{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T22:09:23Z","timestamp":1788905363574,"version":"build-2803163510"},"reference-count":25,"publisher":"Springer Science and Business Media LLC","issue":"7","license":[{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"},{"start":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T00:00:00Z","timestamp":1745884800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.springernature.com\/gp\/researchers\/text-and-data-mining"}],"funder":[{"DOI":"10.13039\/501100012476","name":"Fundamental Research Funds for Central Universities of the Central South University","doi-asserted-by":"publisher","award":["2024ZZTS0287"],"award-info":[{"award-number":["2024ZZTS0287"]}],"id":[{"id":"10.13039\/501100012476","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Hunan Department of Science and Technology Foundation","award":["2023JJ30889"],"award-info":[{"award-number":["2023JJ30889"]}]}],"content-domain":{"domain":["link.springer.com"],"crossmark-restriction":false},"short-container-title":["Eur J Clin Pharmacol"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1007\/s00228-025-03842-6","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T02:08:20Z","timestamp":1745892500000},"page":"1055-1067","update-policy":"https:\/\/doi.org\/10.1007\/springer_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Establishment of a visualization platform for ADR query and analysis: an example of severe skin adverse reactions caused by sulfonylureas"],"prefix":"10.1007","volume":"81","author":[{"given":"Hui-Min","family":"Yu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya-Min","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hang-Xing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-Yang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-qiong","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"297","published-online":{"date-parts":[[2025,4,29]]},"reference":[{"key":"3842_CR1","doi-asserted-by":"publisher","first-page":"c1694","DOI":"10.1136\/bmj.c1694","volume":"340","author":"N Moore","year":"2010","unstructured":"Moore N, B\u00e9gaud B (2010) Improving pharmacovigilance in Europe. BMJ 340:c1694. https:\/\/doi.org\/10.1136\/bmj.c1694","journal-title":"BMJ"},{"issue":"12","key":"3842_CR2","doi-asserted-by":"publisher","first-page":"1991","DOI":"10.1016\/j.clinthera.2018.07.012","volume":"40","author":"P Beninger","year":"2018","unstructured":"Beninger P (2018) Pharmacovigilance: an overview. Clin Ther 40(12):1991\u20132004. https:\/\/doi.org\/10.1016\/j.clinthera.2018.07.012","journal-title":"Clin Ther"},{"issue":"3","key":"3842_CR3","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s40264-013-0018-x","volume":"36","author":"PM Coloma","year":"2013","unstructured":"Coloma PM, Trifir\u00f2 G, Patadia V, Sturkenboom M (2013) Postmarketing safety surveillance: where does signal detection using electronic healthcare records fit into the big picture? Drug Saf 36(3):183\u2013197. https:\/\/doi.org\/10.1007\/s40264-013-0018-x","journal-title":"Drug Saf"},{"key":"3842_CR4","unstructured":"FAERS-U.S (2021) Food and Drug Administration Search Results. In: ed"},{"issue":"12","key":"3842_CR5","doi-asserted-by":"publisher","first-page":"e11447","DOI":"10.2196\/11447","volume":"6","author":"Q Pham","year":"2018","unstructured":"Pham Q, Graham G, Lalloo C, Morita PP, Seto E, Stinson JN, Cafazzo JA (2018) An analytics platform to evaluate effective engagement with pediatric mobile health apps: design, development, and formative evaluation. JMIR Mhealth Uhealth 6(12):e11447. https:\/\/doi.org\/10.2196\/11447","journal-title":"JMIR Mhealth Uhealth"},{"issue":"6","key":"3842_CR6","doi-asserted-by":"publisher","first-page":"1010","DOI":"10.1038\/clpt.2012.50","volume":"91","author":"R Harpaz","year":"2012","unstructured":"Harpaz R, DuMouchel W, Shah NH, Madigan D, Ryan P, Friedman C (2012) Novel data-mining methodologies for adverse drug event discovery and analysis. Clin Pharmacol Ther 91(6):1010\u20131021. https:\/\/doi.org\/10.1038\/clpt.2012.50","journal-title":"Clin Pharmacol Ther"},{"issue":"21","key":"3842_CR7","doi-asserted-by":"publisher","first-page":"4515","DOI":"10.1093\/bioinformatics\/btz409","volume":"35","author":"BS Glicksberg","year":"2019","unstructured":"Glicksberg BS, Oskotsky B, Thangaraj PM, Giangreco N, Badgeley MA, Johnson KW, Datta D, Rudrapatna VA, Rappoport N, Shervey MM, Miotto R, Goldstein TC, Rutenberg E, Frazier R, Lee N, Israni S, Larsen R, Percha B, Li L, Dudley JT, Tatonetti NP, Butte AJ (2019) PatientExploreR: an extensible application for dynamic visualization of patient clinical history from electronic health records in the OMOP common data model. Bioinformatics 35(21):4515\u20134518. https:\/\/doi.org\/10.1093\/bioinformatics\/btz409","journal-title":"Bioinformatics"},{"issue":"4","key":"3842_CR8","first-page":"257","volume":"35","author":"K Ramos","year":"2003","unstructured":"Ramos K, Linscheid R, Schafer S (2003) Real-time information-seeking behavior of residency physicians. Fam Med 35(4):257\u2013260","journal-title":"Fam Med"},{"key":"3842_CR9","doi-asserted-by":"publisher","unstructured":"B\u00f6hm R, von Hehn L, Herdegen T, Klein HJ, Bruhn O, Petri H, H\u00f6cker J (2016) OpenVigil FDA\u2014inspection of U.S. American adverse drug events pharmacovigilance data and novel clinical applications. PLoS One 11 (6): e0157753 https:\/\/doi.org\/10.1371\/journal.pone.0157753","DOI":"10.1371\/journal.pone.0157753"},{"issue":"11","key":"3842_CR10","doi-asserted-by":"publisher","first-page":"2671","DOI":"10.1007\/s40618-024-02441-z","volume":"47","author":"I Caruso","year":"2024","unstructured":"Caruso I, Di Gioia L, Di Molfetta S, Caporusso M, Cignarelli A, Sorice GP, Laviola L, Giorgino F (2024) The real-world safety profile of tirzepatide: pharmacovigilance analysis of the FDA Adverse Event Reporting System (FAERS) database. J Endocrinol Invest 47(11):2671\u20132678. https:\/\/doi.org\/10.1007\/s40618-024-02441-z","journal-title":"J Endocrinol Invest"},{"issue":"4","key":"3842_CR11","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1080\/14740338.2023.2130888","volume":"22","author":"Y Zhao","year":"2023","unstructured":"Zhao Y, Wang H, Zhang Q, Hu Y, Xu Y, Liu W (2023) Evaluation of adverse events of bamlanivimab, bamlanivimab\/etesevimab used for COVID-19 based on FAERS database. Expert Opin Drug Saf 22(4):331\u2013338. https:\/\/doi.org\/10.1080\/14740338.2023.2130888","journal-title":"Expert Opin Drug Saf"},{"key":"3842_CR12","first-page":"607","volume":"2011","author":"G Jiang","year":"2011","unstructured":"Jiang G, Solbrig HR, Chute CG (2011) ADEpedia: a scalable and standardized knowledge base of adverse drug events using semantic web technology. AMIA Annu Symp Proc 2011:607\u2013616","journal-title":"AMIA Annu Symp Proc"},{"issue":"2","key":"3842_CR13","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.artmed.2011.10.004","volume":"54","author":"C Combi","year":"2012","unstructured":"Combi C, Oliboni B (2012) Visually defining and querying consistent multi-granular clinical temporal abstractions. Artif Intell Med 54(2):75\u2013101. https:\/\/doi.org\/10.1016\/j.artmed.2011.10.004","journal-title":"Artif Intell Med"},{"key":"3842_CR14","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1186\/1472-6947-8-21","volume":"8","author":"JB Lamy","year":"2008","unstructured":"Lamy JB, Venot A, Bar-Hen A, Ouvrard P, Duclos C (2008) Design of a graphical and interactive interface for facilitating access to drug contraindications, cautions for use, interactions and adverse effects. BMC Med Inform Decis Mak 8:21. https:\/\/doi.org\/10.1186\/1472-6947-8-21","journal-title":"BMC Med Inform Decis Mak"},{"issue":"9","key":"3842_CR15","doi-asserted-by":"publisher","first-page":"905","DOI":"10.1007\/s40264-020-00945-0","volume":"43","author":"J Spiker","year":"2020","unstructured":"Spiker J, Kreimeyer K, Dang O, Boxwell D, Chan V, Cheng C, Gish P, Lardieri A, Wu E, De S, Naidoo J, Lehmann H, Rosner GL, Ball R, Botsis T (2020) Information visualization platform for postmarket surveillance decision support. Drug Saf 43(9):905\u2013915. https:\/\/doi.org\/10.1007\/s40264-020-00945-0","journal-title":"Drug Saf"},{"key":"3842_CR16","first-page":"517","volume":"150","author":"F Amardeilh","year":"2009","unstructured":"Amardeilh F, Bousquet C, Guillemin-Lanne S, Wiss-Thebault M, Guillot L, Delamarre D, Lillo-Le Louet A, Burgun A (2009) A knowledge management platform for documentation of case reports in pharmacovigilance. Stud Health Technol Inform 150:517\u2013521","journal-title":"Stud Health Technol Inform"},{"key":"3842_CR17","doi-asserted-by":"publisher","first-page":"118","DOI":"10.1016\/j.maturitas.2020.10.005","volume":"143","author":"T Koufakis","year":"2021","unstructured":"Koufakis T, Grammatiki M, Kotsa K (2021) Type 2 diabetes management in people aged over seventy-five years: targets and treatment strategies. Maturitas 143:118\u2013126. https:\/\/doi.org\/10.1016\/j.maturitas.2020.10.005","journal-title":"Maturitas"},{"issue":"2","key":"3842_CR18","doi-asserted-by":"publisher","first-page":"155","DOI":"10.26574\/maedica.2018.13.2.155","volume":"13","author":"N Dev","year":"2018","unstructured":"Dev N (2018) A rare case of drug reaction with eosinophilia and systemic symptoms (DRESS): glimepiride, the unlikely culprit. Maedica (Bucur) 13(2):155\u2013158. https:\/\/doi.org\/10.26574\/maedica.2018.13.2.155","journal-title":"Maedica (Bucur)"},{"issue":"1","key":"3842_CR19","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1111\/j.1365-2125.2007.02863.x","volume":"64","author":"C Ben Salem","year":"2007","unstructured":"Ben Salem C, Hmouda H, Bouraoui K (2007) Glimepiride-induced vasculitis: a case report. Br J Clin Pharmacol 64(1):113\u2013114. https:\/\/doi.org\/10.1111\/j.1365-2125.2007.02863.x","journal-title":"Br J Clin Pharmacol"},{"issue":"9","key":"3842_CR20","doi-asserted-by":"publisher","first-page":"1078","DOI":"10.1111\/dme.12497","volume":"31","author":"S Bauer","year":"2014","unstructured":"Bauer S, Nauck MA (2014) Polypharmacy in people with Type 1 and Type 2 diabetes is justified by current guidelines\u2013a comprehensive assessment of drug prescriptions in patients needing inpatient treatment for diabetes-associated problems. Diabet Med 31(9):1078\u20131085. https:\/\/doi.org\/10.1111\/dme.12497","journal-title":"Diabet Med"},{"issue":"2","key":"3842_CR21","doi-asserted-by":"publisher","first-page":"323","DOI":"10.1007\/s00592-015-0790-4","volume":"53","author":"M Noale","year":"2016","unstructured":"Noale M, Veronese N, Cavallo Perin P, Pilotto A, Tiengo A, Crepaldi G, Maggi S (2016) Polypharmacy in elderly patients with type 2 diabetes receiving oral antidiabetic treatment. Acta Diabetol 53(2):323\u2013330. https:\/\/doi.org\/10.1007\/s00592-015-0790-4","journal-title":"Acta Diabetol"},{"key":"3842_CR22","doi-asserted-by":"publisher","DOI":"10.1016\/j.diabres.2019.107804","volume":"155","author":"L Al-Musawe","year":"2019","unstructured":"Al-Musawe L, Martins AP, Raposo JF, Torre C (2019) The association between polypharmacy and adverse health consequences in elderly type 2 diabetes mellitus patients: a systematic review and meta-analysis. Diabetes Res Clin Pract 155:107804. https:\/\/doi.org\/10.1016\/j.diabres.2019.107804","journal-title":"Diabetes Res Clin Pract"},{"issue":"12","key":"3842_CR23","doi-asserted-by":"publisher","first-page":"1845","DOI":"10.1517\/14740338.2015.1096342","volume":"14","author":"R Ghosh","year":"2015","unstructured":"Ghosh R, Lewis D (2015) Aims and approaches of Web-RADR: a consortium ensuring reliable ADR reporting via mobile devices and new insights from social media. Expert Opin Drug Saf 14(12):1845\u20131853. https:\/\/doi.org\/10.1517\/14740338.2015.1096342","journal-title":"Expert Opin Drug Saf"},{"key":"3842_CR24","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.jbi.2015.02.006","volume":"55","author":"LW Peute","year":"2015","unstructured":"Peute LW, de Keizer NF, Jaspers MW (2015) The value of retrospective and concurrent think aloud in formative usability testing of a physician data query tool. J Biomed Inform 55:1\u201310. https:\/\/doi.org\/10.1016\/j.jbi.2015.02.006","journal-title":"J Biomed Inform"},{"key":"3842_CR25","doi-asserted-by":"publisher","first-page":"717","DOI":"10.3389\/fphar.2018.00717","volume":"9","author":"T Ledieu","year":"2018","unstructured":"Ledieu T, Bouzill\u00e9 G, Polard E, Plaisant C, Thiessard F, Cuggia M (2018) Clinical data analytics with time-related graphical user interfaces: application to pharmacovigilance. Front Pharmacol 9:717. https:\/\/doi.org\/10.3389\/fphar.2018.00717","journal-title":"Front Pharmacol"}],"container-title":["European Journal of Clinical Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-025-03842-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/article\/10.1007\/s00228-025-03842-6\/fulltext.html","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/link.springer.com\/content\/pdf\/10.1007\/s00228-025-03842-6.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T06:12:44Z","timestamp":1749535964000},"score":1,"resource":{"primary":{"URL":"https:\/\/link.springer.com\/10.1007\/s00228-025-03842-6"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4,29]]},"references-count":25,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["3842"],"URL":"https:\/\/doi.org\/10.1007\/s00228-025-03842-6","relation":{},"ISSN":["0031-6970","1432-1041"],"issn-type":[{"value":"0031-6970","type":"print"},{"value":"1432-1041","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4,29]]},"assertion":[{"value":"12 November 2024","order":1,"name":"received","label":"Received","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"14 April 2025","order":2,"name":"accepted","label":"Accepted","group":{"name":"ArticleHistory","label":"Article History"}},{"value":"29 April 2025","order":3,"name":"first_online","label":"First Online","group":{"name":"ArticleHistory","label":"Article History"}},{"order":1,"name":"Ethics","group":{"name":"EthicsHeading","label":"Declarations"}},{"value":"No requirements about ethical approval to develop the visualization platform.","order":2,"name":"Ethics","group":{"name":"EthicsHeading","label":"Ethics approval"}},{"value":"Not applicable.","order":3,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent to participate"}},{"value":"All authors agreed to submit this version of paper for publication.","order":4,"name":"Ethics","group":{"name":"EthicsHeading","label":"Consent for publication"}},{"value":"The authors declare no competing interests.","order":5,"name":"Ethics","group":{"name":"EthicsHeading","label":"Conflict of interest"}}]}}