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Ibuprofen (400\u00a0mg, 600\u00a0mg, 800\u00a0mg), paracetamol (1000\u00a0mg, 500\u00a0mg), paracetamol 1000\u00a0mg\/codeine 60\u00a0mg, and placebo were investigated to establish the multidimensional pharmacodynamic profiles of each drug on acute pain with calculated effect size estimates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A randomized, double-blind, single-dose, placebo-controlled, parallel-group, single-centre, outpatient, and single-dose study used 350 patients (mean age 25\u00a0year, range 18 to 30\u00a0years) of homogenous ethnicity after third molar surgery. Primary outcome was sum pain intensity over 6\u00a0h. Secondary outcomes were time to analgesic onset, duration of analgesia, time to rescue drug intake, number of patients taking rescue drug, sum pain intensity difference, maximum pain intensity difference, time to maximum pain intensity difference, number needed to treat values, adverse effects, overall drug assessment as patient-reported outcome measure (PROM), and the effect size estimates NNT and NNTp.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Ibuprofen doses above 400\u00a0mg do not significantly increase analgesic effect. Paracetamol has a very flat analgesic dose\u2013response profile. Paracetamol 1000\/codeine 60\u00a0mg gives similar analgesia as ibuprofen from 400\u00a0mg, but has a shorter time to analgesic onset. Active drugs show no significant difference in maximal analgesic effect. Other secondary outcomes support these findings. The frequencies of adverse effects were low, mild to moderate in all active groups. NNT and NTTp values did not coincide well with PROMs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Ibuprofen doses above 400\u00a0mg for acute pain offer limited analgesic gain. Paracetamol 1000\u00a0mg\/codeine 60\u00a0mg is comparable to ibuprofen doses from 400\u00a0mg. Calculated effect size estimates and PROM in our study seem not to relate well as clinical analgesic efficacy estimators.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration<\/jats:title>\n                    <jats:p>NCT00699114.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1007\/s00228-021-03231-9","type":"journal-article","created":{"date-parts":[[2021,10,16]],"date-time":"2021-10-16T14:22:07Z","timestamp":1634394127000},"page":"1843-1852","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Analgesic effect of oral ibuprofen 400, 600, and 800\u00a0mg; paracetamol 500 and 1000\u00a0mg; and paracetamol 1000\u00a0mg plus 60\u00a0mg codeine in acute postoperative pain: a single-dose, randomized, placebo-controlled, and double-blind study"],"prefix":"10.1007","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1863-2738","authenticated-orcid":false,"given":"Gaute","family":"Lyngstad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5193-7827","authenticated-orcid":false,"given":"Per","family":"Skjelbred","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3174-1656","authenticated-orcid":false,"given":"David M.","family":"Swanson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3169-3287","authenticated-orcid":false,"given":"Lasse A.","family":"Skoglund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2021,10,16]]},"reference":[{"key":"3231_CR1","doi-asserted-by":"publisher","unstructured":"Moore RA, Derry S, Aldington D, Wiffen PJ (2015) Single dose oral analgesics for acute postoperative pain in adults - an overview of Cochrane reviews. 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