{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T19:07:22Z","timestamp":1789412842133,"version":"build-2803163510"},"reference-count":28,"publisher":"Springer Science and Business Media LLC","issue":"3","license":[{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1007\/s00228-019-02815-w","type":"journal-article","created":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T21:03:31Z","timestamp":1576703011000},"page":"459-465","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Use and prescription appropriateness of drugs for peptic ulcer and gastrooesophageal reflux disease in hospitalized older people"],"prefix":"10.1007","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6802-8710","authenticated-orcid":false,"given":"C","family":"Franchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"PM","family":"Mannucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Nobili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Ardoino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2019,12,18]]},"reference":[{"issue":"5","key":"2815_CR1","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1097\/00001610-200309000-00003","volume":"26","author":"G Der","year":"2003","unstructured":"Der G (2003) An overview of proton pump inhibitors. Gastroenterol Nurs 26(5):182\u2013190","journal-title":"Gastroenterol Nurs"},{"issue":"8","key":"2815_CR2","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1038\/ajg.2016.166","volume":"111","author":"A Lanas","year":"2016","unstructured":"Lanas A (2016) We are using too many PPIs, and we need to stop: a European perspective. Am J Gastroenterol 111(8):1085\u20131086. https:\/\/doi.org\/10.1038\/ajg.2016.166","journal-title":"Am J Gastroenterol"},{"key":"2815_CR3","unstructured":"http:\/\/www.agenziafarmaco.gov.it\/sites\/default\/files\/Rapporto_OsMed-2017.pdf. Accessed January , 2019"},{"issue":"3","key":"2815_CR4","doi-asserted-by":"publisher","first-page":"443","DOI":"10.1016\/j.bpg.2013.06.001","volume":"27","author":"C Reimer","year":"2013","unstructured":"Reimer C (2013) Safety of long-term PPI therapy. Best Pract Res Clin Gastroenterol 27(3):443\u2013454","journal-title":"Best Pract Res Clin Gastroenterol"},{"issue":"2","key":"2815_CR5","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1111\/bcpt.13023","volume":"123","author":"PF Haastrup","year":"2018","unstructured":"Haastrup PF, Thompson W, S\u00f8ndergaard J, Jarb\u00f8l DE (2018) Side effects of long-term proton pump inhibitor use: a review. Basic Clin Pharmacol Toxicol 123(2):114\u2013121. https:\/\/doi.org\/10.1111\/bcpt.13023 Review","journal-title":"Basic Clin Pharmacol Toxicol"},{"issue":"7634","key":"2815_CR6","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1136\/bmj.39406.449456.BE","volume":"336","author":"I Forgacs","year":"2008","unstructured":"Forgacs I, Loganayagam A (2008) Overprescribing proton pump inhibitors. BMJ. 336(7634):2\u20133","journal-title":"BMJ."},{"issue":"12","key":"2815_CR7","doi-asserted-by":"publisher","first-page":"1534","DOI":"10.1002\/pds.4330","volume":"26","author":"C Franchi","year":"2017","unstructured":"Franchi C, Ardoino I, Nobili A, Pasina L, Mannucci PM, Marengoni A, Perticone F, REPOSI investigators (2017) Pattern of in-hospital changes in drug use in the older people from 2010 to 2016. Pharmacoepidemiol Drug Saf 26(12):1534\u20131539","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"2","key":"2815_CR8","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1002\/pds.3938","volume":"25","author":"C Franchi","year":"2016","unstructured":"Franchi C, Marcucci M, Mannucci PM, Tettamanti M, Pasina L, Fortino I, Bortolotti A, Merlino L, Nobili A (2016) Changes in clinical outcomes for community-dwelling older people exposed to incident chronic polypharmacy: a comparison between 2001 and 2009. Pharmacoepidemiol Drug Saf 25(2):204\u2013211","journal-title":"Pharmacoepidemiol Drug Saf"},{"issue":"9","key":"2815_CR9","doi-asserted-by":"publisher","first-page":"2010","DOI":"10.1111\/bcp.13631","volume":"84","author":"C Franchi","year":"2018","unstructured":"Franchi C, Antoniazzi S, Proietti M, Nobili A, Mannucci PM, SIM-AF collaborators (2018) Appropriateness of oral anticoagulant therapy prescription and its associated factors in hospitalized older people with atrial fibrillation. Br J Clin Pharmacol 84(9):2010\u20132019. https:\/\/doi.org\/10.1111\/bcp.13631","journal-title":"Br J Clin Pharmacol"},{"issue":"11","key":"2815_CR10","doi-asserted-by":"publisher","first-page":"2528","DOI":"10.1111\/bcp.13355","volume":"83","author":"I Ardoino","year":"2017","unstructured":"Ardoino I, Rossio R, Di Blanca D, Nobili A, Pasina L, Mannucci PM, Peyvandi F (2017) Franchi C; REPOSI investigators. Appropriateness of antiplatelet therapy for primary and secondary cardio- and cerebrovascular prevention in acutely hospitalized older people. Br J Clin Pharmacol 83(11):2528\u20132540","journal-title":"Br J Clin Pharmacol"},{"issue":"3","key":"2815_CR11","first-page":"395","volume":"72","author":"M Marcucci","year":"2017","unstructured":"Marcucci M, Franchi C, Nobili A, Mannucci PM (2017) Ardoino I; REPOSI investigators. Defining aging phenotypes and related outcomes: clues to recognize frailty in hospitalized older patients. J Gerontol A Biol Sci Med Sci 72(3):395\u2013402","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"2815_CR12","volume-title":"Manual of guidelines for scoring the cumulative illness rating scale for geriatrics (CIRS-G)","author":"MD Miller","year":"1991","unstructured":"Miller MD, Towers A (1991) Manual of guidelines for scoring the cumulative illness rating scale for geriatrics (CIRS-G). University of Pittsburgh, Pittsburg"},{"key":"2815_CR13","unstructured":"http:\/\/www.agenziafarmaco.gov.it\/content\/note-aifa. Accessed January, 2019"},{"issue":"1","key":"2815_CR14","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1186\/s12916-017-0804-x","volume":"15","author":"R Yadlapati","year":"2017","unstructured":"Yadlapati R, Kahrilas PJ (2017) When is proton pump inhibitor use appropriate? BMC Med 15(1):36. https:\/\/doi.org\/10.1186\/s12916-017-0804-x","journal-title":"BMC Med"},{"key":"2815_CR15","doi-asserted-by":"publisher","first-page":"l5495","DOI":"10.1136\/bmj.l5495","volume":"367","author":"E Sverd\u00e9n","year":"2019","unstructured":"Sverd\u00e9n E, Agr\u00e9us L, Dunn JM, Lagergren J (2019) Peptic ulcer disease. BMJ. 367:l5495. https:\/\/doi.org\/10.1136\/bmj.l5495","journal-title":"BMJ."},{"issue":"6","key":"2815_CR16","doi-asserted-by":"publisher","first-page":"665","DOI":"10.1007\/s12603-015-0642-5","volume":"20","author":"R Schepisi","year":"2016","unstructured":"Schepisi R, Fusco S, Sganga F, Falcone B, Vetrano DL, Abbatecola A, Corica F, Maggio M, Ruggiero C, Fabbietti P, Corsonello A, Onder G, Lattanzio F (2016) Inappropriate use of proton pump inhibitors in elderly patients discharged from acute care hospitals. J Nutr Health Aging 20(6):665\u2013670","journal-title":"J Nutr Health Aging"},{"issue":"2","key":"2815_CR17","doi-asserted-by":"publisher","first-page":"205","DOI":"10.1016\/j.ejim.2010.11.009","volume":"22","author":"L Pasina","year":"2011","unstructured":"Pasina L, Nobili A, Tettamanti M, Salerno F, Corrao S, Marengoni A, Iorio A, Marcucci M, Mannucci PM, REPOSI investigators (2011) Prevalence and appropriateness of drug prescriptions for peptic ulcer and gastro-esophageal reflux disease in a cohort of hospitalized elderly. Eur J Intern Med 22(2):205\u2013210","journal-title":"Eur J Intern Med"},{"issue":"10","key":"2815_CR18","doi-asserted-by":"publisher","first-page":"1835","DOI":"10.1007\/s11255-018-1908-8","volume":"50","author":"J Sun","year":"2018","unstructured":"Sun J, Sun H, Cui M, Sun Z, Li W, Wei J, Zhou S (2018) The use of anti-ulcer agents and the risk of chronic kidney disease: a meta-analysis. Int Urol Nephrol 50(10):1835\u20131843. https:\/\/doi.org\/10.1007\/s11255-018-1908-8 Review","journal-title":"Int Urol Nephrol"},{"issue":"11","key":"2815_CR19","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1007\/s00296-018-4142-x","volume":"38","author":"S Hussain","year":"2018","unstructured":"Hussain S, Siddiqui AN, Habib A, Hussain MS, Najmi AK (2018) Proton pump inhibitors' use and risk of hip fracture: a systematic review and meta-analysis. Rheumatol Int 38(11):1999\u20132014. https:\/\/doi.org\/10.1007\/s00296-018-4142-x Review","journal-title":"Rheumatol Int"},{"issue":"1","key":"2815_CR20","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1186\/s12916-016-0718-z","volume":"14","author":"C Scarpignato","year":"2016","unstructured":"Scarpignato C, Gatta L, Zullo A, Blandizzi C, SIF-AIGO-FIMMG Group; Italian Society of Pharmacology, the Italian Association of Hospital Gastroenterologists, and the Italian Federation of General Practitioners (2016) Effective and safe proton pump inhibitor therapy in acid-related diseases - a position paper addressing benefits and potential harms of acid suppression. BMC Med 14(1):179 Review","journal-title":"BMC Med"},{"issue":"6","key":"2815_CR21","doi-asserted-by":"publisher","first-page":"e015735","DOI":"10.1136\/bmjopen-2016-015735","volume":"7","author":"Y Xie","year":"2017","unstructured":"Xie Y, Bowe B, Li T, Xian H, Yan Y, Al-Aly Z (2017) Risk of death among users of proton pump inhibitors: a longitudinal observational cohort study of United States veterans. BMJ Open 7(6):e015735. https:\/\/doi.org\/10.1136\/bmjopen-2016-015735","journal-title":"BMJ Open"},{"issue":"1","key":"2815_CR22","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1007\/s40266-015-0337-y","volume":"33","author":"C Franchi","year":"2016","unstructured":"Franchi C, Ardoino I, Rossio R, Nobili A, Biganzoli EM, Marengoni A, Marcucci M, Pasina L, Tettamanti M, Corrao S, Mannucci PM, REPOSI investigators (2016) Prevalence and risk factors associated with use of QT-prolonging drugs in hospitalized older people. Drugs Aging 33(1):53\u201361. https:\/\/doi.org\/10.1007\/s40266-015-0337-y","journal-title":"Drugs Aging"},{"issue":"1","key":"2815_CR23","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1111\/bcp.12922","volume":"82","author":"C Franchi","year":"2016","unstructured":"Franchi C, Tettamanti M, Djade CD, Pasina L, Mannucci PM, Onder G, Gussoni G, Manfellotto D, Bonassi S, Salerno F, Nobili A, ELICADHE investigators (2016) E-learning in order to improve drug prescription for hospitalized older patients: a cluster-randomized controlled study. Br J Clin Pharmacol 82(1):53\u201363","journal-title":"Br J Clin Pharmacol"},{"issue":"8","key":"2815_CR24","doi-asserted-by":"publisher","first-page":"e634","DOI":"10.1016\/j.amjmed.2019.03.052","volume":"132","author":"C Franchi","year":"2019","unstructured":"Franchi C, Antoniazzi S, Ardoino I, Proietti M, Marcucci M, Santalucia P, Monzani V, Mannucci PM, Nobili A, SIM-AF collaborators (2019) Simulation-based education for physicians to increase oral anticoagulants in hospitalized elderly patients with atrial fibrillation. Am J Med 132(8):e634\u2013e647. https:\/\/doi.org\/10.1016\/j.amjmed.2019.03.052","journal-title":"Am J Med"},{"issue":"9","key":"2815_CR25","doi-asserted-by":"publisher","first-page":"2134","DOI":"10.1111\/bcp.14029","volume":"85","author":"S Antoniazzi","year":"2019","unstructured":"Antoniazzi S, Ardoino I, Proietti M, Monzani V, Mannucci PM, Nobili A, Franchi C, SIM-AF collaborators (2019) Appropriateness of prescription of oral anticoagulant therapy in acutely hospitalized older people with atrial fibrillation. Secondary analysis of the SIM-AF cluster randomized clinical trial. Br J Clin Pharmacol 85(9):2134\u20132142. https:\/\/doi.org\/10.1111\/bcp.14029","journal-title":"Br J Clin Pharmacol"},{"issue":"12","key":"2815_CR26","doi-asserted-by":"publisher","first-page":"932","DOI":"10.2146\/ajhp160670","volume":"74","author":"KW Davis","year":"2017","unstructured":"Davis KW, Hanners RE, Lockwood SM (2017) Implementation of a proton pump inhibitor stewardship program. Am J Health Syst Pharm 74(12):932\u2013937. https:\/\/doi.org\/10.2146\/ajhp160670","journal-title":"Am J Health Syst Pharm"},{"issue":"5","key":"2815_CR27","first-page":"354","volume":"63","author":"B Farrell","year":"2017","unstructured":"Farrell B, Pottie K, Thompson W, Boghossian T, Pizzola L, Rashid FJ, Rojas-Fernandez C, Walsh K, Welch V, Moayyedi P (2017) Deprescribing proton pump inhibitors: evidence-based clinical practice guideline. Can Fam Physician 63(5):354\u2013364","journal-title":"Can Fam Physician"},{"issue":"2","key":"2815_CR28","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1071\/HC15946","volume":"8","author":"K Walsh","year":"2016","unstructured":"Walsh K, Kwan D, Marr P, Papoushek C, Lyon WK (2016) Deprescribing in a family health team: a study of chronic proton pump inhibitor use. J Prim Health Care 8(2):164\u2013171. https:\/\/doi.org\/10.1071\/HC15946","journal-title":"J Prim Health Care"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-019-02815-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/article\/10.1007\/s00228-019-02815-w\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-019-02815-w.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,17]],"date-time":"2020-12-17T01:00:37Z","timestamp":1608166837000},"score":1,"resource":{"primary":{"URL":"http:\/\/link.springer.com\/10.1007\/s00228-019-02815-w"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12,18]]},"references-count":28,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["2815"],"URL":"https:\/\/doi.org\/10.1007\/s00228-019-02815-w","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,12,18]]},"assertion":[{"value":"18 April 2019","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 December 2019","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"18 December 2019","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}