{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T16:28:26Z","timestamp":1747153706286,"version":"3.40.5"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"9","license":[{"start":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T00:00:00Z","timestamp":1590624000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T00:00:00Z","timestamp":1590624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2020,9]]},"DOI":"10.1007\/s00228-020-02907-y","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T21:10:08Z","timestamp":1590700208000},"page":"1341-1342","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Leflunomide-induced recurrent-transient ischaemic attacks in a patient with rheumatoid arthritis: first case report"],"prefix":"10.1007","volume":"76","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0532-6301","authenticated-orcid":false,"given":"Cristian Eduardo","family":"Navarro","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pilar","family":"Enr\u00edquez-Ruano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maira Nataly","family":"Enr\u00edquez-Ruano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2020,5,28]]},"reference":[{"key":"2907_CR1","doi-asserted-by":"publisher","first-page":"771","DOI":"10.1097\/00012995-200020200-00001","volume":"202","author":"J Pritchard","year":"2000","unstructured":"Pritchard J (2000) Drug-induced stroke. Adverse Drug React Bull. 202:771\u2013774","journal-title":"Adverse Drug React Bull."},{"issue":"10","key":"2907_CR2","first-page":"1906","volume":"31","author":"GW Cannon","year":"2004","unstructured":"Cannon GW, Holden WL, Juhaeri J, Dai W, Scarazzini L, Stang P (2004) Adverse events with disease modifying antirheumatic drugs (DMARD): a cohort study of leflunomide compared with other DMARD. J Rheumatol. 31(10):1906\u20131911","journal-title":"J Rheumatol."},{"issue":"6","key":"2907_CR3","first-page":"1160","volume":"32","author":"M Takeishi","year":"2005","unstructured":"Takeishi M, Akiyama Y, Akiba H, Adachi D, Hirano M, Mimura T (2005) Leflunomide induced acute interstitial pneumonia. J Rheumatol. 32(6):1160\u20131163","journal-title":"J Rheumatol."},{"issue":"7\u20138","key":"2907_CR4","doi-asserted-by":"publisher","first-page":"1206","DOI":"10.1345\/aph.1E012","volume":"38","author":"J Chan","year":"2004","unstructured":"Chan J, Sanders DC, Du L, Pillans PI (2004) Leflunomide-associated pancytopenia with or without methotrexate. Ann Pharmacother. 38(7\u20138):1206\u20131211","journal-title":"Ann Pharmacother."},{"issue":"10","key":"2907_CR5","doi-asserted-by":"publisher","first-page":"913","DOI":"10.1136\/ard.60.10.913","volume":"60","author":"DL Scott","year":"2001","unstructured":"Scott DL, Smolen JS, Kalden JR, van de Putte LB, Larsen A, Kvien TK, Schattenkirchner M, Nash P, Oed C, Loew-Friedrich I, European Leflunomide Study Group (2001) Treatment of active rheumatoid arthritis with leflunomide: two year follow up of a double blind, placebo controlled trial versus sulfasalazine. Ann Rheum Dis. 60(10):913\u2013923","journal-title":"Ann Rheum Dis."},{"issue":"4","key":"2907_CR6","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1136\/ard.2004.027193","volume":"64","author":"K Martin","year":"2005","unstructured":"Martin K, Bentaberry F, Dumoulin C, Longy-Boursier M, Lifermann F, Haramburu F, Dehais J, Schaeverbeke T, B\u00e9gaud B, Moore N (2005) Neuropathy associated with leflunomide: a case series. Ann Rheum Dis. 64(4):649\u2013650","journal-title":"Ann Rheum Dis."},{"issue":"1","key":"2907_CR7","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1586\/1744666X.2.1.17","volume":"2","author":"G Kunkel","year":"2006","unstructured":"Kunkel G, Cannon GW (2006) Leflunomide in the treatment of rheumatoid arthritis. Expert Rev Clin Immunol. 2(1):17\u201331","journal-title":"Expert Rev Clin Immunol."},{"issue":"12","key":"2907_CR8","doi-asserted-by":"publisher","first-page":"3790","DOI":"10.1002\/art.22255","volume":"54","author":"DH Solomon","year":"2006","unstructured":"Solomon DH, Avorn J, Katz JN, Weinblatt ME, Setoguchi S, Levin R, Schneeweiss S (2006) Immunosuppressive medications and hospitalization for cardiovascular events in patients with rheumatoid arthritis. Arthritis Rheum. 54(12):3790\u20133798","journal-title":"Arthritis Rheum."},{"issue":"2","key":"2907_CR9","doi-asserted-by":"publisher","first-page":"236","DOI":"10.3899\/jrheum.100564","volume":"38","author":"J Serelis","year":"2011","unstructured":"Serelis J, Panagiotakos DB, Mavrommati M, Skopouli FN (2011) Cardiovascular disease is related to hypertension in patients with rheumatoid arthritis: a Greek cohort study. J Rheumatol. 38(2):236\u2013241","journal-title":"J Rheumatol."},{"issue":"2","key":"2907_CR10","first-page":"1","volume":"10","author":"A Naranjo","year":"2007","unstructured":"Naranjo A, Sokka T, Descalzo MA, Calvo-Al\u00e9n J, H\u00f8rslev-Petersen K, Luukkainen RK et al (2007) Cardiovascular disease in patients with rheumatoid arthritis: results from the QUEST-RA study. Arthritis Res Ther. 10(2):1\u201310","journal-title":"Arthritis Res Ther."},{"issue":"2","key":"2907_CR11","doi-asserted-by":"publisher","first-page":"34","DOI":"10.1111\/j.1753-5174.2009.00019.x","volume":"2","author":"YH Rho","year":"2009","unstructured":"Rho YH, Oeser A, Chung CP, Milne GL, Stein CM (2009) Drugs used in the treatment of rheumatoid arthritis: relationship between current use and cardiovascular risk factors. Arch Drug Inf. 2(2):34\u201340","journal-title":"Arch Drug Inf."},{"issue":"2","key":"2907_CR12","doi-asserted-by":"publisher","first-page":"239","DOI":"10.1038\/clpt.1981.154","volume":"30","author":"C Naranjo","year":"1981","unstructured":"Naranjo C, Busto U, Sellers E (1981) A method for estimating the probability of adverse drug reactions. Clin Pharmacol Ther. 30(2):239\u2013245","journal-title":"Clin Pharmacol Ther."},{"issue":"5","key":"2907_CR13","first-page":"295","volume":"58","author":"HA Bradford","year":"1965","unstructured":"Bradford HA (1965) The environment and disease: association or causation? Proc R Soc Med. 58(5):295\u2013300","journal-title":"Proc R Soc Med."}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-020-02907-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00228-020-02907-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-020-02907-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,5,27]],"date-time":"2021-05-27T23:56:49Z","timestamp":1622159809000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00228-020-02907-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,28]]},"references-count":13,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["2907"],"URL":"https:\/\/doi.org\/10.1007\/s00228-020-02907-y","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"type":"print","value":"0031-6970"},{"type":"electronic","value":"1432-1041"}],"subject":[],"published":{"date-parts":[[2020,5,28]]},"assertion":[{"value":"11 April 2020","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"20 May 2020","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"28 May 2020","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Compliance with ethical standards"}},{"value":"The authors declare that they have no conflict of interest.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflicts of interest"}},{"value":"Ethics approval is not required for case reports at our institution.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement on ethics approval"}},{"value":"The patient gave his informed consent (in Spanish) for the publication of the case and accompanying images.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Statement on informed consent"}},{"value":"The patient gave his informed consent (in Spanish) to participate in this work.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The patient gave his informed consent (in Spanish) for the publication of the case and accompanying images.","order":6,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}}]}}