{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T06:09:21Z","timestamp":1793686161061,"version":"4.5.1"},"reference-count":41,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T00:00:00Z","timestamp":1562198400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,7,4]],"date-time":"2019-07-04T00:00:00Z","timestamp":1562198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1007\/s00228-019-02713-1","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T22:02:39Z","timestamp":1562191359000},"page":"1431-1443","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":116,"title":["Fluoroquinolones and the risk of tendon injury: a systematic review and meta-analysis"],"prefix":"10.1007","volume":"75","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2814-3049","authenticated-orcid":false,"given":"Carlos","family":"Alves","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo","family":"Mendes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Batel","family":"Marques","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,7,4]]},"reference":[{"key":"2713_CR1","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1056\/NEJM199102073240606","volume":"324","author":"JS Wolfson","year":"1991","unstructured":"Wolfson JS, Hooper DC (1991) Fluoroquinolone antimicrobial agents. N Engl J Med 324:384\u2013394","journal-title":"N Engl J Med"},{"key":"2713_CR2","doi-asserted-by":"publisher","first-page":"1404","DOI":"10.1086\/375078","volume":"36","author":"Y Khaliq","year":"2003","unstructured":"Khaliq Y, Zhanel GG (2003) Fluoroquinolone-associated tendinopathy: a critical review of the literature. Clin Infect Dis 36:1404\u20131410","journal-title":"Clin Infect Dis"},{"key":"2713_CR3","doi-asserted-by":"publisher","first-page":"465","DOI":"10.2165\/11587280-000000000-00000","volume":"34","author":"AM Tom\u00e9","year":"2011","unstructured":"Tom\u00e9 AM, Filipe A (2011) Quinolones: review of psychiatric and neurological adverse reactions. Drug Saf 34:465\u2013488","journal-title":"Drug Saf"},{"key":"2713_CR4","doi-asserted-by":"publisher","first-page":"303","DOI":"10.2165\/11531850-000000000-00000","volume":"33","author":"E Poluzzi","year":"2010","unstructured":"Poluzzi E, Raschi E, Motola D, Moretti U, De Ponti F (2010) Antimicrobials and the risk of torsades de pointes: the contribution from data mining of the US FDA adverse event reporting system. Drug Saf 33:303\u2013314","journal-title":"Drug Saf"},{"key":"2713_CR5","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1056\/NEJM199501193320319","volume":"332","author":"C Pierfitte","year":"1995","unstructured":"Pierfitte C, Gillet P, Royer RJ (1995) More on fluoroquinolone antibiotics and tendon rupture. N Engl J Med 332:193","journal-title":"N Engl J Med"},{"key":"2713_CR6","unstructured":"US US Food and Drug Administration. FDA News Release. U.S. Food and Drug Administration. \n                    https:\/\/www.fda.gov\/newsevents\/newsroom\/pressannouncements\/ucm612995.htm\n                    \n                  . Accessed 14 May 2019"},{"key":"2713_CR7","unstructured":"US Food and Drug Administration. Postmarket Drug Safety Information for Patients and Providers. \n                    http:\/\/wayback.archive-it.org\/7993\/20170112032310\/http:\/\/www.fda.gov\/Drugs\/DrugSafety\/PostmarketDrugSafetyInformationforPatientsandProviders\/ucm126085.htm\n                    \n                  . Accessed 14 May 2019"},{"key":"2713_CR8","unstructured":"European Medicines Agency. Disabling and potentially permanent side effects lead to uspension or restrictions of quinolone and fluoroquinolone antibiotics. \n                    https:\/\/www.ema.europa.eu\/en\/medicines\/human\/referrals\/quinolone-fluoroquinolone-containing-medicinal-products\n                    \n                  . Accessed 14 May 2019"},{"key":"2713_CR9","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1007\/s40261-018-0729-y","volume":"39","author":"DR Morales","year":"2019","unstructured":"Morales DR, Slattery J, Pacurariu A, Pinheiro L, McGettigan P, Kurz X (2019) Relative and absolute risk of tendon rupture with fluoroquinolone and concomitant fluoroquinolone\/corticosteroid therapy: population-based nested case-control study. Clin Drug Investig 39:205\u2013213","journal-title":"Clin Drug Investig"},{"key":"2713_CR10","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1007\/s40264-013-0089-8","volume":"36","author":"AL Stephenson","year":"2013","unstructured":"Stephenson AL, Wu W, Cortes D, Rochon PA (2013) Tendon injury and fluoroquinolone use: a systematic review. Drug Saf 36:709\u2013721","journal-title":"Drug Saf"},{"key":"2713_CR11","doi-asserted-by":"publisher","unstructured":"van der Vlist AC, Breda SJ, Oei EHG, Verhaar JAN, de Vos RJ (2019) Br J Sports Med. \n                    https:\/\/doi.org\/10.1136\/bjsports-2018-099991","DOI":"10.1136\/bjsports-2018-099991"},{"key":"2713_CR12","doi-asserted-by":"publisher","unstructured":"Yu X, Jiang DS, Wang J, Wang R, Chen T, Wang K, Cao S, Wei X (2019) Fluoroquinolone use and the risk of collagen-associated adverse events: a systematic review and meta-analysis. Drug Saf. \n                    https:\/\/doi.org\/10.1007\/s40264-019-00828-z","DOI":"10.1007\/s40264-019-00828-z"},{"key":"2713_CR13","doi-asserted-by":"publisher","first-page":"949","DOI":"10.1111\/bcp.13879","volume":"85","author":"R Persson","year":"2019","unstructured":"Persson R, Jick S (2019) Clinical implications of the association between fluoroquinolones and tendon rupture: the magnitude of the effect with and without corticosteroids. Br J Clin Pharmacol 85:949\u2013959","journal-title":"Br J Clin Pharmacol"},{"key":"2713_CR14","doi-asserted-by":"publisher","first-page":"2625","DOI":"10.1111\/sms.13281","volume":"28","author":"T Nyyss\u00f6nen","year":"2018","unstructured":"Nyyss\u00f6nen T, Lantto I, L\u00fcthje P, Selander T, Kr\u00f6ger H (2018) Drug treatments associated with Achilles tendon rupture. A case-control study involving 1118 Achilles tendon ruptures. Scand J Med Sci Sports 28:2625\u20132629","journal-title":"Scand J Med Sci Sports"},{"key":"2713_CR15","doi-asserted-by":"publisher","first-page":"e010077","DOI":"10.1136\/bmjopen-2015-010077","volume":"5","author":"N Daneman","year":"2015","unstructured":"Daneman N, Lu H, Redelmeier DA (2015) Fluoroquinolones and collagen associated severe adverse events: a longitudinal cohort study. BMJ Open 5:e010077","journal-title":"BMJ Open"},{"key":"2713_CR16","doi-asserted-by":"publisher","first-page":"1413","DOI":"10.1136\/bmj.a117","volume":"336","author":"JP Ioannidis","year":"2008","unstructured":"Ioannidis JP, Patsopoulos NA, Rothstein HR (2008) Reasons or excuses for avoiding meta-analysis in forest plots. BMJ 336:1413\u20131415","journal-title":"BMJ"},{"key":"2713_CR17","doi-asserted-by":"publisher","first-page":"2685","DOI":"10.1002\/sim.4780142408","volume":"14","author":"TC Smith","year":"1995","unstructured":"Smith TC, Spiegelhalter DJ, Thomas A (1995) Bayesian approaches to random-effects meta-analysis: a comparative study. Stat Med 14:2685\u20132699","journal-title":"Stat Med"},{"key":"2713_CR18","doi-asserted-by":"publisher","first-page":"383","DOI":"10.1093\/oxfordjournals.aje.a117645","volume":"142","author":"JA Berlin","year":"1995","unstructured":"Berlin JA (1995) Invited commentary: benefits of heterogeneity in meta-analysis of data from epidemiologic studies. Am J Epidemiol 142:383\u2013387","journal-title":"Am J Epidemiol"},{"key":"2713_CR19","doi-asserted-by":"publisher","first-page":"e1000097","DOI":"10.1371\/journal.pmed.1000097","volume":"6","author":"D Moher","year":"2009","unstructured":"Moher D, Liberati A, Tetzlaff J, Altman DG, PRISMA Group (2009) Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 6:e1000097","journal-title":"PLoS Med"},{"key":"2713_CR20","unstructured":"U.S. National Library of Medicine. Medical Subject Headings 2019. U.S. National Library of Medicine. \n                    https:\/\/meshb.nlm.nih.gov\/search\n                    \n                  . Accessed 14 May 2019"},{"key":"2713_CR21","unstructured":"ICH MedDRA Maintenance and Support Services Organization (MSSO). International Council for Harmonisation of technical requirements for Pharmaceuticals for Human use (ICH). \n                    https:\/\/www.meddra.org\/\n                    \n                  . Accessed 14 May 2019"},{"key":"2713_CR22","unstructured":"Elsevier. Embase Indexing and Emtree. \n                    https:\/\/www.elsevier.com\/solutions\/embase-biomedical-research\n                    \n                  . Accessed 14 May 2019"},{"key":"2713_CR23","unstructured":"Wells GA, Shea B, O\u2019Connell D et al (2014). The Newcastle-Ottawa Scale (NOS) for assessing the quality of nonrandomised studies in meta-analyses. \n                    http:\/\/www.ohri.ca\/programs\/clinical_epidemiology\/oxford.asp\n                    \n                  . Accessed 14 May 2019"},{"key":"2713_CR24","doi-asserted-by":"publisher","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","volume":"7","author":"R DerSimonian","year":"1986","unstructured":"DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7:177\u2013188","journal-title":"Control Clin Trials"},{"key":"2713_CR25","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1136\/bmj.327.7414.557","volume":"327","author":"JP Higgins","year":"2003","unstructured":"Higgins JP, Thompson SG, Deeks JJ, Altman DG (2003) Measuring inconsistency in meta-analyses. BMJ 327:557\u2013560","journal-title":"BMJ"},{"key":"2713_CR26","first-page":"277","volume-title":"Introduction to meta-analysis","author":"B Publication bias","year":"2009","unstructured":"B Publication bias (2009) In: Borenstein M, Hedges LV, JPT H, Rothstein HR (eds) Introduction to meta-analysis. Wiley, Chichester, pp 277\u2013291"},{"key":"2713_CR27","doi-asserted-by":"publisher","first-page":"433","DOI":"10.1046\/j.1365-2125.1999.00016.x","volume":"48","author":"PD van der Linden","year":"1999","unstructured":"van der Linden PD, van de Lei J, Nab HW, Knol A, Stricker BH (1999) Achilles tendinitis associated with fluoroquinolones. Br J Clin Pharmacol 48:433\u2013437","journal-title":"Br J Clin Pharmacol"},{"key":"2713_CR28","doi-asserted-by":"publisher","first-page":"499","DOI":"10.1007\/s00228-007-0265-9","volume":"63","author":"J Sode","year":"2007","unstructured":"Sode J, Obel N, Hallas J, Lassen A (2007) Use of fluroquinolone and risk of Achilles tendon rupture: a population-based cohort study. Eur J Clin Pharmacol 63:499\u2013503","journal-title":"Eur J Clin Pharmacol"},{"key":"2713_CR29","doi-asserted-by":"publisher","first-page":"886","DOI":"10.1002\/pds.3285","volume":"21","author":"K Hori","year":"2012","unstructured":"Hori K, Yamakawa K, Yoshida N, Ohnishi K, Kawakami J (2012) Detection of fluoroquinolone-induced tendon disorders using a hospital database in Japan. Pharmacoepidemiol Drug Saf 21:886\u2013889","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"2713_CR30","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1177\/1071100718762089","volume":"39","author":"CJ Humbyrd","year":"2018","unstructured":"Humbyrd CJ, Bae S, Kucirka LM, Segev DL (2018) Incidence, risk factors, and treatment of Achilles tendon rupture in patients with end-stage renal disease. Foot Ankle Int 39:821\u2013828","journal-title":"Foot Ankle Int"},{"key":"2713_CR31","doi-asserted-by":"publisher","first-page":"878","DOI":"10.1002\/phar.2162","volume":"38","author":"DC Jupiter","year":"2018","unstructured":"Jupiter DC, Fang X, Ashmore Z, Shibuya N, Mehta HB (2018) The relative risk of Achilles tendon injury in patients taking quinolones. Pharmacotherapy 38:878\u2013887","journal-title":"Pharmacotherapy"},{"key":"2713_CR32","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.healun.2007.09.021","volume":"27","author":"E Barge-Caballero","year":"2008","unstructured":"Barge-Caballero E, Crespo-Leiro MG, Paniagua-Mart\u00edn MJ, Mu\u00f1iz J, Naya C, Bouzas-Mosquera A, Pi\u00f1\u00f3n-Esteban P, Marzoa-Rivas R, Pazos-L\u00f3pez P, Cursack GC, Cuenca-Castillo JJ, Castro-Beiras A (2008) Quinolone-related Achilles tendinopathy in heart transplant patients: incidence and risk factors. J Heart Lung Transplant 27:46\u201351","journal-title":"J Heart Lung Transplant"},{"key":"2713_CR33","doi-asserted-by":"publisher","first-page":"1801","DOI":"10.1001\/archinte.163.15.1801","volume":"163","author":"PD van der Linden","year":"2003","unstructured":"van der Linden PD, Sturkenboom MC, Herings RM, Leufkens HM, Rowlands S, Stricker BH (2003) Increased risk of Achilles tendon rupture with quinolone antibacterial use, especially in elderly patients taking oral corticosteroids. Arch Intern Med 163:1801\u20131807","journal-title":"Arch Intern Med"},{"key":"2713_CR34","doi-asserted-by":"publisher","first-page":"784","DOI":"10.1002\/pds.1214","volume":"15","author":"JD Seeger","year":"2006","unstructured":"Seeger JD, West WA, Fife D, Noel GJ, Johnson LN, Walker AM (2006) Achilles tendon rupture and its association with fluoroquinolone antibiotics and other potential risk factors in a managed care population. Pharmacoepidemiol Drug Saf 15:784\u2013792","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"2713_CR35","doi-asserted-by":"publisher","first-page":"1228.e23","DOI":"10.1016\/j.amjmed.2012.05.027","volume":"125","author":"BL Wise","year":"2012","unstructured":"Wise BL, Peloquin C, Choi H, Lane NE, Zhang Y (2012) Impact of age, sex, obesity, and steroid use on quinolone-associated tendon disorders. Am J Med 125:1228.e23\u20131228.e28","journal-title":"Am J Med"},{"key":"2713_CR36","doi-asserted-by":"publisher","first-page":"889","DOI":"10.2165\/00002018-200629100-00006","volume":"29","author":"G Corrao","year":"2006","unstructured":"Corrao G, Zambon A, Bert\u00f9 L et al (2006) Evidence of tendinitis provoked by fluoroquinolone treatment: a case-control study. Drug Saf 29:889\u2013896","journal-title":"Drug Saf"},{"key":"2713_CR37","doi-asserted-by":"publisher","first-page":"1306","DOI":"10.1136\/bmj.324.7349.1306","volume":"324","author":"PD van der Linden","year":"2002","unstructured":"van der Linden PD, Sturkenboom MC, Herings RM, Leufkens HG, Stricker BH (2002) Fluoroquinolones and risk of Achilles tendon disorders: case-control study. BMJ 324:1306\u20131307","journal-title":"BMJ"},{"key":"2713_CR38","doi-asserted-by":"publisher","first-page":"364","DOI":"10.1177\/03635465000280031401","volume":"28","author":"RJ Williams 3rd","year":"2000","unstructured":"Williams RJ 3rd, Attia E, Wickiewicz TL, Hannafin JA (2000) The effect of ciprofloxacin on tendon, paratenon, and capsular fibroblast metabolism. Am J Sports Med 28:364\u2013369","journal-title":"Am J Sports Med"},{"key":"2713_CR39","doi-asserted-by":"publisher","first-page":"67","DOI":"10.1002\/jor.21196","volume":"29","author":"WC Tsai","year":"2011","unstructured":"Tsai WC, Hsu CC, Chen CP et al (2011) Ciprofloxacin up-regulates tendon cells to express matrix metalloproteinase-2 with degradation of type I collagen. J Orthop Res 29:67\u201373","journal-title":"J Orthop Res"},{"key":"2713_CR40","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1007\/s002040100243","volume":"75","author":"M Shakibaei","year":"2001","unstructured":"Shakibaei M, de Souza P, van Sickle D, Stahlmann R (2001) Biochemical changes in Achilles tendon from juvenile dogs after treatment with ciprofloxacin or feeding a magnesium-deficient diet. Arch Toxicol 75:369\u2013374","journal-title":"Arch Toxicol"},{"key":"2713_CR41","doi-asserted-by":"publisher","first-page":"394","DOI":"10.1124\/jpet.103.057984","volume":"308","author":"F Pouzaud","year":"2004","unstructured":"Pouzaud F, Bernard-Beaubois K, Thevenin M, Warnet JM, Hayem G, Rat P (2004) In vitro discrimination of fluoroquinolones toxicity on tendon cells: involvement of oxidative stress. J Pharmacol Exp Ther 308:394\u2013402","journal-title":"J Pharmacol Exp Ther"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-019-02713-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00228-019-02713-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-019-02713-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T19:07:50Z","timestamp":1593716870000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00228-019-02713-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7,4]]},"references-count":41,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["2713"],"URL":"https:\/\/doi.org\/10.1007\/s00228-019-02713-1","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,7,4]]},"assertion":[{"value":"15 May 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 June 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"4 July 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}