{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T08:38:25Z","timestamp":1787647105954,"version":"build-2736575974"},"reference-count":30,"publisher":"Springer Science and Business Media LLC","issue":"10","license":[{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T00:00:00Z","timestamp":1718928000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"name":"Hebei Key Project Plan for Medical Science Research","award":["No. 20150887"],"award-info":[{"award-number":["No. 20150887"]}]},{"name":"Hebei Key Project Plan for Medical Science Research","award":["No. 20150887"],"award-info":[{"award-number":["No. 20150887"]}]},{"name":"Hebei Key Project Plan for Medical Science Research","award":["No. 20150887"],"award-info":[{"award-number":["No. 20150887"]}]},{"name":"Hebei Key Project Plan for Medical Science Research","award":["No. 20150887"],"award-info":[{"award-number":["No. 20150887"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1007\/s00228-024-03712-7","type":"journal-article","created":{"date-parts":[[2024,6,21]],"date-time":"2024-06-21T12:01:51Z","timestamp":1718971311000},"page":"1495-1501","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Effect of low-molecular-weight heparin calcium combined with magnesium sulfate and labetalol on coagulation, vascular endothelial function and pregnancy outcome in early-onset severe preeclampsia"],"prefix":"10.1007","volume":"80","author":[{"given":"Yang","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hao","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Du","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2024,6,21]]},"reference":[{"key":"3712_CR1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.780043","volume":"12","author":"M Broekhuizen","year":"2021","unstructured":"Broekhuizen M et al (2021) The placental innate immune system is altered in early-onset preeclampsia, but not in late-onset preeclampsia. Front Immunol 12:780043","journal-title":"Front Immunol"},{"issue":"9761","key":"3712_CR2","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1016\/S0140-6736(10)61351-7","volume":"377","author":"P von Dadelszen","year":"2011","unstructured":"von Dadelszen P et al (2011) Prediction of adverse maternal outcomes in pre-eclampsia: development and validation of the fullPIERS model. Lancet 377(9761):219\u2013227","journal-title":"Lancet"},{"key":"3712_CR3","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i1753","volume":"353","author":"E Bartsch","year":"2016","unstructured":"Bartsch E et al (2016) Clinical risk factors for pre-eclampsia determined in early pregnancy: systematic review and meta-analysis of large cohort studies. BMJ 353:i1753","journal-title":"BMJ"},{"key":"3712_CR4","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1016\/j.ejogrb.2021.06.006","volume":"263","author":"R Zemet","year":"2021","unstructured":"Zemet R et al (2021) Early-onset preeclampsia - the impact of antiphospholipid antibodies on disease severity. Eur J Obstet Gynecol Reprod Biol 263:79\u201384","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"issue":"Suppl 1","key":"3712_CR5","first-page":"1","volume":"145","author":"LC Poon","year":"2019","unstructured":"Poon LC et al (2019) The International Federation of Gynecology and Obstetrics (FIGO) initiative on pre-eclampsia: a pragmatic guide for first-trimester screening and prevention. Int J Gynaecol 145(Suppl 1):1\u201333","journal-title":"Int J Gynaecol"},{"issue":"16","key":"3712_CR6","doi-asserted-by":"publisher","first-page":"3182","DOI":"10.1080\/14767058.2020.1814249","volume":"35","author":"P Vigil-De Gracia","year":"2022","unstructured":"Vigil-De Gracia P, Ludmir J (2022) Conservative management of early-onset severe preeclampsia: comparison between randomized and observational studies a systematic review. J Matern Fetal Neonatal Med 35(16):3182\u20133189","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"1","key":"3712_CR7","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1080\/01443615.2019.1706160","volume":"41","author":"Y Sato","year":"2021","unstructured":"Sato Y et al (2021) Factors contributing to favourable neonatal outcomes in early-onset severe preeclampsia. J Obstet Gynaecol 41(1):60\u201365","journal-title":"J Obstet Gynaecol"},{"issue":"12","key":"3712_CR8","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0113715","volume":"9","author":"TE Gillon","year":"2014","unstructured":"Gillon TE et al (2014) Hypertensive disorders of pregnancy: a systematic review of international clinical practice guidelines. PLoS ONE 9(12):e113715","journal-title":"PLoS ONE"},{"key":"3712_CR9","first-page":"CD000025","volume":"11","author":"L Duley","year":"2010","unstructured":"Duley L et al (2010) (2010) Magnesium sulphate and other anticonvulsants for women with pre-eclampsia. Cochrane Database Syst Rev 11:CD000025","journal-title":"Cochrane Database Syst Rev"},{"issue":"1","key":"3712_CR10","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.ogc.2022.10.003","volume":"50","author":"KF Brookfield","year":"2023","unstructured":"Brookfield KF, Mbata O (2023) Magnesium sulfate use in pregnancy for preeclampsia prophylaxis and fetal neuroprotection: regimens in high-income and low\/middle-income countries. Obstet Gynecol Clin North Am 50(1):89\u201399","journal-title":"Obstet Gynecol Clin North Am"},{"issue":"10","key":"3712_CR11","doi-asserted-by":"publisher","first-page":"795","DOI":"10.1055\/s-0032-1316440","volume":"29","author":"M Abbassi-Ghanavati","year":"2012","unstructured":"Abbassi-Ghanavati M et al (2012) Neonatal effects of magnesium sulfate given to the mother. Am J Perinatol 29(10):795\u2013799","journal-title":"Am J Perinatol"},{"key":"3712_CR12","first-page":"CD001449","volume":"3","author":"L Duley","year":"2006","unstructured":"Duley L, Henderson-Smart DJ, Meher S (2006) Drugs for treatment of very high blood pressure during pregnancy. Cochrane Database Syst Rev 3:CD001449","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"3712_CR13","doi-asserted-by":"publisher","first-page":"185","DOI":"10.1081\/PRG-120015845","volume":"21","author":"MA Belfort","year":"2002","unstructured":"Belfort MA et al (2002) Labetalol decreases cerebral perfusion pressure without negatively affecting cerebral blood flow in hypertensive gravidas. Hypertens Pregnancy 21(3):185\u2013197","journal-title":"Hypertens Pregnancy"},{"issue":"2","key":"3712_CR14","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1097\/01.AOG.0000128902.84876.d4","volume":"104","author":"S Quenby","year":"2004","unstructured":"Quenby S et al (2004) Effects of low-molecular-weight and unfractionated heparin on trophoblast function. Obstet Gynecol 104(2):354\u2013361","journal-title":"Obstet Gynecol"},{"issue":"1","key":"3712_CR15","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/j.ajog.2004.09.029","volume":"192","author":"Bose","year":"2005","unstructured":"Bose et al (2005) Heparin and aspirin attenuate placental apoptosis in vitro: implications for early pregnancy failure. Am J Obstet Gynecol 192(1):23\u201330","journal-title":"Am J Obstet Gynecol"},{"issue":"2","key":"3712_CR16","doi-asserted-by":"publisher","first-page":"154","DOI":"10.1097\/MOP.0b013e3283504da1","volume":"24","author":"LW Doyle","year":"2012","unstructured":"Doyle LW (2012) Antenatal magnesium sulfate and neuroprotection. Curr Opin Pediatr 24(2):154\u2013159","journal-title":"Curr Opin Pediatr"},{"issue":"4","key":"3712_CR17","first-page":"3120","volume":"13","author":"Q Zhang","year":"2021","unstructured":"Zhang Q, Tang X, Shen J (2021) The efficacy and safety of low-molecular-weight heparin calcium combined with Xueshuantong injections in the treatment of elderly acute deep venous thrombosis patients. Am J Transl Res 13(4):3120\u20133128","journal-title":"Am J Transl Res"},{"issue":"1","key":"3712_CR18","doi-asserted-by":"publisher","first-page":"822","DOI":"10.1186\/s13104-019-4865-0","volume":"12","author":"S Ngwenya","year":"2019","unstructured":"Ngwenya S et al (2019) Early onset severe preeclampsia and eclampsia in a low-resource setting, Mpilo Central Hospital, Bulawayo, Zimbabwe. BMC Res Notes 12(1):822","journal-title":"BMC Res Notes"},{"issue":"1","key":"3712_CR19","first-page":"87","volume":"75","author":"G Rocha","year":"2023","unstructured":"Rocha G (2023) Consequences of early-onset preeclampsia on neonatal morbidity and mortality. Minerva Pediatr (Torino) 75(1):87\u201397","journal-title":"Minerva Pediatr (Torino)"},{"issue":"4","key":"3712_CR20","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1016\/j.nwh.2016.07.003","volume":"20","author":"C Phillips","year":"2016","unstructured":"Phillips C, Boyd M (2016) Assessment, management, and health implications of early-onset preeclampsia. Nurs Womens Health 20(4):400\u2013414","journal-title":"Nurs Womens Health"},{"issue":"3","key":"3712_CR21","doi-asserted-by":"publisher","first-page":"671","DOI":"10.1161\/HYPERTENSIONAHA.118.12389","volume":"73","author":"K Kawasaki","year":"2019","unstructured":"Kawasaki K et al (2019) Metabolomic profiles of placenta in preeclampsia. Hypertension 73(3):671\u2013679","journal-title":"Hypertension"},{"key":"3712_CR22","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1186\/1471-2393-13-195","volume":"13","author":"ES Bain","year":"2013","unstructured":"Bain ES, Middleton F, Crowther CA (2013) Maternal adverse effects of different antenatal magnesium sulphate regimens for improving maternal and infant outcomes: a systematic review. BMC Pregnancy Childbirth 13:195","journal-title":"BMC Pregnancy Childbirth"},{"issue":"10","key":"3712_CR23","doi-asserted-by":"publisher","first-page":"655","DOI":"10.1097\/01.ogx.0000238670.29492.84","volume":"61","author":"MA Belfort","year":"2006","unstructured":"Belfort MA, Clark SL, Sibai B (2006) Cerebral hemodynamics in preeclampsia: cerebral perfusion and the rationale for an alternative to magnesium sulfate. Obstet Gynecol Surv 61(10):655\u2013665","journal-title":"Obstet Gynecol Surv"},{"issue":"4","key":"3712_CR24","doi-asserted-by":"publisher","first-page":"951","DOI":"10.1007\/s10877-023-01006-4","volume":"37","author":"SMS Mowafy","year":"2023","unstructured":"Mowafy SMS, Medhat MM (2023) Evaluation of intravenous infusion of labetalol versus magnesium sulfate on cerebral hemodynamics of preeclampsia patients with severe features using transcranial doppler. J Clin Monit Comput 37(4):951\u2013961","journal-title":"J Clin Monit Comput"},{"issue":"5","key":"3712_CR25","doi-asserted-by":"publisher","first-page":"535","DOI":"10.1016\/j.ajog.2022.10.014","volume":"228","author":"YH Liu","year":"2023","unstructured":"Liu YH et al (2023) Comparative effectiveness of prophylactic strategies for preeclampsia: a network meta-analysis of randomized controlled trials. Am J Obstet Gynecol 228(5):535\u2013546","journal-title":"Am J Obstet Gynecol"},{"issue":"6","key":"3712_CR26","doi-asserted-by":"publisher","first-page":"431","DOI":"10.1097\/MBC.0000000000000611","volume":"28","author":"GMT Chang","year":"2017","unstructured":"Chang GMT et al (2017) Inhibition of plasmin generation in plasma by heparin, low molecular weight heparin, and a covalent antithrombin-heparin complex. Blood Coagul Fibrinolysis 28(6):431\u2013437","journal-title":"Blood Coagul Fibrinolysis"},{"issue":"8","key":"3712_CR27","first-page":"CD006681","volume":"8","author":"AA Zee","year":"2017","unstructured":"Zee AA et al (2017) Low molecular weight heparin for prevention of venous thromboembolism in patients with lower-limb immobilization. Cochrane Database Syst Rev 8(8):CD006681","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"3712_CR28","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1111\/j.1479-828X.1995.tb02141.x","volume":"35","author":"RA North","year":"1995","unstructured":"North RA et al (1995) Prevention of preeclampsia with heparin and antiplatelet drugs in women with renal disease. Aust N Z J Obstet Gynaecol 35(4):357\u2013362","journal-title":"Aust N Z J Obstet Gynaecol"},{"issue":"1","key":"3712_CR29","doi-asserted-by":"publisher","first-page":"86","DOI":"10.1161\/01.HYP.0000149950.05182.a3","volume":"45","author":"G Mello","year":"2005","unstructured":"Mello G et al (2005) Low-molecular-weight heparin lowers the recurrence rate of preeclampsia and restores the physiological vascular changes in angiotensin-converting enzyme DD women. Hypertension 45(1):86\u201391","journal-title":"Hypertension"},{"issue":"1","key":"3712_CR30","doi-asserted-by":"publisher","first-page":"35","DOI":"10.3109\/10641950109152640","volume":"20","author":"MJ Kupferminc","year":"2001","unstructured":"Kupferminc MJ et al (2001) Low-molecular-weight heparin for the prevention of obstetric complications in women with thrombophilias. Hypertens Pregnancy 20(1):35\u201344","journal-title":"Hypertens Pregnancy"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-024-03712-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00228-024-03712-7\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-024-03712-7.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T06:08:36Z","timestamp":1726121316000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00228-024-03712-7"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,21]]},"references-count":30,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2024,10]]}},"alternative-id":["3712"],"URL":"https:\/\/doi.org\/10.1007\/s00228-024-03712-7","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,21]]},"assertion":[{"value":"15 March 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"11 June 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"21 June 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}