{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T03:09:31Z","timestamp":1782443371181,"version":"3.54.5"},"reference-count":29,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T00:00:00Z","timestamp":1664928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"},{"start":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T00:00:00Z","timestamp":1664928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springer.com\/tdm"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1007\/s00228-022-03395-y","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T23:03:46Z","timestamp":1664924626000},"page":"1867-1875","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Evaluating the safety and efficacy of daprodustat for anemia of chronic kidney disease: a meta-analysis of randomized clinical trials"],"prefix":"10.1007","volume":"78","author":[{"given":"Kaneez","family":"Fatima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1528-2779","authenticated-orcid":false,"given":"Warda","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4869-0683","authenticated-orcid":false,"given":"Asad Saulat","family":"Fatimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6514-1646","authenticated-orcid":false,"given":"Omar","family":"Mahmud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Umar","family":"Mahar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayesha","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Syed Roohan","family":"Aamir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8499-2582","authenticated-orcid":false,"given":"Muhammad Taha","family":"Nasim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Bilal","family":"Islam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9806-5755","authenticated-orcid":false,"given":"Muhammad Talha","family":"Maniya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9192-5110","authenticated-orcid":false,"given":"Dua","family":"Azim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shayan","family":"Marsia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talal","family":"Almas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2022,10,5]]},"reference":[{"issue":"10225","key":"3395_CR1","doi-asserted-by":"publisher","first-page":"709","DOI":"10.1016\/S0140-6736(20)30045-3","volume":"395","author":"B Bikbov","year":"2020","unstructured":"Bikbov B, Purcell CA, Levey AS, Smith M, Abdoli A, Abebe M, Adebayo OM, Afarideh M, Agarwal SK, Agudelo-Botero M, Ahmadian E (2020) Global, regional, and national burden of chronic kidney disease, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet (London, England) 395(10225):709\u201333","journal-title":"Lancet (London, England)"},{"issue":"34","key":"3395_CR2","doi-asserted-by":"publisher","first-page":"3227","DOI":"10.1093\/eurheartj\/ehab484","volume":"42","author":"FLJ Visseren","year":"2021","unstructured":"Visseren FLJ, Mach F, Smulders YM, Carballo D, Koskinas KC, B\u00e4ck M et al (2021) 2021 ESC Guidelines on cardiovascular disease prevention in clinical practice: developed by the task force for cardiovascular disease prevention in clinical practice with representatives of the European Society of Cardiology and 12 medical societies With. Eur Heart J 42(34):3227\u20133337","journal-title":"Eur Heart J"},{"issue":"8","key":"3395_CR3","first-page":"328","volume":"26","author":"J Portol\u00e9s","year":"2021","unstructured":"Portol\u00e9s J, Mart\u00edn L, Broseta JJ, Cases A (2021) Anemia in chronic kidney disease: from pathophysiology and current treatments, to Future Agents. Front Med 26(8):328","journal-title":"Front Med"},{"issue":"5","key":"3395_CR4","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1053\/j.ajkd.2016.04.018","volume":"68","author":"D Shepshelovich","year":"2016","unstructured":"Shepshelovich D, Rozen-Zvi B, Avni T, Gafter U, Gafter-Gvili A (2016) Intravenous versus oral iron supplementation for the treatment of anemia in CKD: an updated systematic review and meta-analysis. Am J Kidney Dis 68(5):677\u2013690","journal-title":"Am J Kidney Dis"},{"key":"3395_CR5","unstructured":"McMurray J, Parfrey P, Adamson JW, Aljama P, Berns JS, Bohlius J et al (2012) Kidney disease: Improving global outcomes (KDIGO) anemia work group. KDIGO clinical practice guideline for anemia in chronic kidney disease. Kidney Int Suppl 279\u2013335"},{"key":"3395_CR6","unstructured":"US Food and Drug Administration (2011) FDA drug safety communication: modified dosing recommendations to improve the safe use of erythropoiesis-stimulating agents (ESAs) in chronic kidney disease"},{"issue":"1","key":"3395_CR7","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1053\/j.ajkd.2015.06.030","volume":"67","author":"M Bonomini","year":"2016","unstructured":"Bonomini M, Del Vecchio L, Sirolli V, Locatelli F (2016) New treatment approaches for the anemia of CKD. Am J Kidney Dis 67(1):133\u2013142","journal-title":"Am J Kidney Dis"},{"issue":"6","key":"3395_CR8","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.1093\/ndt\/gft033","volume":"28","author":"F Locatelli","year":"2013","unstructured":"Locatelli F, B\u00e1r\u00e1ny P, Covic A, De Francisco A, Del Vecchio L, Goldsmith D et al (2013) Kidney disease: improving global outcomes guidelines on anaemia management in chronic kidney disease: a European Renal Best Practice position statement. Nephrol Dial Transplant 28(6):1346\u20131359","journal-title":"Nephrol Dial Transplant"},{"key":"3395_CR9","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.573645","volume":"11","author":"Q Zheng","year":"2020","unstructured":"Zheng Q, Wang Y, Yang H, Sun L, Fu X, Wei R et al (2020) Efficacy and safety of daprodustat for anemia therapy in chronic kidney disease patients: a systematic review and meta-analysis. Front Pharmacol 11:573645","journal-title":"Front Pharmacol"},{"key":"3395_CR10","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1016\/j.amjcard.2022.02.003","volume":"170","author":"D Patoulias","year":"2022","unstructured":"Patoulias D, Papadopoulos C, Doumas M (2022) Meta-analysis addressing the cardiovascular safety of daprodustat in patients with chronic kidney disease undergoing dialysis or not. Am J Cardiol 170:166\u2013167","journal-title":"Am J Cardiol"},{"key":"3395_CR11","doi-asserted-by":"crossref","unstructured":"Singh AK, Cizman B, Carroll K, McMurray JJ V, Perkovic V, Jha V et al (2022) Efficacy and safety of daprodustat for treatment of anemia of chronic kidney disease in incident dialysis patients: a randomized clinical trial. JAMA Intern Med","DOI":"10.1001\/jamainternmed.2022.0605"},{"key":"3395_CR12","unstructured":"amstar-2_-a-critical-appraisal-tool-for-systematic-reviews-that-include-randomised-or-non-randomised-studies-of-healthcare-interventions,-or-both. Available from: https:\/\/www.bmj.com\/content\/358\/bmj.j4008"},{"key":"3395_CR13","unstructured":"Higgins JPT, Thomas J, Chandler J, Cumpston M, Li T, Page MJ, Welch VA (editors) (2022) Cochrane Handbook for Systematic Reviews of Interventions version 6.3 (updated February 2022). Cochrane. Available from www.training.cochrane.org\/handbook"},{"key":"3395_CR14","unstructured":"Rohatgi A (2021) WebPlotDigitizer Version 4.5 [Internet]. Available from: https:\/\/automeris.io\/WebPlotDigitizer"},{"key":"3395_CR15","doi-asserted-by":"crossref","unstructured":"Burda BU, O\u2019Connor EA, Webber EM, Redmond N, Perdue LA (2017) Estimating data from figures with a web-based program: considerations for a systematic review. Res Synth Methods [Internet] 8(3):258\u201362. Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/28268241\/. [cited 2022 Mar 8]","DOI":"10.1002\/jrsm.1232"},{"key":"3395_CR16","doi-asserted-by":"crossref","unstructured":"Higgins JPT, Savovi\u0107 J, Page MJ, Elbers RG, Sterne JAC (2019) Assessing risk of bias in a randomized trial. Cochrane Handbook for Systematic Reviews of Interventions p. 205\u201328. Wiley Online Books","DOI":"10.1002\/9781119536604.ch8"},{"issue":"7650","key":"3395_CR17","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1136\/bmj.39489.470347.AD","volume":"336","author":"GH Guyatt","year":"2008","unstructured":"Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P et al (2008) GRADE: an emerging consensus on rating quality of evidence and strength of recommendations. BMJ 336(7650):924\u2013926","journal-title":"BMJ"},{"issue":"25","key":"3395_CR18","doi-asserted-by":"publisher","first-page":"2325","DOI":"10.1056\/NEJMoa2113379","volume":"385","author":"AK Singh","year":"2021","unstructured":"Singh AK, Carroll K, Perkovic V, Solomon S, Jha V, Johansen KL et al (2021) Daprodustat for the treatment of anemia in patients undergoing dialysis. N Engl J Med 385(25):2325\u20132335","journal-title":"N Engl J Med"},{"issue":"25","key":"3395_CR19","doi-asserted-by":"publisher","first-page":"2313","DOI":"10.1056\/NEJMoa2113380","volume":"385","author":"AK Singh","year":"2021","unstructured":"Singh AK, Carroll K, McMurray JJV, Solomon S, Jha V, Johansen KL et al (2021) Daprodustat for the treatment of anemia in patients not undergoing dialysis. N Engl J Med 385(25):2313\u20132324","journal-title":"N Engl J Med"},{"key":"3395_CR20","doi-asserted-by":"crossref","unstructured":"Holdstock L, Meadowcroft AM, Maier R, Johnson BM, Jones D, Rastogi A et al (2016) Four-week studies of oral hypoxia-inducible factor\u2013prolyl hydroxylase inhibitor GSK1278863 for treatment of anemia. J Am Soc Nephrol [Internet] 27(4):1234\u201344. Available from:\u00a0https:\/\/pubmed.ncbi.nlm.nih.gov\/26494831\/. [cited 2022 Apr 27]","DOI":"10.1681\/ASN.2014111139"},{"issue":"1","key":"3395_CR21","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1093\/ckj\/sfy014","volume":"12","author":"AM Meadowcroft","year":"2019","unstructured":"Meadowcroft AM, Cizman B, Holdstock L, Biswas N, Johnson BM, Jones D et al (2019) Daprodustat for anemia: a 24-week, open-label, randomized controlled trial in participants on hemodialysis. Clin Kidney J 12(1):139\u2013148","journal-title":"Clin Kidney J"},{"issue":"8","key":"3395_CR22","doi-asserted-by":"publisher","first-page":"1155","DOI":"10.2215\/CJN.16011219","volume":"15","author":"T Akizawa","year":"2020","unstructured":"Akizawa T, Nangaku M, Yonekawa T, Okuda N, Kawamatsu S, Onoue T et al (2020) Efficacy and safety of daprodustat compared with darbepoetin alfa in Japanese hemodialysis patients with anemia: a randomized, double-blind, phase 3 trial. Clin J Am Soc Nephrol 15(8):1155\u20131165","journal-title":"Clin J Am Soc Nephrol"},{"issue":"1","key":"3395_CR23","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1159\/000513103","volume":"52","author":"M Nangaku","year":"2021","unstructured":"Nangaku M, Hamano T, Akizawa T, Tsubakihara Y, Nagai R, Okuda N et al (2021) Daprodustat compared with epoetin beta pegol for anemia in Japanese patients not on dialysis: a 52-week randomized open-label phase 3 trial. Am J Nephrol 52(1):26\u201335","journal-title":"Am J Nephrol"},{"issue":"1","key":"3395_CR24","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1093\/ckj\/sfy013","volume":"12","author":"L Holdstock","year":"2019","unstructured":"Holdstock L, Cizman B, Meadowcroft AM, Biswas N, Johnson BM, Jones D et al (2019) Daprodustat for anemia: a 24-week, open-label, randomized controlled trial in participants with chronic kidney disease. Clin Kidney J 12(1):129\u2013138","journal-title":"Clin Kidney J"},{"key":"3395_CR25","doi-asserted-by":"crossref","unstructured":"Fu Z, Geng X, Chi K, Song C, Wu D, Liu C et al (2022) Efficacy and safety of daprodustat vs rhEPO for anemia in patients with chronic kidney disease: a meta-analysis and trial sequential analysis. Front Pharmacol 13","DOI":"10.3389\/fphar.2022.746265"},{"key":"3395_CR26","doi-asserted-by":"crossref","unstructured":"Coyne DW (2011) Hepcidin: clinical utility as a diagnostic tool and therapeutic target. Kidney Int [Internet] 80(3):240\u20134. Available from: http:\/\/www.kidney-international.org\/article\/S0085253815550345\/fulltext. [cited 2022 Apr 27]","DOI":"10.1038\/ki.2011.141"},{"key":"3395_CR27","doi-asserted-by":"publisher","unstructured":"Ikeda-Taniguchi M, Takahashi K, Shishido K, Honda H (2022) Total iron binding capacity is a predictor for muscle loss in maintenance hemodialysis patients. Clin Exp Nephrol [Internet] 26(6):583\u201392. https:\/\/doi.org\/10.1007\/s10157-022-02193-1. [cited 2022 Sep 20]\u00a0","DOI":"10.1007\/s10157-022-02193-1"},{"key":"3395_CR28","doi-asserted-by":"crossref","unstructured":"Stack AG, Mutwali AI, Nguyen HT, Cronin CJ, Casserly LF, Ferguson J (2014) Transferrin saturation ratio and risk of total and cardiovascular mortality in the general population. QJM An Int J Med [Internet] 107(8):623\u201333. Available from: https:\/\/academic.oup.com\/qjmed\/article\/107\/8\/623\/2948338. [cited 2022 Sep 20]","DOI":"10.1093\/qjmed\/hcu045"},{"key":"3395_CR29","doi-asserted-by":"crossref","unstructured":"Kuragano T, Joki N, Hase H, Kitamura K, Murata T, Fujimoto S et al (2020) Low transferrin saturation (TSAT) and high ferritin levels are significant predictors for cerebrovascular and cardiovascular disease and death in maintenance hemodialysis patients. PLoS One [Internet] 15(9). Available from: https:\/\/pubmed.ncbi.nlm.nih.gov\/32877424\/. [cited 2022 Apr 30]","DOI":"10.1371\/journal.pone.0236277"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-022-03395-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00228-022-03395-y\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-022-03395-y.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,10]],"date-time":"2022-11-10T06:03:12Z","timestamp":1668060192000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00228-022-03395-y"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,5]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["3395"],"URL":"https:\/\/doi.org\/10.1007\/s00228-022-03395-y","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,5]]},"assertion":[{"value":"15 August 2022","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"25 September 2022","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"5 October 2022","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"This study was exempt from full ethical approval by an institutional review board as no original data was included. There were no interactions with any human or animal participants across the duration of this study.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"The authors declare no competing interests.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}