"prefix":"10.1007","volume":"73","author":[{"given":"Cinzia","family":"Ciccacci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Latini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cristina","family":"Politi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandro","family":"Mancinelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria C.","family":"Marazzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Novelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Palombi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Borgiani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2017,7,8]]},"reference":[{"key":"2295_CR1","doi-asserted-by":"publisher","first-page":"1403","DOI":"10.1097\/QAD.0b013e32835f1db0","volume":"27","author":"Z Shubber","year":"2013","unstructured":"Shubber Z, Calmy A, Andrieux-Meyer I, Vitoria M, Renaud-Th\u00e9ry F, Shaffer N, Hargreaves S, Mills EJ, Ford N (2013) Adverse events associated with nevirapine and efavirenz-based first-line antiretroviral therapy: a systematic review and meta-analysis. AIDS 27:1403\u20131412","journal-title":"AIDS"},{"key":"2295_CR2","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1111\/j.1468-1293.2006.00386.x","volume":"7","author":"MC Marazzi","year":"2006","unstructured":"Marazzi MC, Germano P, Liotta G, Guidotti G, Loureiro S, da Cruz GA, Valls Blazquez MC, Narciso P, Perno CF, Mancinelli S, Palombi L (2006) Safety of nevirapine-containing antiretroviral triple therapy regimens to prevent vertical transmission in an African cohort of HIV-1-infected pregnant women. HIV Med 7:338\u2013344","journal-title":"HIV Med"},{"key":"2295_CR3","doi-asserted-by":"publisher","first-page":"S21","DOI":"10.1097\/00126334-200309011-00005","volume":"34","author":"JO Stern","year":"2003","unstructured":"Stern JO, Robinson PA, Love J, Lanes S, Imperiale MS, Mayers DL (2003) A comprehensive hepatic safety analysis of nevirapine in different populations of HIV infected patients. J Acquir Immune Defic Syndr 34:S21\u2013S33","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2295_CR4","doi-asserted-by":"publisher","first-page":"12617","DOI":"10.1371\/journal.pone.0012617","volume":"5","author":"E Aaron","year":"2010","unstructured":"Aaron E, Kempf MC, Criniti S, Tedaldi E, Gracely E, Warriner A, Kumar R, Bachmann LH (2010) Adverse events in a cohort of HIV infected pregnant and non-pregnant women treated with nevirapine versus non-nevirapine antiretroviral medication. PLoS One 5:12617","journal-title":"PLoS One"},{"key":"2295_CR5","doi-asserted-by":"crossref","unstructured":"Coffie PA, Tonwe-Gold B, Tanon AK, Amani-Bosse C, B\u00e9dikou G, Abrams EJ, Dabis F, Ekouevi DK. (2010) Incidence and risk factors of severe adverse events with nevirapine-based antiretroviral therapy in HIV-infected women. MTCT-Plus program, Abidjan, C\u00f4te d'Ivoire. BMC Infect Dis 10:188","DOI":"10.1186\/1471-2334-10-188"},{"key":"2295_CR6","doi-asserted-by":"publisher","first-page":"513","DOI":"10.1111\/j.1742-7843.2011.00780.x","volume":"109","author":"C Gozalo","year":"2011","unstructured":"Gozalo C, G\u00e9rard L, Loiseau P, Morand-Joubert L, Peytavin G, Molina JM, Dellamonica P, Becquemont L, Aboulker JP, Launay O, Verstuyft C, ANRS 081 Study Group (2011) Pharmacogenetics of toxicity, plasma trough concentration and treatment outcome with nevirapine-containing regimen in anti-retroviral-na\u00efve HIV-infected adults: an exploratory study of the TRIANON ANRS 081 trial. Basic Clin Pharmacol Toxicol 109:513\u2013520","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"2295_CR7","doi-asserted-by":"publisher","first-page":"418","DOI":"10.1007\/s11882-013-0418-0","volume":"14","author":"E Karlin","year":"2014","unstructured":"Karlin E, Phillips E (2014) Genotyping for severe drug hypersensitivity. Curr Allergy Asthma Rep 14:418","journal-title":"Curr Allergy Asthma Rep"},{"key":"2295_CR8","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1097\/COH.0000000000000134","volume":"10","author":"DW Haas","year":"2015","unstructured":"Haas DW, Tarr PE (2015) Perspectives on pharmacogenomics of antiretroviral medications and HIV-associated comorbidities. Curr Opin HIV AIDS 10:116\u2013122","journal-title":"Curr Opin HIV AIDS"},{"key":"2295_CR9","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.2217\/pgs.15.128","volume":"16","author":"S Rufini","year":"2015","unstructured":"Rufini S, Ciccacci C, Politi C, Giardina E, Novelli G, Borgiani P (2015) Stevens-Johnson syndrome and toxic epidermal necrolysis: an update on pharmacogenetics studies in drug-induced severe skin reaction. Pharmacogenomics 16:1989\u20132002","journal-title":"Pharmacogenomics"},{"key":"2295_CR10","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1097\/01213011-200501000-00001","volume":"15","author":"M Rotger","year":"2005","unstructured":"Rotger M, Colombo S, Furrer H, Bleiber G, Buclin T, Lee BL, Keiser O, Biollaz J, D\u00e9costerd L, Telenti A, Swiss HIV Cohort Study (2005) Influence of CYP2B6 polymorphism on plasma and intracellular concentrations and toxicity of efavirenz and nevirapine in HIV-infected patients. Pharmacogenet Genomics 15:1\u20135","journal-title":"Pharmacogenet Genomics"},{"key":"2295_CR11","doi-asserted-by":"publisher","first-page":"783","DOI":"10.1086\/507097","volume":"43","author":"DW Haas","year":"2006","unstructured":"Haas DW, Bartlett JA, Andersen JW, Sanne I, Wilkinson GR, Hinkle J, Rousseau F, Ingram CD, Shaw A, Lederman MM, Kim RB Adult AIDS Clinical TrialsGroup (2006) Pharmacogenetics of nevirapine-associated hepatotoxicity: an Adult AIDS Clinical Trials Group collaboration. Clin Infect Dis 43:783\u2013786","journal-title":"Clin Infect Dis"},{"key":"2295_CR12","doi-asserted-by":"publisher","first-page":"23","DOI":"10.2217\/pgs.09.142","volume":"11","author":"C Ciccacci","year":"2010","unstructured":"Ciccacci C, Borgiani P, Ceffa S, Sirianni E, Marazzi MC, Altan AM, Paturzo G, Bramanti P, Novelli G, Palombi L (2010) Nevirapine-induced hepatotoxicity and pharmacogenetics: a retrospective study in a population from Mozambique. Pharmacogenomics 11:23\u201331","journal-title":"Pharmacogenomics"},{"key":"2295_CR13","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1007\/s00228-013-1549-x","volume":"69","author":"C Ciccacci","year":"2013","unstructured":"Ciccacci C, Di Fusco D, Marazzi MC, Zimba I, Erba F, Novelli G, Palombi L, Borgiani P, Liotta G (2013) Association between CYP2B6 polymorphisms and Nevirapine-induced SJS\/TEN: a pharmacogenetics study. Eur J Clin Pharmacol 69:1909\u20131916","journal-title":"Eur J Clin Pharmacol"},{"key":"2295_CR14","doi-asserted-by":"publisher","first-page":"3329","DOI":"10.1093\/jac\/dku315","volume":"69","author":"DF Carr","year":"2014","unstructured":"Carr DF, Chaponda M, Cornejo Castro EM, Jorgensen AL, Khoo S, Van Oosterhout JJ, Dandara C, Kampira E, Ssali F, Munderi P, Lalloo DG, Heyderman RS, Pirmohamed M (2014) CYP2B6 c.983T>C polymorphism is associated with nevirapine hypersensitivity in Malawian and Ugandan HIV populations. J Antimicrob Chemother 69:3329\u20133334","journal-title":"J Antimicrob Chemother"},{"key":"2295_CR15","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1038\/tpj.2011.41","volume":"13","author":"M Tohkin","year":"2013","unstructured":"Tohkin M, Kaniwa N, Saito Y, Sugiyama E, Kurose K, Nishikawa J, Hasegawa R, Aihara M, Matsunaga K, Abe M, Furuya H, Takahashi Y, Ikeda H, Muramatsu M, Ueta M, Sotozono C, Kinoshita S, Ikezawa Z, Japan Pharmacogenomics Data Science Consortium (2013) A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients. Pharmacogenomics J 13:60\u201369","journal-title":"Pharmacogenomics J"},{"key":"2295_CR16","doi-asserted-by":"publisher","first-page":"52","DOI":"10.1186\/1750-1172-6-52","volume":"6","author":"E G\u00e9nin","year":"2011","unstructured":"G\u00e9nin E, Schumacher M, Roujeau JC, Naldi L, Liss Y, Kazma R, Sekula P, Hovnanian A, Mockenhaupt M (2011) Genome-wide association study of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis in Europe. Orphanet J Rare Dis 6:52","journal-title":"Orphanet J Rare Dis"},{"key":"2295_CR17","doi-asserted-by":"publisher","first-page":"275","DOI":"10.1007\/s00228-013-1622-5","volume":"70","author":"P Borgiani","year":"2014","unstructured":"Borgiani P, Di Fusco D, Erba F, Marazzi MC, Mancinelli S, Novelli G, Palombi L, Ciccacci C (2014) HCP5 genetic variant (RS3099844) contributes to Nevirapine-induced Stevens Johnsons Syndrome\/Toxic Epidermal Necrolysis susceptibility in a population from Mozambique. Eur J Clin Pharmacol 70:275\u2013278","journal-title":"Eur J Clin Pharmacol"},{"key":"2295_CR18","doi-asserted-by":"publisher","first-page":"5830","DOI":"10.3390\/ijms16035830","volume":"16","author":"C Ciccacci","year":"2015","unstructured":"Ciccacci C, Rufini S, Mancinelli S, Buonomo E, Giardina E, Scarcella P, Marazzi MC, Novelli G, Palombi L, Borgiani P (2015) A pharmacogenetics study in Mozambican patients treated with nevirapine: full resequencing of TRAF3IP2 gene shows a novel association with SJS\/TEN susceptibility. Int J Mol Sci 16:5830\u20135838","journal-title":"Int J Mol Sci"},{"key":"2295_CR19","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.3109\/13880209.2013.798668","volume":"51","author":"F Lv","year":"2013","unstructured":"Lv F, Song LJ, Wang XH, Qiu F, Li XF (2013) The role of Act1, a NF-\u03baB-activating protein, in IL-6 and IL-8 levels induced by IL-17 stimulation in SW982 cells. Pharm Biol 51:1444\u20131450","journal-title":"Pharm Biol"},{"key":"2295_CR20","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1016\/j.cellsig.2012.10.009","volume":"25","author":"B Venkatesan","year":"2013","unstructured":"Venkatesan B, Valente AJ, Das NA, Carpenter AJ, Yoshida T, Delafontaine JL, Siebenlist U, Chandrasekar B (2013) CIKS (Act1 or TRAF3IP2) mediates high glucose-induced endothelial dysfunction. Cell Signal 25:359\u2013371","journal-title":"Cell Signal"},{"key":"2295_CR21","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1038\/tpj.2015.88","volume":"17","author":"HO Singh","year":"2015","unstructured":"Singh HO, Lata S, Angadi M, Bapat S, Pawar J, Nema V, Ghate MV, Sahay S, Gangakhedkar RR (2015) Impact of GSTM1, GSTT1 and GSTP1 gene polymorphism and risk of ARV-associated hepatotoxicity in HIV-infected individuals and its modulation. Pharmacogenomics J 17:53\u201360","journal-title":"Pharmacogenomics J"},{"key":"2295_CR22","first-page":"231","volume":"148","author":"RC Strange","year":"1999","unstructured":"Strange RC, Fryer AA (1999) The glutathione S-transferases: influence of polymorphism on cancer susceptibility. IARC Sci Publ 148:231\u2013249","journal-title":"IARC Sci Publ"},{"key":"2295_CR23","doi-asserted-by":"publisher","first-page":"92","DOI":"10.3109\/03602532.2011.567391","volume":"43","author":"LG Higgins","year":"2011","unstructured":"Higgins LG, Hayes JD (2011) Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents. Drug Metab Rev 43:92\u2013137","journal-title":"Drug Metab Rev"},{"key":"2295_CR24","doi-asserted-by":"publisher","first-page":"3267","DOI":"10.1016\/j.bbagen.2012.11.019","volume":"1830","author":"PG Board","year":"2013","unstructured":"Board PG, Menon D (2013) Glutathione transferases, regulators of cellular metabolism and physiology. Biochim Biophys Acta 1830:3267\u20133288","journal-title":"Biochim Biophys Acta"},{"key":"2295_CR25","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/S1043-6618(02)00320-1","volume":"47","author":"L Gil","year":"2003","unstructured":"Gil L, Mart\u00ednez G, Gonz\u00e1lez I, Tarinas A, Alvarez A, Giuliani A, Molina R, T\u00e1panes R, P\u00e9rez J, Le\u00f3n OS (2003) Contribution to characterization of oxidative stress in HIV\/AIDS patients. Pharmacol Res 47:217\u2013224","journal-title":"Pharmacol Res"},{"key":"2295_CR26","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1016\/j.mrgentox.2004.11.018","volume":"581","author":"P Chacko","year":"2005","unstructured":"Chacko P, Joseph T, Mathew BS, Rajan B, Pillai MR (2005) Role of xenobiotic metabolizing gene polymorphisms in breast cancer susceptibility and treatment outcome. Mutat Res 581:153\u2013163","journal-title":"Mutat Res"},{"key":"2295_CR27","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1517\/17425250903427980","volume":"6","author":"G Di Pietro","year":"2010","unstructured":"Di Pietro G, Magno LA, Rios-Santos F (2010) Glutathione S-transferases: an overview in cancer research. Expert Opin Drug Metab Toxicol 6:153\u2013170","journal-title":"Expert Opin Drug Metab Toxicol"},{"key":"2295_CR28","doi-asserted-by":"publisher","first-page":"1617","DOI":"10.1016\/j.ejca.2010.02.009","volume":"46","author":"KP Economopoulos","year":"2010","unstructured":"Economopoulos KP, Sergentanis TN (2010) GSTM1, GSTT1, GSTP1, GSTA1 and colorectal cancer risk: a comprehensive meta-analysis. Eur J Cancer 46:1617\u20131631","journal-title":"Eur J Cancer"},{"key":"2295_CR29","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1038\/jid.2008.14","volume":"128","author":"TP Millard","year":"2008","unstructured":"Millard TP, Fryer AA, McGregor JM (2008) A protective effect of glutathione-S-transferase GSTP1*Val (105) against polymorphic light eruption. J Invest Dermatol 128:1901\u20131905","journal-title":"J Invest Dermatol"},{"key":"2295_CR30","doi-asserted-by":"publisher","first-page":"638693","DOI":"10.1155\/2015\/638693","volume":"2015","author":"A Stoian","year":"2015","unstructured":"Stoian A, B\u0103nescu C, B\u0103la\u015fa RI, Mo\u0163\u0103\u0163\u0103ianu A, Stoian M, Moldovan VG, Void\u0103zan S, Dobreanu M (2015) Influence of GSTM1, GSTT1, and GSTP1 polymorphisms on type 2 diabetes mellitus and diabetic sensorimotor peripheral neuropathy risk. Dis Markers 2015:638693","journal-title":"Dis Markers"},{"key":"2295_CR31","doi-asserted-by":"publisher","first-page":"19602","DOI":"10.3390\/ijms160819602","volume":"16","author":"SK Kim","year":"2015","unstructured":"Kim SK, Kang SW, Chung JH, Park HJ, Cho KB, Park MS (2015) Genetic polymorphisms of glutathione-related enzymes (GSTM1, GSTT1, and GSTP1) and schizophrenia risk: a meta-analysis. Int J Mol Sci 16:19602\u201319611","journal-title":"Int J Mol Sci"},{"key":"2295_CR32","doi-asserted-by":"publisher","first-page":"9463","DOI":"10.4238\/2014.November.11.11","volume":"13","author":"FM Feng","year":"2014","unstructured":"Feng FM, Guo M, Chen Y, Li SM, Zhang P, Sun SF, Zhang GS (2014) Genetic polymorphisms in metabolic enzymes and susceptibility to anti-tuberculosis drug-induced hepatic injury. Genet Mol Res 13:9463\u20139471","journal-title":"Genet Mol Res"},{"key":"2295_CR33","first-page":"13346","volume":"18","author":"G Wu","year":"2015","unstructured":"Wu G, Jiang B, Liu X, Shen Y, Yang S (2015) Association of GSTs gene polymorphisms with treatment outcome of advanced non-small cell lung cancer patients with cisplatin-based chemotherapy. Int J Clin Exp Pathol 18:13346\u201313352","journal-title":"Int J Clin Exp Pathol"},{"key":"2295_CR34","doi-asserted-by":"publisher","first-page":"16675","DOI":"10.4238\/2015.December.11.15","volume":"14","author":"P Yuan","year":"2015","unstructured":"Yuan P, Yuan L, Xu BL, Wang CZ, Yang HZ, Li Y (2015) Predictive potential role of glutathione S-transferases polymorphisms in response to chemotherapy and breast cancer prognosis. Genet Mol Res 14:16675\u201316681","journal-title":"Genet Mol Res"},{"key":"2295_CR35","unstructured":"Marazzi MC, Guidotti G, Liotta G, Palombi L. (2005) DREAM: an integrated faith-based initiative to treat HIV\/AIDS in Mozambique X. [Internet]. Geneva: World Health Organization; Available from: www.who.int\/hiv\/pub\/casestudies\/mozambiquedream.pdf"},{"key":"2295_CR36","doi-asserted-by":"publisher","first-page":"S408","DOI":"10.1016\/j.legalmed.2009.01.073","volume":"11","author":"J Fujihara","year":"2009","unstructured":"Fujihara J, Yasuda T, Iida R, Takatsuka H, Fujii Y, Takeshita H (2009) Cytochrome P450 1A1, glutathione S-transferases M1 and T1 polymorphisms in Ovambos and Mongolians. Leg Med (Tokyo) 11:S408\u2013S410","journal-title":"Leg Med (Tokyo)"},{"key":"2295_CR37","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1515\/CCLM.2002.167","volume":"40","author":"C Dandara","year":"2002","unstructured":"Dandara C, Sayi J, Masimirembwa CM, Magimba A, Kaaya S, De Sommers K, Snyman JR, Hasler JA (2002) Genetic polymorphism of cytochrome P450 1A1 (Cyp1A1) and glutathione transferases (M1, T1 and P1) among Africans. Clin Chem Lab Med 40:952\u2013957","journal-title":"Clin Chem Lab Med"},{"key":"2295_CR38","first-page":"994","volume":"12","author":"F Sun","year":"2008","unstructured":"Sun F, Chen Y, Xiang Y, Zhan S (2008) Drug-metabolising enzyme polymorphisms and predisposition to antituberculosis drug-induced liver injury: a meta-analysis. Int J Tuberc Lung Dis 12:994\u20131002","journal-title":"Int J Tuberc Lung Dis"},{"key":"2295_CR39","doi-asserted-by":"publisher","first-page":"12","DOI":"10.1016\/j.gene.2013.11.024","volume":"535","author":"L Lu","year":"2014","unstructured":"Lu L, Wu W, Tu Y, Yang Z, He L, Guo M (2014) Association of glutathione S-transferase M1\/T1 polymorphisms with susceptibility to vitiligo. Gene 535:12\u201316","journal-title":"Gene"},{"key":"2295_CR40","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1111\/j.1744-313X.2010.00987.x","volume":"38","author":"HR Cho","year":"2011","unstructured":"Cho HR, Uhm YK, Kim HJ, Ban JY, Chung JH, Yim SV, Choi BK, Lee MH (2011) Glutathione S-transferase M1 (GSTM1) polymorphism is associated with atopic dermatitis susceptibility in a Korean population. Int J Immunogenet 38:145\u2013150","journal-title":"Int J Immunogenet"},{"key":"2295_CR41","doi-asserted-by":"publisher","first-page":"1862","DOI":"10.1021\/tx800177k","volume":"21","author":"J Chen","year":"2008","unstructured":"Chen J, Mannargudi BM, Xu L, Uetrecht JP (2008) Demonstration of the metabolic pathway responsible for nevirapine-induced skin rash. Chem Res Toxicol 21:1862\u20131870","journal-title":"Chem Res Toxicol"},{"key":"2295_CR42","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1021\/tx400098z","volume":"26","author":"AM Sharma","year":"2013","unstructured":"Sharma AM, Novalen M, Tanino T, Uetrecht JP (2013) 12-OH-nevirapine sulfate, formed in the skin, is responsible for nevirapine-induced skin rash. Chem Res Toxicol 26:817\u2013827","journal-title":"Chem Res Toxicol"},{"key":"2295_CR43","doi-asserted-by":"publisher","first-page":"2136","DOI":"10.1021\/acs.chemrestox.6b00250","volume":"29","author":"SJ Dekker","year":"2016","unstructured":"Dekker SJ, Zhang Y, Vos JC, Vermeulen NP, Commandeur JN (2016) Different reactive metabolites of nevirapine require distinct glutathione S-transferase isoforms for bioinactivation. Chem Res Toxicol 29:2136\u20132144","journal-title":"Chem Res Toxicol"},{"key":"2295_CR44","doi-asserted-by":"publisher","first-page":"1330","DOI":"10.1093\/cid\/cit021","volume":"56","author":"DF Carr","year":"2013","unstructured":"Carr DF, Chaponda M, Jorgensen AL, Castro EC, van Oosterhout JJ, Khoo SH, Lalloo DG, Heyderman RS, Alfirevic A, Pirmohamed M (2013) Association of human leukocyte antigen alleles and nevirapine hypersensitivity in a Malawian HIV-infected population. Clin Infect Dis 56:1330\u20131339","journal-title":"Clin Infect Dis"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00228-017-2295-2\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-017-2295-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-017-2295-2.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,7,29]],"date-time":"2022-07-29T15:47:21Z","timestamp":1659109641000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00228-017-2295-2"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,8]]},"references-count":44,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["2295"],"URL":"https:\/\/doi.org\/10.1007\/s00228-017-2295-2","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,8]]},"assertion":[{"value":"23 February 2017","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 June 2017","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"8 July 2017","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}},{"value":"No funding was received for the preparation of this study.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Funding"}},{"value":"All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and\/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all individual participants included in the study.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethical statement"}},{"value":"This content has been made available to all.","name":"free","label":"Free to read"}]}}