{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T09:39:09Z","timestamp":1758706749915,"version":"3.37.3"},"reference-count":13,"publisher":"Springer Science and Business Media LLC","issue":"6","license":[{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"},{"start":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T00:00:00Z","timestamp":1708646400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0"}],"funder":[{"name":"Diakonhjemmet Hospital"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec>\n                <jats:title>Purpose<\/jats:title>\n                <jats:p>Lamotrigine was previously reported to reduce serum concentration of quetiapine. The aim of this study was to investigate whether lamotrigine dose or quetiapine formulation was of importance for the drug interaction.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Methods<\/jats:title>\n                <jats:p>Patients combining lamotrigine with quetiapine (cases) were included retrospectively from a routine therapeutic drug monitoring (TDM) service, as were a control group of patients using quetiapine without any interacting drugs. The case and control groups were divided into groups using immediate release (IR) and extended release (XR) quetiapine. The case group was further split into high-dose (&gt;\u2009200 mg\/day) and low-dose (\u2264\u2009200 mg\/day) lamotrigine users. Quetiapine concentration-to-dose (C\/D) ratio and metabolite-to-parent ratio (MPR) were compared between the control group and dose-separated case groups using ANOVA test and <jats:italic>t<\/jats:italic>-tests.<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Results<\/jats:title>\n                <jats:p>In total, 406 patients were included. The mean C\/D ratio of IR quetiapine was 46% lower in the high-dose lamotrigine group compared with the control group (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), while no interaction effect was present in the low dose lamotrigine group (<jats:italic>P<\/jats:italic>\u2009=\u20090.7). Regardless of lamotrigine dose, there was no difference in quetiapine C\/D ratio for patients using the XR formulation (<jats:italic>P<\/jats:italic>\u2009=\u20090.4). The quetiapine MPR was unaffected regardless of formulation and lamotrigine dose (<jats:italic>P<\/jats:italic>\u2009\u2265\u20090.06).<\/jats:p>\n              <\/jats:sec><jats:sec>\n                <jats:title>Conclusion<\/jats:title>\n                <jats:p>The effect of lamotrigine in reducing quetiapine concentration is only significant for patients using quetiapine IR tablets who are treated with lamotrigine doses\u2009&gt;\u2009200 mg\/day. Because of high variability in the interaction effect, TDM of quetiapine should be recommended during co-prescription of high-dose lamotrigine.<\/jats:p>\n              <\/jats:sec>","DOI":"10.1007\/s00228-024-03655-z","type":"journal-article","created":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T17:03:02Z","timestamp":1708707782000},"page":"839-845","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Dose-dependent effect of lamotrigine on quetiapine serum concentration in patients using instant release tablets"],"prefix":"10.1007","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7300-5329","authenticated-orcid":false,"given":"Kristine","family":"Hole","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silje K","family":"Lorentsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karoline L","family":"Nordby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Slettvik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ida TG","family":"S\u00f8rum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6190-2751","authenticated-orcid":false,"given":"Espen","family":"Molden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3888-5919","authenticated-orcid":false,"given":"Tore","family":"Haslemo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,2,23]]},"reference":[{"issue":"14","key":"3655_CR1","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.1001\/jama.2023.18588","volume":"330","author":"AA Nierenberg","year":"2023","unstructured":"Nierenberg AA et al (2023) Diagnosis and treatment of bipolar disorder: a review. 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Since the study was based on existing data retrospectively retrieved from a routine TDM service, ethical approval was granted without the requirement of patient consent.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics and consent to participate"}},{"value":"The authors declare no competing interests.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}