{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:55:57Z","timestamp":1777877757245,"version":"3.51.4"},"reference-count":34,"publisher":"Springer Science and Business Media LLC","issue":"12","license":[{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T00:00:00Z","timestamp":1726099200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1007\/s00228-024-03748-9","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T13:06:04Z","timestamp":1726146364000},"page":"1883-1892","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Preventive effects of first-generation antihistamine on emergence agitation or delirium: a systematic review"],"prefix":"10.1007","volume":"80","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9869-1177","authenticated-orcid":false,"given":"Kazumasa","family":"Kotake","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8944-2937","authenticated-orcid":false,"given":"Satoru","family":"Matsunuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3023-2411","authenticated-orcid":false,"given":"Naoya","family":"Kitamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yumi","family":"Noritake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuhiro","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"297","published-online":{"date-parts":[[2024,9,12]]},"reference":[{"key":"3748_CR1","doi-asserted-by":"publisher","first-page":"442","DOI":"10.1046\/j.1460-9592.2002.00868.x","volume":"12","author":"JW Cole","year":"2002","unstructured":"Cole JW, Murray DJ, McAllister JD, Hirshberg GE (2002) Emergence behaviour in children: defining the incidence of excitement and agitation following anaesthesia. Paediatr Anaesth 12:442\u2013447. https:\/\/doi.org\/10.1046\/j.1460-9592.2002.00868.x","journal-title":"Paediatr Anaesth"},{"key":"3748_CR2","first-page":"77","volume":"12","author":"A Takeuchi","year":"2011","unstructured":"Takeuchi A, Ahern TL, Henderson SO (2011) Excited delirium. West J Emerg Med 12:77\u201383","journal-title":"West J Emerg Med"},{"key":"3748_CR3","doi-asserted-by":"publisher","first-page":"719","DOI":"10.1111\/aas.13774","volume":"65","author":"B Wei","year":"2021","unstructured":"Wei B, Feng Y, Chen W et al (2021) Risk factors for emergence agitation in adults after general anesthesia: a systematic review and meta-analysis. Acta Anaesthesiol Scand 65:719\u2013729. https:\/\/doi.org\/10.1111\/aas.13774","journal-title":"Acta Anaesthesiol Scand"},{"key":"3748_CR4","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1093\/bja\/ael094","volume":"96","author":"C Lepous\u00e9","year":"2006","unstructured":"Lepous\u00e9 C, Lautner CA, Liu L et al (2006) Emergence delirium in adults in the post-anaesthesia care unit. Br J Anaesth 96:747\u2013753. https:\/\/doi.org\/10.1093\/bja\/ael094","journal-title":"Br J Anaesth"},{"key":"3748_CR5","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1007\/s00540-016-2212-3","volume":"30","author":"X Mei","year":"2016","unstructured":"Mei X, Tong J (2016) The plasma levels of brain-derived neurotrophic factor are positively associated with emergence agitation in the elderly after gastrointestinal surgery. J Anesth 30:811\u2013816. https:\/\/doi.org\/10.1007\/s00540-016-2212-3","journal-title":"J Anesth"},{"key":"3748_CR6","doi-asserted-by":"publisher","first-page":"843","DOI":"10.1007\/s12630-010-9338-9","volume":"57","author":"D Yu","year":"2010","unstructured":"Yu D, Chai W, Sun X, Yao L (2010) Emergence agitation in adults: risk factors in 2,000 patients. Can J Anaesth 57:843\u2013848. https:\/\/doi.org\/10.1007\/s12630-010-9338-9","journal-title":"Can J Anaesth"},{"key":"3748_CR7","doi-asserted-by":"publisher","first-page":"61","DOI":"10.4103\/sja.SJA_419_17","volume":"12","author":"P Kurhekar","year":"2018","unstructured":"Kurhekar P, Vinod K, Rajarathinam B et al (2018) Randomized comparison between dexmedetomidine and midazolam for prevention of emergence agitation after nasal surgeries. Saudi J Anaesth 12:61\u201366. https:\/\/doi.org\/10.4103\/sja.SJA_419_17","journal-title":"Saudi J Anaesth"},{"key":"3748_CR8","doi-asserted-by":"publisher","first-page":"2203","DOI":"10.1056\/NEJMra033121","volume":"351","author":"FER Simons","year":"2004","unstructured":"Simons FER (2004) Advances in H1-antihistamines. N Engl J Med 351:2203\u20132217. https:\/\/doi.org\/10.1056\/NEJMra033121","journal-title":"N Engl J Med"},{"key":"3748_CR9","doi-asserted-by":"publisher","first-page":"S22","DOI":"10.1097\/WOX.0b013e3181f385d9","volume":"4","author":"DS Church","year":"2011","unstructured":"Church DS, Church MK (2011) Pharmacology of antihistamines. World Allergy Organ J 4:S22\u2013S27. https:\/\/doi.org\/10.1097\/WOX.0b013e3181f385d9","journal-title":"World Allergy Organ J"},{"key":"3748_CR10","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1111\/j.1398-9995.2009.02325.x","volume":"65","author":"MK Church","year":"2010","unstructured":"Church MK, Maurer M, Simons FER et al (2010) Risk of first-generation H(1)-antihistamines: a GA(2)LEN position paper. Allergy 65:459\u2013466. https:\/\/doi.org\/10.1111\/j.1398-9995.2009.02325.x","journal-title":"Allergy"},{"key":"3748_CR11","doi-asserted-by":"publisher","first-page":"2091","DOI":"10.1001\/archinte.161.17.2091","volume":"161","author":"JV Agostini","year":"2001","unstructured":"Agostini JV, Leo-Summers LS, Inouye SK (2001) Cognitive and other adverse effects of diphenhydramine use in hospitalized older patients. Arch Intern Med 161:2091\u20132097. https:\/\/doi.org\/10.1001\/archinte.161.17.2091","journal-title":"Arch Intern Med"},{"key":"3748_CR12","doi-asserted-by":"publisher","first-page":"n71","DOI":"10.1136\/bmj.n71","volume":"372","author":"MJ Page","year":"2021","unstructured":"Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 372:n71. https:\/\/doi.org\/10.1136\/bmj.n71","journal-title":"BMJ"},{"key":"3748_CR13","doi-asserted-by":"publisher","first-page":"145","DOI":"10.1186\/1939-4551-1-9-145","volume":"1","author":"FER Simons","year":"2008","unstructured":"Simons FER, Simons KJ (2008) H1 antihistamines: current status and future directions. World Allergy Organ J 1:145\u2013155. https:\/\/doi.org\/10.1186\/1939-4551-1-9-145","journal-title":"World Allergy Organ J"},{"key":"3748_CR14","doi-asserted-by":"publisher","unstructured":"Bowman EML, Sweeney AM, McAuley DF et al (2024) Assessment and report of individual symptoms in studies of delirium in postoperative populations: a systematic review. Age Ageing 53. https:\/\/doi.org\/10.1093\/ageing\/afae077","DOI":"10.1093\/ageing\/afae077"},{"key":"3748_CR15","doi-asserted-by":"publisher","first-page":"941","DOI":"10.7326\/0003-4819-113-12-941","volume":"113","author":"SK Inouye","year":"1990","unstructured":"Inouye SK, van Dyck CH, Alessi CA et al (1990) Clarifying confusion: the confusion assessment method. A new method for detection of delirium. Ann Intern Med 113:941\u2013948. https:\/\/doi.org\/10.7326\/0003-4819-113-12-941","journal-title":"Ann Intern Med"},{"key":"3748_CR16","doi-asserted-by":"publisher","first-page":"464","DOI":"10.1186\/s12912-024-02121-6","volume":"23","author":"C Huang","year":"2024","unstructured":"Huang C, Wu B, Chen H et al (2024) Delirium in psychiatric settings: risk factors and assessment tools in patients with psychiatric illness: a scoping review. BMC Nurs 23:464. https:\/\/doi.org\/10.1186\/s12912-024-02121-6","journal-title":"BMC Nurs"},{"key":"3748_CR17","doi-asserted-by":"publisher","first-page":"526","DOI":"10.7326\/M13-1927","volume":"160","author":"SK Inouye","year":"2014","unstructured":"Inouye SK, Kosar CM, Tommet D et al (2014) The CAM-S: development and validation of a new scoring system for delirium severity in 2 cohorts. Ann Intern Med 160:526\u2013533. https:\/\/doi.org\/10.7326\/M13-1927","journal-title":"Ann Intern Med"},{"key":"3748_CR18","doi-asserted-by":"publisher","first-page":"R115","DOI":"10.1186\/cc11407","volume":"16","author":"D Gusmao-Flores","year":"2012","unstructured":"Gusmao-Flores D, Salluh JIF, Chalhub R\u00c1, Quarantini LC (2012) The confusion assessment method for the intensive care unit (CAM-ICU) and intensive care delirium screening checklist (ICDSC) for the diagnosis of delirium: a systematic review and meta-analysis of clinical studies. Crit Care 16:R115. https:\/\/doi.org\/10.1186\/cc11407","journal-title":"Crit Care"},{"key":"3748_CR19","doi-asserted-by":"publisher","first-page":"l4898","DOI":"10.1136\/bmj.l4898","volume":"366","author":"JAC Sterne","year":"2019","unstructured":"Sterne JAC, Savovi\u0107 J, Page MJ et al (2019) RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 366:l4898","journal-title":"BMJ"},{"key":"3748_CR20","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1186\/s42077-020-00074-x","volume":"12","author":"TN Abdelrahman","year":"2020","unstructured":"Abdelrahman TN, Kasem AA (2020) Role of preemptive chlorpheniramine maleate in reducing postoperative agitation after functional endoscopic sinus surgeries (FESS). Ain-Shams J Anesthesiology 12:26. https:\/\/doi.org\/10.1186\/s42077-020-00074-x","journal-title":"Ain-Shams J Anesthesiology"},{"key":"3748_CR21","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1016\/j.jclinane.2016.03.046","volume":"34","author":"GS De Oliveira Jr","year":"2016","unstructured":"De Oliveira GS Jr, Bialek J, Marcus R-J, McCarthy R (2016) Dose-ranging effect of systemic diphenhydramine on postoperative quality of recovery after ambulatory laparoscopic surgery: a randomized, placebo-controlled, double-blinded, clinical trial. J Clin Anesth 34:46\u201352. https:\/\/doi.org\/10.1016\/j.jclinane.2016.03.046","journal-title":"J Clin Anesth"},{"key":"3748_CR22","doi-asserted-by":"publisher","first-page":"829","DOI":"10.1007\/s12630-009-9175-x","volume":"56","author":"TJ Gan","year":"2009","unstructured":"Gan TJ, Candiotti KA, Klein SM et al (2009) Double-blind comparison of granisetron, promethazine, or a combination of both for the prevention of postoperative nausea and vomiting in females undergoing outpatient laparoscopies. Can J Anaesth 56:829\u2013836. https:\/\/doi.org\/10.1007\/s12630-009-9175-x","journal-title":"Can J Anaesth"},{"key":"3748_CR23","doi-asserted-by":"publisher","first-page":"1467","DOI":"10.1007\/s00405-021-06904-4","volume":"279","author":"MR Khajavi","year":"2022","unstructured":"Khajavi MR, Saffarian A, Majidi F et al (2022) Prophylactic administration of diphenhydramine\/paracetamol reduced emergence agitation and postoperative pain following maxillofacial surgeries: a randomized controlled trial. Eur Arch Otorhinolaryngol 279:1467\u20131471. https:\/\/doi.org\/10.1007\/s00405-021-06904-4","journal-title":"Eur Arch Otorhinolaryngol"},{"key":"3748_CR24","doi-asserted-by":"publisher","first-page":"596","DOI":"10.1016\/s0952-8180(99)00103-8","volume":"11","author":"S Khalil","year":"1999","unstructured":"Khalil S, Philbrook L, Rabb M et al (1999) Ondansetron\/promethazine combination or promethazine alone reduces nausea and vomiting after middle ear surgery. J Clin Anesth 11:596\u2013600. https:\/\/doi.org\/10.1016\/s0952-8180(99)00103-8","journal-title":"J Clin Anesth"},{"key":"3748_CR25","first-page":"800","volume":"33","author":"M Mansoori","year":"2015","unstructured":"Mansoori M, Boroumand AB (2015) The Effect of Zolpidem or Promethazine Premedication on Agitation, Sedation and Cognitive disorders before and after coronary artery bypass graft surgery. J Isfahan Med School 33:800\u2013812","journal-title":"J Isfahan Med School"},{"key":"3748_CR26","doi-asserted-by":"publisher","first-page":"180","DOI":"10.1177\/1060028015624938","volume":"50","author":"M Mohammadi","year":"2016","unstructured":"Mohammadi M, Ahmadi M, Khalili H et al (2016) Cyproheptadine for the Prevention of Postoperative Delirium: a pilot study. Ann Pharmacother 50:180\u2013187. https:\/\/doi.org\/10.1177\/1060028015624938","journal-title":"Ann Pharmacother"},{"key":"3748_CR27","doi-asserted-by":"publisher","first-page":"4371","DOI":"10.1007\/s11695-021-05589-2","volume":"31","author":"P Pourfakhr","year":"2021","unstructured":"Pourfakhr P, Aghabagheri M, Zabihi Mahmoudabadi H et al (2021) Prophylactic Administration of Diphenhydramine\/Acetaminophen and Ondansetron Reduced Postoperative Nausea and vomiting and Pain following laparoscopic sleeve gastrectomy: a Randomized Controlled Trial. Obes Surg 31:4371\u20134375. https:\/\/doi.org\/10.1007\/s11695-021-05589-2","journal-title":"Obes Surg"},{"key":"3748_CR28","doi-asserted-by":"publisher","first-page":"e936367","DOI":"10.12659\/MSM.936367","volume":"28","author":"L Tian","year":"2022","unstructured":"Tian L, Liu Y, Fei Y et al (2022) Effect of Clemastine Fumarate on Perioperative hemodynamic instability mediated by Anaphylaxis during cardiopulmonary bypass surgery. Med Sci Monit 28:e936367. https:\/\/doi.org\/10.12659\/MSM.936367","journal-title":"Med Sci Monit"},{"key":"3748_CR29","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1093\/bjaceaccp\/mks046","volume":"13","author":"S Pierre","year":"2013","unstructured":"Pierre S, Whelan R (2013) Nausea and vomiting after surgery. Contin Educ Anaesth Crit Care Pain 13:28\u201332. https:\/\/doi.org\/10.1093\/bjaceaccp\/mks046","journal-title":"Contin Educ Anaesth Crit Care Pain"},{"key":"3748_CR30","doi-asserted-by":"publisher","first-page":"137","DOI":"10.2174\/2772432817666220601162006","volume":"19","author":"SAA Rizvi","year":"2024","unstructured":"Rizvi SAA, Ferrer G, Khawaja UA, Sanchez-Gonzalez MA (2024) Chlorpheniramine, an Old drug with new potential clinical applications: a Comprehensive Review of the literature. Curr Rev Clin Exp Pharmacol 19:137\u2013145. https:\/\/doi.org\/10.2174\/2772432817666220601162006","journal-title":"Curr Rev Clin Exp Pharmacol"},{"key":"3748_CR31","doi-asserted-by":"publisher","first-page":"S835","DOI":"10.1067\/mai.2003.1550","volume":"111","author":"TB Casale","year":"2003","unstructured":"Casale TB, Blaiss MS, Gelfand E et al (2003) First do no harm: managing antihistamine impairment in patients with allergic rhinitis. J Allergy Clin Immunol 111:S835\u2013S842. https:\/\/doi.org\/10.1067\/mai.2003.1550","journal-title":"J Allergy Clin Immunol"},{"key":"3748_CR32","doi-asserted-by":"publisher","first-page":"751","DOI":"10.1517\/14740338.2011.579899","volume":"10","author":"P Gerretsen","year":"2011","unstructured":"Gerretsen P, Pollock BG (2011) Drugs with anticholinergic properties: a current perspective on use and safety. Expert Opin Drug Saf 10:751\u2013765. https:\/\/doi.org\/10.1517\/14740338.2011.579899","journal-title":"Expert Opin Drug Saf"},{"key":"3748_CR33","doi-asserted-by":"publisher","first-page":"164","DOI":"10.1016\/j.neuron.2015.06.003","volume":"87","author":"X Yu","year":"2015","unstructured":"Yu X, Ye Z, Houston CM et al (2015) Wakefulness is governed by GABA and histamine cotransmission. Neuron 87:164\u2013178. https:\/\/doi.org\/10.1016\/j.neuron.2015.06.003","journal-title":"Neuron"},{"key":"3748_CR34","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1016\/j.anai.2023.07.019","volume":"131","author":"S Linton","year":"2023","unstructured":"Linton S, Hossenbaccus L, Ellis AK (2023) Evidence-based use of antihistamines for treatment of allergic conditions. Ann Allergy Asthma Immunol 131:412\u2013420. https:\/\/doi.org\/10.1016\/j.anai.2023.07.019","journal-title":"Ann Allergy Asthma Immunol"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-024-03748-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00228-024-03748-9\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-024-03748-9.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,12]],"date-time":"2024-11-12T18:03:00Z","timestamp":1731434580000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00228-024-03748-9"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,12]]},"references-count":34,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["3748"],"URL":"https:\/\/doi.org\/10.1007\/s00228-024-03748-9","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,12]]},"assertion":[{"value":"14 April 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"26 August 2024","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"12 September 2024","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"The authors declare no competing interests.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Competing interests"}}]}}