{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:38:18Z","timestamp":1787647098051,"version":"build-2736575974"},"reference-count":31,"publisher":"Springer Science and Business Media LLC","issue":"11","license":[{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T00:00:00Z","timestamp":1624406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1007\/s00228-021-03174-1","type":"journal-article","created":{"date-parts":[[2021,6,23]],"date-time":"2021-06-23T05:02:44Z","timestamp":1624424564000},"page":"1687-1695","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Population pharmacokinetics of intravenous and oral ciprofloxacin in children to optimize dosing regimens"],"prefix":"10.1007","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9898-2609","authenticated-orcid":false,"given":"D.","family":"Hirt","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Oualha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Pasquiers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Blanot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Rubinstazjn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Glorion","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. El","family":"Messaoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Drummond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Toubiana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"B\u00e9ranger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana","family":"Boujaafar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Capito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Winter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. L.","family":"L\u00e9ger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Berthaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"In\u00e8s","family":"Gana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Foissac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. M.","family":"Tr\u00e9luyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Bouazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Benaboud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,6,23]]},"reference":[{"key":"3174_CR1","doi-asserted-by":"publisher","first-page":"1287","DOI":"10.1542\/peds.2006-1722","volume":"118","author":"Committee on Infectious Diseases","year":"2006","unstructured":"Committee on Infectious Diseases (2006) The use of systemic fluoroquinolones. Pediatrics 118:1287\u20131292. https:\/\/doi.org\/10.1542\/peds.2006-1722","journal-title":"Pediatrics"},{"key":"3174_CR2","doi-asserted-by":"publisher","unstructured":"Schaad UB, Wedgwood J, Ruedeberg A, et al (1997) Ciprofloxacin as antipseudomonal treatment in patients with cystic fibrosis. Pediatr Infect Dis J 16:106\u2013111; discussion 123\u2013126. https:\/\/doi.org\/10.1097\/00006454-199701000-00032","DOI":"10.1097\/00006454-199701000-00032"},{"key":"3174_CR3","first-page":"723","volume":"10","author":"UB Schaad","year":"1991","unstructured":"Schaad UB, Stoupis C, Wedgwood J et al (1991) Clinical, radiologic and magnetic resonance monitoring for skeletal toxicity in pediatric patients with cystic fibrosis receiving a three-month course of ciprofloxacin. Pediatr Infect Dis J 10:723\u2013729","journal-title":"Pediatr Infect Dis J"},{"key":"3174_CR4","doi-asserted-by":"publisher","first-page":"555","DOI":"10.1111\/j.1651-2227.1995.tb13694.x","volume":"84","author":"KM Pradhan","year":"1992","unstructured":"Pradhan KM, Arora NK, Jena A et al (1992) (1995) Safety of ciprofloxacin therapy in children: magnetic resonance images, body fluid levels of fluoride and linear growth. Acta Paediatr Oslo Nor 84:555\u2013560. https:\/\/doi.org\/10.1111\/j.1651-2227.1995.tb13694.x","journal-title":"Acta Paediatr Oslo Nor"},{"key":"3174_CR5","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1016\/S0140-6736(97)11457-X","volume":"352","author":"MA Salam","year":"1998","unstructured":"Salam MA, Dhar U, Khan WA, Bennish ML (1998) Randomised comparison of ciprofloxacin suspension and pivmecillinam for childhood shigellosis. Lancet Lond Engl 352:522\u2013527. https:\/\/doi.org\/10.1016\/S0140-6736(97)11457-X","journal-title":"Lancet Lond Engl"},{"key":"3174_CR6","doi-asserted-by":"publisher","first-page":"44","DOI":"10.1136\/adc.74.1.44","volume":"74","author":"DB Bethell","year":"1996","unstructured":"Bethell DB, Hien TT, Phi LT et al (1996) Effects on growth of single short courses of fluoroquinolones. Arch Dis Child 74:44\u201346. https:\/\/doi.org\/10.1136\/adc.74.1.44","journal-title":"Arch Dis Child"},{"issue":"Suppl 2","key":"3174_CR7","first-page":"S27","volume":"4","author":"G Drusano","year":"1998","unstructured":"Drusano G, Labro MT, Cars O et al (1998) Pharmacokinetics and pharmacodynamics of fluoroquinolones. Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis 4(Suppl 2):S27\u2013S41","journal-title":"Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis"},{"key":"3174_CR8","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1128\/aac.37.5.1073","volume":"37","author":"A Forrest","year":"1993","unstructured":"Forrest A, Nix DE, Ballow CH et al (1993) Pharmacodynamics of intravenous ciprofloxacin in seriously ill patients. Antimicrob Agents Chemother 37:1073\u20131081. https:\/\/doi.org\/10.1128\/aac.37.5.1073","journal-title":"Antimicrob Agents Chemother"},{"key":"3174_CR9","doi-asserted-by":"publisher","first-page":"1725","DOI":"10.1093\/jac\/dkq211","volume":"65","author":"SA Zelenitsky","year":"2010","unstructured":"Zelenitsky SA, Ariano RE (2010) Support for higher ciprofloxacin AUC 24\/MIC targets in treating Enterobacteriaceae bloodstream infection. J Antimicrob Chemother 65:1725\u20131732. https:\/\/doi.org\/10.1093\/jac\/dkq211","journal-title":"J Antimicrob Chemother"},{"key":"3174_CR10","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1007\/s00228-020-02873-5","volume":"76","author":"A Abdulla","year":"2020","unstructured":"Abdulla A, Rogouti O, Hunfeld NGM et al (2020) Population pharmacokinetics and target attainment of ciprofloxacin in critically ill patients. Eur J Clin Pharmacol 76:957\u2013967. https:\/\/doi.org\/10.1007\/s00228-020-02873-5","journal-title":"Eur J Clin Pharmacol"},{"key":"3174_CR11","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciz1163","author":"SDT Sassen","year":"2019","unstructured":"Sassen SDT, Math\u00f4t RAA, Pieters R et al (2019) Population pharmacokinetics and dynamics of Ciprofloxacin prophylaxis in pediatric ALL patients. Clin Infect Dis Off Publ Infect Dis Soc Am. https:\/\/doi.org\/10.1093\/cid\/ciz1163","journal-title":"Clin Infect Dis Off Publ Infect Dis Soc Am"},{"key":"3174_CR12","doi-asserted-by":"publisher","first-page":"1662","DOI":"10.1093\/jac\/dkz069","volume":"74","author":"JA Roberts","year":"2019","unstructured":"Roberts JA, Alobaid AS, Wallis SC et al (2019) Defining optimal dosing of ciprofloxacin in patients with septic shock. J Antimicrob Chemother 74:1662\u20131669. https:\/\/doi.org\/10.1093\/jac\/dkz069","journal-title":"J Antimicrob Chemother"},{"key":"3174_CR13","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1542\/peds.58.2.259","volume":"58","author":"GJ Schwartz","year":"1976","unstructured":"Schwartz GJ, Haycock GB, Edelmann CM, Spitzer A (1976) A simple estimate of glomerular filtration rate in children derived from body length and plasma creatinine. Pediatrics 58:259\u2013263","journal-title":"Pediatrics"},{"key":"3174_CR14","doi-asserted-by":"publisher","DOI":"10.1002\/bmc.4506","volume":"33","author":"Y Zheng","year":"2019","unstructured":"Zheng Y, Wang Z, Lui G et al (2019) Simultaneous quantification of levofloxacin, pefloxacin, ciprofloxacin and moxifloxacin in microvolumes of human plasma using high-performance liquid chromatography with ultraviolet detection. Biomed Chromatogr BMC 33:e4506. https:\/\/doi.org\/10.1002\/bmc.4506","journal-title":"Biomed Chromatogr BMC"},{"key":"3174_CR15","unstructured":"Bioanalytical Method ValidationGuidance for Industry. https:\/\/www.fda.gov\/media\/70858\/download. Accessed 31 Jul 2020"},{"key":"3174_CR16","doi-asserted-by":"publisher","first-page":"303","DOI":"10.1146\/annurev.pharmtox.48.113006.094708","volume":"48","author":"BJ Anderson","year":"2008","unstructured":"Anderson BJ, Holford NHG (2008) Mechanism-based concepts of size and maturity in pharmacokinetics. Annu Rev Pharmacol Toxicol 48:303\u2013332. https:\/\/doi.org\/10.1146\/annurev.pharmtox.48.113006.094708","journal-title":"Annu Rev Pharmacol Toxicol"},{"key":"3174_CR17","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1007\/BF01060893","volume":"9","author":"LB Sheiner","year":"1981","unstructured":"Sheiner LB, Beal SL (1981) Some suggestions for measuring predictive performance. J Pharmacokinet Biopharm 9:503\u2013512. https:\/\/doi.org\/10.1007\/BF01060893","journal-title":"J Pharmacokinet Biopharm"},{"key":"3174_CR18","unstructured":"European committee on antimicrobial susceptibility testing Antimicrobial wild type distributions of microorganisms.\u00a0https:\/\/mic.eucast.org\/Eucast2\/SearchController\/search.jsp?action=performSearch&BeginIndex=0&Micdif=mic&NumberIndex=50&Antib=47&Specium=-1. Accessed Jan 2021"},{"key":"3174_CR19","doi-asserted-by":"publisher","first-page":"29","DOI":"10.1128\/AAC.40.1.29","volume":"40","author":"HG Schaefer","year":"1996","unstructured":"Schaefer HG, Stass H, Wedgwood J et al (1996) Pharmacokinetics of ciprofloxacin in pediatric cystic fibrosis patients. Antimicrob Agents Chemother 40:29\u201334. https:\/\/doi.org\/10.1128\/AAC.40.1.29","journal-title":"Antimicrob Agents Chemother"},{"key":"3174_CR20","doi-asserted-by":"publisher","first-page":"3170","DOI":"10.1128\/aac.47.10.3170-3178.2003","volume":"47","author":"S Payen","year":"2003","unstructured":"Payen S, Serreau R, Munck A et al (2003) Population pharmacokinetics of ciprofloxacin in pediatric and adolescent patients with acute infections. Antimicrob Agents Chemother 47:3170\u20133178. https:\/\/doi.org\/10.1128\/aac.47.10.3170-3178.2003","journal-title":"Antimicrob Agents Chemother"},{"key":"3174_CR21","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1177\/0091270003254802","volume":"43","author":"P Rajagopalan","year":"2003","unstructured":"Rajagopalan P, Gastonguay MR (2003) Population pharmacokinetics of ciprofloxacin in pediatric patients. J Clin Pharmacol 43:698\u2013710","journal-title":"J Clin Pharmacol"},{"key":"3174_CR22","doi-asserted-by":"publisher","first-page":"6572","DOI":"10.1128\/AAC.03568-14","volume":"58","author":"W Zhao","year":"2014","unstructured":"Zhao W, Hill H, Le Guellec C et al (2014) Population pharmacokinetics of ciprofloxacin in neonates and young infants less than three months of age. Antimicrob Agents Chemother 58:6572\u20136580. https:\/\/doi.org\/10.1128\/AAC.03568-14","journal-title":"Antimicrob Agents Chemother"},{"key":"3174_CR23","doi-asserted-by":"publisher","first-page":"3423","DOI":"10.1093\/jac\/dky328","volume":"73","author":"A Facchin","year":"2018","unstructured":"Facchin A, Bui S, Leroux S et al (2018) Variability of ciprofloxacin pharmacokinetics in children: impact on dose range in sickle cell patients. J Antimicrob Chemother 73:3423\u20133429. https:\/\/doi.org\/10.1093\/jac\/dky328","journal-title":"J Antimicrob Chemother"},{"key":"3174_CR24","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1001\/jama.199.4.252","volume":"199","author":"H Lubowitz","year":"1967","unstructured":"Lubowitz H, Slatopolsky E, Shankel S et al (1967) Glomerular filtration rate. Determination in patients with chronic renal disease. JAMA 199:252\u2013256. https:\/\/doi.org\/10.1001\/jama.199.4.252","journal-title":"JAMA"},{"key":"3174_CR25","doi-asserted-by":"publisher","first-page":"61","DOI":"10.1007\/s00228-019-02761-7","volume":"76","author":"M Rapp","year":"2020","unstructured":"Rapp M, Urien S, Foissac F et al (2020) Population pharmacokinetics of meropenem in critically ill children with different renal functions. Eur J Clin Pharmacol 76:61\u201371. https:\/\/doi.org\/10.1007\/s00228-019-02761-7","journal-title":"Eur J Clin Pharmacol"},{"key":"3174_CR26","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1007\/s40262-017-0602-9","volume":"57","author":"A B\u00e9ranger","year":"2018","unstructured":"B\u00e9ranger A, Oualha M, Urien S et al (2018) Population pharmacokinetic model to optimize cefotaxime dosing regimen in critically ill children. Clin Pharmacokinet 57:867\u2013875. https:\/\/doi.org\/10.1007\/s40262-017-0602-9","journal-title":"Clin Pharmacokinet"},{"key":"3174_CR27","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1007\/s40262-018-0682-1","volume":"58","author":"A B\u00e9ranger","year":"2019","unstructured":"B\u00e9ranger A, Benaboud S, Urien S et al (2019) Piperacillin population pharmacokinetics and dosing regimen optimization in critically ill children with normal and augmented renal clearance. Clin Pharmacokinet 58:223\u2013233. https:\/\/doi.org\/10.1007\/s40262-018-0682-1","journal-title":"Clin Pharmacokinet"},{"key":"3174_CR28","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1002\/phar.2231","volume":"39","author":"AM Cook","year":"2019","unstructured":"Cook AM, Hatton-Kolpek J (2019) Augmented renal clearance. Pharmacotherapy 39:346\u2013354. https:\/\/doi.org\/10.1002\/phar.2231","journal-title":"Pharmacotherapy"},{"key":"3174_CR29","doi-asserted-by":"publisher","first-page":"422","DOI":"10.1016\/j.jcrc.2007.11.011","volume":"23","author":"ARH van Zanten","year":"2008","unstructured":"van Zanten ARH, Polderman KH, van Geijlswijk IM et al (2008) Ciprofloxacin pharmacokinetics in critically ill patients: a prospective cohort study. J Crit Care 23:422\u2013430. https:\/\/doi.org\/10.1016\/j.jcrc.2007.11.011","journal-title":"J Crit Care"},{"key":"3174_CR30","first-page":"1979","volume":"5","author":"M Hodel","year":"2009","unstructured":"Hodel M, Genn\u00e9 D (2009) Antibiotics: drug and food interactions. Rev Med Suisse 5:1979\u20131984","journal-title":"Rev Med Suisse"},{"key":"3174_CR31","doi-asserted-by":"publisher","first-page":"2336","DOI":"10.1093\/jac\/dkr314","volume":"66","author":"N Thuo","year":"2011","unstructured":"Thuo N, Ungphakorn W, Karisa J et al (2011) Dosing regimens of oral ciprofloxacin for children with severe malnutrition: a population pharmacokinetic study with Monte Carlo simulation. J Antimicrob Chemother 66:2336\u20132345. https:\/\/doi.org\/10.1093\/jac\/dkr314","journal-title":"J Antimicrob Chemother"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-021-03174-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00228-021-03174-1\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-021-03174-1.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T06:48:57Z","timestamp":1672555737000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00228-021-03174-1"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,23]]},"references-count":31,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2021,11]]}},"alternative-id":["3174"],"URL":"https:\/\/doi.org\/10.1007\/s00228-021-03174-1","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,23]]},"assertion":[{"value":"26 January 2021","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"10 June 2021","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"23 June 2021","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}